Protective effect of melatonin on β-cell damage in streptozotocin-induced diabetes in rats
References (44)
- et al.
Possible protective effect of melatonin and/or desferroxamine against streptozotocin-induced hyperglycaemia in mice
Pharmacol Res
(2000) - et al.
Cytokine-induced inhibition of insulin release from mause pancreatic beta cells deficient in inducible nitric oxide synthase
Biochem Biophys Res Commun
(2001) - et al.
Lipid peroxidation and retinopathy in streptozotocin induced diabetes
Free Radic Biol Med
(1991) - et al.
Melatonin stimulates brain glutathione peroxidase activity
Neurochem Int
(1995) - et al.
Reduced mononuclear leukocyte ascorbic acid content in adults with insulin-dependent diabetes ellitus consuming adequate dietary vitamin C
Metabolism
(1991) - et al.
Melatonin and taurine reduce early glomerulopathy in diabetic rats
Free Radic Biol Med
(1999) - et al.
Protective effect of boldine on oxidative mitochondrial damage in streptozotocin-induced diabetic rats
Pharmacol Res
(2000) - et al.
Renoprotective effect of valsartan and enalapril in STZ-induced diabetes in rats
Acta Histochem
(2002) Protein measurement with the folin phenol reagent
J Biol Chem
(1951)- et al.
Effect of L-arginine-nitric oxide system in chemical induced diabetes mellitus
Free Radic Biol Med
(1998)
Lipid peroxide levels of serum lipoprotein fraction of diabetic proteins
Biochem Med
Pharmacological actions of melatonin in oxygen radical pathophysiology
Life Sci
The pyridoindole antioxidant stobadine attenuates histochemical changes in kidney of streptozotocin-induced diabetic rats
Acta Histochem
Parameters of oxidative stress in children with Type 1 diabetes mellitus and their relatives
J Diabetes Complications
Protein glycation and oxidative stress in diabetes mellitus and ageing
Free Radic Biol Med
Characteristic changes of stress protein expression in streptozotocin-induced diabetic rats
Life Sci
Environmental factors in the ethiology of type 1diabetes
Am J Med Genet
Melatonin protects against streptozotocin, but not interleukin-1beta-induced damage of rodent pancreatic beta cells
J Pineal Res
Comparative analysis of the protective effects of melatonin and vitamin E on streptozotocin-induced diabetes mellitus
J Pineal Res
A textbook of histology
Consequences of the diabetic status on the oxidant/antioxidant balance
Diabetes Metab
Influence of melatonin on free radicalinduced changes in rat pancreatic beta-cells in vitro
J Pineal Res
Cited by (67)
Diabetes mellitus and melatonin: Where are we?
2022, BiochimieA novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic β-cells in mouse and human islets
2022, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :Administration of melatonin in vitro protects β-cells from glucotoxicity, increases its survival, and reduces oxidative stress in both human islets from T2D patients and rodent INS-1832/13 β-cells [27,28]. Further, melatonin administration restored β-cell mass (proliferation and neogenesis), improved glucose tolerance, and reduced blood glucose levels in various T1D rodent models [14,29–32]. Further, in human pancreatic islets, melatonin treatment increases insulin secretion and promotes β-cell survival via decreased c-JUN N-terminal kinase (JNK) activation [33].
Melatonin relieves diabetic complications and regenerates pancreatic beta cells by the reduction in NF-kB expression in streptozotocin induced diabetic rats
2022, Saudi Journal of Biological SciencesMelatonin regulates the expression of inflammatory cytokines, VEGF and apoptosis in diabetic retinopathy in rats
2020, Chemico-Biological InteractionsPotential therapeutic role of melatonin on STZ-induced diabetic central neuropathy: A biochemical, histopathological, immunohistochemical and ultrastructural study
2018, Acta HistochemicaCitation Excerpt :Mel is also a potent endogenous antioxidant (Karaaslan and Suzen, 2015; Reiter et al., 2016) and inhibits oxidative stress by activating the master endogenous Nrf2 antioxidant defense pathway (Yu et al., 2017), as well as other antioxidant enzymes (Reiter et al., 2000). In addition, it enhances insulin growth factor production and tyrosine phosphorylation of insulin receptor (Sharma et al., 2015), activates muscular glucose uptake (Ha et al., 2006), elevates hepatocyte glucose release (Poon et al., 2001), downregulates insulin-dependent glucose transport in the adipocytes (Brydon et al., 2001), lowers adrenal cortisol secretion (Weitzman et al., 1971), and protects pancreatic β-cells against apoptosis and stimulates their neogenesis (Costes et al., 2015; Simsek et al., 2012; Yavuz et al., 2003). These physiological functions of Mel are mediated via the activation of its two receptors–MT1 and MT2 (Dubocovich and Markowska, 2005).