- 作 者: ( "xianqun fan" OR "xian-qun fan" )
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Predicting the risk of distant and local recurrence for patients with ocular adnexal extranodal marginal zone lymphoma: a matched case–control studyBritish Journal of Ophthalmology (IF 5.908) Pub Date : 2022-08-01 ,DOI:10.1136/bjo-2022-321656Jiahao Shi, Tianyu Zhu, Min Zhou, Xiaowen Zhou, Xin Song, Yefei Wang, Renbing Jia, Ziyao Yu, Yixiong Zhou, Xianqun FanBackground/aims Extranodal marginal zone lymphoma of ocular adnexa (OA-EMZL) is the most frequent type of ocular adnexal lymphomas, with a high rate of disease recurrence. Precise patient stratification based on disease recurrence is understudied. This study aims to identify risk factors of distant recurrence (DR) and local recurrence (LR) to construct a prognostic model optimising rapid decision of ...
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LIN28B inhibition sensitizes cells to p53-restoring PPI therapy through unleashed translational suppressionOncogenesis (IF 6.524) Pub Date : 2022-07-02 ,DOI:10.1038/s41389-022-00412-8Jiahao Shi, Xiaoliang Jin, Yihao Wang, Tianyu Zhu, Dongmei Zhang, Qian Li, Xiaomin Zhong, Yaqi Deng, Jianfeng Shen, Xianqun Fan
p53 is the most highly mutated tumor suppressor across multiple types of human cancers. The level and function of p53 are fine-tuned through multifaced mechanisms in which the protein–protein interaction between p53 and MDM2 is considered as a major circuit. Recent studies suggest therapeutic strategy attempts to restore p53 function by small molecule inhibitors targeting p53–MDM2 interaction can be
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Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanomaOncogene (IF 8.756) Pub Date : 2022-06-13 ,DOI:10.1038/s41388-022-02364-0Yongyun Li, Jie Yang, Qianqian Zhang, Shiqiong Xu, Wei Sun, Shengfang Ge, Xiaowei Xu, Martine J. Jager, Renbing Jia, Jianming Zhang, Xianqun FanUnlike cutaneous melanoma, uveal melanoma (UM) is characterized by mutations in GNAQ and GNA11 and remains a fatal disease because there is essentially no effective targeted therapy or immunotherapy available. We report the discovery of the copper ionophore elesclomol as a GNAQ/11-specific UM inhibitor. Elesclomol was identified in a differential cytotoxicity screen of an in-house tool compound library ...
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Robot-Assisted Orbital Fat Decompression Surgery: First in HumanTranslational Vision Science & Technology (IF 3.048) Pub Date : 2022-05-02 ,DOI:10.1167/tvst.11.5.8Yi Wang, Jing Sun, Xingtong Liu, Yinwei Li, Xianqun Fan, Huifang ZhouDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Purpose: To explore the safety and feasibility of robot-assisted orbital fat decompression surgery. Methods: Ten prospectively enrolled patients (18 eyes) with Graves’ ophthalmopathy underwent robot-assisted orbital fat decompression surgery with the da Vinci Xi surgical system. Intraoperative blood loss, operative time, and complications were recorded. For every patient, the exophthalmos of the operated
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American Joint Committee on Cancer Tumor Staging System Predicts the Outcome and Metastasis Pattern in Conjunctival MelanomaOphthalmology (IF 14.277) Pub Date : 2022-03-01 ,DOI:10.1016/j.ophtha.2022.02.029Shichong Jia, Tianyu Zhu, Hanhan Shi, Chunyan Zong, Yongyang Bao, Xuyang Wen, Shengfang Ge, Jing Ruan, Shiqiong Xu, Renbing Jia, Xianqun Fan
Purpose To assess the predictive value of the tumor staging system in the AJCC Cancer Staging Manual, Eighth Edition, and histologic features for outcomes and metastasis patterns in conjunctival melanoma (CM). Design Retrospective, single-center cohort study. Participants Eighty-three patients with CM were treated at Shanghai Ninth People’s Hospital between 2000 and 2021. Methods We reviewed the clinical
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Ocular NanomedicineAdvanced Science (IF 17.521) Pub Date : 2022-02-12 ,DOI:10.1002/advs.202003699Zhimin Tang, Xianqun Fan, Yu Chen, Ping Gu
Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting the rapid development of versatile alternatives for satisfactory diagnostics and therapeutics. Given advances in material science, nanochemistry, and nanobiotechnology, a broad spectrum of functional nanosystems has been explored to satisfy the extensive
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The m6A reading protein YTHDF3 potentiates tumorigenicity of cancer stem-like cells in ocular melanoma through facilitating CTNNB1 translationOncogene (IF 8.756) Pub Date : 2022-02-03 ,DOI:10.1038/s41388-021-02146-0Yangfan Xu, Xiaoyu He, Shanzheng Wang, Baofa Sun, Ruobing Jia, Peiwei Chai, Fang Li, Ying Yang, Shengfang Ge, Renbing Jia, Yun-Gui Yang, Xianqun FanN6-methyladenosine (m6A) is the most universal internal RNA modification on messenger RNAs and regulates the fate and functions of m6A-modified transcripts through m6A-specific binding proteins. Nevertheless, the functional role and potential mechanism of the m6A reading proteins in ocular melanoma tumorigenicity, especially cancer stem-like cell (CSC) properties, remain to be elucidated. Herein, we ...
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Metformin promotes histone deacetylation of optineurin and suppresses tumour growth through autophagy inhibition in ocular melanomaClinical and Translational Medicine (IF 7.919) Pub Date : 2022-01-24 ,DOI:10.1002/ctm2.660Ai Zhuang, Peiwei Chai, Shaoyun Wang, Sipeng Zuo, Jie Yu, Shichong Jia, Shengfang Ge, Renbing Jia, Yixiong Zhou, Wodong Shi, Xiaofang Xu, Jing Ruan, Xianqun Fan
To explore the therapeutic potential and the underlying mechanism of metformin, an adenosine monophosphate-activated kinase (AMPK) activator, in ocular melanoma.
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Diffuse pattern, orbital invasion, perineural invasion and Ki-67 are associated with nodal metastasis in patients with eyelid sebaceous carcinomaBritish Journal of Ophthalmology (IF 5.908) Pub Date : 2022-01-21 ,DOI:10.1136/bjophthalmol-2021-320547Xiang Gu, Minyue Xie, Yingxiu Luo, Xin Song, Shiqiong Xu, Xianqun Fan
Background Metastasis dominates the prognosis of eyelid sebaceous carcinoma (SC). This study aimed to explore risk factors for nodal metastasis and develop a nomogram to predict nodal metastasis in patients with eyelid SC. Methods A retrospective case–control study was performed, comprising 320 patients with eyelid SC. Cox analyses were employed to investigate predictors of metastasis-free survival
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Diffuse pattern, orbital invasion, perineural invasion and Ki-67 are associated with nodal metastasis in patients with eyelid sebaceous carcinoma.British Journal of Ophthalmology (IF 5.908) Pub Date : 2022-01-21 ,DOI:10.1136/bjophthalmol-2021-320547Xiang Gu,Minyue Xie,Yingxiu Luo,Xin Song,Shiqiong Xu,Xianqun Fan
BACKGROUND Metastasis dominates the prognosis of eyelid sebaceous carcinoma (SC). This study aimed to explore risk factors for nodal metastasis and develop a nomogram to predict nodal metastasis in patients with eyelid SC. METHODS A retrospective case-control study was performed, comprising 320 patients with eyelid SC. Cox analyses were employed to investigate predictors of metastasis-free survival
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Monitoring Retinoblastoma by Machine Learning of Aqueous Humor Metabolic Fingerprinting (Small Methods 1/2022)Small Methods (IF 15.367) Pub Date : 2022-01-18 ,DOI:10.1002/smtd.202270005Wanshan Liu, Yingxiu Luo, Jingjing Dai, Ludi Yang, Lin Huang, Ruimin Wang, Wei Chen, Yida Huang, Shiyu Sun, Jing Cao, Jiao Wu, Minglei Han, Jiayan Fan, Mengjia He, Kun Qian, Xianqun Fan, Renbing Jia
Advanced Metabolic Analysis
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Nanoprotection Against Retinal Pigment Epithelium Degeneration via Ferroptosis Inhibition (Small Methods 12/2021)Small Methods (IF 15.367) Pub Date : 2021-12-13 ,DOI:10.1002/smtd.202170063Zhimin Tang, Minfeng Huo, Yahan Ju, Xiaochan Dai, Ni Ni, Yan Liu, Huiqin Gao, Dandan Zhang, Hao Sun, Xianqun Fan, Yu Chen, Ping Gu
Back Cover
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Novel insights into exosomal circular RNAs: Redefining intercellular communication in cancer biologyClinical and Translational Medicine (IF 7.919) Pub Date : 2021-12-12 ,DOI:10.1002/ctm2.636Huimin Lin, Jie Yu, Xiang Gu, Shengfang Ge, Xianqun Fan
Exosomes, a special type of membrane-bound extracellular vesicle regarded as an ideal carrier for intercellular messages, play an essential role in intercellular communication both locally and systematically. Recent studies have reported that circular RNAs (circRNAs), members of the noncoding RNA family, are abundant and stable in exosomes. As an essential mediator of intercellular communication within
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Monitoring Retinoblastoma by Machine Learning of Aqueous Humor Metabolic FingerprintingSmall Methods (IF 15.367) Pub Date : 2021-12-02 ,DOI:10.1002/smtd.202101220Wanshan Liu, Yingxiu Luo, Jingjing Dai, Ludi Yang, Lin Huang, Ruimin Wang, Wei Chen, Yida Huang, Shiyu Sun, Jing Cao, Jiao Wu, Minglei Han, Jiayan Fan, Mengjia He, Kun Qian, Xianqun Fan, Renbing JiaThe most common intraocular pediatric malignancy, retinoblastoma (RB), accounts for ≈10% of cancer in children. Efficient monitoring can enhance living quality of patients and 5-year survival ratio of RB up to 95%. However, RB monitoring is still insufficient in regions with limited resources and the mortality may even reach over 70% in such areas. Here, an RB monitoring platform by machine learning ...
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Regulation of epigenetic homeostasis in uveal melanoma and retinoblastomaProgress in Retinal and Eye Research (IF 19.704) Pub Date : 2021-12-01 ,DOI:10.1016/j.preteyeres.2021.101030Peiwei Chai, Ruobing Jia, Yongyun Li, Chuandi Zhou, Xiang Gu, Ludi Yang, Hanhan Shi, Hao Tian, Huimin Lin, Jie Yu, Ai Zhuang, Shengfang Ge, Renbing Jia, Xianqun FanDepartment of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, PR China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200025, PR China.Uveal melanoma (UM) and retinoblastoma (RB), which cause blindness and even death, are the most frequently observed primary intraocular malignancies in adults and children, respectively. Epigenetic studies have shown that changes in the epigenome contribute to the rapid progression of both UM and RB following classic genetic changes. The loss of epigenetic homeostasis plays an important role in oncogenesis ...
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Oncolytic Virotherapy: From Bench to BedsideFrontiers in Cell and Developmental Biology (IF 6.081) Pub Date : 2021-11-26 ,DOI:10.3389/fcell.2021.790150Ludi Yang, Xiang Gu, Jie Yu, Shengfang Ge, Xianqun Fan
Oncolytic viruses are naturally occurring or genetically engineered viruses that can replicate preferentially in tumor cells and inhibit tumor growth. These viruses have been considered an effective anticancer strategy in recent years. They mainly function by direct oncolysis, inducing an anticancer immune response and expressing exogenous effector genes. Their multifunctional characteristics indicate
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Nanoprotection Against Retinal Pigment Epithelium Degeneration via Ferroptosis InhibitionSmall Methods (IF 15.367) Pub Date : 2021-11-10 ,DOI:10.1002/smtd.202100848Zhimin Tang, Minfeng Huo, Yahan Ju, Xiaochan Dai, Ni Ni, Yan Liu, Huiqin Gao, Dandan Zhang, Hao Sun, Xianqun Fan, Yu Chen, Ping GuLethal oxidative stress and ferrous ion accumulation-mediated degeneration/death in retinal pigment epithelium (RPE) exert an indispensable impact on retinal degenerative diseases with irreversible visual impairment, especially in age-related macular degeneration (AMD), but corresponding pathogenesis-oriented medical intervention remains controversial. In this study, the potent iron-binding nanoscale ...
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Intraepithelial growth pattern for eyelid sebaceous carcinoma: a cohort of 214 patients from a single institutionBritish Journal of Ophthalmology (IF 5.908) Pub Date : 2021-10-16 ,DOI:10.1136/bjophthalmol-2021-319789Chuandi Zhou, Peiwei Chai, Wenwen Xia, Jiang Li, Renbing Jia, Xianqun FanAims To determine the distribution of three different intraepithelial growth patterns (pagetoid, bowenoid and papillary) in eyelid sebaceous carcinoma (SC) and correlate them with the clinical characteristics and prognosis. Methods A retrospective cohort study. The medical charts and pathological sections were retrospectively reviewed. All eligible patients were followed up for recurrence, metastasis ...
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Contemporary Update of Retinoblastoma in China: Three-Decade Changes in Epidemiology, Clinical Features, Treatments, and OutcomesAmerican Journal of Ophthalmology (IF 5.488) Pub Date : 2021-10-06 ,DOI:10.1016/j.ajo.2021.09.026Zhou, Fanglin He, Jiayan Fan, Xuyang Wen, Yi Ding, Yanping Han, Jingwen Ding, Mei Jin, Zhenyin Liu, Sha Wang, Minglei Han, Hongfeng Yuan, Hong Sun, Yishuang Xiao, Li Wu, Jiancang Wang, Yangjun Li, Xianqun FanPURPOSE To report three-decade changes of clinical characteristics, progress of treatments, and risk factors associated with mortality and enucleation in patients with retinoblastoma in China. DESIGN Retrospective cohort study. METHODS This multicenter study included 2552 patients diagnosed with retinoblastoma in 38 medical centers in 31 provinces in China from 1989 to 2017, with follow-up data. Kendall's ...
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Therapeutic nanocoating of ocular surfaceNano Today (IF 18.962) Pub Date : 2021-10-02 ,DOI:10.1016/j.nantod.2021.101309Liangbo Chen, Feng Wu, Yan Pang, Dan Yan, Siyi Zhang, Fangjie Chen, Nianxuan Wu, Danni Gong, Jinyao Liu, Yao Fu, Xianqun FanTopical drug delivery is critical for treating ocular diseases but suffers from significant defects including low drug availability, long-term frequent administration, and damage to ocular surface, which largely restrict treatment efficacy and influence quality of life. Here, we describe the formation of a durable and protective therapeutic nanocoating on ocular surface by simply instilling biomimetic ...
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Eye-Preserving Therapies for Advanced RetinoblastomaOphthalmology (IF 14.277) Pub Date : 2021-09-15 ,DOI:10.1016/j.ophtha.2021.09.002Xuyang Wen, Yi Ding, Jingwen Ding, Mei Jin, Zhenyin Liu, Sha Wang, Minglei Han, Hongfeng Yuan, Yishuang Xiao, Li Wu, Jiancang Wang, Yangjun Li, Jiawei Yu, Yuechun Wen, Juan Ye, Rong Liu, Zhijun Chen, Xianqun FanPurpose This study attempted to estimate the impact of eye-preserving therapies for the long-term prognosis of patients with advanced retinoblastoma with regard to overall survival and ocular salvage. Design Retrospective cohort study covering all 31 provinces (38 retinoblastoma treating centers) of mainland China. Participants One thousand six hundred seventy-eight patients diagnosed with group D ...
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Orbital Growth is Associated with Eyeball Size: A Study Using CT-based Three-dimensional TechniquesCurrent Eye Research (IF 2.555) Pub Date : 2021-08-08 ,DOI:10.1080/02713683.2021.1963784Fuxiang Ye, Yongrong Ji, Yuhong Chen, Fanglin He, Xianqun FanABSTRACT Aim of the study This study was aimed to investigate the growth patterns and the relationship of the eyeball and the orbit using computed tomography (CT)-based three-dimensional (3D) techniques. Materials and Methods A total of 175 Chinese patients who had undergone craniofacial or orbital CT scans were enrolled. This study only included data from the unaffected eye and orbit. Images were ...
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The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironmentBioactive Materials (IF 16.874) Pub Date : 2021-07-01 ,DOI:10.1016/j.bioactmat.2020.12.010Muyue Yang, Jipeng Li, Ping Gu, Xianqun Fan
The tumor development and metastasis are closely related to the structure and function of the tumor microenvironment (TME). Recently, TME modulation strategies have attracted much attention in cancer immunotherapy. Despite the preliminary success of immunotherapeutic agents, their therapeutic effects have been restricted by the limited retention time of drugs in TME. Compared with traditional delivery
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Predictors for Surgeries With the Endoscope-Navigation System for Traumatic Optic Neuropathy and its Clinical Assessment.The Journal of Craniofacial Surgery (IF 1.172) Pub Date : 2021-06-02 ,DOI:10.1097/scs.0000000000007749Xuefei Song, Yefei Wang, Lunhao Li, Hui Pan, Yinwei Li, Huifang Chen, Xiaoxuan Yang, Caiwen Xiao, Xianqun FanTo assess surgeries with the endoscope-navigation system (ENS) in patients who underwent traumatic optic neuropathy (TON) and find predictors for best corrected visual acuity (BCVA) outcomes. ...
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Risk factors for ophthalmic artery stenosis and occlusion in patients with retinoblastoma treated with intra-arterial chemotherapyBritish Journal of Ophthalmology (IF 5.908) Pub Date : 2021-05-26 ,DOI:10.1136/bjophthalmol-2021-319118Min Zhou, Xuyang Wen, Shichong Jia, Yanping Han, Xiaoyu He, Minglei Han, Wei Xu, Jiayan Fan, Renbing Jia, Xianqun Fan
Purpose To explore the risk factors for ophthalmic artery (OA) stenosis and occlusion after intra-arterial chemotherapy (IAC) with selective ophthalmic artery catheterisation (OAC) in the treatment of retinoblastoma. Design Retrospective, single centre case-control study. Methods The study was conducted including consecutive patients with unilateral or bilateral intraocular retinoblastoma undergoing
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Comparison of intra-arterial chemotherapy efficacy delivered through the ophthalmic artery or external carotid artery in a cohort of retinoblastoma patientsFrontiers in Medicine (IF 5.058) Pub Date : 2021-05-10 ,DOI:10.3389/fmed.2021.658305Shichong Jia, Xuyang Wen, Min Zhou, Xiaoyu He, Minglei Han, Jiayan Fan, Renbing Jia, Xianqun FanDepartment of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
PURPOSE To evaluate the efficacy of an external carotid artery (ECA) alternative route in intra-arterial chemotherapy (IAC) for treatment of retinoblastoma. METHODS In this retrospective, single-centre, case-control study, 98 retinoblastoma patients who received successful IAC were included. The drug delivery routes were the primary ophthalmic artery (OA) route and the ECA route when OA catheterization
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Clinical and pathological risk factors for worse stage and mortality of eyelid and periocular squamous cell carcinomaBritish Journal of Ophthalmology (IF 5.908) Pub Date : 2021-04-20 ,DOI:10.1136/bjophthalmol-2020-317546Yingxiu Luo, Huifang Chen, Shengfang Ge, Yamin Rao, Jie Yu, Xianqun Fan, Renbing Jia, Shiqiong Xu, Yefei WangBackground The clinical and pathological risk factors for worse T stage and prognosis in eyelid and periocular squamous cell carcinomas (SCCs) remain unclear. P63 was reported to predict a worse prognosis in other SCCs; however, this correlation was not validated in eyelid and periocular SCCs. Methods We reported on a retrospective case series of 85 consecutive patients with eyelid and periocular SCCs ...
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Ocular surface changes in Graves' ophthalmopathy.International Journal of Ophthalmology Pub Date : 2021-04-18 ,DOI:10.18240/ijo.2021.04.20Rou Sun,Hui-Fang Zhou,Xian-Qun Fan
Many patients with Graves' ophthalmopathy (GO) suffer from dry eye syndrome (DES), and this is one of the most common reasons of eye discomfort in patients with GO. The prevalence of DES in patients with GO is significantly higher than normal subjects. The ocular surface changes involving changes in tears, cornea, conjunctiva and glands occur in GO patients. However, the mechanism of how DES occurs
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Ocular surface changes in Graves' ophthalmopathy.International Journal of Ophthalmology Pub Date : 2021-04-18 ,DOI:10.18240/ijo.2021.04.20Rou Sun,Hui-Fang Zhou,Xian-Qun Fan
Many patients with Graves' ophthalmopathy (GO) suffer from dry eye syndrome (DES), and this is one of the most common reasons of eye discomfort in patients with GO. The prevalence of DES in patients with GO is significantly higher than normal subjects. The ocular surface changes involving changes in tears, cornea, conjunctiva and glands occur in GO patients. However, the mechanism of how DES occurs
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