- 作 者: "jiang le"
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β-Elemene enhances erlotinib sensitivity through induction of ferroptosis by upregulating lncRNA H19 in EGFR-mutant non-small cell lung cancerPharmacological Research (IF 10.334) Pub Date : 2023-03-21 ,DOI:10.1016/j.phrs.2023.106739Cong Xu, Ze-Bo Jiang, Le Shao, Zi-Ming Zhao, Xing-Xing Fan, Xinbing Sui, Li-Li Yu, Xuan-Run Wang, Ruo-Nan Zhang, Wen-Jun Wang, Ya-Jia Xie, Yi-Zhong Zhang, Xiao-Wen Nie, Chun Xie, Ju-Min Huang, Jing Wang, Jue Wang, Elaine Lai-Han Leung, Qi-Biao Wu
Nearly half of all Asian non-small cell lung cancer (NSCLC) patients harbour epidermal growth factor receptor (EGFR) mutations, and first-generation EGFR tyrosine kinase inhibitors (TKIs) are one of the first-line treatments that have improved the outcomes of these patients. Unfortunately, 20% of these patients can not benefit from the treatment. The basis of this primary resistance is poorly understood
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Construction and Simulation of High-Quality Development of China's Resource-Based Cities Driven by Innovation Based on System Dynamics.International Journal of Environmental Research and Public Health (IF 4.614) Pub Date : 2023-03-09 ,DOI:10.3390/ijerph20064812Shuai Liu,Guoxin Jiang,Le Chang,Chao Huang
Innovation is the primary driving force for development; the high-quality development of resource-based cities is ultimately driven by innovation. We constructed an innovation-driven high-quality development system for resource-based cities, including resource, economic, social, and environmental subsystems; according to the interaction between the internal elements of each subsystem, a dynamic model
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Transcriptomic Profiling of Fusarium pseudograminearum in Response to Carbendazim, Pyraclostrobin, Tebuconazole, and Phenamacril.Journal of Fungi (IF 5.724) Pub Date : 2023-03-08 ,DOI:10.3390/jof9030334Yuan Zhang,Kai He,Xuhao Guo,Jia Jiang,Le Qian,Jianqiang Xu,Zhiping Che,Xiaobo Huang,Shengming Liu
Fusarium pseudograminearum has been identified as a significant pathogen. It causes Fusarium crown rot (FCR), which occurs in several major wheat-producing areas in China. Chemical control is the primary measure with which to control this disease. In this study, transcriptome sequencing (RNA-Seq) was used to determine the different mechanisms of action of four frequently used fungicides including carbendazim
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Optic disc and retinal vascular features in first 6 years of Chinese childrenFrontiers in Pediatrics (IF 3.569) Pub Date : 2023-02-23 ,DOI:10.3389/fped.2023.1101768Guina Liu, Anna Jiang, Le Cao, Saiguang Ling, Xi Wang, Shaochong Bu, Fang Lu
Purpose Retinal microvasculature plays an important role in children's fundus lesions and even in their later life. However, little was known on the features of normal retina in early life. The purpose of this study was to explore the normal retinal features in the first 6 years of life and provide information for future research. Methods Children, aged from birth to 6 years old and diagnosed with
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Mechanical properties of auxetic circular and square tubes filled with aluminum foamEngineering Structures (IF 5.582) Pub Date : 2023-02-09 ,DOI:10.1016/j.engstruct.2023.115732Ru Yuan Huo, Dong Han, Yi Zhang, Wei Jiang, Le Yang Fan, Xin Wei Peng, Ge Chen Jie Shi, Ming Hao Chu, Xiang Yu Zhang, Yi Min Xie, Xin RenThe incorporation of aluminum foam in auxetic tubes can significantly enhance the overall stability, stiffness and energy absorption properties. In this work, a comparative study of the mechanical properties between auxetic circular and square tubes was conducted. The foam-filled auxetic square tube (FFAST) has the best specific energy absorption (SEA) up to 1.45 among the four auxetic tubes, and exhibits ...
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Resistance risk assessment of Fusarium pseudograminearum from wheat to prothioconazolePesticide Biochemistry and Physiology (IF 4.966) Pub Date : 2023-01-24 ,DOI:10.1016/j.pestbp.2023.105346Jiangqiao Wei, Xuhao Guo, Jia Jiang, Le Qian, Jianqiang Xu, Zhiping Che, Xiaobo Huang, Shengming LiuFusarium crown rot (FCR), primarily caused by Fusarium pseudograminearum, poses significant threats to cereal crops worldwide. Prothioconazole is a demethylation inhibitor (DMI) fungicide used to control FCR. However, the risk of resistance in F. pseudograminearum to prothioconazole has not yet been evaluated. In this study, the sensitivity of a total of 255 F. pseudograminearum strains obtained from ...
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Endoscopic fully covered self-expandable metal stent and vacuum-assisted drainage to treat postoperative colorectal cancer anastomotic stenosis with fistulaSurgical Endoscopy (IF 3.453) Pub Date : 2023-01-23 ,DOI:10.1007/s00464-022-09831-5Shenghe Deng, Ke Liu, Junnan Gu, Yinghao Cao, Fuwei Mao, Yifan Xue, Zhenxing Jiang, Le Qin, Ke Wu, Kailin Cai
Background Digestive tract reconstruction is required after the surgical resection of a colorectal malignant tumor. Some patients may have concomitant anastomotic complications, such as anastomotic stenosis with fistula (ASF), postoperatively. Therefore, we evaluated the efficacy and safety of endoscopic fully covered self-expandable metal stent and homemade vacuum sponge-assisted drainage (FSEM-HVSD)
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Circ_0057558 accelerates the development of prostate cancer through miR-1238–3p/SEPT2 axisPathology - Research and Practice (IF 3.309) Pub Date : 2023-01-20 ,DOI:10.1016/j.prp.2023.154317Zhaofa Yin, Ling Zhang, Rong Liu, Liang Tong, Chaoxiang Jiang, Le KangBackground Prostate cancer (PCa) is one of the most common malignant tumors in males with high morbidity and mortality. Existing studies have demonstrated that circ_0057558 may be a molecular marker affecting PCa. However, its detailed roles in PCa remain unclear. Methods The levels of circ_0057558, miR-1238–3p and Septin 2 (SEPT2) were measured by quantitative real-time polymerase chain reaction (qRT-PCR) ...
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Pigments of aminophenoxazinones and viridomycins produced by termite-associated Streptomyces tanashiensis BYF-112Frontiers in Microbiology (IF 6.064) Pub Date : 2023-01-16 ,DOI:10.3389/fmicb.2022.1110811Shuxiang Zhang, Jun Wu, Zhou Jiang, Le Zhang, Tao Song, Xinhua Liu, Caiping Yin, Yinglao Zhang
Termite-associated Streptomyces tanashiensis BYF-112 was found as a potential source for yellow and green pigments, which were stable under the tested temperature, light and metal ions. Eight metabolites (1–8), including four new natural yellow pigments aminophenoxazinones (1–4), and two rarely iron dependent green pigments viridomycin A and F (9–10) were isolated from BYF-112 cultured in YMS and YMS
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A Computer Simulation of SARS-CoV-2 Mutation Spectra for Empirical Data Characterization and Analysis.Biomolecules (IF 6.064) Pub Date : 2022-12-28 ,DOI:10.3390/biom13010063Ming Xiao,Fubo Ma,Jun Yu,Jianghang Xie,Qiaozhen Zhang,Peng Liu,Fei Yu,Yuming Jiang,Le Zhang
It is very important to compute the mutation spectra, and simulate the intra-host mutation processes by sequencing data, which is not only for the understanding of SARS-CoV-2 genetic mechanism, but also for epidemic prediction, vaccine, and drug design. However, the current intra-host mutation analysis algorithms are not only inaccurate, but also the simulation methods are unable to quickly and precisely
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Drug-Coated versus Uncoated Balloon for Side Branch Protection in Coronary Bifurcation Lesions Treated with Provisional Stenting Using Drug-Eluting Stents: A Meta-analysisInternational Journal of Clinical Practice (IF 3.149) Pub Date : 2022-12-21 ,DOI:10.1155/2022/5892589Zhi-Ming Jiang, Le Liu
Background. Provisional stenting using drug-eluting stents (DES) has become the preferred treatment for coronary bifurcation lesions (CBLs). We performed a meta-analysis to compare the effects of side branch (SB) protection using a drug-coated balloon (DCB) versus an uncoated balloon (UCB) during the procedure. Methods. Relevant randomized and nonrandomized studies were identified by searching the
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Cardiovascular Outcomes Observed with Ticagrelor versus Clopidogrel in Type 2 Diabetes Mellitus Patients with Acute Coronary Syndrome: A Meta-analysisDiabetes Therapy (IF 3.595) Pub Date : 2022-12-21 ,DOI:10.1007/s13300-022-01354-5Zhiming Jiang, Le Liu, Pravesh Kumar Bundhun
Introduction Type 2 diabetes mellitus (T2DM) is often associated with macrovascular complications including cardiovascular diseases (CVDs), resulting in acute coronary syndrome (ACS). Newer potent antiplatelet agents have recently been approved for use in clinical practice. In this analysis, we aimed to systematically compare the cardiovascular outcomes observed with ticagrelor versus clopidogrel in
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Reconstruction of the coronoid process with the olecranon tip for chronic elbow dislocation in children: A rare case report and literature reviewFrontiers in Pediatrics (IF 3.569) Pub Date : 2022-11-24 ,DOI:10.3389/fped.2022.977866Yikun Jiang, Le Qi, Chuangang Peng, Qiwei Li, Peng Zhang, Yanbing Wang, Dankai Wu
The coronoid process of the ulna, as a key part of the elbow joint, plays an important role in maintaining elbow joint stability. Reconstruction of the coronoid process is necessary in both acute and chronic coronoid defects to restore elbow stability and avoid early joint degeneration. The olecranon tip may be a useful autologous osteochondral graft for reconstructing the same shape of the ulna coronoid
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Sheng-ji Hua-yu ointment ameliorates cutaneous wound healing in diabetes via up-regulating CCN1Journal of Ethnopharmacology (IF 5.195) Pub Date : 2022-11-24 ,DOI:10.1016/j.jep.2022.115954Dan Yang, Yi-mei Tan, Ying Zhang, Jian-kun Song, Yue Luo, Ying Luo, Xiao-ya Fei, Yi Ru, Bin Li, Jing-si Jiang, Le KuaiEthnopharmacological relevance Diabetic ulcers (DUs) are one of the most severe complications of diabetes, and efficacious therapeutic means are currently lacking. Sheng-ji Hua-yu (SJHY) ointment is a classical Chinese traditional prescription that can significantly attenuate DU defects, but the specific mechanism remains to be fully elucidated. Aim of the study In order to verify the underlying mechanism ...
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Boosting CO2 electroreduction to formate via bismuth oxide clustersNano Research (IF 10.269) Pub Date : 2022-11-09 ,DOI:10.1007/s12274-022-5073-0Xiaole Jiang, Le Lin, Youwen Rong, Rongtan Li, Qike Jiang, Yaoyue Yang, Dunfeng GaoSupported metal (oxide) clusters, with both rich surface sites and high atom utilization efficiency, have shown improved activity and selectivity for many catalytic reactions over nanoparticle and single atom catalysts. Yet, the role of cluster catalysts has been rarely reported in CO2 electroreduction reaction (CO2RR), which is a promising route for converting CO2 to liquid fuels like formic acid ...
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Characterisation of key biomarkers in diabetic ulcers via systems bioinformaticsInternational Wound Journal (IF 3.099) Pub Date : 2022-10-01 ,DOI:10.1111/iwj.13900Zhan Zhang, Ying Zhang, Dan Yang, Yue Luo, Ying Luo, Yi Ru, Jiankun Song, Xiaoya Fei, Yiran Chen, Bin Li, Jingsi Jiang, Le KuaiDiabetic ulcers (DUs) are characterised by a high incidence and disability rate. However, its pathogenesis remains elusive. Thus, a deep understanding of the underlying mechanisms for the pathogenesis of DUs has vital implications. The weighted gene co-expression network analysis was performed on the main data from the Gene Expression Omnibus database. Gene Ontology (GO) terms, Kyoto Encyclopedia of ...
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Role of S protein transmembrane domain mutations in the development of occult hepatitis B virus infectionEmerging Microbes & Infections (IF 19.568) Pub Date : 2022-09-21 ,DOI:10.1080/22221751.2022.2114849Xinyi Jiang, Le Chang, Ying Yan, Huimin Ji, Huizhen Sun, Yingzi Xiao, Shi Song, Kaihao Feng, Abudulimutailipu Nuermaimaiti, Lunan Wang
ABSTRACT Occult HBV infection (OBI) is a special infection status during Hepatitis B virus (HBV) infection. The underlying mechanism of its occurrence remains unclear. This study conducted sequencing analysis on 104 OBI plasma samples and 524 HBsAg positive samples from 29 blood centres, and searched for high-frequency mutations in transmembrane domain (TMD) of S protein in the OBI population. Plasmids
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Molecular self-assembly derived hollow mesoporous carbon nanospheres with different pore and wall structure as ultra-stable anode for sodium-ion batteriesElectrochimica Acta (IF 7.336) Pub Date : 2022-08-23 ,DOI:10.1016/j.electacta.2022.141080Jia Wen, Zhiwei Ding, Xiping Wang, Rong Jiang, Le Ma, Linlin Guan, Yang Ren, Zhu Liu, Xu Chen, Xiaowei ZhouTwo kinds of hollow mesoporous carbon nanospheres (HMCNs) are synthesized by molecular self-assembly in solution, carbonization and followed etching technique with different silicon precursors “tetraethyl orthosilicate (TEOS, labeled as E) and tetrapropyl orthosilicate (TPOS, labeled as P)”. The growth and Na+ storage mechanisms of HMCNs are proposed via systematically structural characterization and ...
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Simultaneous transcriptome and proteome profiling in a single mouse oocyte with a deep single-cell multi-omics approachbioRxiv - Cell Biology Pub Date : 2022-08-18 ,DOI:10.1101/2022.08.17.504335Yi-Rong Jiang, Le Zhu, Lan-Rui Cao, Qiong Wu, Jian-Bo Chen, Yu Wang, Jie Wu, Tian-Yu Zhang, Zhao-Lun Wang, Zhi-Ying Guan, Qin-Qin Xu, Qian-Xi Fan, Shao-Wen Shi, Hui-Feng Wang, Jian-Zhang Pan, Xu-Dong Fu, Yong-Cheng Wang, Qun Fang
Nowadays, although single-cell multi-omics technologies are undergoing rapid development, simultaneous transcriptome and proteome analysis of a single-cell individual still faces great challenges. Here, we developed a single-cell simultaneous transcriptome and proteome (scSTAP) analysis platform based on microfluidics, high-throughput sequencing and mass spectrometry technology, to achieve deep and
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Sustainable traditional grass cloth fiber dyeing using the Taguchi L16 (4^4) orthogonal designScientific Reports (IF 4.996) Pub Date : 2022-08-16 ,DOI:10.1038/s41598-022-18213-9Lina Lin, Tiancheng Jiang, Le Li, Md. Nahid Pervez, Cong Zhang, Chao Yan, Yingjie Cai, Vincenzo Naddeo
For many centuries, traditional grass cloth has been used as an important raw material for home textiles in China, but its market can be expanded by incorporating color. Reactive Red 2 (R2), Reactive Blue 194 (B194), and Reactive Orange 5 (O5) were used in this work to explore the dyeing behavior of sustainable traditional grass fiber using industrial dyeing methods. Initially, an L16 (4^4) orthogonal
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Changes in High-Risk HPV Infection Prevalence and Associated Factors in Selected Rural Areas of China: A Multicenter Population-Based StudyFrontiers in Medicine (IF 5.058) Pub Date : 2022-07-12 ,DOI:10.3389/fmed.2022.911367Yan-Qin Yu, Ming-Yue Jiang, Le Dang, Rui-Mei Feng, Mohamed S. Bangura, Wen Chen, You-Lin Qiao
Background The Chinese government has taken action to prevent cervical cancer by implementing the National Cervical Cancer Screening Programme in Rural Areas (NACCSPRA), which was launched in 2009. Numerous studies have demonstrated that long-term cervical cancer screening alters human papillomavirus (HPV) infection rates and cervical disease detection. Nearly 80 million women have been screened over
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Intracellular K+-Responsive Block Copolymer Micelles for Targeted Drug Delivery of CurcuminFrontiers in Bioengineering and Biotechnology (IF 6.064) Pub Date : 2022-06-30 ,DOI:10.3389/fbioe.2022.919189Mingyue Jiang, Le Chen, Bo Chen, Qinghua Yu, Xianming Zhang, Weihong Jing, Limei Ma, Tao Deng, Zhangyou Yang, Chao Yu
Curcumin (CUR) is a natural bioactive compound that has attracted attention as a “golden molecule” due to its therapeutic properties against several types of tumors. Nonetheless, the antitumor application of CUR is hampered due to its extremely low aqueous solubility and chemical instability. Herein, a novel type of CUR-loaded polymeric micelles with intracellular K+-responsive controlled-release properties
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HD-RMPC: A Hierarchical Distributed and Robust Model Predictive Control Framework for Urban Traffic Signal TimingJournal of Advanced Transportation (IF 2.249) Pub Date : 2022-06-08 ,DOI:10.1155/2022/8131897Yilong Ren, Han Jiang, Le Zhang, Runkun Liu, Haiyang Yu
Due to the nonlinearity and dynamics of transportation systems, traffic signal control (TSC) in urban traffic networks has always been an important challenge. In recent years, model predictive control (MPC) has shown extraordinary potential in TSC due to its outstanding ability to model dynamic systems. However, the relatively complex online computing, lack of reasonable setpoints for target solving
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Relationship and effect of miR-1-3p expression and BDNF level in patients with primary hypertension complicated with depression.Cellular and Molecular Biology Pub Date : 2022-05-22 ,DOI:10.14715/cmb/2022.68.1.10Jihong Ding,Chunyu Jiang,Le Yang,Xianyan Wang
This experiment was designed to explore the relationship and effect of miR-1-3p expression and BDNF level in patients with primary hypertension complicated with depression. The subjects of the study were 145 patients with hypertension with a small fluctuation range of blood pressure in recent three months. Within 48 hours after admission, patients were evaluated with the Hospital Anxiety and Depression
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Long Non-Coding RNA RFPL3S Functions as a Biomarker of Prognostic and Immunotherapeutic Prediction in Testicular Germ Cell TumorFrontiers in Immunology (IF 8.786) Pub Date : 2022-05-20 ,DOI:10.3389/fimmu.2022.859730Jie Guo, Shuang Wang, Zhenzhen Jiang, Le Tang, Zhizhong Liu, Jian Cao, Zhaolan Hu, Xiao Chen, Yanwei Luo, Hao Bo
The incidence of testicular germ cell tumor (TGCT) is currently on the rise worldwide, of which 15%-30% of patients have occur recurrence and metastasis. However, clinical methods for diagnosing TGCT and judging its prognosis remained inadequate. In this study, we aimed to explore the possibility of testis-specific long-chain non-coding RNA (lncRNA) Ret finger protein-like 3S (RFPL3S) as a biomarker
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Direct observation of terahertz topological valley transportOptics Express (IF 3.833) Pub Date : 2022-04-20 ,DOI:10.1364/oe.454750Yu-Liang Hong, Gong-Hui Tang, Ru-Wen Peng, Ren-Hao Fan, Zhong-Li Ma, Zheng Wang, Yue Jiang, Le-Di Chen, and Mu Wang
Topological photonics offers the possibility of robust transport and efficiency enhancement of information processing. Terahertz (THz) devices, such as waveguides and beam splitters, are prone to reflection loss owing to their sensitivity to defects and lack of robustness against sharp corners. Thus, it is a challenge to reduce backscattering loss at THz frequencies. In this work, we constructed THz
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Arc erosion behaviour of in-situ TiB2/Cu composites with a three-dimensional network structureMaterials Research Express (IF 2.025) Pub Date : 2022-04-06 ,DOI:10.1088/2053-1591/ac6091Yihui Jiang, Le Han, Yingqin Xu, Fei Cao, Xiang Du, Fei Han, Lei Cai, Jialin Zhu
Copper matrix composites (CMCs) with tailored heterogeneous structures at the mesoscopic scale are promising candidates for electrical contact materials. In this work, CMCs reinforced by an in situ formed three-dimensional network of TiB2 particles were synthesized from Cu, Ti and B powder mixtures by reactive hot-pressing. The arc erosion behaviour of the fabricated CMCs was investigated by an electrical
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Higher Education Management Analysis of Smart Transportation Big Data Application under the Background of Internet +Wireless Communications and Mobile Computing (IF 2.146) Pub Date : 2022-04-04 ,DOI:10.1155/2022/5809214Qi Jiang, Le Zhang
Big data is an unprecedented approach, in line with the development trend of today’ s era of rapid technological development; the ultimate purpose is to analyze and process the corresponding software and data of the huge data collected. This paper is aimed at studying the higher education management of big data application in the context of Internet + and at providing comprehensive optimization and
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The Neuroprotection of Verbascoside in Alzheimer’s Disease Mediated through Mitigation of Neuroinflammation via Blocking NF-κB-p65 SignalingNutrients (IF 4.546) Pub Date : 2022-03-29 ,DOI:10.3390/nu14071417Shanshan Chen, Honghan Liu, Shimiao Wang, Hongbo Jiang, Le Gao, Lu Wang, Lesheng Teng, Chunyue Wang, Di Wang
Verbascoside (VB) is a phenylethanoid glycoside extracted from the herbaceous plant Verbascum sinuatum and plays a neuroprotective role in Alzheimer’s disease (AD). The goal of this study was to explore the neuroprotective mechanism of VB. Based on the proteomics analysis, immunohistochemistry, immunofluorescence, Western blot, and ELISA were utilized to explore the neuroprotective mechanism of VB
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Experimental Study on the Characteristics and Formation Mechanism of Dynamic Filter Cake for Slurry Shield TunnelingMinerals (IF 2.818) Pub Date : 2022-03-09 ,DOI:10.3390/min12030331Yang Bai, Binsong Jiang, Le Yang, Yunqiu Liu, He Zheng, Yapeng Li
The key to guaranteeing excavation face stability in slurry shield tunneling is the formation of an impermeable dynamic filter cake. At the same time, the effect of the cutter head and rotation speed should be taken into account. We studied the characteristics and formation mechanism of the dynamic filter cake using a newly developed experimental apparatus. The experiment results show that the hysteretic
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