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Vascular Parameters for Ambulatory Monitoring of Congestive Heart Failure Patients: Proof of Concept

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Abstract

Purpose

Prompt detection of congestion is an essential target in order to prevent heart failure (HF) related hospitalization, being ambulatory monitoring a promising strategy to do so. A successful non-invasive ambulatory monitoring system requires automatic devices for physiological data recording; these data must give information about HF deterioration early enough to predict HF-related adverse events. This work aims to evaluate seven vascular parameters for the ambulatory monitoring of congestive heart failure patients.

Methods

Seven vascular parameters are proposed as indicators of HF deterioration. These parameters are obtained using venous occlusion plethysmography; a technique that uses hardware able of being miniaturized and easily integrated into wearables for ambulatory monitoring. The ability of the proposed vascular parameters to detect congestion is evaluated in eight healthy volunteers and ten congestive heart failure patients with different congestion levels—mild, moderate and severe.

Results

Most parameters distinguish between healthy volunteers and heart failure patients, and some of them present significant differences between volunteers and low levels of congestion—mild or moderate.

Conclusion

Home monitoring of some of the proposed parameters could detect HF deterioration on its onset and alert to health personnel.

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Abbreviations

ADIP:

Analog–digital impedance plethysmograph

ANOVA:

Analysis of variance

BF:

Blood flow

Ccalf :

Venous compliance

CFC:

Capillary filtration coefficient

DAP:

Diastolic arterial pressure

ECG:

Electrocardiogram

HF:

Heart failure

HV:

Healthy volunteers

M:

Mild congestion

MAP:

Mean arterial pressure

MoC:

Moderate congestion

NFF:

Net fluid filtration

OC:

Occluder cuff

P:

Patients

SAP:

Systolic arterial pressure

SC:

Severe congestion

SVR:

Systemic vascular resistance

VC:

Venous capacitance

VOP:

Venous occlusion plethysmography

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Conflict of interest

All authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments.

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Authors and Affiliations

  1. Laboratorio de Medios e Interfases (LAMEIN)-Departamento de Bioingeniería, Facultad de Ciencias Exactas y Tecnología, Universidad Nacional de Tucumán, Av. Independencia 1900, Tucumán, Argentina

    C. B. Goy & R. E. Madrid

  2. Instituto Superior de Investigaciones Biológicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Chacabuco 461, Tucumán, Argentina

    C. B. Goy, L. M. Yanicelli, N. Vargas, R. E. Madrid & M. C. Herrera

  3. Laboratorio de Investigaciones Cardiovasculares Multidisciplinarias-Departamento de Bioingeniería, Facultad de Ciencias Exactas y Tecnología, Universidad Nacional de Tucumán, Av. Independencia 1900, Tucumán, Argentina

    C. B. Goy, L. M. Yanicelli, N. Vargas & M. C. Herrera

  4. Departamento de Ing. Eléctrica, Electrónica y Computación, Facultad de Ciencias Exactas y Tecnología, Universidad Nacional de Tucumán, Av. Independencia 1900, Tucumán, Argentina

    C. B. Goy

  5. Instituto de Cardiología, Av. Mitre 760, Tucumán, Argentina

    L. L. Lobo Marquez & J. Tazar

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  1. C. B. Goy
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  2. L. M. Yanicelli
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  3. N. Vargas
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  6. R. E. Madrid
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Correspondence to C. B. Goy.

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Associate Editor Ajit P. Yoganathan oversaw the review of this article.

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Goy, C.B., Yanicelli, L.M., Vargas, N. et al. Vascular Parameters for Ambulatory Monitoring of Congestive Heart Failure Patients: Proof of Concept. Cardiovasc Eng Tech 10, 618–627 (2019). https://doi.org/10.1007/s13239-019-00432-3

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  • DOI: https://doi.org/10.1007/s13239-019-00432-3

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