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Activation of Su(Hw)-Controlled Genes Is Associated with Increase in GAF Binding

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

The interaction of the GAF protein with the promoters of neuron-specific genes during activation and repression of transcription was studied. We showed that, while the Su(Hw) protein remains stably associated with the promoters of these genes at different transcriptional state, the GAF protein level is significantly higher when transcription is activated.

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ACKNOWLEDGMENTS

This work was carried out using the infrastructure of the Center for Collective Use of the Institute of Gene Biology, Russian Academy of Sciences “Biology of the Living Cell and Drug Biomedical Nanotransporters.”

Funding

This study was supported by the Russian Foundation for Basic Research (project no. 17-54-45098).

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia

    P. V. Elizar’ev, D. A. Chetverina, L. S. Melnikova, A. K. Golovnin,  P. G. Georgiev & M. M. Erokhin

  2. CSIR—Center for Cellular and Molecular Biology (CCMB), Hyderabad, India

    A. Srivastava & R. K. Mishra

Authors
  1. P. V. Elizar’ev
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  2. D. A. Chetverina
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  3. L. S. Melnikova
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  4. A. Srivastava
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  5. R. K. Mishra
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  6. A. K. Golovnin
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  7. P. G. Georgiev
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  8. M. M. Erokhin
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Corresponding author

Correspondence to M. M. Erokhin.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by M. Batrukova

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Elizar’ev, P.V., Chetverina, D.A., Melnikova, L.S. et al. Activation of Su(Hw)-Controlled Genes Is Associated with Increase in GAF Binding. Dokl Biochem Biophys 488, 293–295 (2019). https://doi.org/10.1134/S1607672919050016

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  • DOI: https://doi.org/10.1134/S1607672919050016

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