Nanotechnology for photodynamic therapy: a perspective from the Laboratory of Dr. Michael R. Hamblin in the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School

References

[1] Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, Korbelik M, Moan J, Mroz P, Nowis D, Piette J, Wilson BC, Golab J. Photodynamic therapy of cancer: an update. CA: Cancer J. Clin. 2011, 61, 250–281.Search in Google Scholar

[2] Dandler J, Scheer H. Inhibition of aggregation of [Pd]-bacteriochlorophyllides in mesoporous silica. Langmuir 2009, 25, 11988–11992.Search in Google Scholar

[3] Hamblin MR, Newman EL. On the mechanism of the tumour-localising effect in photodynamic therapy. J. Photochem. Photobiol. B 1994, 23, 3–8.Search in Google Scholar

[4] Nakamura H, Jun F, Maeda H. Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls. Exp. Opin. Drug Deliv. 2015, 12, 53–64.Search in Google Scholar

[5] Derycke AS, de Witte PA. Liposomes for photodynamic therapy. Adv. Drug Deliv. Rev. 2004, 56, 17–30.Search in Google Scholar

[6] Chawla P, Chawla V, Maheshwari R, Saraf SA, Saraf SK. Fullerenes: from carbon to nanomedicine. Mini Rev. Med. Chem. 2010, 10, 662–677.Search in Google Scholar

[7] Duncan LK, Jinschek JR, Vikesland PJ. C60 colloid formation in aqueous systems: effects of preparation method on size, structure, and surface charge. Environ. Sci. Technol. 2008, 42, 173–178.Search in Google Scholar

[8] Hotze EM, Labille J, Alvarez P, Wiesner MR. Mechanisms of photochemistry and reactive oxygen production by fullerene suspensions in water. Environ. Sci. Technol. 2008, 42, 4175–4180.Search in Google Scholar

[9] Culotta L, Koshland DE, Jr. Buckyballs: wide open playing field for chemists. Science 1991, 254, 1706–1709.Search in Google Scholar

[10] Gamaleia NF, Shton IO. Gold mining for PDT: great expectations from tiny nanoparticles. Photodiagnosis Photodyn. Ther. 2015, 12, 221–231.Search in Google Scholar

[11] Vankayala R, Lin CC, Kalluru P, Chiang CS, Hwang KC. Gold nanoshells-mediated bimodal photodynamic and photothermal cancer treatment using ultra-low doses of near infra-red light. Biomaterials 2014, 35, 5527–5538.Search in Google Scholar

[12] Li Y, Wen T, Zhao R, Liu X, Ji T, Wang H, Shi X, Shi J, Wei J, Zhao Y, Wu X, Nie G. Localized electric field of plasmonic nanoplatform enhanced photodynamic tumor therapy. ACS Nano 2014, 8, 11529–11542.Search in Google Scholar

[13] Lakshmanan S, Hamblin MR, Nanoscopic Electrofocusing for Bio-Nanoelectronic Devices, Yuhasz W, Ed., IOP Science Publishing: Philadelphia, USA, 2015.Search in Google Scholar

[14] Abiodun-Solanke IMF, Ajayi DM, Arigbede AO. Nanotechnology and its application in dentistry. Ann. Med. Health Sci. Res. 2014, 4, S171–S177.Search in Google Scholar

[15] Mitsiadis TA, Woloszyk A, Jimenez-Rojo L. Nanodentistry: combining nanostructured materials and stem cells for dental tissue regeneration. Nanomedicine (Lond) 2012, 7, 1743–1753.Search in Google Scholar

[16] Shetty NJ, Swati P, David K. Nanorobots: future in dentistry. Saudi Dent. J. 2013, 25, 49–52.Search in Google Scholar

[17] Coutts IG, Hamblin MR. Synthesis of spiroheterocycles by oxidative coupling of phenolic sulphonamides. J. Chem. Soc. Chem. Commun. 1980, 949–950.Search in Google Scholar

[18] Coutts IG, Hamblin MR. Spirodienones Part 2: the synthesis of some heterocyclic spirodienones by phenolic coupling. J. Chem. Soc. Perkin I 1981, 1294–1298.Search in Google Scholar

[19] Coutts IG, Hamblin MR, Tinley EJ. The enzymatic oxidation of phenolic tetrahydroisoquinoline-1-carboxylic acids. J. Chem. Soc. Perkin I 1979, 2744–2750.Search in Google Scholar

[20] Grundon MF, Hamblin MR, Harrison DM. Biosynthesis of aromatic isoprenoids part 5: the preparation of 1-(3,3-dimethylallyl)-L-tryptophan and cyclo-L-alanyl tryptophan and their non-incorporation into echinulin. J. Chem. Soc. Perkin I 1980, 1294–1298.Search in Google Scholar

[21] Buchanan JG, Hamblin MR, Sood GR, Wightman RH. The biosynthesis of pyrazofurin and formycin. J. Chem. Soc. Chem. Commun. 1980, 917–918.Search in Google Scholar

[22] Buchanan JG, Hamblin MR, Kumar A, Wightman RH. The biosynthesis of showdomycin – studies with stable isotopes and the determination of principal precursors. J. Chem. Soc. Chem. Commun. 1984, 1515–1517.Search in Google Scholar

[23] Hamblin MR, Newman EL. Photosensitizer targeting in photodynamic therapy. I. Conjugates of haematoporphyrin with albumin and transferrin. J. Photochem. Photobiol. B 1994, 26, 45–56.Search in Google Scholar

[24] Hamblin MR, Newman EL. Photosensitizer targeting in photodynamic therapy. II. Conjugates of haematoporphyrin with serum lipoproteins. J. Photochem. Photobiol. B 1994, 26, 147–157.Search in Google Scholar

[25] Soukos NS, Hamblin MR, Hasan T. The effect of charge on cellular uptake and phototoxicity of polylysine chlorin(e6) conjugates. Photochem. Photobiol. 1997, 65, 723–729.Search in Google Scholar

[26] Hamblin MR, Miller JL, Hasan T. Effect of charge on the interaction of site-specific photoimmunoconjugates with human ovarian cancer cells. Cancer Res. 1996, 56, 5205–5210.Search in Google Scholar

[27] Molpus KL, Hamblin MR, Rizvi I, Hasan T. Intraperitoneal photoimmunotherapy of ovarian carcinoma xenografts in nude mice using charged photoimmunoconjugates. Gynecol. Oncol. 2000, 76, 397–404.Search in Google Scholar

[28] Del Governatore M, Hamblin MR, Shea CR, Rizvi I, Molpus KG, Tanabe KK, Hasan T. Experimental photoimmunotherapy of hepatic metastases of colorectal cancer with a 17.1A chlorin(e6) immunoconjugate. Cancer Res. 2000, 60, 4200–4205.Search in Google Scholar

[29] Hamblin MR, Rajadhyaksha M, Momma T, Soukos NS, Hasan T. In vivo fluorescence imaging of the transport of charged chlorin e6 conjugates in a rat orthotopic prostate tumour. Br. J. Cancer 1999, 81, 261–268.Search in Google Scholar

[30] Soukos NS, Ximenez-Fyvie LA, Hamblin MR, Socransky SS, Hasan T. Targeted antimicrobial photochemotherapy. Antimicrob. Agents Chemother. 1998, 42, 2595–2601.Search in Google Scholar

[31] Demidova TN, Hamblin MR. Macrophage-targeted photodynamic therapy. Int. J. Immunopathol. Pharmacol. 2004, 17, 117–126.Search in Google Scholar

[32] Hamblin MR, Miller JL, Ortel B. Scavenger-receptor targeted photodynamic therapy. Photochem. Photobiol. 2000, 72, 533–540.Search in Google Scholar

[33] Liu Q, Hamblin MR. Macrophage-targeted photodynamic therapy: scavenger receptor expression and activation state. Int. J. Immunopathol. Pharmacol. 2005, 18, 391–402.Search in Google Scholar

[34] Tawakol A, Castano AP, Anatelli F, Bashian G, Stern J, Zahra T, Gad F, Chirico S, Ahmadi A, Fischman AJ, Muller JE, Hamblin MR. Photosensitizer delivery to vulnerable atherosclerotic plaque: comparison of macrophage-targeted conjugate versus free chlorine(e6). J. Biomed. Opt. 2006, 11, 21008.Search in Google Scholar

[35] Tawakol A, Castano AP, Gad F, Zahra T, Bashian G, Migrino RQ, Ahmadi A, Stern J, Anatelli F, Chirico S, Shirazi A, Syed S, Fischman AJ, Muller JE, Hamblin MR. Intravascular detection of inflamed atherosclerotic plaques using a fluorescent photosensitizer targeted to the scavenger receptor. Photochem. Photobiol. Sci. 2008, 7, 33–39.Search in Google Scholar

[36] Gad F, Zahra T, Hasan T, Hamblin MR. Effects of growth phase and extracellular slime on photodynamic inactivation of gram-positive pathogenic bacteria. Antimicrob. Agents Chemother. 2004, 48, 2173–2178.Search in Google Scholar

[37] Hamblin MR, Miller JL, Rizvi I, Loew HG, Hasan T. Pegylation of charged polymer-photosensitiser conjugates: effects on photodynamic efficacy. Br. J. Cancer 2003, 89, 937–943.Search in Google Scholar

[38] Hamblin MR, Miller JL, Rizvi I, Ortel B. Degree of substitution of chlorin(e6) conjugated to charged poly-L-lysine chains affects their cellular uptake, localization and phototoxicity towards macrophages and cancer cells. J. X-ray Sci. Technol. 2002, 10, 139–152.Search in Google Scholar

[39] Hamblin MR, Miller JL, Rizvi I, Ortel B, Maytin EV, Hasan T. Pegylation of a chlorin(e6) polymer conjugate increases tumor targeting of photosensitizer. Cancer Res. 2001, 61, 7155–7162.Search in Google Scholar

[40] Hamblin MR, O’Donnell DA, Murthy N, Rajagopalan K, Michaud N, Sherwood ME, Hasan T. Polycationic photosensitizer conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteria. J. Antimicrob. Chemother. 2002, 49, 941–951.Search in Google Scholar

[41] Hamblin MR. Antimicrobial photodynamic therapy and photodynamic inactivation, or killing bugs with dyes and light – a symposium-in-print. Photochem. Photobiol. 2012, 88, 496–498.Search in Google Scholar

[42] Hamblin MR, Hasan T. Photodynamic therapy: a new antimicrobial approach to infectious disease? Photochem. Photobiol. Sci. 2004, 3, 436–450.Search in Google Scholar

[43] Hamblin MR, Jori G. Photodynamic Inactivation of Microbial Pathogens: Medical and Environmental Applications, Hader GP, Jori G. Eds., RSC Publishing: Cambridge, UK, 2011.Search in Google Scholar

[44] Huang L, Dai T, Hamblin MR. Antimicrobial photodynamic inactivation and photodynamic therapy for infections. Methods Mol. Biol. 2010, 635, 155–173.Search in Google Scholar

[45] Demidova TN, Gad F, Zahra T, Francis KP, Hamblin MR. Monitoring photodynamic therapy of localized infections by bioluminescence imaging of genetically engineered bacteria. J. Photochem. Photobiol. B 2005, 81, 15–25.Search in Google Scholar

[46] Hamblin MR, O’Donnell DA, Murthy N, Contag CH, Hasan T. Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging. Photochem Photobiol. 2002, 75, 51–57.Search in Google Scholar

[47] Gad F, Zahra T, Francis KP, Hasan T, Hamblin MR. Targeted photodynamic therapy of established soft-tissue infections in mice. Photochem Photobiol Sci. 2004, 3, 451–458.Search in Google Scholar

[48] Lambrechts SA, Demidova TN, Aalders MC, Hasan T, Hamblin MR. Photodynamic therapy for Staphylococcus aureus infected burn wounds in mice. Photochem. Photobiol. Sci. 2005, 4, 503–509.Search in Google Scholar

[49] Dai T, Tegos GP, Zhiyentayev T, Mylonakis E, Hamblin MR. Photodynamic therapy for methicillin-resistant Staphylococcus aureus infection in a mouse skin abrasion model. Lasers Surg. Med. 2010, 42, 38–44.Search in Google Scholar

[50] Dai T, Tegos GP, Lu Z, Huang L, Zhiyentayev T, Franklin MJ, Baer DG, Hamblin MR. Photodynamic therapy for Acinetobacter baumannii burn infections in mice. Antimicrob. Agents Chemother. 2009, 53, 3929–3934.Search in Google Scholar

[51] Hamblin MR, Zahra T, Contag CH, McManus AT, Hasan T. Optical monitoring and treatment of potentially lethal wound infections in vivo. J. Infect. Dis. 2003, 187, 1717–1726.Search in Google Scholar

[52] Mroz P, Pawlak A, Satti M, Lee H, Wharton T, Gali H, Sarna T, Hamblin MR. Functionalized fullerenes mediate photodynamic killing of cancer cells: type I versus type II photochemical mechanism. Free Radic. Biol. Med. 2007, 43, 711–719.Search in Google Scholar

[53] Tegos GP, Demidova TN, Arcila-Lopez D, Lee H, Wharton T, Gali H, Hamblin MR. Cationic fullerenes are effective and selective antimicrobial photosensitizers. Chem. Biol. 2005, 12, 1127–1135.Search in Google Scholar

[54] Sharma SK, Chiang LY, Hamblin MR. Photodynamic therapy with fullerenes in vivo: reality or a dream? Nanomedicine (UK) 2011, 6, 1813–1825.Search in Google Scholar

[55] Mroz P, Xia Y, Asanuma D, Konopko A, Zhiyentayev T, Huang YY, Sharma SK, Dai T, Khan UJ, Wharton T, Hamblin MR. Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma. Nanomedicine 2011, 7, 965–974.Search in Google Scholar

[56] Lu Z, Dai T, Huang L, Kurup DB, Tegos GP, Jahnke A, Wharton T, Hamblin MR. Photodynamic therapy with a cationic functionalized fullerene rescues mice from fatal wound infections. Nanomedicine (UK) 2010, 5, 1525–1533.Search in Google Scholar

[57] Yin R, Wang M, Huang YY, Landi G, Vecchio D, Chiang LY, Hamblin MR. Antimicrobial photodynamic inactivation with decacationic functionalized fullerenes: oxygen independent photokilling in presence of azide and new mechanistic insights. Free Radic. Biol. Med. 2015, 79, 14–27.Search in Google Scholar

[58] Yin R, Wang M, Huang YY, Huang HC, Avci P, Chiang LY, Hamblin MR. Photodynamic therapy with decacationic [60]fullerene monoadducts: effect of a light absorbing electron-donor antenna and micellar formulation. Nanomedicine 2014, 10, 795–808.Search in Google Scholar

[59] Zhang Y, Dai T, Wang M, Vecchio D, Chiang LY, Hamblin MR. Potentiation of antimicrobial photodynamic inactivation mediated by a cationic fullerene by added iodide: in vitro and in vivo studies. Nanomedicine (Lond) 2015, 10, 603–614.Search in Google Scholar

[60] Huang YY, Balasubramanian T, Yang E, Luo D, Diers JR, Bocian DF, Lindsey JS, Holten D, Hamblin MR. Stable synthetic bacteriochlorins for photodynamic therapy: role of dicyano peripheral groups, central metal substitution (2H, Zn, Pd), and Cremophor EL delivery. ChemMedChem. 2012, 7, 2155–2167.Search in Google Scholar

[61] Garcia-Diaz M, Kawakubo M, Mroz P, Sagrista ML, Mora M, Nonell S, Hamblin MR. Cellular and vascular effects of the photodynamic agent temocene are modulated by the delivery vehicle. J. Control Release. 2012, 162, 355–363.Search in Google Scholar

[62] Karimi M, Avci P, Mobasseri R, Hamblin MR, Naderi-Manesh H. The novel albumin-chitosan core-shell nanoparticles for gene delivery: preparation, optimization and cell uptake investigation. J. Nanopart. Res. 2013, 15, 1651.Search in Google Scholar

[63] Karimi M, Solati N, Amiri M, Mirshekari H, Mohamed E, Taheri M, Hashemkhani M, Saeidi A, Estiar MA, Kiani P, Ghasemi A, Basri SM, Aref AR, Hamblin MR. Carbon nanotubes part I: preparation of a novel and versatile drug-delivery vehicle. Exp. Opin. Drug Deliv. 2015, 12, 1071–1087.Search in Google Scholar

[64] Karimi M, Solati N, Ghasemi A, Estiar MA, Hashemkhani M, Kiani P, Mohamed E, Saeidi A, Taheri M, Avci P, Aref AR, Amiri M, Baniasadi F, Hamblin MR. Carbon nanotubes part II: a remarkable carrier for drug and gene delivery. Exp. Opin. Drug Deliv. 2015, 12, 1089–1105.Search in Google Scholar

[65] Lovell JF, Jin CS, Huynh E, Jin H, Kim C, Rubinstein JL, Chan WC, Cao W, Wang LV, Zheng G. Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents. Nat. Mater. 2011, 10, 324–332.Search in Google Scholar

[66] Jin CS, Cui L, Wang F, Chen J, Zheng G. Targeting-triggered porphysome nanostructure disruption for activatable photodynamic therapy. Adv. Health. Mater. 2014, 3, 1240–1249.Search in Google Scholar

[67] Marotta DE, Cao W, Wileyto EP, Li H, Corbin I, Rickter E, Glickson JD, Chance B, Zheng G, Busch TM. Evaluation of bacteriochlorophyll-reconstituted low-density lipoprotein nanoparticles for photodynamic therapy efficacy in vivo. Nanomedicine (Lond) 2011, 6, 475–487.Search in Google Scholar

[68] Wang S, Fan W, Kim G, Hah HJ, Lee YE, Kopelman R, Ethirajan M, Gupta A, Goswami LN, Pera P, Morgan J, Pandey RK. Novel methods to incorporate photosensitizers into nanocarriers for cancer treatment by photodynamic therapy. Lasers Surg. Med. 2011, 43, 686–695.Search in Google Scholar

[69] Gupta A, Wang S, Pera P, Rao KV, Patel N, Ohulchanskyy TY, Missert J, Morgan J, Koo-Lee YE, Kopelman R, Pandey RK. Multifunctional nanoplatforms for fluorescence imaging and photodynamic therapy developed by post-loading photosensitizer and fluorophore to polyacrylamide nanoparticles. Nanomedicine 2012, 8, 941–950.Search in Google Scholar

[70] Zheng G, Shibata M, Dougherty TJ, Pandey RK. Wittig reactions on photoprotoporphyrin IX: new synthetic models for the special pair of the photosynthetic reaction center. J. Org. Chem. 2000, 65, 543–557.Search in Google Scholar

[71] Kozyrev A, Ethirajan M, Chen P, Ohkubo K, Robinson BC, Barkigia KM, Fukuzumi S, Kadish KM, Pandey RK. Synthesis, photophysical and electrochemistry of near-IR absorbing bacteriochlorins related to bacteriochlorophyll a. J. Org. Chem. 2012, 77, 10260–10271.Search in Google Scholar

[72] Kozyrev AN, Chen Y, Goswami LN, Tabaczynski WA, Pandey RK. Characterization of porphyrins, chlorins, and bacteriochlorins formed via allomerization of bacteriochlorophyll a. Synthesis of highly stable bacteriopurpurinimides and their metal complexes. J. Org. Chem. 2006, 71, 1949–1960.Search in Google Scholar

[73] Bellnier DA, Henderson BW, Pandey RK, Potter WR, Dougherty TJ. Murine pharmacokinetics and antitumor efficacy of the photodynamic sensitizer 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a. J. Photochem. Photobiol. B 1993, 20, 55–61.Search in Google Scholar

[74] Pliss A, Kuzmin AN, Kachynski AV, Prasad PN. Nonlinear optical imaging and Raman microspectrometry of the cell nucleus throughout the cell cycle. Biophys. J. 2010, 99, 3483–3491.Search in Google Scholar

[75] Wang Y, He GS, Prasad PN, Goodson T, 3rd. Ultrafast dynamics in multibranched structures with enhanced two-photon absorption. J. Am. Chem. Soc. 2005, 127, 10128–10129.Search in Google Scholar

[76] Yoshida M, Prasad PN. Fabrication of channel waveguides from sol-gel-processed polyvinylpyrrolidone/SiO(2) composite materials. Appl. Opt. 1996, 35, 1500–1506.Search in Google Scholar

[77] He GS, Markowicz PP, Lin TC, Prasad PN. Observation of stimulated emission by direct three-photon excitation. Nature 2002, 415, 767–770.Search in Google Scholar

[78] Ohulchanskyy TY, Roy I, Goswami LN, Chen Y, Bergey EJ, Pandey RK, Oseroff AR, Prasad PN. Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer. Nano Lett. 2007, 7, 2835–2842.Search in Google Scholar

[79] Bhawalkar JD, Kumar ND, Zhao CF, Prasad PN. Two-photon photodynamic therapy. J. Clin. Laser Med. Surg. 1997, 15, 201–204.Search in Google Scholar

[80] Chen G, Yang C, Prasad PN. Nanophotonics and nanochemistry: controlling the excitation dynamics for frequency up- and down-conversion in lanthanide-doped nanoparticles. Acc. Chem. Res. 2013, 46, 1474–1486.Search in Google Scholar

[81] Clark HA, Kopelman R, Tjalkens R, Philbert MA. Optical nanosensors for chemical analysis inside single living cells. 2. Sensors for pH and calcium and the intracellular application of PEBBLE sensors. Anal. Chem. 1999, 71, 4837–4843.Search in Google Scholar

[82] Lieberman K, Harush S, Lewis A, Kopelman R. A light source smaller than the optical wavelength. Science 1990, 247, 59–61.Search in Google Scholar

[83] Tyner KM, Kopelman R, Philbert MA. Nanosized voltmeter enables cellular-wide electric field mapping. Biophys. J. 2007, 93, 1163–1174.Search in Google Scholar

[84] Li Y, Burke DT, Kopelman R, Burns MA. Asynchronous magnetic bead rotation (AMBR) microviscometer for label-free DNA analysis. Biosensors (Basel) 2014, 4, 76–89.Search in Google Scholar

[85] Yan F, Kopelman R. The embedding of meta-tetra(hydroxyphenyl)-chlorin into silica nanoparticle platforms for photodynamic therapy and their singlet oxygen production and pH-dependent optical properties. Photochem. Photobiol. 2003, 78, 587–591.Search in Google Scholar

[86] Tang W, Xu H, Kopelman R, Philbert MA. Photodynamic characterization and in vitro application of methylene blue-containing nanoparticle platforms. Photochem. Photobiol. 2005, 81, 242–249.Search in Google Scholar

[87] Qin M, Hah HJ, Kim G, Nie G, Lee YE, Kopelman R. Methylene blue covalently loaded polyacrylamide nanoparticles for enhanced tumor-targeted photodynamic therapy. Photochem. Photobiol. Sci. 2011, 10, 832–841.Search in Google Scholar

[88] Schneider R, Schmitt F, Frochot C, Fort Y, Lourette N, Guillemin F, Muller JF, Barberi-Heyob M. Design, synthesis, and biological evaluation of folic acid targeted tetraphenylporphyrin as novel photosensitizers for selective photodynamic therapy. Bioorg. Med. Chem. 2005, 13, 2799–2808.Search in Google Scholar

[89] Morosini V, Bastogne T, Frochot C, Schneider R, Francois A, Guillemin F, Barberi-Heyob M. Quantum dot-folic acid conjugates as potential photosensitizers in photodynamic therapy of cancer. Photochem. Photobiol. Sci. 2011, 10, 842–851.Search in Google Scholar

[90] Brevet D, Gary-Bobo M, Raehm L, Richeter S, Hocine O, Amro K, Loock B, Couleaud P, Frochot C, Morere A, Maillard P, Garcia M, Durand JO. Mannose-targeted mesoporous silica nanoparticles for photodynamic therapy. Chem. Commun. (Camb) 2009, 1475–1477.Search in Google Scholar

[91] Thomas N, Pernot M, Vanderesse R, Becuwe P, Kamarulzaman E, Da Silva D, Francois A, Frochot C, Guillemin F, Barberi-Heyob M. Photodynamic therapy targeting neuropilin-1: interest of pseudopeptides with improved stability properties. Biochem. Pharmacol. 2010, 80, 226–235.Search in Google Scholar

[92] Frochot C, Di Stasio B, Vanderesse R, Belgy MJ, Dodeller M, Guillemin F, Viriot ML, Barberi-Heyob M. Interest of RGD-containing linear or cyclic peptide targeted tetraphenylchlorin as novel photosensitizers for selective photodynamic activity. Bioorg. Chem. 2007, 35, 205–220.Search in Google Scholar

[93] Fenton C, Perry CM. Verteporfin: a review of its use in the management of subfoveal choroidal neovascularisation. Drugs Aging 2006, 23, 421–445.Search in Google Scholar

[94] Zhang M, Jin J, Chang YN, Chang X, Xing G. Toxicological properties of nanomaterials. J. Nanosci. Nanotechnol. 2014, 14, 717–729.Search in Google Scholar

[95] Borton D, Micera S, Millan Jdel R, Courtine G. Personalized neuroprosthetics. Sci. Transl. Med. 2013, 5, pp. 210rv2. DOI: 10.1126/scitranslmed.3005968.Search in Google Scholar

[96] Melo MA, Guedes SF, Xu HH, Rodrigues LK. Nanotechnology-based restorative materials for dental caries management. Trends Biotechnol. 2013, 31, 459–467.Search in Google Scholar

[97] Gursoy H, Ozcakir-Tomruk C, Tanalp J, Yilmaz S. Photodynamic therapy in dentistry: a literature review. Clin. Oral Invest. 2013, 17, 1113–1125.Search in Google Scholar