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Dose-dense paclitaxel and carboplatin vs. conventional paclitaxel and carboplatin as neoadjuvant chemotherapy for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer: a retrospective study

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Abstract

Background

The purpose of this study was to determine the optimal regimen of neoadjuvant chemotherapy (NAC) for advanced epithelial ovarian, fallopian tube, and peritoneal cancers.

Methods

A clinical information survey involving 171 patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer was conducted. These patients underwent NAC followed by interval debulking surgery at the Hyogo Cancer Center (Hyogo, Japan) between January 2006 and December 2015.

Results

The median observation period was 41 (range 4–138) months. Dose-dense paclitaxel and carboplatin (TC) was administered in 101 patients (59%); tri-weekly TC was administered 70 patients (41%). Median progression-free survival was 21 [95% confidence interval (CI) 18–23] months and 15 (95% CI 13–17) months in the dose-dense TC and conventional-TC group [hazard ratio (HR) = 0.69, 95% CI 0.46–0.96; p = 0.02], respectively. The median overall survival was 59 (95% CI 46–72) and 40 (95% CI 32–57) months in the dose-dense TC group and conventional-TC group (HR = 0.72, 95% CI 0.48–1.06; p = 0.09). Multivariate analysis for progression-free survival demonstrated that dose-dense TC represented an independent prognostic factor (HR = 0.70, 95% CI 0.50–0.99; p = 0.04).

Conclusions

Dose-dense TC is a promising regimen of NAC for advanced epithelial ovarian cancer.

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Authors and Affiliations

  1. Department of Gynecologic Oncology, Hyogo Cancer Center, 13-70 Kitaoji-cho, Akashi-City, 673-8558, Hyogo, Japan

    Takashi Shibutani, Shoji Nagao, Kazuhiro Suzuki, Michiko Kaneda, Kasumi Yamamoto, Tomoatsu Jimi, Hiroko Yano, Miho Kitai, Takaya Shiozaki, Kazuko Matsuoka, Tamotsu Sudo & Satoshi Yamaguchi

Authors
  1. Takashi Shibutani
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  2. Shoji Nagao
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  3. Kazuhiro Suzuki
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  4. Michiko Kaneda
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  5. Kasumi Yamamoto
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  6. Tomoatsu Jimi
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  7. Hiroko Yano
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  8. Miho Kitai
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  9. Takaya Shiozaki
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  10. Kazuko Matsuoka
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  11. Tamotsu Sudo
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  12. Satoshi Yamaguchi
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Contributions

TS designed the study, analyzed the data, and wrote the initial draft of the manuscript. SN contributed to design of the research, analysis and interpretation of the data, and assisted in the preparation of the manuscript. KS, MK, KY, TJ, HY, MK, TS, KM, TS, and SY have contributed to data collection and interpretation, and critically reviewed the manuscript. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Shoji Nagao.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Institutional Review Board of the Hyogo Cancer Center (Hyogo, Japan).

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Shibutani, T., Nagao, S., Suzuki, K. et al. Dose-dense paclitaxel and carboplatin vs. conventional paclitaxel and carboplatin as neoadjuvant chemotherapy for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer: a retrospective study. Int J Clin Oncol 25, 502–507 (2020). https://doi.org/10.1007/s10147-019-01567-y

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  • DOI: https://doi.org/10.1007/s10147-019-01567-y

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