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Dangerous play—splitting the message may leave you empty handed

Nature Structural & Molecular Biology volume 16, pages 907–908 (2009)Cite this article

An important aspect of eukaryotic gene expression is the efficient integration of transcription, pre-mRNA processing and nuclear export. A new study demonstrates that pre-mRNA transcript continuity is an essential component for maintaining productive coupling of transcription and RNA processing events.

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Figure 1: Transcript continuity during pre-mRNA processing.

References

  1. Fong, N. Nat. Struct. Mol. Biol. 16, 916–922 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Pandit, S., Wang, D. & Fu, X.D. Curr. Opin. Cell Biol. 20, 260–265 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Lacadie, S.A. & Rosbash, M. Mol. Cell 19, 65–75 (2005).

    Article  CAS  PubMed  Google Scholar 

  4. Listerman, I., Sapra, A.K. & Neugebauer, K.M. Nat. Struct. Mol. Biol. 13, 815–822 (2006).

    Article  CAS  PubMed  Google Scholar 

  5. Tardiff, D.F., Lacadie, S.A. & Rosbash, M. Mol. Cell 24, 917–929 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Dye, M.J., Gromak, N. & Proudfoot, N.J. Mol. Cell 21, 849–859 (2006).

    Article  CAS  PubMed  Google Scholar 

  7. Bruzik, J.P. & Maniatis, T. Proc. Natl. Acad. Sci. USA 92, 7056–7059 (1995).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Konforti, B.B. & Konarska, M.M. RNA 1, 815–827 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Black, D.L. Annu. Rev. Biochem. 72, 291–336 (2003).

    Article  CAS  PubMed  Google Scholar 

  10. Kotlajich, M.V., Crabb, T.L. & Hertel, K.J. Mol. Cell. Biol. 29, 1072–1082 (2009).

    Article  CAS  PubMed  Google Scholar 

  11. Galburt, E.A. et al. Nature 446, 820–823 (2007).

    Article  CAS  PubMed  Google Scholar 

  12. Perrotta, A.T., Shih, I. & Been, M.D. Science 286, 123–126 (1999).

    Article  CAS  PubMed  Google Scholar 

  13. Stage-Zimmermann, T.K. & Uhlenbeck, O.C. RNA 4, 875–889 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Hicks, M.J., Yang, C.R., Kotlajich, M.V. & Hertel, K.J. PLoS Biol. 4, e147 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  15. de la Mata, M. et al. Mol. Cell 12, 525–532 (2003).

    Article  CAS  PubMed  Google Scholar 

  16. Batsché, E., Yaniv, M. & Muchardt, C. Nat. Struct. Mol. Biol. 13, 22–29 (2006).

    Article  PubMed  Google Scholar 

  17. Muñoz, M.J. et al. Cell 137, 708–720 (2009).

    Article  PubMed  Google Scholar 

  18. Kim, Y.K. & Kim, V.N. EMBO J. 26, 775–783 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Yvonne Klaue and Klemens J. Hertel are in the Department of Microbiology & Molecular Genetics, University of California, Irvine, California, USA.,

    Yvonne Klaue & Klemens J Hertel

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  1. Yvonne Klaue
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  2. Klemens J Hertel
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Correspondence to Klemens J Hertel.

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Klaue, Y., Hertel, K. Dangerous play—splitting the message may leave you empty handed. Nat Struct Mol Biol 16, 907–908 (2009). https://doi.org/10.1038/nsmb0909-907

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