Journal of Lipid Research
Research ArticlesChemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells
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This work was supported by National Institutes of Health Grant P01 CA171983 and by a grant from the Brody Brothers Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors declare that they have no conflicts of interest with the contents of this article.
- AML
acute myelogenous leukemia
- AC
acid ceramidase
- Ara-C
cytarabine
- dnr
daunorubicin
- CerS
ceramide synthase
- Des1
dihydroceramide desaturase 1
- FCCP
carbonyl cyanide p-trifluoromethoxyphenylhydrazone
- GC
glucosylceramide
- GCS
glucosylceramide synthase
- LDH
lactate dehydrogenase
- OXPHOS
oxidative phosphorylation
- PDMP
d,l-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol
- P-gp
P-glycoprotein
- PI
propidium iodide
- SACLAC
2-chloro-N-(2S,3R)-1,3-dihydroxyoctadecan-2-yl acetamide
- SL
sphingolipid
- SPHK1
sphingosine kinase 1
- S1P
sphingosine 1-phosphate
Abbreviations:
This paper was presented in part at the Keystone Symposia on Molecular and Cellular Biology, Lipidomics and Functional Metabolic Pathways in Disease, Steamboat Springs, CO, March 31–April 4, 2019, and the 4th International Workshop on the Molecular Medicine of Sphingolipids, the Weizmann Institute of Science & Ein Gedi, Israel, October 14–19, 2018.
- 1
Present address of T. S. Davis: Gillings School of Global Public Health, Department of Nutrition, 135 Dauer Dr., University of North Carolina, Chapel Hill, NC 27599.
- 2
Present address of M. R. MacDougall: US Marine Corps, MATSG-21, NAS Pensacola, 211 Farrar Rd, Pensacola, FL 32506.