Editorial overview: Collusion between genes and environment in the pathogenesis of allergic disease

doi:10.1016/j.coi.2019.09.002

Current Opinion in Immunology

Volume 60, October 2019, Pages iii-v

https://doi.org/10.1016/j.coi.2019.09.002 Get rights and content

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Funding

This research was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, N.I.H.

Dr Guerrerio received her M.D. Ph.D degrees from Johns Hopkins University where she also completed a residency in pediatrics and fellowship in allergy and immunology. Dr Guerrerio is currently Chief of the Food Allergy Research Unit at the National Institutes of Health. Her research program is focused on understanding the genetic and immunologic mechanisms that lead to food allergy, eosinophilic esophagitis, and related diseases, and identifying strategies to improve the care of these patients.

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2022, Lactic Acid Bacteria in Food Biotechnology: Innovations and Functional Aspects
Health-promoting attributes of lactic acid bacteria (LAB) have been extensively studied. Advances in genome analysis have provided the necessary tools for assessing these features from a genomic perspective. Descriptions of metabolic pathways, regulatory mechanisms, and gene networks have improved our understanding regarding these properties. Among them, regulation of antiallergy immune responses and production of bioactive peptides, γ-aminobutyric acid, and vitamins, especially of the B complex, have been at the epicenter of intensive study over the last decade. The potential of LAB to reduce allergic and intolerance responses to wheat proteins and produce an array of functional ingredients has been characterized as a species-specific and, in some cases, a strain-dependent trait. The present chapter aimed to collect and critically discuss all related information on the subject.

Josh Milner received his MD from the Albert Einstein College of Medicine, trained in Pediatrics at the Childrens National Medical Center, and in Allergy/Immunology at the NIAID where is now Chief of the Laboratory of Allergic Diseases. His basic, translational and clinical research focuses on Primary Atopic Disorders, and the immunopathogenesis of single gene lesions.

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