Elsevier

Current Opinion in Pharmacology

Volume 35, August 2017, Pages vii-ix
Current Opinion in Pharmacology

Editorial

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Conclusions

A variable array of different cell types and extracellular components compose the tumor microenvironment. This heterogeneity imposes microenvironmental conditions and affects both tumor development and response to therapy. Hematopoietic components (macrophages, B and T cells, neutrophils, natural killer (NK) cells), mesenchimal (fibroblasts, endothellial cells) represent up to and more of 50% of the total mass of solid tumors and may provide specialized niches for cancer stem cells [3]. Cancer

Prof. Antonio Sica, is Associate Professor of General Pathology at the Department of Pharmaceutical Sciences of the University of Piemonte Orientale “A. Avogradro” and director of the laboratory of Molecular Immunology at the Istituto Clinico Humanitas, Rozzano, Milan, Italy. He obtained his PhD in Immunology at the Istituto di Ricerche Farmacologiche Mario Negri, Milan, in 1989. He joined the National Cancer Institute (1990-1995). During his scientific career he provided contributions to the

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Prof. Antonio Sica, is Associate Professor of General Pathology at the Department of Pharmaceutical Sciences of the University of Piemonte Orientale “A. Avogradro” and director of the laboratory of Molecular Immunology at the Istituto Clinico Humanitas, Rozzano, Milan, Italy. He obtained his PhD in Immunology at the Istituto di Ricerche Farmacologiche Mario Negri, Milan, in 1989. He joined the National Cancer Institute (1990-1995). During his scientific career he provided contributions to the field of Inflammation and Immunity. He first described the divergent regulation of chemokine receptors and ligands, in response to pro- and anti-inflammatory signals. His research is mainly focused on the investigation of inflammatory cells and molecules expressed within the tumor microenvironment and and their role in tumor development. His research focuses on the mechanisms driving the tumor-promoting phenotype of Tumor-Associated Macrophages and Myeloid-Derived Suppressor Cells, as well as on the mechanism supporting their pathological expansion that occurs during cancer development.

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