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An autosomal genome-wide screen for celiac disease in Bedouin families

Genes & Immunity volume 9, pages 81–86 (2008)Cite this article

Abstract

Celiac disease is a common, familial autoimmune disease caused by exposure to gliadin in wheat, and related prolamins in barley and rye. The prevalence of the disease is approximately 1:133. Celiac disease can cause significant morbidity. The only treatment is a gluten-free diet. A genome-wide search of 405 microsatellite markers was performed on samples from 18 Bedouin families with a minimum of two cases of celiac disease. Non-parametric and parametric (including both dominant and recessive models of inheritance) linkage analyses were performed. The most significant genome-wide linkage evidence was at chromosome 3p26 with an HLod of 3.21, under the dominant model. The only other HLod or NPL greater than 2 was at 4q35, with an HLod of 2.15 under a dominant model. The region at 3p26, previously reported in two linkage analyses, harbors interleukin receptor genes, plausible candidates for celiac disease.

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Acknowledgements

This study was funded by NIH DK50678. Genotyping services were provided by the Center for Inherited Disease Research (CIDR). CIDR is fully funded through a federal contract from NIH to the Johns Hopkins University. Contract number is N01-HG-65403. We thank Rivka Carmi, MD, for starting this collaboration with SLN and for reading the manuscript, Linda Steele for database and data management and M Binsztok, MD, for his assistance with the families.

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Authors and Affiliations

  1. Department of Epidemiology, University of California Irvine, Irvine, CA, USA

    Y C Ding, C P Garner & S L Neuhausen

  2. Pediatric Gastroenterology and Nutrition Unit, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University, Beer Sheva, Israel

    Z Weizman, B Yerushalmi & K Elbedour

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  1. Y C Ding
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  2. Z Weizman
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  4. K Elbedour
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  6. S L Neuhausen
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Correspondence to S L Neuhausen.

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Ding, Y., Weizman, Z., Yerushalmi, B. et al. An autosomal genome-wide screen for celiac disease in Bedouin families. Genes Immun 9, 81–86 (2008). https://doi.org/10.1038/sj.gene.6364439

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