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Resonators for In Vivo Imaging: Practical Experience

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Abstract

Resonators for preclinical electron paramagnetic resonance imaging have been designed primarily for rodents and rabbits and have internal diameters between 16 and 51 mm. Lumped-circuit resonators include loop-gap, Alderman–Grant, and saddle coil topologies and surface coils. Bimodal resonators are useful for isolating the detected signal from incident power and reducing dead time in pulse experiments. Resonators for continuous wave, rapid scan, and pulse experiments are described. Experience at the University of Chicago and University of Denver in design of resonators for in vivo imaging is summarized.

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References

  1. S.S. Eaton, G.R. Eaton, Biol. Magn. Reson. 21, 59–114 (2004)

    Google Scholar 

  2. S. Matsumoto, K. Yamada, H. Hirata, K. Yasukawa, F. Hyodo, K. Ichikawa, H. Utsumi, Magn. Reson. Med. 57, 806–811 (2007)

    Article  Google Scholar 

  3. N. Devasahayam, S. Subramanian, R. Murugesan, J.A. Cook, M. Afeworki, R. Tschudin, J.B. Mitchell, M.C. Krishna, J. Magn. Reson. 142, 168–176 (2000)

    Article  ADS  Google Scholar 

  4. M. Afeworki, M.D. Gooitzen, N. Devasahayam, R. Murugesan, J. Cook, D. Coffin, J.A. Larsen, J.B. Mitchell, S. Subramanian, M.C. Krishna, Magn. Reson. Med. 43, 375–382 (2000)

    Article  Google Scholar 

  5. K. Matsumoto, B. Chandrika, J.A.B. Lohman, J.B. Mitchell, M. Krishna, S. Subramanian, Magn. Reson. Med. 50, 865–874 (2003)

    Article  Google Scholar 

  6. H. Hirata, G. He, Y. Deng, I. Salikhov, S. Petryakov, J.L. Zweier, J. Magn. Reson. 190, 124–134 (2008)

    Article  ADS  Google Scholar 

  7. S. Matsumoto, M.G. Espey, H. Utsumi, N. Devasahayam, K.-I. Matsumoto, A. Matsumoto, H. Hirata, D.A. Wink, P. Kuppusamy, S. Subramanian, J.B. Mitchell, M.C. Krishna, Magn. Reson. Med. 59, 616–625 (2008)

    Article  Google Scholar 

  8. N.P. Morales, Y. Yamaguchi, K. Murakami, N. Kosem, H. Utsumi, Biol. Pharm. Bull. 35, 1035–1040 (2012)

    Article  Google Scholar 

  9. K. Takeshita, H. Utsumi, A. Hamada, Biochem. Biophys. Res. Commun. 177, 874–880 (1991)

    Article  Google Scholar 

  10. Y. Kawada, H. Hirata, H. Fujii, J. Magn. Reson. 184, 29–38 (2007)

    Article  ADS  Google Scholar 

  11. H. Sato-Akaba, H. Fujii, H. Hirata, Rev. Sci. Instrum. 79, 123701 (2008)

    Article  ADS  Google Scholar 

  12. S. Petryakov, A. Samouilov, M. Roytenberg, H. Li, J.L. Zweier, Magn. Reson. Med. 56, 654–659 (2006)

    Article  Google Scholar 

  13. A.A. Gorodetsky, I.A. Kirilyuk, V.V. Khramtsov, D.A. Komarov, Magn. Reson. Med. 76, 350–358 (2016)

    Article  Google Scholar 

  14. S. Petryakov, A. Samouilov, E. Kesselring, T. Wasowicz, G.L. Caia, J.L. Zweier, J. Magn. Reson. 188, 68–73 (2007)

    Article  ADS  Google Scholar 

  15. A. Samouilov, G.L. Caia, E. Kesselring, S. Petryakov, T. Wasowicz, J.L. Zweier, Magn. Reson. Med. 58, 156–166 (2007)

    Article  Google Scholar 

  16. K. Takeshita, T. Takajo, H. Hirata, M. Ono, H. Utsumi, J. Investig. Dermatol. 122, 1463–1470 (2004)

    Article  Google Scholar 

  17. S. Petryakov, M. Chzhan, A. Samouilov, G. He, P. Kuppusamy, J.L. Zweier, J. Magn. Reson. 151, 124–128 (2001)

    Article  ADS  Google Scholar 

  18. S. Petryakov, A. Samouilov, M. Chzhan-Roytenberg, E. Kesselring, Z. Sun, J.L. Zweier, J. Magn. Reson. 198, 8–14 (2009)

    Article  ADS  Google Scholar 

  19. G.A. Rinard, S.S. Eaton, G.R. Eaton, C.P. Poole Jr., H.A. Farach, Handbook of Electron Spin Resonance 2, 1–23 (1999)

    Google Scholar 

  20. J.S. Hyde, W. Froncisz, T. Oles, J. Magn. Reson. 82, 223–230 (1989)

    ADS  Google Scholar 

  21. F.J. Rosenbaum, Rev. Sci. Instrum. 35, 1550–1554 (1964)

    Article  ADS  Google Scholar 

  22. H.J. Schneider, P. Dullenkopf, Rev. Sci. Instrum. 48, 832–834 (1977)

    Article  ADS  Google Scholar 

  23. J.S. Hyde, W. Froncisz, Proc. Natl. Electron. Conf. 35, 602–606 (1981)

    Google Scholar 

  24. Y.F. Panferov, O.Y. Grinberg, A.A. Dubinskii, Y.S. Lebedev, Instruments and Experimental Techniques (translated from Russian) 4, 153–154 (1982)

    Google Scholar 

  25. C.P. Lin, M.K. Bowman, J.R. Norris, J. Magn. Reson. 65, 369–374 (1985)

    ADS  Google Scholar 

  26. G.A. Rinard, R.W. Quine, B.T. Ghim, S.S. Eaton, G.R. Eaton, J. Magn. Reson. A 122, 50–57 (1996)

    Article  ADS  Google Scholar 

  27. J.S. Hyde, W. Froncisz, A. Kusumi, Rev. Sci. Instrum. 53, 1934–1937 (1982)

    Article  ADS  Google Scholar 

  28. A. Webb, Prog. NMR Spectrosc. 83, 1–20 (2014)

    Article  Google Scholar 

  29. G.A. Rinard, R.W. Quine, G.R. Eaton, S.S. Eaton, Magn. Reson. Eng. 15, 37–46 (2002)

    Article  Google Scholar 

  30. G.A. Rinard, R.W. Quine, J.R. Biller, G.R. Eaton, Concepts Magn. Reson. B Magn. Reson. Eng. 37B, 86–91 (2010)

    Article  Google Scholar 

  31. G. He, S.P. Evalappan, H. Hirata, Y. Deng, S. Petryakov, P. Kuppusamy, J.L. Zweier, Magn. Reson. Med. 48, 1057–1062 (2002)

    Article  Google Scholar 

  32. B. Epel, S.V. Sundramoorthy, C. Mailer, H.J. Halpern, Concepts Magn. Reson. Part B Magn. Reson. Eng. 33B, 163–176 (2008)

    Article  Google Scholar 

  33. A. Schweiger, G. Jeschke, Principles of Pulse Electron Paramagnetic Resonance (Oxford University Press, Oxford, 2001)

    Google Scholar 

  34. G.A. Rinard, R.W. Quine, S.S. Eaton, G.R. Eaton, J. Magn. Reson. A 105, 137–144 (1993)

    Article  ADS  Google Scholar 

  35. B. Epel, S.V. Sundramoorthy, M. Krzykowska-Serda, M.C. Maggio, M. Tseytlin, G.R. Eaton, S.S. Eaton, G.M. Rosen, J.P.Y. Kao, H.J. Halpern, J. Magn. Reson. 276, 31–36 (2017)

    Article  ADS  Google Scholar 

  36. R.W. Quine, G.A. Rinard, S.S. Eaton, G.R. Eaton, Magn. Reson. Eng. 15, 59–91 (2002)

    Article  Google Scholar 

  37. G.A. Rinard, R.W. Quine, S.S. Eaton, G.R. Eaton, W. Froncisz, J. Magn. Reson. A 108, 71–81 (1994)

    Article  ADS  Google Scholar 

  38. B. Epel, S.V. Sundramoorthy, C. Mailer, H.J. Halpern, Conc. Magn. Reson. B Magn. Reson. Eng. 33B, 163–176 (2008)

    Article  Google Scholar 

  39. B. Epel, S.V. Sundramoorthy, E.D. Barth, C. Mailer, H.J. Halpern, Med. Phys. 38, 2045–2052 (2011)

    Article  Google Scholar 

  40. P. Seifi, B. Epel, C. Mailer, H.J. Halpern, Med. Phys. 37, 5412–5420 (2010)

    Article  Google Scholar 

  41. B. Epel, C.R. Haney, D. Hleihel, C. Wardrip, E.D. Barth, H.J. Halpern, Med. Phys. 37, 2553–2559 (2010)

    Article  Google Scholar 

  42. F. Hyodo, S. Matsumoto, N. Devasahayam, C. Dharmaraj, S. Subramanian, J.B. Mitchell, M.C. Krishna, J. Magn. Reson. 197, 181–185 (2009)

    Article  ADS  Google Scholar 

  43. M. Tseitlin, A. Dhami, R.W. Quine, G.A. Rinard, S.S. Eaton, G.R. Eaton, Appl. Magn. Reson. 30, 651–656 (2006)

    Article  Google Scholar 

  44. H.B. Elajaili, J.R. Biller, G.M. Rosen, J.P.Y. Kao, M. Tseytlin, L.A. Buchanan, G.A. Rinard, R.W. Quine, J. McPeak, Y. Shi, S.S. Eaton, G.R. Eaton, J. Magn. Reson. 260, 77–82 (2015)

    Article  ADS  Google Scholar 

  45. S.V. Sundramoorthy, B. Epel, H.J. Halpern, J. Magn. Reson. 240, 45–51 (2014)

    Article  ADS  Google Scholar 

  46. R.W. Quine, G.A. Rinard, Y. Shi, L. Buchanan, J.R. Biller, S.S. Eaton, G.R. Eaton, Conc. Magn. Reson. Magn. Reson. Eng. 46B, 123–133 (2016)

    Article  Google Scholar 

  47. Y. Shi, R.W. Quine, G.A. Rinard, L. Buchanan, S.S. Eaton, G.R. Eaton, B. Epel, S.W. Seagle, H.J. Halpern, Z. Phys. Chem. 231, 923–937 (2017)

    Article  Google Scholar 

  48. Y. Shi, R.W. Quine, G.A. Rinard, L. Buchanan, S.S. Eaton, G.R. Eaton, B. Epel, S.W. Seagle, H.J. Halpern, Adv. Exp. Med. Biol. 977, 327–334 (2017)

    Article  Google Scholar 

  49. J.R. Biller, M. Tseitlin, R.W. Quine, G.A. Rinard, H.A. Weismiller, H. Elajaili, G.M. Rosen, J.P. Kao, S.S. Eaton, G.R. Eaton, J. Magn. Reson. 242, 162–168 (2014)

    Article  ADS  Google Scholar 

  50. S.V. Sundramoorthy, B. Epel, C. Mailer, H.J. Halpern, Concepts Magn. Reson. 35B, 133–138 (2009)

    Article  Google Scholar 

  51. M. Tseitlin, S.S. Eaton, G.R. Eaton, J. Magn. Reson. 209, 277–281 (2011)

    Article  ADS  Google Scholar 

  52. M. Tseitlin, D.G. Mitchell, S.S. Eaton, G.R. Eaton, J. Magn. Reson. 223, 80–84 (2012)

    Article  ADS  Google Scholar 

  53. B. Epel, S.V. Sundramoorthy, H.J. Halpern, Conc. Magn. Reson. 39B, 167–172 (2011)

    Article  Google Scholar 

  54. P. Seifi, B. Epel, S.V. Sundramoorthy, C. Mailer, H.J. Halpern, Med. Phys. 38, 3062–3068 (2011)

    Article  Google Scholar 

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Acknowledgements

This work was supported by National Institutes of Health Grants P41 EB002034 (HH, PI), R01 CA98575 (HH, PI), CA211408 (BE, PI) and CA177744 (GRE, PI).

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Correspondence to Gareth R. Eaton.

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Rinard, G.A., Quine, R.W., Buchanan, L.A. et al. Resonators for In Vivo Imaging: Practical Experience. Appl Magn Reson 48, 1227–1247 (2017). https://doi.org/10.1007/s00723-017-0947-0

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