Abstract
The laboratory rat (Rattus norvegicus) has a long tradition as experimental animal in transplantation and autoimmunity research and, hence, there has been an inherent interest in its major histocompatibility complex (MHC), the RT1 complex. Available inbred rat strains and their derived RT1-congenic and intra-RT1 recombinant congenic strains were crucial for definition and characterization of RT1 genes and alleles and essentially advanced elucidation of the RT1 genomic organization in the past. The Immuno Polymorphism Database (IPD) harbors a section for rat MHC genes and alleles (IPD-MHC RT1) since 2005. The curator for IPD-MHC RT1 provides official designations for newly described genes and alleles of RT1. This is the first nomenclature report of RT1 genes and alleles that are currently included in IPD-MHC RT1.
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References
Arimura Y, Tang WR, Koda T, Kakinuma M (1995) Structure of novel rat major histocompatibility complex class II genes RT1.Ha and Hb. Immunogenetics 41:320–325
Bogden AE, Aptekman PM (1960) The R-l factor, a histocompatibility antigen in the rat. Cancer Res 20:1372–1382
Dai K-Z, Ryan JC, Naper C, Vaage JT (2018) Identification of MHC class Ib ligands for stimulatory and inhibitory Ly49 receptors and induction of potent NK cell alloresponses in rats. J Immunol 200:2847–2859
Daws MR, Dai K-Z, Zinöcker S, Naper C, Kveberg L, Hedrich HJ, Rolstad B, Vaage JT (2012) Identification of an MHC class I ligand for the single member of a killer cell lectin-like receptor family, KLRH1. J Immunol 189:5178–5184
Ettinger RA, Moustakas AK, Lobaton SD (2004) Open reading frame sequencing and structure-based alignment of polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles. Immunogenetics 56:585–596
Günther E, Walter L (2001) The major histocompatibility complex of the rat (Rattus norvegicus). Immunogenetics 53:520–542
Günther E, Wurst W (1984) Cytotoxic T lymphocytes of the rat are predominantly restricted by RT1.A and not RT1.C-determined major histocompatibility class I antigens. Immunogenetics 20:1–12
Hurt P, Walter L, Sudbrak R, Klages S, Müller I, Shiina T, Inoko H, Lehrach H, Günther E, Reinhardt R, Himmelbauer H (2004) The genomic sequence and comparative analysis of the rat major histocompatibility complex. Genome Res 14:631–639
Ioannidu S, Walter L, Dressel R, Günther E (2001) Physical map and expression profile of genes of the telomeric class I gene region of the rat MHC. J Immunol 166:3957–3965
Klein J, Bontrop RE, Dawkins RL, Erlich HA, Gyllensten UB, Heise ER, Jones PP, Parham P, Wakeland EK, Watkins DI (1990) Nomenclature for the major histocompatibility complexes of different species: a proposal. Immunogenetics 31:217–219
Křen V, Veselý P, Frenzl B, Štark O (1960) Inhibition of the runting syndrome in rats. Folia Biol (Praha) 6:333–341
Lambracht-Washington D, Fischer Lindahl K (2002) Does the rat have an H2-D orthologue next to Bat1? Immunogenetics 53:1039–1046
Monzón-Casanova E, Rudolf R, Starick L, Müller I, Söllner C, Müller N, Westphal N, Miyoshi-Akiyama T, Uchiyama T, Berberich I, Walter L, Herrmann T (2016) The forgotten: identification and functional characterization of MHC class II molecules H2-Eb2 and RT1-Db2. J Immunol 196:988–999
Naper C, Hayashi S, Joly E, Butcher GW, Rolstad B, Vaage JT, Ryan JS (2002a) Ly49i2 is an inhibitory rat natural killer cell receptor for an MHC class Ia molecule (RT1-A1c). Eur J Immunol 32:2031–2036
Naper C, Hayashi S, Kveberg L, Niemi EC, Lanier LL, Vaage JT, Ryan JC (2002b) Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligands. J Immunol 169:22–30
Roos C, Walter L (2005) Considerable haplotypic diversity in the RT1-CE class I gene region of the rat major histocompatibility complex. Immunogenetics 56:773–777
Shegarfi H, Kane KP, Nestvold J (2018) Listeria monocytogenes infection enhances the interaction between rat non-classical MHC-Ib molecule and Ly49 receptors. Innate Immun 24:252–261
Tuncel J, Haag S, Yau AC, Norin U, Baud A, Lönnblom E, Maratou K, Ytterberg AJ, Ekman D, Thordardottir S, Johannesson M, Gillett A, EURATRANS Consortium, Stridh P, Jagodic M, Olsson T, Fernández-Teruel A, Zubarev RA, Mott R, Aitman TJ, Flint J, Holmdahl R (2014) Natural polymorphisms in Tap2 influence negative selection and CD4∶CD8 lineage commitment in the rat. PLoS Genet 10:e1004151
Vestberg M, Brunsberg U, Bergsteinsdottir K, Karlsson M, Gustafsson K, Wedekind D, Hedrich H, Holmdahl R (1998) Limited polymorphism in the first domain of the rat MHC class II RT1-D molecule. Immunogenetics 48:344–349
Walter L, Günther E (2000) Physical mapping and evolution of the centromeric class I gene-containing region of the rat MHC. Immunogenetics 51:829–837
Walter L, Tiemann C, Heine L, Günther E (1995) Genomic organization and sequence of the rat major histocompatibility complex class Ia gene RT1.Au. Immunogenetics 41:332
Walter L, Hurt P, Himmelbauer H, Sudbrak R, Günther E (2002) Physical mapping of the major histocompatibility complex class II and class III regions of the rat. Immunogenetics 54:268–275
Wang M, Stepkowski SM, Tian L, Langowski JL, Hebert JS, Kloc M, Yu J, Kahan BD (1996) Nucleotide sequences of three distinct clones coding for rat heavy chain class I major histocompatibility antigens. Immunogenetics 43:318–320
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The author is deeply grateful for the ongoing outstanding support and dedicated work of the individuals that are involved in maintaining the IPD-MHC database.
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This article is part of the Topical Collection on “Nomenclature, databases and bioinformatics in Immunogenetics"
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Walter, L. Nomenclature report on the major histocompatibility complex genes and alleles of the laboratory rat (Rattus norvegicus). Immunogenetics 72, 5–8 (2020). https://doi.org/10.1007/s00251-019-01131-y
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DOI: https://doi.org/10.1007/s00251-019-01131-y