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Impact of treatment-related weight changes from diagnosis to hematopoietic stem-cell transplantation on clinical outcome of acute myeloid leukemia

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Abstract

We hypothesized that treatment-related weight loss is associated with worse outcomes following HSCT. Overall, 184 patients with AML who underwent induction therapy were classified according to d-BMI (BMI at transplant minus BMI at diagnosis) (kg/m2) as < −2, − 2 to + 2, and > + 2. At 1 year, OS was 67.9% (95% CI, 60.7–74.2), DFS was 64.1% (95% CI, 56.7–70.6), and GRFS was 40.2% (95% CI, 33.1–47.2). For d-BMI groups < − 2, − 2 to + 2, and > + 2, GRFS at 1 year was 16.1% (95% CI, 5.1–31.4), 45.4% (95% CI, 36.4–53.7), and 41.7% (95% CI, 22.2–60.1), respectively (P = 0.0067). Multivariate analysis showed that both worse OS (HR, 1.78; 95% CI, 1.02–3.14; P = 0.007) and GRFS (HR, 2.34; 95% CI, 1.26–4.35; P = 0.007) were associated with reduced BMI (d-BMI < − 2). Treatment-related weight reduction in AML was associated with poor outcome after HSCT.

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Acknowledgements

I appreciate for all authors who participated in the research and preparation of the manuscript. I would like to show my deepest gratitude to my supervisor, Dr. Etsuko-Yamazaki, Dr. Shin-Fujisawa, Dr. Heiwa-Kanamori, and Prof. Hideaki-Nakajima. This work was supported by Yokohama Cooperative Study Group for Hematology (YACHT).

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Authors and Affiliations

  1. Department of Stem Cell and Immune Regulation, Graduate School of Medicine, Yokohama City University, Yokohama, Japan

    Taiki Ando, Haruka Teshigawara, Eriko Ogusa & Hideaki Nakajima

  2. Department of Hematology, Yokohama City University Medical Center, 4-57 Urafune, Minami-ku, Yokohama, Kanagawa, Japan

    Taiki Ando, Shin Fujisawa, Eriko Ogusa, Yoshimi Ishii, Kazuho Miyashita & Kenji Motohashi

  3. Department of Hematology and Clinical Immunology, School of Medicine, Yokohama City University, Yokohama, Japan

    Haruka Teshigawara, Takuya Miyazaki, Maki Hagihara, Kenji Matsumoto, Etsuko Yamazaki & Hideaki Nakajima

  4. Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan

    Takayoshi Tachibana, Masatsugu Tanaka & Heiwa Kanamori

  5. Department of Hematology/Oncology, Yamato Municipal Hospital, Yamato, Japan

    Chizuko Hashimoto

  6. Department of Hematology, Shizuoka Red Cross Hospital, Shizuoka, Japan

    Hideyuki Koharazawa & Jun Taguchi

  7. Department of Hematology, Fujisawa City Hospital, Fujisawa, Japan

    Katsumichi Fujimaki

  8. Department of Hematology, Saiseikai Yokohama Nanbu Hospital, Yokohama, Japan

    Hiroyuki Fujita

  9. Clinical Laboratory Department, Yokohama City University Hospital, Yokohama, Japan

    Etsuko Yamazaki

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  1. Taiki Ando
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  2. Shin Fujisawa
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  19. Etsuko Yamazaki
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  20. Hideaki Nakajima
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Yokohama Cooperative Study Group for Hematology (YACHT)

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Correspondence to Taiki Ando.

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Ando, T., Fujisawa, S., Teshigawara, H. et al. Impact of treatment-related weight changes from diagnosis to hematopoietic stem-cell transplantation on clinical outcome of acute myeloid leukemia. Int J Hematol 109, 673–683 (2019). https://doi.org/10.1007/s12185-019-02647-5

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  • DOI: https://doi.org/10.1007/s12185-019-02647-5

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