Casein kinase I delta (CKIδ) is involved in lymphocyte physiology
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Cited by (27)
Identification of WNT4 alternative splicing patterns and effects on proliferation of granulosa cells in goat
2022, International Journal of Biological MacromoleculesCitation Excerpt :Although two alternatively spliced products of WNT4 were found in the ovaries of Yunshang black goats, studies on the relevance of alternatively spliced products of WNT4 to animal reproduction have not been reported. In previous studies, most of the WNT signaling components, including LRP5/6, APC, GSK3β, CK1 and β-catenin, and the transcription factor TCF/LEF, were found to have alternatively spliced products effects on the relevant molecular mechanisms [25–30]. Therefore, we suspect that the appearance of WNT4 alternatively spliced products affects the function of goat ovaries through the WNT signaling pathway.
Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)
2019, GeneCitation Excerpt :The function of CK1δ in lymphoid neoplasms was first described using a mouse model leading to the observation that the expression level of CK1δ is increased in cells of hyperplastic B follicles and advanced B cell lymphomas in p53-deficient mice. Later, CK1δ mRNA and protein levels were also analyzed in 18 lymphoma cell lines and strong expression of CK1δ could be found in all analyzed cell lines (Maritzen et al., 2003; Winkler et al., 2015). Interestingly, in some other studies low expression of CK1δ in cancer tissues has also been described (Fig. 8 and Table 5).
Molecular basis for the regulation of the circadian clock kinases CK1δ and CK1ε
2017, Cellular SignallingCitation Excerpt :The mechanism by which p53 up-regulates CK1δ is not clear, and it may function at either the transcriptional level or the post-transcriptional level [28]. In agreement with CK1δ activity being reduced in p53 −/− lymphocytes [21], p53 and CK1δ might regulate each other with a positive relationship [28]. On the clinical side, spinal nerve injury decreased CK1ε mRNA (with 2.8-fold reduction) and protein levels in the spinal cord of the neuropathic pain-resistant N-type Ca2 + channel deficient mice, while CK1ε protein expression (but not messenger levels) was up-regulated in the dorsal root ganglion and spinal cord neurons in wild type mice [82].
Casein kinase 1δ activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity
2010, Archives of Biochemistry and BiophysicsCitation Excerpt :These kinases are implicated in a variety of cellular functions, including vesicle trafficking, DNA repair, cell division and progression, circadian rhythms and apoptosis [17]. Interestingly, CKI δ, like dCK, has been shown to display high activity in lymphocytes [18,19] and to play an important role in the DNA damage response [9,20,21]. Moreover, CKI δ protein levels were found to be p53-dependently elevated upon etoposide treatment [20] that also induces increase of Ser-74 phosphorylation and dCK activity in leukemic cells [7,14].
Clock-cancer connection in non-Hodgkin's lymphoma
2008, Medical HypothesesInteraction of casein kinase 1 delta (CK1δ) with the light chain LC2 of microtubule associated protein 1A (MAP1A)
2005, Biochimica et Biophysica Acta - Molecular Cell Research