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The common variants of E-selectin gene in Graves’ disease

Genes & Immunity volume 9, pages 182–186 (2008)Cite this article

Abstract

Adhesion molecules are involved in cell invasion in autoimmune thyroid disease. It was also reported that patients with untreated Graves’ disease (GD) had high serum level of soluble form of E-selectin (sE-selectin), the concentration of which correlated with the activity of the disease. The aim of the present study was to elucidate whether the common variants in E-selectin gene (SELE) were associated with the development of GD. Six tagSNPs within SELE were studied in 297 patients with GD and 208 healthy subjects in Chinese population. Our data showed that common SELE variants were associated with GD (P=0.012–0.036). Haplotype analysis of the single nucleotide polymorphisms revealed an association of a haplotype ATAACC with GD (P=0.005). Furthermore, quantitative trait analysis showed a significant association of SELE haplotype with sE-selectin levels (P=0.0438). This study therefore could provide us to a certain degree the insight that common SELE variants may be associated with susceptibility to GD in Chinese population, though the limitation of sample size and multiple test problems exists.

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Acknowledgements

The present study would not have been possible without the participation of the patients and healthy volunteers. The study is supported by the grants from the E-Institute of Shanghai Universities (no. E03007) and Shanghai Leading Academic Discipline Project (Project no. Y0204).

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Author notes

  1. H Chen and B Cui: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, PR China

    H Chen, B Cui, S Wang, Z Zhao, H Sun, X Gu, Y Zhao, X Li & G Ning

  2. Laboratory Endocrine & Metabolic Diseases of Institute of Health Science, Shanghai JiaoTong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China

    H Chen, B Cui, S Wang, X Li & G Ning

  3. Division of Endocrine and Metabolic Diseases, E-Institute of Shanghai Universities, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, PR China

    X Li & G Ning

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  1. H Chen
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Correspondence to G Ning.

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Chen, H., Cui, B., Wang, S. et al. The common variants of E-selectin gene in Graves’ disease. Genes Immun 9, 182–186 (2008). https://doi.org/10.1038/sj.gene.6364452

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