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Effect of six Korean plants on glucagon like peptide-1 release

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Abstract

Glucagon like peptide-1 (GLP-1) plays a major role in the regulation of energy homeostasis as it causes satiety and suppresses appetite. Angelica dahurica, Coreanomecon hylomeconoides, Chrysanthemum morifolium, Portulaca oleracea, Stellaria alsine, and Stellaria media have traditionally been used as famine relief foods in Korea. The aim of the present study was to determine whether the aqueous ethanolic extracts of the six plants stimulate GLP-1 secretion. The results demonstrated that each extract of the plants stimulated GLP-1 secretion from enteroendocrine NCI-H716 cells, respectively. Among the extracts examined, the extract of Portulaca oleracea showed the highest activity on GLP-1 release. The results may suggest that the GLP-1 secretion induced by the six plants is a possible mechanism for the six plants exerting effects on satiety increase and appetite suppression.

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Acknowledgements

This research was supported by a Grant from Small Grant for Exploratory Research of Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (Grant No. 2016R1D1A1A02937328), and a Grant from the National Research Council of Science and Technology (Grant Nos. CAP-16-07-KIOM, GN160800-01).

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  1. Division of Food Function Research, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do, 55365, Republic of Korea

    Hyunnho Cho, Kyong Kim, Dae-Ja Jang & Hye Young Kim

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  1. Hyunnho Cho
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  2. Kyong Kim
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  3. Dae-Ja Jang
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Correspondence to Hye Young Kim.

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Cho, H., Kim, K., Jang, DJ. et al. Effect of six Korean plants on glucagon like peptide-1 release. Food Sci Biotechnol 28, 1571–1576 (2019). https://doi.org/10.1007/s10068-019-00603-x

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  • DOI: https://doi.org/10.1007/s10068-019-00603-x

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