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Journal of Environmental Pathology, Toxicology and Oncology

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ISSN Print: 0731-8898

ISSN Online: 2162-6537

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D-Pinitol Ameliorates Imiquimod-Induced PsoriasisLike Skin Inflammation in a Mouse Model via the NF-κB Pathway

Volume 38, Issue 3, 2019, pp. 285-295
DOI: 10.1615/JEnvironPatholToxicolOncol.2019030782
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ABSTRACT

Psoriasis is an autoregulated immune and inflammation-based skin disease affecting approximately 3-4% of the worldwide population. Pinitol, conservatively used in ayurvedic medicine, has been shown to disclose an antiinflammatory effect, hold back the T-helper cells, and postpone cardiovascular diseases. In the present study we aimed to reveal the effect of D-pinitol on imiquimod (IMQ)-induced psoriasis-like skin inflammation in a mouse model via the nuclear factor-κB (NF-κB) pathway genes. In the current study, we found that D-pinitol ameliorated the skin abrasion and abridged epithelial thickness, inflammation numbers, and collagen-occupied regions in IMQ-induced psoriasis-like mice. The same results (epithelial thickness, inflammation numbers, and collagen-occupied regions) we achieved in dorsal skin regions. In addition, D-pinitol modified the lipid profile and antioxidant enzyme levels, which means that the IMQ-induced group showed elevated malondialdehyde when compared to D-pinitol. Downregulated expression of glutathione, superoxide dismutase, and catalase in the IMQ-induced group was incomparable with D-pinitol, control, and standard group. Additionally, inflammatory and NF-kB pathway gene levels in the psoriatic mouse skin, which includes tumor necrosis factor-α, interleukin [IL]-6, IL-17A, IL-23,TRAF3, NIK, IKKα, and RelB, were dramatically increased or decreased by treatment with D-pinitol. Histological and morphometric studies disclose the efficiency of D-pinitol. Finally, we found that D-pinitol reserved the TRAF3, NIK, IKKα, and RelB in the psoriatic skin, signifying that it restrains the commencement of NF-κB signaling pathways. The present results suggest that D-pinitol could prove to have tremendous preventive potential against the treatment and prevention of inflammatory disease.

REFERENCES
  1. Slominski AT, Zmijewski MA, Skobowiat C, Zbytek B, Slominski RM, Steketee JD. Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system. Adv Anat Embryol Cell Biol. 2012;212:1-115.

  2. Griffiths CEM, van de Kerkhof P, Czarnecka-Operacz M. 16 Psoriasis and atopic dermatitis. Dermatol Ther (Heidelb) 2017;7(Suppl 1):31-41.

  3. Hwang ST, Nijsten T, Elder JT. Recent highlights in psoriasis research. J Invest Dermatol. 2017;137(3):550-556 doi:10.1016/j.jid.2016.11.007.

  4. Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med. 2009;361(5):496-509. doi: 10.1056/NEJMra0804595.

  5. Lowes MA, Bowcock AM, Krueger JG. Pathogenesis 18 and therapy of psoriasis. Nature. 2007;445(7130):866.

  6. Pasparakis M, Haase I, Nestle FO. Mechanisms regulating skin immunity and inflammation. Nat Rev Immunol. 2014;14(5):289-301.

  7. Zhang AJ, Li C, To KK, Zhu HS, Lee AC, Li CG, Chan JF, Hung IF, Yuen KY. Toll-like receptor 7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza A (H1N1) pdm09 virus infection in BALB/c mice. Clin Vaccine Immunol. 2014 Apr 1;21(4):570-9.

  8. Nyberg WA, Espinosa A. Imiquimod induces ER stress and Ca2+ influx independently of TLR7 and TLR8. Biochem Biophys Res Comm. 2016 May 13;473(4): 789-94.

  9. van der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus AM, Florencia E, Prens EP, Lubberts E. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 22 axis. J Immunol. 2009 May 1;182(9):5836-45.

  10. Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair RP, Voorhees JJ, Elder JT, Wang XJ. Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoria- 23 sis. PLoS One. 2011 Apr 4;6(4):e18266.

  11. Flutter B, Nestle FO. TLRs to cytokines: mechanistic insights from the imiquimod mouse model of psoriasis. Eur J Immunol. 2013;43(12):3138-46.

  12. Quivy V, Van Lint C. Regulation at multiple levels of NF-kappaB-mediated transactivation by protein acetylation. Biochem Pharmacol. 2004;68(6):1221-29.

  13. Perera GK, Di Meglio P, Nestle FO. Psoriasis. Annu Rev Pathol. 2012;7:385-422.

  14. Lizzul PF, Aphale A, Malaviya R, Sun Y, Masud S, Dombrovskiy V, Gottlieb AB. Differential expression of phosphorylated NF-KB/RelA in normal and psoriatic epidermis and downregulation of NF-KB in response to treatment with etanercept. J Invest Dermatol. 2005 Jun 1;124(6):1275-83.

  15. Rahman M, Alam K, Zaki Ahmad M, Gupta G, Afzal M, Akhter S, Kazmi I, Jalees Ahmad F, Anwar F. Classical to current approach for treatment of psoriasis: a review. Endocr Metab Immune Disord-Drug Targets (Formerly Curr Drug Targets-Immune Endocr Metab Disord). 2012 Sep 1;12(3):287-302.

  16. Corson TW, Crews CM. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell. 2007;130(5): 769-774. doi: 10.1016/j. cell.2007.08.021.

  17. Deng S, May BH, Zhang AL, Lu C, Xue CC. Topical herbal medicine combined with pharmacotherapy for psoriasis: a systematic review and meta-analysis. Arch Dermatol Res. 2013;305(3): 179-189. doi: 10.1007/s00403-013-1316-y.

  18. Kong D, Li Y, Wang Z, Banerjee S, Sarkar FH. Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-KB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. Cancer Res. 2007;67:3310-19.

  19. Jayasooriya RGPT, Lee YG, Kang CH, Lee KT, Choi YH, Park SY, Hwang JK, Kim GY. Piceatannol inhibits MMP-9-dependent invasion of tumor necrosis factora-stimulated DU145 cells by suppressing the Akt mediated nuclear factor-KB pathways. Oncol Lett. 2013; 5:341-47.

  20. Bhat KA, Shah BA, Gupta KK, Pandey A, Bani S, Taneja SC. Semi-synthetic analogs of pinitol as potential inhibitors of TNF-a cytokine expression in human neutrophils. Bioorg Med Chem Lett. 2009;19:1939-43.

  21. Kim MJ, Yoo KH, Kim JH, Seo YT, Ha BW, Kho JH, Shin YG, Chung CH. Effect of pinitol on glucose metabolism and adipocytokines in uncontrolled type 2 diabetes. Diabetes Res Clin Pract. 2007;77:S247- 51.

  22. Rengarajan T, Nandakumar N, Rajendran P, Haribabu L, Nishigaki I, Balasubramanian MP. D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-KB. Asian Pac J Cancer Prev. 2014 Jan 1;15(4):1757-62.

  23. Rengarajan T, Nandakumar N, Rajendran P, Ganesh MK, Balasubramanian MP, Nishigaki I. D-pinitol mitigates tumor growth by modulating interleukins and hormones and induces apoptosis in rat breast carcinogenesis through inhibition of NF-kB. J Physiol Biochem. 2015;71:191e204.

  24. National Research Council. Guide for the care and use of laboratory animals. Washington DC: National Academies Press; 2011.

  25. Chen H, Lu C, Liu H, Wang M, Zhao H, Yan Y, Han L. Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-kB pathway. Int Immunopharmacol. 2017 Jul 1;48:110-7.

  26. Bai S, Zhang Z, Hou S, Liu X. Influence of different types of contact hypersensitivity on imiquimod-induced psoriasis-like inflammation in mice. Mol Med Rep. 2016;14:671-680. doi: 10.3892/mmr.2016. 5299.

  27. Kim CG, Kang M, Lee YH, Min WG, Kim YH, Kang SJ, Song CH, Park SJ, Park JH, Han CH, Lee YJ. Bathing effects of various seawaters on allergic (atopic) dermatitis-like skin lesions induced by 2, 4-dinitrochlo-robenzene in hairless mice. Evid Based Comp Alt Med. 2015;2015.

  28. Ko J, Lee JI, Munoz-Furlong A, Li XM, Sicherer SH. Use of complementary and alternative medicine by food-allergic patients. Ann Allergy Asthma Immunol. 2006;-97(3):365-69.

  29. Abdou AG, Hanout HM. Evaluation of survivin and NF-kappaB in psoriasis, an immunohistochemical study. J Cutan Pathol. 2008;35:445-51. doi: 10.1111/j.1600-0560.2007.00841.

  30. Moorchung N, Kulaar JS, Chatteijee M, Vasudevan B, Tripathi T, Dutta V. Role of NF-kappaB in the pathogenesis of psoriasis elucidated by itsstaining in skin biopsy specimens. Int J Dermatol. 2014;53:570-4. doi: 10.1111/ ijd.12050.

  31. Andres RM, Montesinos MC, Navalon P, Paya M, Ter- encio MC. NFkappaB and STAT3 inhibition as a therapeutic strategy in psoriasis: in vitro and in vivo effects of BTH. J Invest Dermatol. 2013;33:2362-71. doi: 10.1038/ jid.2013.182.

  32. Aarebrot AK, Solberg SM, Davies R, Bader LI, Holmes TD, Gavasso S, Bryceson YT, Jonsson R, Sandvik LF, Appel S. Phosphorylation of intracellular signalling molecules in peripheral blood cells from patients with psoriasis on originator or biosimilar infliximab. Br J Dermatol. 2018 Aug;179(2):371-80.

  33. Wang Y, Zhao J, Di T, Wang M, Ruan Z, Zhang L, Xie X, Meng Y, Lin Y, Liu X, Wang N. Suppressive effect of p, P-dimethylacryloyl alkannin on activated dendritic cells in psoriasis by the TLR7/8 pathway. Int Immunopharmacol. 2016 Nov 1;40:410-8.

  34. Meng QF, Zhang Z, Wang YJ, Chen W, Li FF, Yue LT, Zhang CJ, Li H, Zhang M, Wang CC, Zhang P. Astilbin ameliorates experimental autoimmune myasthenia gravis by decreased Th17 cytokines and up-regulated T regulatory cells. J Neuroimmunol. 2016 Sep 15;298:138-45.

  35. Zhao J, Di T, Wang Y, Wang Y, Liu X, Liang D, Li P. Pae- oniflorin inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response and cytokine secretion. European J Pharmacol. 2016 Feb 5;772:131-43.

  36. Lee JS, Lee CM, Jeong YI, Jung ID, Kim BH, Seong EY, Kim JI, Choi IW, Chung HY, Park YM. D-pinitol regulates Th1/Th2 balance via suppressing Th2 immune response in ovalbumin-induced asthma. FEBS Lett. 2007 Jan 9;581(1):57-64.

  37. Sivakumar S, Palsamy P, Subramanian SP. Attenuation of oxidative stress and alteration of hepatic tissue ultra-structure by D-pinitol in streptozotocin-induced diabetic rats. Free Radic Res. 2010;44(6):668-78.

  38. Lin TH, Tan TW, Tsai TH, Chen CC, Hsieh TF, Lee SS, Liu HH, Chen WC, Tang CH. D-pinitol inhibits prostate cancer metastasis through inhibition of aVp3 integrin by modulating FAK, c-Src and NF-KB pathways. Int J Mol Sci. 2013 May;14(5):9790-802.

  39. Rengarajan T, Rajendran P, Nandakumar N, Lokeshkumar B, Balasubramanian MP. D-Pinitol protects against carbon tetrachloride-induced hepatotoxicity in rats. J Environ Pathol Toxicol Oncol. 2015;34(4):287-98.

  40. Rengarajan T, Rajendran P, Nandakumar N, Balasubramanian MP, Nishigaki I. Free radical scavenging and antioxidant activity of D-pinitol against 7, 12 dimethylbenz (a) anthracene induced breast cancer in Sprague Dawley rats. Asian Pacific J Tropical Disease. 2014 Oct 1;4(5):384-90.

  41. Sivakumar S, Palsamy P, Subramanian SP. Attenuation of oxidative stress and alteration of hepatic tissue ultra-structure by D-pinitol in streptozotocininduced diabetic rats. Free Radic Res. 2010;44:668e78.

  42. Works MG, Yin F, Yin CC, Yiu Y, Shew K, Tran TT, Dunlap N, Lam J, Mitchell T, Reader J, Stein PL. Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL- 23/IL-17 axis. J Immunol. 2014 Oct 1;193(7):3278-87.

  43. van der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus AM, Florencia E, Prens EP, Lubberts E. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol. 2009 May 1;182(9):5836-45.

  44. Hou Y, Zhu L, Tian H, Sun HX, Wang R, Zhang L, Zhao Y. IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis. Protein Cell. 2018 Dec 1;9(12):1027-38.

  45. Iinuma S, Kishibe M, Saito N, Igawa S, Honma M, Takahashi H, Bando Y, Yoshida S, Iizuka H, Ishida-Yamamoto A. Klk8 is required for microabscess formation in a mouse imiquimod model of psoriasis. Exper Dermatol. 2015 Nov;24(11):887.

  46. Lee YS, Lee MH, Kim HJ, Won HR, Kim CH. Non-thermal atmospheric plasma ameliorates imiquimod-induced psoriasis-like skin inflammation in mice through inhibition of immune responses and up-regulation of PD-L1 expression. Sci Rep. 2017;7:15564. doi: 10.1038/ s41598-017-15725-7.

  47. Sun Y, Zhang J, Huo R, Zhai T, Li H, Wu P, Zhu X, Zhou Z, Shen B, Li N. Paeoniflorin inhibits skin lesions in imiquimod-induced psoriasis-like mice by downreg-ulating inflammation. Int Immunopharmacol. 2015 Feb 1;24(2):392-9.

  48. Goodman WA, Levine AD, Massari JV, Sugiyama H, McCormick TS, Cooper KD. IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells. J Immunol. 2009;183:3170-6. doi: 10.4049/jimmunol.0803721.

  49. Zhang L, Li Y, Yang X, Wei J, Zhou S, Zhao Z, Cheng J, Duan H, Jia T, Lei Q, Huang J. Characterization of Th17 and FoxP3+ Treg cells in paediatric psoriasis patients. Scand J Immunol. 2016 Mar;83(3):174-80.

  50. Han L, Sun J, Lu CJ, Zhao RZ, Lu Y, Lin HJ, Wei JA. Formula PS0RI-CM01 inhibits the inflammatory cytokine and chemokine release in keratinocytes via NF-KB expression. Int Immunopharmacol. 2017 Mar 1;44: 226-33.

  51. Tsuruta D. NF-kappaB links keratinocytes and lymphocytes in the pathogenesis of psoriasis. Recent Pat Inflamm Allergy Drug Discov. 2009;3:40-8.

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  2. Qiu Jieying, Yan Xixi, Liao Yingyi, Yu Deguan, Wen Congcong, Xiang Zheng, An UPLC-MS/MS method for quantification of D-pinitol in rat plasma and its application to a pharmacokinetic and bioavailability study, Journal of Chromatography B, 1163, 2021. Crossref

  3. Xu Di, Wang Jie, Downregulation of Cathepsin B Reduces Proliferation and Inflammatory Response and Facilitates Differentiation in Human HaCaT Keratinocytes, Ameliorating IL-17A and SAA-Induced Psoriasis-Like Lesion, Inflammation, 44, 5, 2021. Crossref

  4. Azab Abdullatif, D-Pinitol—Active Natural Product from Carob with Notable Insulin Regulation, Nutrients, 14, 7, 2022. Crossref

  5. Gromova Olga A., Torshin Ivan Yu., Tetruashvili Nana K., Prospects of exogenous inositols in maintaining of skin, hair and nails condition: A review, Gynecology, 24, 4, 2022. Crossref

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