Letter to the EditorChallenge of ex vivo-stimulated CD4+ CD25+ regulatory T cell-mediated alloantigen-specific immunosuppression by murine cardiac transplantation
Section snippets
Ethical approval
This study was approved by the institutional review board of Mie University (Ethics Review Committee of Mie University Graduate School of Medicine, Tsu, Japan).
Funding disclosure and conflict of interest
All authors received no financial support, and have no conflicts of interest.
Authors' contribution
T. Hori performed experiments and wrote the report. T. Kato and S. Uemoto designed the study and supervised the report.
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Cited by (2)
Immunosenescence evaluation of peripheral blood lymphocyte subsets in 957 healthy adults from 20 to 95 years old
2022, Experimental GerontologyCitation Excerpt :CD25 and CD28 were selected as indicators. CD25 is a key surface marker of regulatory T cells with inhibitory functions (Arroyo et al., 2017; Hori et al., 2017), and CD28 is an essential costimulation molecule during T cell stimulation (Frohlich et al., 2016; Zhang et al., 2019a, 2019b). CD25hi cells were gated in CD4 T cells (Fig. 5A), and CD28+ cells were gated in CD8 T cells (Fig. 5B).
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