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Generalizing from the results of randomized studies of treatment: Can non-randomized studies be of help?

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References

  1. Benson K, Hartz AJ. A comparison of observational studies and randomized controlled trials. N Engl J Med. 2000;342:1878–86.

    Article  CAS  PubMed  Google Scholar 

  2. Pocock SJ, Elbourne DR. Randomized trials or observational tribulations? N Engl J Med. 2000;342:1907–9.

    Article  CAS  PubMed  Google Scholar 

  3. Goldberg IJ. To drink or not to drink? N Engl J Med. 2003;348:163–4.

    Article  PubMed  Google Scholar 

  4. Weiss NS, Clinical epidemiology: the study of the occurrence of illness. Oxford, New York; 2006.

  5. Elting LS. Author reply. Cancer. 2007;109:342.

    Article  Google Scholar 

  6. Weiss NS, Koepsell TD, Psaty BM. Generalizability of the results of randomized trials. Arch Intern Med. 2008;168:133–5.

    Article  PubMed  Google Scholar 

  7. Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med. 1999;341:709–17.

    Article  CAS  PubMed  Google Scholar 

  8. Juurlink DN, Mamdani M, Kopp A, et al. Drug–drug interactions among elderly patients hospitalized for drug toxicity. JAMA. 2003;289:1652–8.

    Article  CAS  PubMed  Google Scholar 

  9. Grant RM, Lama JR, Anderson PI, et al. Pre-exposure prophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363:2587–99.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. McCormack S, Dunn DT, Sesai M, et al. Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomized trial. Lancet. 2016;387:53–60.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Elting LS, Cooksley C, Bekele BN, et al. Generalizability of cancer clinical trial results: prognostic differences between participants and nonparticipants. Cancer. 2006;106:2452–8.

    Article  PubMed  Google Scholar 

  12. Van de Water W, Kiderlen M, Bastiaannet F, et al. External validity of a trial comprised of elderly patients with hormone receptor-positive breast cancer. JNCI. 2014;106:1–8.

    Article  Google Scholar 

  13. Atrial Fibrillation Investigators. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized controlled trials. Arch Intern Med. 1994;154:1449–57.

    Article  Google Scholar 

  14. Stern S, Altkorn D, Levinson W. Anticoagulation for chronic atrial fibrillation. JAMA. 2000;283:2901–3.

    Article  CAS  PubMed  Google Scholar 

  15. Horwitz RI, Singer BH. Why evidence-based medicine failed in patient care and medicine-based evidence will succeed. J Clin Epidemiol. 2017;84:14–7.

    Article  PubMed  Google Scholar 

  16. Lauer MS, Collins FS. Using science to improve the nation’s health system: NIH’s commitment to comparative effectiveness research. JAMA. 2010;303:2182–3.

    Article  CAS  PubMed  Google Scholar 

  17. Goldman B. Treatments that work for people just like you. Winter: Stanford Medicine; 2016. p. 32.

    Google Scholar 

  18. Weiss NS. The new world of data linkages in clinical epidemiology: Are we being brave or foolhardy? Epidemiology. 2011;22:292–4.

    Article  PubMed  Google Scholar 

  19. Baxter NN, Goldwasser MA, Paszat LF, et al. Association of colonoscopy and death from colorectal cancer. Ann Intern Med. 2009;150:1–8.

    Article  PubMed  Google Scholar 

  20. Weiss NS, Dhillon PK, Etzioni R. Case-control studies of the efficacy of cancer screening: overcoming bias from non-random patterns of screening. Epidemiology. 2004;15:409–13.

    Article  PubMed  Google Scholar 

  21. Ray WA, Griffin MR, Schaffner W, et al. Psychotropic drug use and risk of fracture. N Engl Med. 1987;316:363–9.

    Article  CAS  Google Scholar 

  22. Gerstman BB, Friesman JP, Hine LK. Use of subsequent anticoagulants to increase the predictive value of Medicaid deep venous thromboembolism diagnosis. Epidemiology. 1990;1:122–7.

    Article  CAS  PubMed  Google Scholar 

  23. Jackson LA, Jackson ML, Nelson JC, et al. Evidence of bias in estimates of influenza vaccine effectiveness in seniors. Int J Epidemiol. 2006;35:337–44.

    Article  PubMed  Google Scholar 

  24. Pignon JP, Tribodet H, Scagliotti GV, et al. Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group. J Clin Oncol. 2008;26:3552–9.

    Article  PubMed  Google Scholar 

  25. Ganti AK, Williams CD, Gajra A, et al. Effect of age on the efficacy of adjuvant chemotherapy for resected non-small cell lung cancer. Cancer. 2015;121:2578–85.

    Article  PubMed  Google Scholar 

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Correspondence to Noel S. Weiss.

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Weiss, N.S. Generalizing from the results of randomized studies of treatment: Can non-randomized studies be of help?. Eur J Epidemiol 34, 715–718 (2019). https://doi.org/10.1007/s10654-019-00516-3

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  • DOI: https://doi.org/10.1007/s10654-019-00516-3

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