Hemodynamic force is required for vascular smooth muscle cell recruitment to blood vessels during mouse embryonic development
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Graphical abstract
In normal flow embryos, vascular maturation occurs by the recruitment of vSMCs in the mesoderm to blood vessels exposed to high flow. This is followed by the attachment of the vSMCs to the high-flow vessels. In reduced-flow embryos, the vessels are exposed to lower flow, which minimizes the amount of recruited vSMCs towards any particular vessel.
Keywords
Mouse embryo
Vascular maturation
Vascular smooth muscle cell
Hemodynamic force
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