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Abdominal fat and metabolic risk in obese children and adolescents

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Abstract

The aim of this study was to investigate fat distribution, mainly abdominal fat, and its relationship with metabolic risk variables in a group of 126 children and adolescents (60 males and 66 females) aged 5.0 to 14.9. According to IOTF criteria, 46 were classified as normal weight, 28 overweight and 52 obese. Weight, height, waist (WC) and hip circumferences were measured. The body mass index (BMI) was calculated. Total body fat, trunkal and abdominal fat were also assessed by dual energy x-ray absorptiometry (DXA). Glucose, insulin, HDL-Cholesterol, triglycerides (TG), ferritine, homocystein and C-reactive protein (CRP) were measured. Obesity status was related with insulin concentrations, CRP, TG and HDL. Obese patients had higher abdominal fat and higher CRP values than overweight and normal subjects. All markers of central body adiposity were related with insulin and lipid metabolism; however, they were not related with homocystein or ferritin. A simple anthropometric measurement, like waist circumference, seems to be a good predictor of the majority of the obesity related metabolic risk variables.

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References

  1. Bueno, G., Bueno, O., Moreno, L.A., García, R. et al. (2006): Diversity of metabolic syndrome risk factors in obese children and adolescents. J Physiol Biochem, 62, 123–132.

    Article  Google Scholar 

  2. Cole, T.J., Bellizzi, M.C., Flegal, K.M., Dietz, W.H. (2000): Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ, 320, 1240–1243.

    Article  CAS  PubMed  Google Scholar 

  3. Denzer, C., Thiere, D., Muche, R., Koenig. W. et al. (2009): Gender-specific prevalences of fatty liver in obese children and adolescents: roles of body fat distribution, sex steroids, and insulin resistance. J Clin Endocrinol Metab, 94, 3872–3881.

    Article  CAS  PubMed  Google Scholar 

  4. González-Gil, E.M., Bueno-Lozano, G., Bueno-Lozano, O., Moreno, L.A. et al. (2009): Serum transaminases concentrations in obese children and adolescents. J Physiol Biochem, 65, 51–59.

    Article  PubMed  Google Scholar 

  5. Goodman, E., Dolan, L. M., Morrison, J. A., Daniels, S. R. (2005): Factor analysis of clustered cardiovascular risks in adolescence: obesity is the predominant correlate of risk among youth. Circulation, 111, 1970–1977.

    Article  PubMed  Google Scholar 

  6. Huang, R., Mori, T., Burke, V., Newham, J. et al. (2009): Synergy between adiposity, insulin resistance, metabolic risk factors, and inflammation in adolescents. Diabetes Care, 32, 695–701.

    Article  CAS  PubMed  Google Scholar 

  7. Kelishadi, R., Hashemi, M., Mohammadifard, N., Asgary, S., Khavarian, N. (2008): Association of changes in oxidative and proinflammatory states with changes in vascular function after a lifestyle modification trial among obese children. Clin Chem, 54, 147–153.

    Article  CAS  PubMed  Google Scholar 

  8. Lee, C.M., Huxley, R.R., Wildman, R.P., Woodward, M. (2008): Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysis. J Clin Epidemiol, 61, 646–653.

    Article  PubMed  Google Scholar 

  9. Martos, R., Valle, M., Morales, R., Cañete, R. et al. (2006): Hyperhomocysteinemia correlates with insulin resistance and low-grade systemic inflammation in obese prepubertal children. Metabolism, 55, 72–77.

    Article  CAS  PubMed  Google Scholar 

  10. Moliner-Urdiales, D., Ruiz, J.R., Ortega, F.B., Rey-López, J.P. et al. (2009): Association of objectively assessed physical activity with total and central body fat in Spanish adolescents; The HELENA Study. Int J Obes, 33, 1126–1135.

    Article  CAS  Google Scholar 

  11. Moreno, L.A., Mesana, M.I., González-Gross, M., Gil, C.M. et al. (2007): Body fat distribution reference standards in Spanish adolescents: The AVENA Study. Int J Obes, 31, 1798–1805.

    Article  CAS  Google Scholar 

  12. Moreno, L.A., Pineda, I., RodrÍguez, G., Fleta, J., Sarria, A., Bueno, M. (2002): Waist circumference for the screening of the metabolic syndrome in children. Acta Paediatr, 91, 1307–1312.

    Article  CAS  PubMed  Google Scholar 

  13. Oshaug, A., Bugge, K.H., Bjønnes, C.H., Borch-Iohnsen, B., Neslein, I.L. (1995): Associations between serum ferritin and cardiovascular risk factors in healthy young men. A cross sectional study. Eur J Clin Nutr, 49, 430–438.

    CAS  PubMed  Google Scholar 

  14. Papandreou, D., Rousso, I., Makedou, A., Arvanitidou, M., Mavromichalis, I. (2007). Association of blood pressure, obesity and serum homocysteine levels in healthy children. Acta Paediatr, 96, 1819–1823.

    Article  CAS  PubMed  Google Scholar 

  15. Reinehr, T., Kleber, M., Toschke, A.M. (2009): Lifestyle intervention in obese children is associated with a decrease of the metabolic syndrome prevalence. Atherosclerosis, 207, 174–180.

    Article  CAS  PubMed  Google Scholar 

  16. Reinehr, T., Wunsch, R. (2009): Relationships between cardiovascular risk profile, ultrasonographic measurement of intra-abdominal adipose tissue and waist cricumference in obese children. Clinical Nutrition. doi: 10.1016/j.clnu.2009.06.004.

  17. Ruiz, J.R., Ortega, F.B., Wärnberg, J., Moreno, L.A. et al. (2008): Inflammatory proteins and muscle strength in adolescents: the Avena study. Arch Pediatr Adolesc Med, 162, 462–468.

    Article  PubMed  Google Scholar 

  18. Steinberger, J., Daniels, S.R., Eckel, R.H., Hayman, L. et al. (2009): Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation, 119, 628–647.

    Article  PubMed  Google Scholar 

  19. Tanner J.M., Whitehouse R.H. (1976): Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child, 51, 170–179.

    Article  CAS  PubMed  Google Scholar 

  20. Tresaco, B., Moreno, L.A., Ruiz, J.R., Ortega, F. B. et al. (2009): Truncal and abdominal fat as determinants of high triglycerides and low HDL-cholesterol in adolescents. Obesity, 17, 1086–1091.

    Article  CAS  PubMed  Google Scholar 

  21. Wärnberg, J., Nova, E., Moreno, L.A., Romeo, J. et al. (2006): Inflammatory proteins are related to total and abdominal adiposity in a healthy adolescent population: the AVENA Study. Am J Clin Nutr, 84, 505–512.

    PubMed  Google Scholar 

  22. Wärnberg, J., Nova, E., Romeo, J., Moreno, L.A. et al. (2007): Lifestyle-related determinants of inflammation in adolescence. Br J Nutr, 98, 116–120.

    Article  Google Scholar 

  23. Williams, M.J., Poulton, R., Williams, S. (2002): Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women. Atherosclerosis, 165, 179–84.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to L. A. Moreno.

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Revenga-Frauca, J., González-Gil, E.M., Bueno-Lozano, G. et al. Abdominal fat and metabolic risk in obese children and adolescents. J Physiol Biochem 65, 415–420 (2009). https://doi.org/10.1007/BF03185937

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  • DOI: https://doi.org/10.1007/BF03185937

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