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Global diffusion limitations during the initial phase of the formation of a protein corona around nanoparticles

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Abstract

Herein, I illustrate analytically how the global diffusion limitations can influence the first phase of the protein-corona formation at nanoparticles under conditions of intravascular injection. In particular, the concentrations of proteins near the boundaries of the injection region are shown to be comparable with those far from the region. In contrast, the concentrations of proteins inside the injection region may be dramatically smaller than those outside, and the ratio of these two concentrations for proteins of different size may be much higher, by a few orders of magnitude, for smaller proteins. These differences in the spatial distribution of proteins are expected to play a key role in the Vroman effect at the onset of the protein-corona formation.

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Authors and Affiliations

  1. Section of Biological Physics, Department of Physics, Chalmers University of Technology, Göteborg, Sweden

    Vladimir P. Zhdanov

  2. Boreskov Institute of Catalysis, Russian Academy of Sciences, Novosibirsk, Russia

    Vladimir P. Zhdanov

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  1. Vladimir P. Zhdanov
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Correspondence to Vladimir P. Zhdanov.

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Zhdanov, V.P. Global diffusion limitations during the initial phase of the formation of a protein corona around nanoparticles. J Biol Phys 45, 173–181 (2019). https://doi.org/10.1007/s10867-019-09522-8

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  • DOI: https://doi.org/10.1007/s10867-019-09522-8

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