Abstract
Knowledge of microdosimetric quantities of certain radionuclides is important in radio immune cancer therapies. Specific energy distribution of radionuclides, which are bound to the cell, is the microdosimetric quantity essential in the process of radionuclide selection for patient tumour treatment. The aim of this paper is to establish an applicable method to determine microdosimetric quantities for various radionuclides. The established method is based on knowledge of microdosimetric quantities of monoenergetic electrons. In this paper these quantities are determined for the single-cell model for a range of electron energies up to \(2.3\,{\text{MeV}}\), using the Monte Carlo transport code PENELOPE. The results show that using monoenergetic specific energies, reconstruction of the specific energy of beta-emitting radionuclides can be successfully done with very high accuracy. Microdosimetric quantities share information about the physical processes involved and give insight about energy depositions, which is of use in the procedure of radionuclide selection for a given type of therapy.
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The research was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia through the project 171021.
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Markovic, V.M., Stevanovic, N. & Nikezic, D. Monte Carlo investigation of electron specific energy distribution in a single cell model. Radiat Environ Biophys 59, 161–171 (2020). https://doi.org/10.1007/s00411-019-00815-z
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DOI: https://doi.org/10.1007/s00411-019-00815-z