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Effectiveness of Revive SE in the RAPID registry

Revive Acute Ischemic Stroke Patients ImmeDiately (RAPID) Prospective Multicenter Trial

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Abstract

Purpose

The prospective, multicenter Revive Acute ischemic stroke Patients ImmeDiately (RAPID) trial was carried out to evaluate the real-world safety and efficacy of the Revive SE stent retriever.

Methods

From January 2017 the study planned to enroll 100 patients with acute ischemic stroke who were treated with the Revive SE as a first pass. The study primary outcomes were rates of favorable reperfusion using the modified thrombolysis in cerebral infarction score [mTICI] 2b/3 and rates of favorable outcome with the modified Rankin Scale (mRS) ≤2 at 3 months. The secondary outcomes were time interval from puncture to vascular reperfusion, number of passes by Revive SE stent-retriever, incidence of distal embolization and into new territories and rate of symptomatic intracranial hemorrhage (SICH) within 24 h post intervention.

Results

A total of 100 treated patients (mean age: 65.6 ± 11.3 years) were enrolled. The median National Institutes of Health Stroke Scale before the procedure was 16. Target vessel occlusions were as follows: middle cerebral artery (MCA) M1 in 48, M2 in 6, anterior cerebral artery (ACA) in 3, internal carotid artery (ICA) in 22, basilar artery (BA) in 17, and vertebral artery (VA) in 4. Reperfusion rate with Revive SE without rescue devices was 69%. Reperfusion rate with Revive SE only was 83.3% in MCA M2, followed by 82.4% in BA. Thromboembolic complications and SICH developed in 10% and 2% of patients, respectively. Overall, a satisfactory reperfusion was achieved in 92% and a favorable outcome at 90 days in 48%.

Conclusion

Use of the Revive SE for thrombectomy appeared to be effective and safe but these findings need be confirmed in larger clinical trials (RAPID ClinicalTrials.gov number, NCT03007082).

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Abbreviations

AIS:

Acute ischemic stroke

ACA:

Anterior cerebral artery

ASITN/SIR:

American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology

BA:

Basilar artery

ICA:

Internal carotid artery

MCA:

Middle cerebral artery

mRS:

Modified Rankin Scale

mTICI:

Modified Thrombolysis in Cerebral Infarction

NIHSS:

National Institute of Health Stroke Scale

SICH:

Symptomatic intracranial hemorrhage

VA:

Vertebral artery

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Funding

Funding

This study was funded by Johnson & Johnson Medical Company.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Shanghai Changhai Hospital, Naval Military Medical University, 168 Changhai Road, 200433, Shanghai, China

    Yongxin Zhang, Zifu Li, Lei Zhang, Bo Hong, Pengfei Yang & Jianmin Liu

  2. Department of Neurology, the People’s Liberation Army No. 306 Hospital, Beijing, China

    Wanling Wen

  3. Department of Neurology, Anhui No. 2 Provincial People’s Hospital, Hefei, China

    Changchun Chen

  4. Department of Neurosurgery, Yunfu People’s Hospital, Yunfu, China

    Zhilin Wu

  5. The Affiliated Hospital of Guizhou Medical University, Guiyang, China

    Xin Xiang

  6. Nanjing First Hospital, Nanjing, China

    Hongchao Shi

  7. The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China

    Sheng Guan

  8. Liaocheng People’s Hospital, Liaocheng, China

    Guisheng Jiang

  9. The First People’s Hospital of Changzhou, Changzhou, China

    Ya Peng

  10. Department of Neurosurgery, Shengjing Hospital, China Medical University, Shenyang, China

    Zhiqing Li

  11. Cerebrovascular Disease Center, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai, China

    Yongwei Zhang

Authors
  1. Yongxin Zhang
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  2. Wanling Wen
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  4. Zhilin Wu
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  5. Xin Xiang
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  6. Hongchao Shi
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  7. Sheng Guan
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  8. Guisheng Jiang
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  9. Ya Peng
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  10. Zhiqing Li
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  11. Zifu Li
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  12. Lei Zhang
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  13. Yongwei Zhang
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  14. Bo Hong
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  15. Pengfei Yang
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  16. Jianmin Liu
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Corresponding authors

Correspondence to Pengfei Yang or Jianmin Liu.

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Conflict of interest

Y. Zhang, W. Wen, C. Chen, Z. Wu, X. Xiang, H. Shi, S. Guan, G. Jiang, Y. Peng, Z. Li, Z. Li, L. Zhang, Y. Zhang, B. Hong, P. Yang and J. Liu declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

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Zhang, Y., Wen, W., Chen, C. et al. Effectiveness of Revive SE in the RAPID registry. Clin Neuroradiol 30, 495–502 (2020). https://doi.org/10.1007/s00062-019-00798-w

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