Abstract
Hydrazide ligand, (Z)-N’-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)isonicotinohydrazide, 1 forms from a 1:1 Schiff base condensation reaction between isoniazid (INH) and 1,10-phenanthroline-5,6-dione (phendione). Ag+ and Mn2+ complexes with 1:2 metal:ligand stoichiometry are prepared: [Ag(1)2]NO3, [Ag(1)2]BF4 and [Mn(1)2](NO3)2. Polymeric {[Ag(1)(NO3)]}n has 1:1 stoichiometry and forms upon infusion of CH2Cl2 into a DMSO solution of [Ag(1)2]NO3. {[Ag(1)(NO3)]}n was structurally characterized using X-ray crystallography. Metal-free 1 and its 1:2 complexes exhibit very good, broad-spectrum antimicrobial activity and are not excessively toxic to mammalian cells (A549 lineage).
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We gratefully acknowledge Maynooth University John and Pat Hume Scholarship Award for MA. We also gratefully acknowledge the financial support for the biological studies from the Brazilian agencies CNPq, FAPERJ and CAPES.
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Ahmed, M., Rooney, D., McCann, M. et al. Synthesis and antimicrobial activity of a phenanthroline-isoniazid hybrid ligand and its Ag+ and Mn2+ complexes. Biometals 32, 671–682 (2019). https://doi.org/10.1007/s10534-019-00204-5
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DOI: https://doi.org/10.1007/s10534-019-00204-5