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Potential clinical utility of a novel optical tomographic imaging for the quantitative assessment of hand rheumatoid arthritis

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Abstract

Optical tomographic imaging (OTI) was reported to be a novel technique for the early diagnosis and disease activity assessment of rheumatoid arthritis (RA). This study aimed to evaluate the clinical utility of OTI for the detection of hand synovitis of RA patients. Manu-scan was used to perform imaging targeting the proximal interphalangeal (PIP) and metacarpophalangeal (MCP) joints in 12 RA patients and three controls. The enrolled RA patients also underwent magnetic resonance imaging (MRI) and bone scintigraphy (BS) to provide reference images. Of the 181 joints feasible for OTI analysis, 140 joints (111 in RA patients and 29 in controls, 77.3%) in which the difference of the OTI indices in the two measurements was within 20% were evaluated. The OTI indices in RA joints were significantly lower than those in control joints (p < 0.001). Overall, the OTI indices in RA joints decreased as the synovitis grades on MRI or BS increased. Moreover, OTI was able to discriminate between RA and control joints (AUC = 0.815, 95% CI 0.739–0.891), even if RA joints were normal on physical examination (AUC = 0.714, 95% CI 0.594–0.834). OTI was in good agreement (kappa = 0.60) with MRI for evaluating synovitis in RA patients and showed positive results in 11.4% of clinically asymptomatic joints. OTI in this study showed the potential to be a supplementary imaging modality for the quantification of synovial inflammation in PIP and MCP joints of RA patients. Further large-scale trials are needed to confirm these findings.

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Funding

The study was supported by LG Electronics and the OTI device (Manu-scan) was also provided by LG Electronics. This research was partly supported by a grant from the Ministry of Science, ICT and Future planning (NRF-2015M3A9B6052011).

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea

    Dong Jin Go

  2. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Medical Research Institute, Seoul National University, Seoul, Korea

    Dong Jin Go, Sang Jin Lee & Yeong Wook Song

  3. Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea

    Sang Jin Lee

  4. Department of Internal Medicine, Bethesda Hospital, Yangsan, Korea

    Sang Hyun Joo

  5. Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea

    Gi Jeong Cheon

  6. Department of Radiology, Seoul National University Hospital, Seoul, Korea

    Sung Hwan Hong

  7. Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Korea

    Yeong Wook Song

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  1. Dong Jin Go
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Correspondence to Yeong Wook Song.

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Go, D.J., Lee, S.J., Joo, S.H. et al. Potential clinical utility of a novel optical tomographic imaging for the quantitative assessment of hand rheumatoid arthritis. Rheumatol Int 39, 2103–2110 (2019). https://doi.org/10.1007/s00296-019-04424-3

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  • DOI: https://doi.org/10.1007/s00296-019-04424-3

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