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The hype and hope of new food allergy treatments Nat. Med. (IF 82.9) Pub Date : 2024-04-22 Kirsten P. Perrett
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Strategies for controlling pneumococcal disease and outbreaks during humanitarian emergencies Nat. Med. (IF 82.9) Pub Date : 2024-04-22 Molly Cliff, Paul Welaga, Nuredin Mohammed, Patrick Ansah, Robert S. Heyderman, Caroline Trotter, Brenda Kwambana-Adams
Streptococcus pneumoniae infection accounts for nearly one-fifth of all meningitis deaths globally, half of which occur in Sub-Saharan Africa. Pneumococcal conjugate vaccines (PCVs) prevent vaccine-serotype disease and have been rolled out as part of infant immunization programs worldwide1. Despite widespread PCV usage, the burden of pneumococcal meningitis remains highest within the so called ‘African
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mRNA therapy for a rare childhood disease Nat. Med. (IF 82.9) Pub Date : 2024-04-22
An mRNA-based drug aims to replace a faulty enzyme and restore metabolic function in children with propionic acidemia — with encouraging early clinical results.
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Repurposing a diabetes drug to treat Parkinson’s disease Nat. Med. (IF 82.9) Pub Date : 2024-04-20
In a multicenter clinical trial, patients with early-stage Parkinson’s disease treated with lixisenatide, a drug currently used for the treatment of diabetes, showed improvement in their motor scores compared with those on placebo.
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Using unlabeled data to enhance fairness of medical AI Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Rajiv Movva, Pang Wei Koh, Emma Pierson
AI models for tasks such as pathology and dermatology struggle to generalize to new patient groups or hospitals that they were not trained on; learning more robust features from unlabeled data could prevent overfitting to the training distribution and thereby increase fairness.
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Microplastics are everywhere — we need to understand how they affect human health Nat. Med. (IF 82.9) Pub Date : 2024-04-19
As evidence emerges describing the accumulation of small plastic particles in various organs and tissues of the body, a much deeper understanding of the effects of these particles on human health is urgently needed.
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Demographic bias in misdiagnosis by computational pathology models Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Anurag Vaidya, Richard J. Chen, Drew F. K. Williamson, Andrew H. Song, Guillaume Jaume, Yuzhe Yang, Thomas Hartvigsen, Emma C. Dyer, Ming Y. Lu, Jana Lipkova, Muhammad Shaban, Tiffany Y. Chen, Faisal Mahmood
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Risk-based lung cancer screening performance in a universal healthcare setting Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Martin C. Tammemägi, Gail E. Darling, Heidi Schmidt, Meghan J. Walker, Deanna Langer, Yvonne W. Leung, Kathy Nguyen, Beth Miller, Diego Llovet, William K. Evans, Daniel N. Buchanan, Gabriela Espino-Hernandez, Usman Aslam, Amanda Sheppard, Aisha Lofters, Micheal McInnis, Julian Dobranowski, Steven Habbous, Christian Finley, Marianne Luettschwager, Erin Cameron, Caroline Bravo, Anna Banaszewska, Katherin
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Climate change and health: understanding mechanisms will inform mitigation and prevention strategies Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Diddier Prada, Andrea A. Baccarelli, Allison Kupsco, Robbie M. Parks
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Post-election responsibilities for public health in the Democratic Republic of the Congo Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Faraan O. Rahim, William C. Lieber, Julian T. Hertz, Bruce Shinga Wembulua, Patrick A. Ndeba, Richard M. Lukelwa
Since gaining independence in 1960, the Democratic Republic of the Congo (DRC) has faced a complicated series of challenges marked by armed conflict, political instability and economic hardships. Tensions in the DRC are on an escalating trajectory as the Congolese army and its allied militias battle with the March 23 Movement group in North and South Kivu. Attempts to restore peace through the Nairobi
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Opportunities and challenges following approval of resmetirom for MASH liver disease Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Jeffrey V. Lazarus, Dana Ivancovsky Wajcman, Henry E. Mark, Zobair M. Younossi, Christopher J. Kopka, Nevin Cohen, Meena B. Bansal, Michael Betel, Paul N. Brennan
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An autoantibody signature predictive for multiple sclerosis Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Colin R. Zamecnik, Gavin M. Sowa, Ahmed Abdelhak, Ravi Dandekar, Rebecca D. Bair, Kristen J. Wade, Christopher M. Bartley, Kerry Kizer, Danillo G. Augusto, Asritha Tubati, Refujia Gomez, Camille Fouassier, Chloe Gerungan, Colette M. Caspar, Jessica Alexander, Anne E. Wapniarski, Rita P. Loudermilk, Erica L. Eggers, Kelsey C. Zorn, Kirtana Ananth, Nora Jabassini, Sabrina A. Mann, Nicholas R. Ragan,
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Causal machine learning for predicting treatment outcomes Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Stefan Feuerriegel, Dennis Frauen, Valentyn Melnychuk, Jonas Schweisthal, Konstantin Hess, Alicia Curth, Stefan Bauer, Niki Kilbertus, Isaac S. Kohane, Mihaela van der Schaar
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Brain-Permeable Immunoproteasome-Targeting Macrocyclic Peptide Epoxyketones for Alzheimer’s Disease J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Ji Eun Park, Chhabi L. Chaudhary, Deepak Bhattarai, Kyung Bo Kim
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Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Esra Balıkçı, Anne-Sophie M. C. Marques, Ludwig G. Bauer, Raina Seupel, James Bennett, Brigitt Raux, Karly Buchan, Klemensas Simelis, Usha Singh, Catherine Rogers, Jennifer Ward, Carol Cheng, Tamas Szommer, Kira Schützenhofer, Jonathan M. Elkins, David L. Sloman, Ivan Ahel, Oleg Fedorov, Paul E. Brennan, Kilian V. M. Huber
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Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Mengyang Chang, Feng Gao, Giri Gnawali, Hang Xu, Yue Dong, Xiang Meng, Wenpan Li, Zhiren Wang, Byrdie Lopez, Jennifer S. Carew, Steffan T. Nawrocki, Jianqin Lu, Qing-Yu Zhang, Wei Wang
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Gemfibrozil-Platinum(IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Xue-Qing Song, Xu Guo, Yi-Xin Ding, Yi-Xuan Han, Zhi-Hao You, Yali Song, Yanan Yuan, Longfei Li
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Monophosphoryl Lipid A-Rhamnose Conjugates as a New Class of Vaccine Adjuvants J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Rajendra Rohokale, Jiatong Guo, Zhongwu Guo
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Arene–Arene Coupled Disulfamethazines (or Sulfadiazine)-Phenanthroline-Metal(II) Complexes were Synthesized by In Situ Reactions and Inhibited the Growth and Development of Triple-Negative Breast Cancer through the Synergistic Effect of Antiangiogenesis, Anti-Inflammation, Pro-Apoptosis, and Cuproptosis J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Bing-Bing Xu, Nan Jin, Ji-Cheng Liu, Ai-Qiu Liao, Hong-Yu Lin, Xiu-Ying Qin
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Discovery of a Meisoindigo-Derived PROTAC as the ATM Degrader: Revolutionizing Colorectal Cancer Therapy via Synthetic Lethality with ATR Inhibitors J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Ting-Ting Liu, Qing Wang, Yuxing Zhou, Baixin Ye, Tingting Liu, Linyang Yan, Jinbao Fan, Jiahao Xu, Yingjun Zhou, Zanxian Xia, Xu Deng
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RNA-editing drugs advance into clinical trials Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-18
ADAR-based editors that can change the mRNA code offer new opportunities in both rare genetic diseases and common complex ones.
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Development and validation of a new algorithm for improved cardiovascular risk prediction Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Julia Hippisley-Cox, Carol A. C. Coupland, Mona Bafadhel, Richard E. K. Russell, Aziz Sheikh, Peter Brindle, Keith M. Channon
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Targeting KRAS in cancer Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Anupriya Singhal, Bob T. Li, Eileen M. O’Reilly
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An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Amit Saraf, Rohan Gurjar, Swarnendu Kaviraj, Aishwarya Kulkarni, Durgesh Kumar, Ruta Kulkarni, Rashmi Virkar, Jayashri Krishnan, Anjali Yadav, Ekta Baranwal, Ajay Singh, Arjun Raghuwanshi, Praveen Agarwal, Laxman Savergave, Sanjay Singh
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Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer J. Med. Chem. (IF 7.3) Pub Date : 2024-04-17 Lufeng Zheng, Yuxin Zhang, Shuang Mei, Tianyuan Xie, Yunting Zou, Yuting Wang, Han Jing, Shengtao Xu, Pierre Dramou, Zhen Xu, Jindong Li, Yang Zhou, Miao-Miao Niu
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Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors J. Med. Chem. (IF 7.3) Pub Date : 2024-04-17 Sven Falke, Julia Lieske, Alexander Herrmann, Jure Loboda, Katarina Karničar, Sebastian Günther, Patrick Y. A. Reinke, Wiebke Ewert, Aleksandra Usenik, Nataša Lindič, Andreja Sekirnik, Klemen Dretnik, Hideaki Tsuge, Vito Turk, Henry N. Chapman, Winfried Hinrichs, Gregor Ebert, Dušan Turk, Alke Meents
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Design, Synthesis, and Biological Evaluation of β-Trifluoroethoxydimethyl Selenides as Potent Antiosteoporosis Agents J. Med. Chem. (IF 7.3) Pub Date : 2024-04-17 Yao Wu, Bin Li, Linkun Ying, Yao Chen, Yuxin Zhang, Chaoming Hu, Yichi Zhang, Lele Yi, Weiwei Xue, Shengbin Huang, Zengqiang Song
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Three-step cures for autoimmune diseases? Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-17
Robert Plenge, head of Research at Bristol Myers Squibb, discusses his vision of sequential immunotherapy for autoimmune diseases — including multiple sclerosis.
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The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy Nat. Med. (IF 82.9) Pub Date : 2024-04-17 Ryan M. Jamiolkowski, Quynh-Anh Nguyen, Jordan S. Farrell, Ryan J. McGinn, David A. Hartmann, Jeff J. Nirschl, Mateo I. Sanchez, Vivek P. Buch, Ivan Soltesz
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Nicotine e-cigarettes: considerations for healthcare providers Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Benjamin A. Toll, Tracy T. Smith, Brian A. King
Tobacco use continues to be the leading cause of preventable disease and death in the United States. There are no safe tobacco products; however, the health risks for tobacco products exist on a continuum, with combustible products such as cigarettes being the most harmful. Decades of research have documented that cigarette smoking harms nearly every organ of the body; cigarette smoke contains nearly
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A framework for implementing patient-reported outcomes in clinical care: the PROTEUS-practice guide Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Norah L. Crossnohere, Nicola Anderson, Judith Baumhauer, Melanie Calvert, Rebecca Esparza, Sandi Gulbransen, Lotte Haverman, Yuchen Li, Carolyn Petersen, Ameeta Retzer, Christopher Sidey-Gibbons, Angela M. Stover, Elissa Thorner, Garrett Ursin, Galina Velikova, Elliott Sparkman Walker, Michael Brundage, Claire Snyder
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Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Marie-France Hivert, Frédérique White, Catherine Allard, Kaitlyn James, Sana Majid, François Aguet, Kristin G. Ardlie, Jose C. Florez, Andrea G. Edlow, Luigi Bouchard, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe
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Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Fei Tian, Dong Liu, Na Wei, Qianqian Fu, Lin Sun, Wei Liu, Xiaolong Sui, Kathryn Tian, Genevieve Nemeth, Jingyu Feng, Jingjing Xu, Lin Xiao, Junya Han, Jingjie Fu, Yinhua Shi, Yichen Yang, Jia Liu, Chunhong Hu, Bin Feng, Yan Sun, Yunjun Wang, Guohua Yu, Dalu Kong, Meiyun Wang, Wencai Li, Kexin Chen, Xiangchun Li
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Transparent medical image AI via an image–text foundation model grounded in medical literature Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Chanwoo Kim, Soham U. Gadgil, Alex J. DeGrave, Jesutofunmi A. Omiye, Zhuo Ran Cai, Roxana Daneshjou, Su-In Lee
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Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson’s disease Nat. Med. (IF 82.9) Pub Date : 2024-04-15 Gennaro Pagano, Kirsten I. Taylor, Judith Anzures Cabrera, Tanya Simuni, Kenneth Marek, Ronald B. Postuma, Nicola Pavese, Fabrizio Stocchi, Kathrin Brockmann, Hanno Svoboda, Dylan Trundell, Annabelle Monnet, Rachelle Doody, Paulo Fontoura, Geoffrey A. Kerchner, Patrik Brundin, Tania Nikolcheva, Azad Bonni
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Synthesis and Structure–Activity Relationships for Glutamate Transporter Allosteric Modulators J. Med. Chem. (IF 7.3) Pub Date : 2024-04-16 Andréia C. K. Fontana, Adi N.R. Poli, Jitendra Gour, Yellamelli V.V. Srikanth, Nicholas Anastasi, Devipriya Ashok, Apeksha Khatiwada, Katelyn L. Reeb, Mary Hongying Cheng, Ivet Bahar, Scott M. Rawls, Joseph M. Salvino
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Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy J. Med. Chem. (IF 7.3) Pub Date : 2024-04-16 Bo-Xin Zheng, Wei Long, Wende Zheng, Yaoxun Zeng, Xiao-Chun Guo, Ka-Hin Chan, Meng-Ting She, Alan Siu-Lun Leung, Yu-Jing Lu, Wing-Leung Wong
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The antibody–drug conjugate landscape Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-16
Discover the world’s best science and medicine | Nature.com
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Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy J. Med. Chem. (IF 7.3) Pub Date : 2024-04-15 Tonia Kirschner, Matthias P. Müller, Daniel Rauh
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Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity J. Med. Chem. (IF 7.3) Pub Date : 2024-04-15 Xinrong Xiang, Zhengyi Dai, Baozhu Luo, Ninglin Zhao, Song Liu, Jing Sui, Jiasheng Huang, Yuanzheng Zhou, Jinlong Gu, Jiangnan Zhang, Tao Yang, Rui Bao, Youfu Luo
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Design, synthesis, and biological evaluation of novel benzimidazole derivatives as anti-cervical cancer agents through PI3K/Akt/mTOR pathway and tubulin inhibition Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-16 Si-Si Li, Jun-Jie Chen, Miao-Miao Zhang, Wei-Xu Wang, Wei-Yi Zhang, Cheng Ma
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Development of benzimidazole-based compounds as novel capsid assembly modulators for the treatment of HBV infection Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-16 Kaixin Du, Xianyang Wang, Yuxin Bai, Xue Zhang, Jie Xue, Shanshan Li, Youhua Xie, Zhipei Sang, Yu Tang, Xin Wang
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Design, Synthesis, and Pharmacological Evaluation of Spiro[carbazole-3,3′-pyrrolidine] Derivatives as cGAS Inhibitors for Treatment of Acute Lung Injury J. Med. Chem. (IF 7.3) Pub Date : 2024-04-15 Mingjie Chen, Shuyue Lei, Zihua Zhou, Meng Wang, Chunlan Feng, Xiaoling Gao, Chunyong Ding, Zilan Song, Wei Tang, Ao Zhang
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Targeting immunogenic cell stress and death for cancer therapy Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-15 Lorenzo Galluzzi, Emma Guilbaud, Darby Schmidt, Guido Kroemer, Francesco M. Marincola
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Data-oriented protein kinase drug discovery Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-15 Elena Xerxa, Jürgen Bajorath
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Novel selective agents for the degradation of AR/AR-V7 to treat advanced prostate cancer Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-15 Yifei Yang, Guangyao Lv, Ruijuan Xiu, Huijie Yang, Wenyan Wang, Pengfei Yu, Jianzhao Zhang, Liang Ye, Hongbo Wang, Jingwei Tian
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Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-15 Mohammed Hawash, Samer Abdallah, Mahmoud Abudayyak, Yarob Melhem, Mohammed Abu Shamat, Meera Aghbar, Irfan Çapan, Murad Abualhasan, Anil Kumar, Michał Kamiński, Tomasz Góral, Paulina Maria Dominiak, Shorooq Sobuh
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Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs J. Med. Chem. (IF 7.3) Pub Date : 2024-04-13 Yanying Sun, Zhenzhen Zhou, Na Wang, Fabao Zhao, Ying Liu, Xiaoxuan Xu, Xiaohan Wang, Zhenbang Gou, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang, Xinyong Liu
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Iridium(III)-Based PD-L1 Agonist Regulates p62 and ATF3 for Enhanced Cancer Immunotherapy J. Med. Chem. (IF 7.3) Pub Date : 2024-04-13 Dongping Deng, Mengmeng Wang, Yan Su, Hongbao Fang, Yuncong Chen, Zhi Su
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Structure-Guided Discovery and Preclinical Assessment of Novel (Thiophen-3-yl)aminopyrimidine Derivatives as Potent ERK1/2 Inhibitors J. Med. Chem. (IF 7.3) Pub Date : 2024-04-13 Wen Shuai, Huan Xiao, Panpan Yang, Yiwen Zhang, Faqian Bu, Yongya Wu, Qiu Sun, Guan Wang, Liang Ouyang
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Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader J. Med. Chem. (IF 7.3) Pub Date : 2024-04-12 Md Kabir, Lihuai Qin, Kaixiu Luo, Yan Xiong, Rebecca A. Sidi, Kwang-Su Park, Jian Jin
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Discovery of novel amide derivatives as potent quorum sensing inhibitors of Pseudomonas aeruginosa Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-13 Zhe He, Ming-Ming Guan, Lan-Tu Xiong, Xuan Li, Yan Zeng, Xile Deng, Alastair N. Herron, Zi-Ning Cui
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Molecular Imaging of Alzheimer’s Disease-Related Sigma-1 Receptor in the Brain via a Novel Ru-Mediated Aromatic 18F-deoxyfluorination Probe J. Med. Chem. (IF 7.3) Pub Date : 2024-04-12 Ping Bai, Frederick A. Bagdasarian, Yulong Xu, Yanli Wang, Yongle Wang, Ashley Gomm, Yanting Zhou, Rui Wu, Hsiao-Ying Wey, Rudolph E. Tanzi, Can Zhang, Yu Lan, Changning Wang
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Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease J. Med. Chem. (IF 7.3) Pub Date : 2024-04-12 Yugendar R. Alugubelli, Jing Xiao, Kaustav Khatua, Sathish Kumar, Long Sun, Yuying Ma, Xinyu R. Ma, Veerabhadra R. Vulupala, Sandeep Atla, Lauren R. Blankenship, Demonta Coleman, Xuping Xie, Benjamin W. Neuman, Wenshe Ray Liu, Shiqing Xu
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FDA new drug approvals in Q1 2024 Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-12
Discover the world’s best science and medicine | Nature.com
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Small molecule improves muscle function in myasthenia gravis Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-11
Discover the world’s best science and medicine | Nature.com
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Designer antibiotics by generative AI Nat. Med. (IF 82.9) Pub Date : 2024-04-12
Researchers developed an AI model that designs novel, synthesizable antibiotic compounds — several of which showed potent in vitro activity against priority pathogens.
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Discovery of the First-in-Class G9a/GLP PROTAC Degrader J. Med. Chem. (IF 7.3) Pub Date : 2024-04-11 Julia Velez, Yulin Han, Hyerin Yim, Peiyi Yang, Zhijie Deng, Kwang-su Park, Md Kabir, H. Ümit Kaniskan, Yan Xiong, Jian Jin
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Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles J. Med. Chem. (IF 7.3) Pub Date : 2024-04-11 Moritz Schwarz, Maksym Kurkunov, Florian Wittlinger, Ramona Rudalska, Guiqun Wang, Martin Peter Schwalm, Alexander Rasch, Benedikt Wagner, Stefan A. Laufer, Stefan Knapp, Daniel Dauch, Matthias Gehringer
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Comparative Study of Sonodynamic and Photoactivated Cancer Therapies with Re(I)-Tricarbonyl Complexes Comprising Phenanthroline Ligands J. Med. Chem. (IF 7.3) Pub Date : 2024-04-11 Rajesh Kushwaha, Virendra Singh, Silda Peters, Ashish Kumar Yadav, Tumpa Sadhukhan, Biplob Koch, Samya Banerjee