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APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division

Nature Cell Biology volume 8, pages 539–540 (2006)Cite this article

Abstract

Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.

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Figure 1: APCcdh1 activity in germinal-vesicle oocytes.
Figure 2: APCcdh1 maintains germinal-vesicle arrest.

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Acknowledgements

The Wellcome Trust supported this work with a project grant (075744) and equipment grant (065354) to K.T.J. We thank M. Aitchison for the preparation of figures.

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Author notes

  1. Alexandra Reis and Heng-Yu Chang: These authors contributed equally to this work.

Authors and Affiliations

  1. Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle-upon-Tyne, Newcastle, NE2 4HH, UK

    Alexandra Reis, Heng-Yu Chang, Mark Levasseur & Keith T. Jones

Authors
  1. Alexandra Reis
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  2. Heng-Yu Chang
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  3. Mark Levasseur
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  4. Keith T. Jones
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Corresponding author

Correspondence to Keith T. Jones.

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The authors declare no competing financial interests.

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Supplementary Figure S1, Supplementary Table S1 and Supplementary Methods (PDF 223 kb)

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Reis, A., Chang, HY., Levasseur, M. et al. APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division. Nat Cell Biol 8, 539–540 (2006). https://doi.org/10.1038/ncb1406

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