Elsevier

Virology

Volume 411, Issue 2, 15 March 2011, Pages 260-272
Virology

Review
Stem cell-based anti-HIV gene therapy

https://doi.org/10.1016/j.virol.2010.12.039Get rights and content
Under an Elsevier user license
open archive

Abstract

Human stem cell-based therapeutic intervention strategies for treating HIV infection have recently undergone a renaissance as a major focus of investigation. Unlike most conventional antiviral therapies, genetically engineered hematopoietic stem cells possess the capacity for prolonged self-renewal that would continuously produce protected immune cells to fight against HIV. A successful strategy therefore has the potential to stably control and ultimately eradicate HIV from patients by a single or minimal treatment. Recent progress in the development of new technologies and clinical trials sets the stage for the current generation of gene therapy approaches to combat HIV infection. In this review, we will discuss two major approaches that are currently underway in the development of stem cell-based gene therapy to target HIV: one that focuses on the protection of cells from productive infection with HIV, and the other that focuses on targeting immune cells to directly combat HIV infection.

Keywords

HIV
Gene therapy
Stem cells
Intracellular immunization
Genetic immune therapy

Cited by (0)