Abstract
In July of 2013, a pipeline connecting an offshore oil platform to a tanker caused crude oil to spill into the Sea of Rayong off the coast of Thailand. The resulting oil slick, estimated to be between 50 and 190 m3 (336–1200 barrels), washed ashore 1 day later on the island of Samet. We conducted a study to quantify internal dose of polycyclic aromatic hydrocarbons (PAHs) and benzene in 1262 oil spill cleanup workers, and to examine factors related to their dose. Frozen stored urine samples (n = 1343) collected from the workers during the 1 month cleanup period were used to measure the concentration of 1-hydroxypyrene-glucuronide (1-OHPG), cotinine and creatinine. Data from questionnaires and urinary trans,trans-muconic acid (t,t-MA), a benzene metabolite, measured previously as part of a worker health surveillance plan, were linked with the laboratory data. The internal dose of urinary 1-OHPG was highest in individuals who worked during the first 3 days of cleanup work (median 0.97 pmol/ml) and was 66.7% lower (median 0.32 pmol/ml) among individuals who worked in the final week of the study (days 21–28). After adjusting for age, cotinine and creatinine by regression analysis, the decline in urinary 1-OHPG concentration with days of cleanup remained significant (P-trend < 0.001). A decreasing trend by days of cleanup was also observed for detectable urinary t,t-MA percentage (P-trend < 0.001). Rayong oil spill cleanup workers exhibited evidence of elevated levels of PAH and benzene exposure during the early weeks of cleanup, compared to near background levels 4 weeks after cleanup began. Long-term health monitoring of oil spill cleanup workers is advised.
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References
Abdel-Shafy HI, Mansour Mona S M (2016) A review on polycyclic aromatic hydrocarbons: source, environmental impact, effect on human health and remediation. Egypt J Petrol 25(1):107–123. https://doi.org/10.1016/j.ejpe.2015.03.011
Agency for Toxic Substances and Disease Registry (ATSDR) (1995) Toxicological profile for polycyclic aromatic hydrocarbons. In: Chemical sampling information, 369. Online: U.S. Department of Healthand Human Services. http://www.atsdr.cdc.gov/toxprofiles/tp69.pdf
Aguilera F, Mendez J, Pasaro E, Laffon B (2010) Review on the effects of exposure to spilled oils on human health. J Appl Toxicol 30(4):291–301. https://doi.org/10.1002/jat.1521
Alegbeleye OO, Opeolu BO, Jackson VA (2017) Polycyclic aromatic hydrocarbons: a critical review of environmental occurrence and bioremediation. Environ Manag. https://doi.org/10.1007/s00267-017-0896-2
Altman DG, Royston P (2006) The cost of dichotomising continuous variables. BMJ 332(7549):1080. https://doi.org/10.1136/bmj.332.7549.1080
Centers for Disease Control and Prevention (CDCP) (2015) Fourth national report on human exposure to environmental chemicals. Department of Health and Human Services, pp 1–1095
Chanvaivit S, Navasumrit P, Hunsonti P, Autrup H, Ruchirawat M (2007) Exposure assessment of benzene in thai workers, DNA-repair capacity and influence of genetic polymorphisms. Mutat Res 626:79–87. https://doi.org/10.1016/j.mrgentox.2006.09.007
Cheong HK, Ha M, Lee JS, Kwon H, Ha EH, Hong YC, Choi Y et al (2011) Hebei spirit oil spill exposure and subjective symptoms in residents participating in clean-up activities. Environ Health Toxicol 26:e2011007. https://doi.org/10.5620/eht.2011.26.e2011007
D’Andrea MA, Reddy GK (2014) Health risks associated with crude oil spill exposure. Am J Med 127(9):886 e9-13. https://doi.org/10.1016/j.amjmed.2014.04.035
Ehrenhauser FS, Avij P, Shu X, Dugas V, Woodson I, Liyana-Arachchi T, Zhang Z, Hung FR, Valsaraj KT (2013) Bubble bursting as an aerosol generation mechanism during an oil spill in the deep-sea environment: laboratory experimental demonstration of the transport pathway. Environ Sci Process Impacts 16:65–73. https://doi.org/10.1039/C3EM00390F
Gunier RB, Reynolds P, Hurley SE, Yerabati S, Hertz A, Strickland P, Horn-Ross PL (2006) Estimating exposure to polycyclic aromatic hydrocarbons: a comparison of survey, biological monitoring, and geographic information system-based methods. Cancer Epidemiol Biomark Prev 15:1376–1381. https://doi.org/10.1158/1055-9965.EPI-05-0799
Ha M, Kwon H, Cheong HK, Lim S, Yoo SJ, Kim EJ, Park SG, Lee J, Chung BC (2012) Urinary metabolites before and after cleanup and subjective symptoms in volunteer participants in cleanup of the hebei spirit oil spill. Sci Total Environ 429(July):167–173. https://doi.org/10.1016/j.scitotenv.2012.04.036
Intawong C, Sithisarankul P (2015) Interlaboratory comparison for urinary trans,trans-muconic acid testing in Rayong Province. Thammasat Med J 15(3):363–376
International Agency for Research on Cancer (IARC) (1983) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 32. Polynuclear aromatic compounds: part 1. Chemical, environmental and experimental data. World Health Organization, International Agency for Research on Cancer, Lyons
Kang D, Rothman N, Cho SH, Lim HS, Kwon HJ, Kim SM, Schwartz B, Strickland PT (1995) Association of exposure to polycyclic aromatic hydrocarbons (estimated from job category) with concentration of 1-hydroxypyrene glucuronide in urine from workers at a steel plant. Occup Environ Med 52(9):593–599
Laemun N, Mutsuji D, Samana K, Srisang J, Saipang T (2014) Lessons from oil spill incident, Rayong, fiscal year 2014. Environmental medicine section. Thai Bureau of occupational and environmental health report, p 67
Laffon B, Pasaro E, Valdiglesias V (2016) Effects of exposure to oil spills on human health: updated review. J Toxicol Environ Health B Crit Rev 19(3–4):105–128. https://doi.org/10.1080/10937404.2016.1168730
Lee SM, Ha M, Kim EJ, Jeong WC, Hur J, Park SG, Kwon H et al (2009) The effects of wearing protective devices among residents and volunteers participating in the cleanup of the hebei spirit oil spill. J Prev Med Public Health 42(2):89–95. https://doi.org/10.3961/jpmph.2009.42.2.89
Liang K-Y, Zeger SL (1986) Longitudinal data analysis using generalized linear models. Biometrika 73(1):13–22. https://doi.org/10.1093/biomet/73.1.13
Melikian AA, Prahalad AK, Secker-Walker RH (1994) Comparison of the levels of the urinary benzene metabolite trans,trans-muconic acid in smokers and nonsmokers, and the effects of pregnancy. Cancer Epidemiol Biomark Prev 3(3):239–244
Murphy D, Gemmell B, Vaccari L, Li C, Bacosa H, Evans M, Gemmell C, Harvey T, Jalali M, Niepa TH (2016) An in-depth survey of the oil spill literature since 1968: long term trends and changes since deepwater horizon. Mar Pollut Bull 113(1–2):371–379. https://doi.org/10.1016/j.marpolbul.2016.10.028
Occupational Safety and Health Administration (OSHA) (1999) Petroleum refinining process. In: OSHA technical manual (OTM). U.S. Department of Labor. https://www.osha.gov/dts/osta/otm/otm_iv/otm_iv_2.html
PTT Global Chemical (2013) Summary of PTTGC oil spill incident and execution. http://www.pttgc-oilspill.com/Uploads/Document/20130802-PTTGC-PROGRESS-EN.pdf
Panalaks T (1976) Determination and identification of polycyclic aromatic hydrocarbons in smoked and charcoal-broiled food products by high pressure liquid chromatography and gas chromatography. J Environ Sci Health B 11(4):299–315. https://doi.org/10.1080/03601237609372045
Petchpoung K, Kaojarern S, Yoovathaworn K, Sura T, Sirivarasai J (2011) The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentration in thai bus drivers. Environ Toxicol Pharmacol 31:160–164. https://doi.org/10.1016/j.etap.2010.10.006
Radhakrishna Rao C (1948) Large sample tests of statistical hypotheses concerning several parameters with applications to problems of estimation. Math Proc Camb Philos Soc 44:50–57. https://doi.org/10.1017/S0305004100023987
Rheanpumikankit S, Chanthip I, Naiyana P (2015) Health surveillance for oil spill responders, Praw Bay, Samet Island, Rayong Province. J Prapokklao Hosp Clin Med Educ Center 32(3):229–243
Rothman N, Poirier MC, Baser ME, Hansen JA, Gentile C, Bowman ED, Strickland PT (1990) Formation of polycyclic aromatic hydrocarbon-DNA adducts in peripheral white blood cells during consumption of charcoal-broiled beef. Carcinogenesis 11(7):1241–1243
Shimada T, Fujii-Kuriyama Y (2004) Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1. Cancer Sci 95(1):1–6
Sithisarankul P, Chanthip I (2015) preliminary report of health effects among oil spill cleanup workers and volunteers, Thaliand, 2013. J Health Res 3(29):197–201
SRNT Subcommittee on Biochemical Verification (2002) Biochemical verification of tobacco use and cessation. Nicotine Tob Res 4(2):149–159. https://doi.org/10.1080/14622200210123581
Strickland PT, Kang D, Bowman ED, Fitzwilliam A, Downing TE, Rothman N, Groopman JD, Weston A (1994) Identification of 1-hydroxypyrene glucuronide as a major pyrene metabolite in human urine by synchronous fluorescence spectroscopy and gas chromatography-mass spectrometry. Carcinogenesis 15(3):483–487
U.S. Coast Guard (2010) U.S. geological survey: deepwater horizon MC252 gulf incident oil budget. National Oceanic and Atmospheric Administration, p 10
Weaver VM, Buckley T, Groopman JD (2000) Lack of specificity of trans,trans-muconic acid as a benzene biomarker after ingestion of sorbic acid-preserved foods. Cancer Epidemiol Biomark Prev 9(7):749–755
Zielinska-Danch W, Wardas W, Sobczak A, Szoltysek-Boldys I (2007) Estimation of urinary cotinine cut-off points distinguishing non-smokers, passive and active smokers. Biomarkers 12(5):484–496. https://doi.org/10.1080/13547500701421341
Acknowledgements
This study was supported by the Johns Hopkins NIOSH Education and Research Center [T42 OH008428] through a pilot project grant, and funding from the Faculty of Medicine, Prince of Songkla University [REC 57-278-07-1]. We would like to acknowledge the assistance and support of Dr. Pornchai Sithisarakul, Dr. Pitchaya Phakthongsuk, Dr. Chantana Padungtod, Dr. Chanon Kongkamol and Dr. Sunthorn Rheanpumikankit, during the course of this study.
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Ingviya, T., Intawong, C., Abubaker, S. et al. Exposure Assessment of Rayong Oil Spill Cleanup Workers. Expo Health 12, 617–628 (2020). https://doi.org/10.1007/s12403-019-00320-0
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DOI: https://doi.org/10.1007/s12403-019-00320-0