Elsevier

Neurobiology of Stress

Volume 11, November 2019, 100189
Neurobiology of Stress

Neuro-autonomic changes induced by remote ischemic preconditioning (RIPC) in healthy young adults: Implications for stress

https://doi.org/10.1016/j.ynstr.2019.100189Get rights and content
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Highlights

  • Brief ischemia/reperfusion episodes of distant organs (RIPC) protect other organs.

  • Mechanism of RIPC is not known but it involves neuronal activity.

  • RIPC applied to volunteers was interspersed with mild mental and physical stress.

  • RIPC was confirmed by hyperemia in the limb and metabolic response to hypoxia.

  • Heart rate variability shows that RIPC modulates ANS to increase stress resistance.

Abstract

The mechanisms underlying the protective effects of remote ischemic preconditioning (RIPC) are not presently clear. Recent studies in experimental models suggest the involvement of the autonomic nervous system (ANS) in cardioprotection. The aim of this study was to investigate the changes in ANS in healthy young volunteers divided into RIPC (n = 22) or SHAM (n = 18) groups. RIPC was induced by 1 cycle of 4 min inflation/5 min deflation followed by 2 cycles of 5 min inflation/5 min deflation of a cuff placed on the upper left limb. The study included analysis of heart rate (HR), blood pressure (BP), heart rate variability (HRV), measurements of microcirculation and porphyrin fluorescence in the limb before and after the RIPC. RIPC caused reactive hyperemia in the limb and reduced blood porphyrin level. A mental load (serial sevens test) and mild motor stress (hyperventilation) were performed on all subjects before and after RIPC or corresponding rest in the SHAM group. Reduction of HR occurred during the experiments in both RIPC and SHAM groups reflecting RIPC-independent adaptation of the subjects to the experimental procedure. However, in contrast to the SHAM group, RIPC altered several of the spectral indices of HRV during the serial sevens test and hyperventilation. This was expressed predominantly as an increase in power of the very low-frequency band of the spectrum, increased values of detrended fluctuation analysis and weakening of correlation between the HRV parameters and HR. In conclusion, RIPC induces changes in the activity of ANS that are linked to stress resistance.

Keywords

Remote ischemic preconditioning
Heart rhythm variability
Autonomic nervous system

Abbreviations

ANS
autonomic nervous system
BP
blood pressure
DBP
diastolic blood pressure
DFA
detrended fluctuation analysis
HF
high frequency
HR
heart rate
HRV
heart rate variability
LF
low frequency
RIPC
remote ischaemic preconditioning
SBP
systolic blood pressure
VLF
very low frequency

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