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Annual Review of Nutrition

Volume 36, 2016

Lactation and Maternal Cardio-Metabolic Health*

Abstract

Researchers hypothesize that pregnancy and lactation are part of a continuum, with lactation meant to “reset” the adverse metabolic profile that develops as a part of normal pregnancy, and that when lactation does not occur, women maintain an elevated risk of cardio-metabolic diseases. Several large prospective and retrospective studies, mostly from the United States and other industrialized countries, have examined the associations between lactation and cardio-metabolic outcomes. Less evidence exists regarding an association of lactation with maternal postpartum weight status and dyslipidemia, whereas more evidence exists for an association with diabetes, hypertension, and subclinical and clinical cardiovascular disease.

Keyword(s): breastfeeding, cardiovascular disease, diabetes, dyslipidemia, hypertension, metabolic syndrome
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2016-07-17
2024-04-19
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Literature Cited

  1. Al-Sahab B, Lanes A, Feldman M, Tamim H. 1.  2010. Prevalence and predictors of 6-month exclusive breastfeeding among Canadian women: a national survey. BMC Pediatr. 10:20 [Google Scholar]
  2. Amir LH, Donath S. 2.  2007. A systematic review of maternal obesity and breastfeeding intention, initiation and duration. BMC Pregnancy Childbirth 7:9 [Google Scholar]
  3. Aune D, Norat T, Romundstad P, Vatten LJ. 3.  2014. Breastfeeding and the maternal risk of type 2 diabetes: a systematic review and dose-response meta-analysis of cohort studies. Nutr. Metab. Cardiovasc. Dis. 24:107–15 [Google Scholar]
  4. Bellamy L, Casas JP, Hingorani AD, Williams D. 4.  2009. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet 373:1773–79 [Google Scholar]
  5. Bobrow KL, Quigley MA, Green J, Reeves GK, Beral V. 5.  Million Women Study Collab. 2013. Persistent effects of women's parity and breastfeeding patterns on their body mass index: results from the Million Women Study. Int. J. Obes. (Lond.) 37:712–17 [Google Scholar]
  6. Brandhagen M, Lissner L, Brantsaeter AL, Meltzer HM, Haggkvist AP. 6.  et al. 2014. Breast-feeding in relation to weight retention up to 36 months postpartum in the Norwegian Mother and Child Cohort Study: modification by socio-economic status?. Public Health Nutr. 17:1514–23 [Google Scholar]
  7. Bromiker R, Rachamim A, Hammerman C, Schimmel M, Kaplan M, Medoff-Cooper B. 7.  2006. Immature sucking patterns in infants of mothers with diabetes. J. Pediatr. 149:640–43 [Google Scholar]
  8. Bronner YL, Auerbach KG. 8.  2005. Maternal nutrition during lactation. Breastfeeding and Human Lactation J Riordan, K Wambach 437–56 Sudbury, MA: Jones & Bartlett Publ. [Google Scholar]
  9. Buchanan TA. 9.  1991. Glucose metabolism during pregnancy: normal physiology and implications for diabetes mellitus. Isr. J. Med. Sci. 27:432–41 [Google Scholar]
  10. Butte NF, Hopkinson JM, Mehta N, Moon JK, Smith EO. 10.  1999. Adjustments in energy expenditure and substrate utilization during late pregnancy and lactation. Am. J. Clin. Nutr. 69:299–307 [Google Scholar]
  11. Catalano PM, Tyzbir ED, Roman NM, Amini SB, Sims EA. 11.  1991. Longitudinal changes in insulin release and insulin resistance in nonobese pregnant women. Am. J. Obstet. Gynecol. 165:1667–72 [Google Scholar]
  12. 12. Cent. Dis. Control Prev. 2015. Breastfeeding Among U.S. Children Born 2000–2012, CDC National Immunization Survey. http://www.cdc.gov/breastfeeding/data/NIS_data/
  13. Cho GJ, Park HT, Shin JH, Kim T, Hur JY. 13.  et al. 2009. The relationship between reproductive factors and metabolic syndrome in Korean postmenopausal women: Korea National Health and Nutrition Survey 2005. Menopause 16:998–1003 [Google Scholar]
  14. Chouinard-Castonguay S, Weisnagel SJ, Tchernof A, Robitaille J. 14.  2013. Relationship between lactation duration and insulin and glucose response among women with prior gestational diabetes. Eur. J. Endocrinol. 168:515–23 [Google Scholar]
  15. Cohen A, Pieper CF, Brown AJ, Bastian LA. 15.  2006. Number of children and risk of metabolic syndrome in women. J. Womens Health (Larchmt.) 15:763–73 [Google Scholar]
  16. Cure P, Hoffman HJ, Cure-Cure C. 16.  2015. Parity and diabetes risk among Hispanic women from Colombia: cross-sectional evidence. Diabetol. Metab. Syndr. 7:7 [Google Scholar]
  17. Darmady JM, Postle AD. 17.  1982. Lipid metabolism in pregnancy. Br. J. Obstet. Gynaecol. 89:211–15 [Google Scholar]
  18. Endres LK, Straub H, McKinney C, Plunkett B, Minkovitz CS. 18.  et al. 2015. Postpartum weight retention risk factors and relationship to obesity at 1 year. Obstet. Gynecol. 125:144–52 [Google Scholar]
  19. Feig DS, Zinman B, Wang X, Hux JE. 19.  2008. Risk of development of diabetes mellitus after diagnosis of gestational diabetes. CMAJ 179:229–34 [Google Scholar]
  20. Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P. 20.  et al. 2007. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 116:39–48 [Google Scholar]
  21. Groer MW, Jevitt CM, Sahebzamani F, Beckstead JW, Keefe DL. 21.  2013. Breastfeeding status and maternal cardiovascular variables across the postpartum. J. Womens Health (Larchmt.) 22:453–59 [Google Scholar]
  22. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. 22.  2009. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 9:88 [Google Scholar]
  23. Gunderson EP. 23.  2014. Impact of breastfeeding on maternal metabolism: implications for women with gestational diabetes. Curr. Diabetes Rep. 14:460 [Google Scholar]
  24. Gunderson EP, Jacobs DR Jr., Chiang V, Lewis CE, Feng J. 24.  et al. 2010. Duration of lactation and incidence of the metabolic syndrome in women of reproductive age according to gestational diabetes mellitus status: a 20-year prospective study in CARDIA (Coronary Artery Risk Development in Young Adults). Diabetes 59:495–504 [Google Scholar]
  25. Gunderson EP, Lewis CE, Wei GS, Whitmer RA, Quesenberry CP, Sidney S. 25.  2007. Lactation and changes in maternal metabolic risk factors. Obstet. Gynecol. 109:729–38 [Google Scholar]
  26. Gunderson EP, Quesenberry CP Jr., Ning X, Jacobs DR Jr., Gross M. 26.  et al. 2015. Lactation duration and midlife atherosclerosis. Obstet. Gynecol. 126:381–90 [Google Scholar]
  27. He X, Hu C, Chen L, Wang Q, Qin F. 27.  2014. The association between gestational weight gain and substantial weight retention 1-year postpartum. Arch. Gynecol. Obstet. 290:493–99 [Google Scholar]
  28. Herrera E. 28.  2000. Metabolic adaptations in pregnancy and their implications for the availability of substrates to the fetus. Eur. J. Clin. Nutr. 54:Suppl. 1S47–51 [Google Scholar]
  29. Herrera E, Ramos P, Lopez-Luna P, Lasuncion MA. 29.  1994. Metabolic interactions during pregnancy in preparation for lactation. Dairy Products in Human Health and Nutrition EA Serrano Rios 189–97 Balkema, Rotterdam: CRC Press [Google Scholar]
  30. Ip S, Chung M, Raman G, Chew P, Magula N. 30.  et al. 2007. Breastfeeding and maternal and infant health outcomes in developed countries. Rep. AHRQ Publ. No. 07-E007. Rockville, MD: Agency Healthc. Res. Qual. [Google Scholar]
  31. Jager S, Jacobs S, Kroger J, Fritsche A, Schienkiewitz A. 31.  et al. 2014. Breast-feeding and maternal risk of type 2 diabetes: a prospective study and meta-analysis. Diabetologia 57:1355–65 [Google Scholar]
  32. Kallio MJ, Siimes MA, Perheentupa J, Salmenpera L, Miettinen TA. 32.  1992. Serum cholesterol and lipoprotein concentrations in mothers during and after prolonged exclusive lactation. Metabolism 41:1327–30 [Google Scholar]
  33. Kim C. 33.  2014. Maternal outcomes and follow-up after gestational diabetes mellitus. Diabet. Med. 31:292–301 [Google Scholar]
  34. Kinoshita T, Itoh M. 34.  2006. Longitudinal variance of fat mass deposition during pregnancy evaluated by ultrasonography: the ratio of visceral fat to subcutaneous fat in the abdomen. Gynecol. Obstet. Investig. 61:115–18 [Google Scholar]
  35. Kjos SL, Henry O, Lee RM, Buchanan TA, Mishell DR Jr. 35.  1993. The effect of lactation on glucose and lipid metabolism in women with recent gestational diabetes. Obstet. Gynecol. 82:451–55 [Google Scholar]
  36. Kramer MS, Chalmers B, Hodnett ED, Sevkovskaya Z, Dzikovich I. 36.  et al. 2001. Promotion of Breastfeeding Intervention Trial (PROBIT): a randomized trial in the Republic of Belarus. JAMA 285:413–20 [Google Scholar]
  37. Lawlor DA, Emberson JR, Ebrahim S, Whincup PH, Wannamethee SG. 37.  et al. 2003. Is the association between parity and coronary heart disease due to biological effects of pregnancy or adverse lifestyle risk factors associated with child-rearing? Findings from the British Women's Heart and Health Study and the British Regional Heart Study. Circulation 107:1260–64 [Google Scholar]
  38. Lee SY, Kim MT, Jee SH, Yang HP. 38.  2005. Does long-term lactation protect premenopausal women against hypertension risk? A Korean women's cohort study. Prev. Med. 41:433–38 [Google Scholar]
  39. Linne Y, Dye L, Barkeling B, Rossner S. 39.  2003. Weight development over time in parous women—the SPAWN study—15 years follow-up. Int. J. Obes. Relat. Metab. Disord. 27:1516–22 [Google Scholar]
  40. Lippi G, Albiero A, Montagnana M, Salvagno GL, Scevarolli S. 40.  et al. 2007. Lipid and lipoprotein profile in physiological pregnancy. Clin. Lab. 53:173–77 [Google Scholar]
  41. Lobner K, Knopff A, Baumgarten A, Mollenhauer U, Marienfeld S. 41.  et al. 2006. Predictors of postpartum diabetes in women with gestational diabetes mellitus. Diabetes 55:792–97 [Google Scholar]
  42. Lupton SJ, Chiu CL, Lujic S, Hennessy A, Lind JM. 42.  2013. Association between parity and breastfeeding with maternal high blood pressure. Am. J. Obstet. Gynecol. 208:454.e1–7 [Google Scholar]
  43. Martin JE, Hure AJ, Macdonald-Wicks L, Smith R, Collins CE. 43.  2014. Predictors of post-partum weight retention in a prospective longitudinal study. Matern. Child Nutr. 10:496–509 [Google Scholar]
  44. Matias SL, Dewey KG, Quesenberry CP Jr., Gunderson EP. 44.  2014. Maternal prepregnancy obesity and insulin treatment during pregnancy are independently associated with delayed lactogenesis in women with recent gestational diabetes mellitus. Am. J. Clin. Nutr. 99:115–21 [Google Scholar]
  45. McClure CK, Catov JM, Ness RB, Schwarz EB. 45.  2012. Maternal visceral adiposity by consistency of lactation. Matern. Child Health J. 16:316–21 [Google Scholar]
  46. McClure CK, Catov JM, Ness RB, Schwarz EB. 46.  2012. Lactation and maternal subclinical cardiovascular disease among premenopausal women. Am. J. Obstet. Gynecol. 207:46.e1–8 [Google Scholar]
  47. McClure CK, Schwarz EB, Conroy MB, Tepper PG, Janssen I, Sutton-Tyrrell KC. 47.  2011. Breastfeeding and subsequent maternal visceral adiposity. Obesity (Silver Spring) 19:2205–13 [Google Scholar]
  48. Morris EA, Hale SA, Badger GJ, Magness RR, Bernstein IM. 48.  2015. Pregnancy induces persistent changes in vascular compliance in primiparous women. Am. J. Obstet. Gynecol. 212:633e1–6 [Google Scholar]
  49. Mueller NT, Mueller NJ, Odegaard AO, Gross MD, Koh WP. 49.  et al. 2013. Higher parity is associated with an increased risk of type-II diabetes in Chinese women: the Singapore Chinese Health Study. BJOG 120:1483–89 [Google Scholar]
  50. 50. Natl. Cholest. Educ. Program Expert Panel Detect. Eval. Treat. High Blood Cholest. Adults. 2002. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106:3143–421 [Google Scholar]
  51. Natland Fagerhaug T, Forsmo S, Jacobsen GW, Midthjell K, Andersen LF, Ivar Lund Nilsen T. 51.  2013. A prospective population-based cohort study of lactation and cardiovascular disease mortality: the HUNT study. BMC Public Health 13:1070 [Google Scholar]
  52. Natland ST, Nilsen TI, Midthjell K, Andersen LF, Forsmo S. 52.  2012. Lactation and cardiovascular risk factors in mothers in a population-based study: the HUNT-study. Int. Breastfeed. J. 7:8 [Google Scholar]
  53. Ness RB, Kramer RA, Flegal KM. 53.  1993. Gravidity, blood pressure, and hypertension among white women in the Second National Health and Nutrition Examination Survey. Epidemiology 4:303–9 [Google Scholar]
  54. Neville CE, McKinley MC, Holmes VA, Spence D, Woodside JV. 54.  2014. The relationship between breastfeeding and postpartum weight change—a systematic review and critical evaluation. Int. J. Obes. (Lond.) 38:577–90 [Google Scholar]
  55. Nicholson WK, Asao K, Brancati F, Coresh J, Pankow JS, Powe NR. 55.  2006. Parity and risk of type 2 diabetes: the Atherosclerosis Risk in Communities Study. Diabetes Care 29:2349–54 [Google Scholar]
  56. Nommsen-Rivers LA, Glueck C, Huang B, Wang P, Dolan LM. 56.  2014. Lactation sufficiency is predicted by fasting plasma glucose at 1 month postpartum. FASEB J. 28:131.1 [Google Scholar]
  57. O'Sullivan EJ, Perrine CG, Rasmussen KM. 57.  2015. Early breastfeeding problems mediate the negative association between maternal obesity and exclusive breastfeeding at 1 and 2 months postpartum. J. Nutr. 145:2369–78 [Google Scholar]
  58. Oken E, Patel R, Guthrie LB, Vilchuck K, Bogdanovich N. 58.  et al. 2013. Effects of an intervention to promote breastfeeding on maternal adiposity and blood pressure at 11.5 y postpartum: results from the Promotion of Breastfeeding Intervention Trial, a cluster-randomized controlled trial. Am. J. Clin. Nutr. 98:1048–56 [Google Scholar]
  59. Ouzounian JG, Elkayam U. 59.  2012. Physiologic changes during normal pregnancy and delivery. Cardiol. Clin. 30:317–29 [Google Scholar]
  60. Pesa JA, Shelton MM. 60.  1999. Health-enhancing behaviors correlated with breastfeeding among a national sample of mothers. Public Health Nurs. 16:120–24 [Google Scholar]
  61. Polak JF, Szklo M, Kronmal RA, Burke GL, Shea S. 61.  et al. 2013. The value of carotid artery plaque and intima-media thickness for incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. J. Am. Heart Assoc. 2:e000087 [Google Scholar]
  62. Promislow JH, Gladen BC, Sandler DP. 62.  2005. Maternal recall of breastfeeding duration by elderly women. Am. J. Epidemiol. 161:289–96 [Google Scholar]
  63. Qureshi IA, Xi XR, Limbu YR, Bin HY, Chen MI. 63.  1999. Hyperlipidaemia during normal pregnancy, parturition and lactation. Ann. Acad. Med. Singapore 28:217–21 [Google Scholar]
  64. Ram KT, Bobby P, Hailpern SM, Lo JC, Schocken M. 64.  et al. 2008. Duration of lactation is associated with lower prevalence of the metabolic syndrome in midlife—SWAN, the Study of Women's Health Across the Nation. Am. J. Obstet. Gynecol. 198:268.e1–6 [Google Scholar]
  65. Rooney BL, Schauberger CW. 65.  2002. Excess pregnancy weight gain and long-term obesity: one decade later. Obstet. Gynecol. 100:245–52 [Google Scholar]
  66. Schwarz EB, Brown JS, Creasman JM, Stuebe A, McClure CK. 66.  et al. 2010. Lactation and maternal risk of type 2 diabetes: a population-based study. Am. J. Med. 123:863.e1–6 [Google Scholar]
  67. Schwarz EB, McClure CK, Tepper PG, Thurston R, Janssen I. 67.  et al. 2010. Lactation and maternal measures of subclinical cardiovascular disease. Obstet. Gynecol. 115:41–48 [Google Scholar]
  68. Schwarz EB, Ray RM, Stuebe AM, Allison MA, Ness RB. 68.  et al. 2009. Duration of lactation and risk factors for maternal cardiovascular disease. Obstet. Gynecol. 113:974–82 [Google Scholar]
  69. Stuebe AM. 69.  2015. Does breastfeeding prevent the metabolic syndrome, or does the metabolic syndrome prevent breastfeeding?. Semin. Perinatol. 39:290–95 [Google Scholar]
  70. Stuebe AM, Kleinman K, Gillman MW, Rifas-Shiman SL, Gunderson EP, Rich-Edwards J. 70.  2010. Duration of lactation and maternal metabolism at 3 years postpartum. J. Womens Health (Larchmt.) 19:941–50 [Google Scholar]
  71. Stuebe AM, Michels KB, Willett WC, Manson JE, Rexrode K, Rich-Edwards JW. 71.  2009. Duration of lactation and incidence of myocardial infarction in middle to late adulthood. Am. J. Obstet. Gynecol. 200:138.e1–8 [Google Scholar]
  72. Stuebe AM, Rich-Edwards JW. 72.  2009. The reset hypothesis: lactation and maternal metabolism. Am. J. Perinatol. 26:81–88 [Google Scholar]
  73. Stuebe AM, Rich-Edwards JW, Willett WC, Manson JE, Michels KB. 73.  2005. Duration of lactation and incidence of type 2 diabetes. JAMA 294:2601–10 [Google Scholar]
  74. Stuebe AM, Schwarz EB, Grewen K, Rich-Edwards JW, Michels KB. 74.  et al. 2011. Duration of lactation and incidence of maternal hypertension: a longitudinal cohort study. Am. J. Epidemiol. 174:1147–58 [Google Scholar]
  75. Torris C, Thune I, Emaus A, Finstad SE, Bye A. 75.  et al. 2013. Duration of lactation, maternal metabolic profile, and body composition in the Norwegian EBBA I-study. Breastfeed. Med. 8:8–15 [Google Scholar]
  76. Turner MJ, Layte R. 76.  2013. Obesity levels in a national cohort of women 9 months after delivery. Am. J. Obstet. Gynecol. 209:124.e1–7 [Google Scholar]
  77. Villegas R, Gao YT, Yang G, Li HL, Elasy T. 77.  et al. 2008. Duration of breast-feeding and the incidence of type 2 diabetes mellitus in the Shanghai Women's Health Study. Diabetologia 51:258–66 [Google Scholar]
  78. Weiser TM, Lin M, Garikapaty V, Feyerharm RW, Bensyl DM, Zhu BP. 78.  2009. Association of maternal smoking status with breastfeeding practices: Missouri, 2005. Pediatrics 124:1603–10 [Google Scholar]
  79. Wiklund P, Xu L, Lyytikainen A, Saltevo J, Wang Q. 79.  et al. 2012. Prolonged breast-feeding protects mothers from later-life obesity and related cardio-metabolic disorders. Public Health Nutr. 15:67–74 [Google Scholar]
  80. 80. World Health Organ. 2011. Global Atlas on Cardiovascular Disease Prevention and Control Geneva: World Health Organ.
  81. Zhang BZ, Zhang HY, Liu HH, Li HJ, Wang JS. 81.  2015. Breastfeeding and maternal hypertension and diabetes: a population-based cross-sectional study. Breastfeed. Med. 10:163–67 [Google Scholar]
/content/journals/10.1146/annurev-nutr-071715-051213
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Lactation and Maternal Cardio-Metabolic Health*
Annual Review of Nutrition 36, 627 (2016); https://doi.org/10.1146/annurev-nutr-071715-051213
/content/journals/10.1146/annurev-nutr-071715-051213
/content/journals/10.1146/annurev-nutr-071715-051213
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