Gene expression in highly sensitized dialysis patients waiting for a kidney transplant: A real-time PCR analysis

doi:10.1016/j.trim.2015.10.003

Transplant Immunology

Volume 33, Issue 3, November 2015, Pages 166-167

https://doi.org/10.1016/j.trim.2015.10.003 Get rights and content

Highlights

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We investigated gene expression in highly sensitized patients waiting for a kidney graft.
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Cytokines involved in B cell activation and antibody production were increased in these patients.
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Cytokine blockade may be an additional desensitizing strategy in this risk category.

Section snippets

Conflicts of interest

All the authors have read and approved the manuscript and have no conflict of interest to declare.

Funding

AT is supported by research grants from the Clinical Nephrology Unit, Department of Internal Medicine, DIMI University of Genova, Italy. FG is recipient of grants from the Fondazione Malattie Renali del Bambino, Genova, Italy.

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Evidence for antibody-mediated injury as a major determinant of late kidney allograft failure
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There are more references available in the full text version of this article.

Cited by (1)

De Novo Donor-Specific HLA Antibodies Developing Early or Late after Transplant Are Associated with the Same Risk of Graft Damage and Loss in Nonsensitized Kidney Recipients
2017, Journal of Immunology Research

^☆: Letter to the Editor

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Gene expression in highly sensitized dialysis patients waiting for a kidney transplant: A real-time PCR analysis☆

Highlights

Section snippets

Conflicts of interest

Funding

Am. J. Transplant.

Am. J. Transplant.

Blood

Antiallograft antibodies: relevance, detection, and monitoring

Curr Opin Organ Transplant

Evidence for antibody-mediated injury as a major determinant of late kidney allograft failure

Transplantation