Selective G protein βγ-subunit compositions mediate phospholipase C activation in the vomeronasal organ
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2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionWnt-5a/frizzled9 receptor signaling through the Gα<inf>o</inf>-Gβγ complex regulates dendritic spine formation
2016, Journal of Biological ChemistryCitation Excerpt :We found that in neurons at rest (non-stimulated), Gβγ interacts with Gαo, as reported previously (68) and that this interaction is reduced after Wnt-5a treatment, suggesting that Gβγ is activated and released. The Gαo protein participates in several transduction cascades, although there is good evidence that PLC is a key downstream enzyme in this cascade, and it has also been suggested that Gβγ, which activates PLC, mediates this molecular step (69). Additionally, it has been proposed that Gβγ is involved in canonical Wnt signaling through its ability to recruit Dvl to the plasma membrane.
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2016, Chemosensory Transduction: The Detection of Odors, Tastes, and Other ChemostimuliMolecular Basis of Pheromone Detection in Insects
2005, Comprehensive Molecular Insect ScienceVomeronasal phenotype and behavioral alterations in Gαi2 mutant mice
2003, Current BiologyCitation Excerpt :Proliferation appeared unchanged at this age; there was no significant difference in the numbers of phospho-histone H3-positive cells in the neuroepithelial part of the VN organ (3.2 ± 0.4 cells per section for mutants versus 3.4 ± 0.3 for controls). The decrease in the apical VN neuronal population in Gαi2 mutant mice may be a direct effect of the absence of sensory activity due to lack of the Gα subunit for the heterotrimeric G protein Gαi2β2γ2, through which the V1R receptors conceivably signal [20]. An alternative explanation is that in the mutant, apical VN axons may be less efficient in finding the AOB target and consequently may benefit less from neurotrophic support by target neurons.