Abstract
To investigate the effects of Gastrodia elata Blume (GEB) and 4-hydroxybenzyl alcohol (HBA) on brain damage, GEB or HBA was administered orally for 14 days before middle cerebral artery occlusion (MCAO). After 24 h reperfusion, the proportion of circling was significantly reduced in the GEB (79%) or HBA (69%) group compared to the MCAO group (100%) in the corner test, and the removal time in the adhesive removal test was significantly decreased in the GEB (117 ± 21.0 s) and HBA (101 ± 20.9 s) groups compared to the MCAO group (161 ± 12.6 s). GEB treatment significantly reduced infarct volume compared to the MCAO group. In the GEB and HBA group, necrosis of nerve cells in hippocampus and cortex, expressions of TNF-α and TUNEL positive cells were significantly reduced compared to the MCAO group. These results suggest that GEB and HBA prevents brain damage by anti-inflammatory and anti-apoptotic effects.
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This study was supported by Brain Korea 21 Plus (No. 31Z20130012916), Jeonju University Industry-Academia Collaboration Foundation (Shin, 2015) and Eulji Univeristy (Shin, 2018).
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Seok, P.R., Oh, S.J., Choi, J.W. et al. The protective effects of Gastrodia elata Blume extracts on middle cerebral artery occlusion in rats. Food Sci Biotechnol 28, 857–864 (2019). https://doi.org/10.1007/s10068-018-0516-9
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DOI: https://doi.org/10.1007/s10068-018-0516-9