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Encapsulation of volatile compounds in silk microparticles

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Abstract

Various techniques have been employed to entrap fragrant oils within microcapsules or microparticles in the food, pharmaceutical, and chemical industries for improved stability and delivery. In the present work, we describe the use of silk protein microparticles for encapsulating fragrant oils using ambient processing conditions to form an all-natural biocompatible matrix. These microparticles are stabilized via physical crosslinking, requiring no chemical agents, and are prepared with aqueous and ambient processing conditions using polyvinyl alcohol–silk emulsions. The particles were loaded with fragrant oils via direct immersion of the silk particles within an oil bath. The oil-containing microparticles were coated using alternating silk and polyethylene oxide layers to control the release of the oil from the microspheres. Particle morphology and size, oil loading capacity, release rates as well as silk–oil interactions and coating treatments were characterized. Thermal analysis demonstrated that the silk coatings can be tuned to alter both retention and release profiles of the encapsulated fragrance. These oil-containing particles demonstrate the ability to adsorb and controllably release oils, suggesting a range of potential applications including cosmetic and fragrance utility.

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Acknowledgments

The authors thank Dr. Eleanor Pritchard for earlier work on these concepts, Dr. Peggy Cebe and Dr. Nicholas Guziewicz for their assistance with the TGA, and Dr. Jing Zhou and Samuel M. Kessel for their assistance with particle formation, coating, and purification. We thank the NIH (P41 EB002520) and Firmenich for support of this research.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA

    Roberto Elia, Jin Guo, Fiorenzo Omenetto & David L. Kaplan

  2. Firmenich Inc., Plainsboro, NJ, 08536, USA

    Stephanie Budijono & Valery Normand

  3. Firmenich SA, 1, Route des Jeunes, 1211, Geneva 8, Switzerland

    Daniel Benczédi

Authors
  1. Roberto Elia
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  2. Jin Guo
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  3. Stephanie Budijono
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  4. Valery Normand
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  6. Fiorenzo Omenetto
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  7. David L. Kaplan
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Correspondence to David L. Kaplan.

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Elia, R., Guo, J., Budijono, S. et al. Encapsulation of volatile compounds in silk microparticles. J Coat Technol Res 12, 793–799 (2015). https://doi.org/10.1007/s11998-015-9668-1

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  • DOI: https://doi.org/10.1007/s11998-015-9668-1

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