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Neuroimaging characteristics and long-term prognosis of myxoma-related intracranial diseases

  • Diagnostic Neuroradiology
  • Published:
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Abstract

Purpose

Myxoma-related intracranial diseases were rarely documented in history. The main purpose of our study is to provide a more comprehensive and detailed understanding of the pathogenesis, imaging features, surgical procedures and pathology of such patients through long-term follow-up.

Methods

From March 2012 to July 2018, baseline information that included neuroimaging and neuropathology data from 12 cardiac myxoma patients with neurological symptoms were retrospectively analysed, and the treatment options were discussed. Nine patients underwent long-term postoperative follow-up.

Results

Twelve cardiac myxoma patients with neurological symptoms were identified, and among them, 10 patients were postoperative patients who had undergone excision of cardiac myxoma, 5 patients had received craniotomy, and the others had received conservative treatment. Positive neuroimaging findings were found in all patients, including cerebral infarction (12/12, 100%), multiple intracranial aneurysms (8/12, 67%), and extravascular metastasis (6/12, 50%). After a long-term average follow-up of 27 months, an increased number of metastatic lesions or an enlargement of the intracranial aneurysms was found in 4 patients.

Conclusions

Neuroimaging findings of myxoma-related intracranial lesions were diversed and usually presented as multiple cerebral infarction, aneurysm formation, focal intracranial haemorrhage and space-occupying lesions. Progress is over a long period of time after primary tumour resection. It is necessary for patients to be regularly examined within 2 years after cardiac myxoma resection using MRI+CTA/MRA/DSA in order to be ruled out. Stable and effective chemotherapy drugs are urgently needed.

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Funding

This study was funded by the “13th Five-Year Plan” National Science and Technology Supporting Plan (2015BAI12B04) and the Beijing Municipal Administration of Hospitals’ Mission Plan (SML20150501).

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China

    Shuo Zhang, Qian Zhang, Xiaowen Song, Xin Chen, Jun Wu, Yong Cao, Shuo Wang & Jizong Zhao

  2. China National Clinical Research Center for Neurological Diseases, Beijing, People’s Republic of China

    Shuo Zhang, Qian Zhang, Xiaowen Song, Xin Chen, Jun Wu, Yong Cao, Shuo Wang & Jizong Zhao

  3. Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

    Hai Yu

  4. Departments of Neurosurgery, Jishuitan Hospital, Peking University, Beijing, People’s Republic of China

    Longqi Liu

  5. Department of Neuroimaging, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China

    Rujing Sun

  6. Departments of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

    Xianzeng Tong

  7. Departments of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, China

    Yueshan Piao

Authors
  1. Shuo Zhang
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  2. Qian Zhang
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  3. Hai Yu
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  4. Longqi Liu
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  5. Rujing Sun
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  6. Xiaowen Song
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  7. Xianzeng Tong
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  8. Yueshan Piao
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  9. Xin Chen
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  10. Jun Wu
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  11. Yong Cao
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  12. Shuo Wang
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  13. Jizong Zhao
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Corresponding author

Correspondence to Jizong Zhao.

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The authors declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

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Cite this article

Zhang, S., Zhang, Q., Yu, H. et al. Neuroimaging characteristics and long-term prognosis of myxoma-related intracranial diseases. Neuroradiology 62, 307–317 (2020). https://doi.org/10.1007/s00234-019-02314-w

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  • DOI: https://doi.org/10.1007/s00234-019-02314-w

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