Skip to main content
Log in

Space-time Bayesian small area disease risk models: development and evaluation with a focus on cluster detection

  • Published:
Environmental and Ecological Statistics Aims and scope Submit manuscript

Abstract

This paper extends the spatial local-likelihood model and the spatial mixture model to the space-time (ST) domain. For comparison, a standard random effect space-time (SREST) model is examined to allow evaluation of each model’s ability in relation to cluster detection. To pursue this evaluation, we use the ST counterparts of spatial cluster detection diagnostics. The proposed criteria are based on posterior estimates (e.g., misclassification rate) and some are based on post-hoc analysis of posterior samples (e.g., exceedance probability). In addition, we examine more conventional model fit criteria including mean square error (MSE). We illustrate the methodology with a real ST dataset, Georgia throat cancer mortality data for the years 1994–2005, and a simulated dataset where different levels and shapes of clusters are embedded. Overall, it is found that conventional SREST models fair well in ST cluster detection and in goodness-of-fit, while for extreme risk detection the local likelihood ST model does best.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Agarwal DK, Gelfand AE, Citron-Pousty S (2002) Zero-inflated models with application to spatial count data. Environ Ecol Stat 9: 341–355 doi:10.1023/A:1020910605990

    Article  Google Scholar 

  • Besag J, York J, Mollie A (1991) Bayesian image restoration with two applications in spatial statistics (with discussion). Ann Inst Stat Math 43: 1–59 doi:10.1007/BF00116466

    Article  Google Scholar 

  • Best N, Richardson S, Thomas A (2005) A comparison of Bayesian spatial models for disease mapping. Stat Methods Med Res 14: 35–59 doi:10.1191/0962280205sm388oa

    Article  PubMed  Google Scholar 

  • Clark AB, Lawson AB (2002) Spatio-temporal cluster modelling of small area health data, Ch 14. In: Lawson AB, Denison D(eds) Spatial cluster modelling. Chapman and Hall, London

    Google Scholar 

  • Fernandez C, Green PJ (2002) Modelling spatially correlated data via mixtures: a Bayesian approach. J R Stat Soc B 64: 805–826 doi:10.1111/1467-9868.00362

    Article  Google Scholar 

  • Gamerman D, Lopes HF (2006) Markov chain Monte Carlo: stochastic simulation for Bayesian inference, 2nd edn. Chapman & Hall/CRC, Boca Raton, FL

    Google Scholar 

  • Gelfand AE, Ghosh SK (1998) Model choice: a minimum posterior predictive loss. Biometrika 85: 1–11 doi:10.1093/biomet/85.1.1

    Article  Google Scholar 

  • Green PJ, Richardson S (2002) Hidden Markov models and disease mapping. J Am Stat Assoc 97: 1–16 doi:10.1198/016214502388618870

    Article  Google Scholar 

  • Haas TA (1995) Local prediction of a spatio-temporal process with an application to wet sulfate deposition. J Am Stat Assoc 90: 1189–1199 doi:10.2307/2291511

    Article  Google Scholar 

  • Higdon H (2007) A primer on space-time modeling from a Bayesian perspective, Ch 6. In: Finkenstadt B, Held L, Isham V(eds) Statistical methods for spatio-temporal systems. Chapman & Hall/CRC, Florida

    Google Scholar 

  • Hossain MM, Lawson AB (2005) Local likelihood disease clustering: development and evaluation. Environ Ecol Stat 12: 259–273 doi:10.1007/s10651-005-1512-9

    Article  Google Scholar 

  • Hossain MM, Lawson AB (2006) Cluster detection diagnostics for small area health data: with reference to evaluation of local likelihood models. Stat Med 25: 771–786 doi:10.1002/sim.2401

    Article  PubMed  Google Scholar 

  • Kauermann G, Opsomer JD (2003) Local likelihood estimation in generalized additive models. Scand J Stat 30: 317–337 doi:10.1111/1467-9469.00333

    Article  Google Scholar 

  • Kelsall JE, Wakefield JC (1999) Discussion of “Bayesian models for spatially correlated disease and exposure data” by Best et al. In: Bernardo JM, Berger JO, Dawid AP, Smith AFM(eds) Bayesian statistics 6. Oxford University Press, Oxford, p 151

    Google Scholar 

  • Knorr-Held L (2000) Bayesian modelling of inseparable space-time variation in disease risk. Stat Med 19:2555–2567. doi:10.1002/1097-0258(20000915/30)19:17/18<2555::AID-SIM587>3.0.CO;2-#

    Google Scholar 

  • Knorr-Held L, Besag J (1998) Modelling risk from a disease in time and space. Stat Med 17:2045–2060. doi:10.1002/(SICI)1097-0258(19980930)17:18<2045::AID-SIM943>3.0.CO;2-P

    Google Scholar 

  • Lawson AB (2006) Cluster detection: a critique and a Bayesian proposal. Stat Med 25: 897–916 doi:10.1002/sim.2417

    Article  PubMed  Google Scholar 

  • Lawson AB, Denison DGT (2002) Spatial cluster modeling: an overview, Ch 1. In: Lawson AB, Denison D(eds) Spatial cluster modelling. Chapman and Hall, Boca Raton, FL

    Google Scholar 

  • R Development Core Team (2004) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria

  • Richardson S, Green PJ (1997) On Bayesian analysis of mixtures with an unknown number of components. J R Stat Soc B 59(4): 731–792 doi:10.1111/1467-9868.00095

    Article  Google Scholar 

  • Richardson S, Thomson A, Best N, Elliott P (2004) Interpreting posterior relative risk estimates in disease-mapping studies. Environ Health Perspect 112: 1016–1025

    PubMed  Google Scholar 

  • Spiegelhalter D, Best N, Carlin B, Linde A (2002) Bayesian measures of model complexity and fit (with discussion). J Roy Statist Soc Ser B Methodological 64: 583–639 doi:10.1111/1467-9868.00353

    Article  Google Scholar 

  • Spiegelhalter D, Thomas A, Best N, Lunn D (2003) WinBUGS user manual. MRC Biostatistics Unit. Institute of Public Health, Cambridge, UK

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Md. Monir Hossain.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hossain, M.M., Lawson, A.B. Space-time Bayesian small area disease risk models: development and evaluation with a focus on cluster detection. Environ Ecol Stat 17, 73–95 (2010). https://doi.org/10.1007/s10651-008-0102-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10651-008-0102-z

Keywords

Navigation