- 作 者: ( "xiaoju zhou" OR "xiao-ju zhou" )
-
Monocarboxylate transporter 4 promotes the migration of non‑cancerous L929 fibroblast cells by activating the IGF1/IGF1R/PIK3R3/SGK1 axis.Oncology Letters (IF 2.9) Pub Date : 2023-09-11 , DOI:10.3892/ol.2023.14047Xiaoju Zhou, Shuo Wang, Yanyan Li, He Zhao, Xue Han, Yue Yu, Yu Chen, Yu Yang, Xiaonan Ma, Hongjing Huo, Manting Zhang, Yongshan Zhao, Ningning Ma
The tumor microenvironment (TME) and Warburg effect are critical for the regulation of tumor metastasis. The monocarboxylate transporter (MCT) family members, particularly MCT4, which is encoded by the solute carrier family 16 member 3 gene, play an important role in the regulation of the TME and mediation of the Warburg effect by transporting lactate out of cancer cells. Migration and invasion are
...
-
Dual-Ligand-Functionalized Liposomes Based on Glycyrrhetinic Acid and cRGD for Hepatocellular Carcinoma Targeting and TherapyMolecular Pharmaceutics (IF 4.9) Pub Date : 2023-03-23 , DOI:10.1021/acs.molpharmaceut.2c00842Mingxing Qiu, Jiong Wang, Jiaojiao Bai, Xiaoxu Li, Cuiqing Tian, Zhi Liu, Chaoran Zheng, Andrew R. Clark, Xinwei Cheng, Xiaoyan Liao, Song Wu, Robert J. Lee, Xiaoju ZhouHepatocellular carcinoma (HCC) is one of the most common cancers, with high mortality. Chemotherapy is one of the main treatment options for HCC. However, the high toxicity and poor specificity of chemotherapeutic drugs have limited their clinical application. In this study, dual-ligand liposomes modified with glycyrrhetinic acid (GA) and cyclic arginine–glycine–aspartic acid (cRGD) (GA/cRGD-LP) were ...
-
The role of serum inflammatory in mycoplasma pneumonia infection with respiratory asthmaJournal of Asthma (IF 1.9) Pub Date : 2023-02-02 , DOI:10.1080/02770903.2022.2158101Xiaoju Zhou, Wei Jiang, Qianyi Zhou, Wenjie YangAbstract Objective With the growing frequency of Mycoplasma pneumoniae infections linked to respiratory asthma (MP-RA), particularly in children, the quest for novel diagnostic molecular markers has become critical. We examined the link between serum immunoglobulin, inflammatory variables, vitamin A, and vitamin D levels in MP-RA patients and then found markedly diagnostic indicators. Methods From ...
-
Anchoring β-CD on simvastatin-loaded rHDL for selective cholesterol crystals dissolution and enhanced anti-inflammatory effects in macrophage/foam cellsEuropean Journal of Pharmaceutics and Biopharmaceutics (IF 4.9) Pub Date : 2022-04-18 , DOI:10.1016/j.ejpb.2022.04.005Jianhua He, Xiaoju Zhou, Fengfei Xu, Hongliang He, Shuangyan Ma, Xinyue Liu, Mengyuan Zhang, Wenli Zhang, Jianping LiuMacrophage/foam cells and cholesterol crystals (CCs) have been regarded as the central triggers of maladaptive inflammation in atherosclerotic plaque. Despite the tremendous progress of recombinant high-density lipoprotein (rHDL) serving for targeted drug delivery to alleviate inflammation in macrophage/foam cells, the active attempt to modulate/improve its CCs dissolution capacity remains poorly explored ...
-
Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug deliveryBioactive Materials (IF 18.9) Pub Date : 2022-04-07 , DOI:10.1016/j.bioactmat.2022.03.041Jianhua He, Wenli Zhang, Xiaoju Zhou, Fengfei Xu, Jiahui Zou, Qiqi Zhang, Yi Zhao, Hongliang He, Hu Yang, Jianping Liu
Nanoparticle-based therapeutics represent potential strategies for treating atherosclerosis; however, the complex plaque microenvironment poses a barrier for nanoparticles to target the dysfunctional cells. Here, we report reactive oxygen species (ROS)-responsive and size-reducible nanoassemblies, formed by multivalent host-guest interactions between β-cyclodextrins (β-CD)-anchored discoidal recombinant
...
-
Research and design of gasoline generator inverterJournal of Physics: Conference Series Pub Date : 2021-11-01 , DOI:10.1088/1742-6596/2125/1/012067Xiaoju Zhou,yun huang
Abstract The paper introduces the design of gasoline generator inverter. First of all, I made a simple introduction to the gasoline generator, and a detailed description of the inverter circuit respectively. Then the hardware and software design process of the system are described in detail. In the process of hardware design, I designed the whole circuit and each module, and made a printed circuit
...
-
Strong Tough Polyampholyte Hydrogels via the Synergistic Effect of Ionic and Metal–Ligand BondsAdvanced Functional Materials (IF 19.0) Pub Date : 2021-06-29 , DOI:10.1002/adfm.202103917Yiwan Huang, Longya Xiao, Ju Zhou, Tao Liu, Yongqi Yan, Shijun Long, Xuefeng LiDespite existing in biological systems, developing synthetic polyampholyte (PA) hydrogels constructed by both ionic and metal–ligand bonds remains challenging. Herein, a simple secondary equilibrium approach is proposed to fabricate strong and tough PA hydrogels via the synergy of ionic and metal–ligand bonds. The original PA gels (constructed by ionic bonds) are first dialyzed in multivalent metal-ion ...
-
Effectiveness of Educational Intervention on Influenza Vaccine Uptake: A Meta-Analysis of Randomized Controlled TrialsIranian Journal of Public Health (IF 1.4) Pub Date : 2020-12-07 , DOI:10.18502/ijph.v49i12.4805Xiaoju ZHOU, Xuequn ZHAO, Jun LIU, Wenjie YANG
The Influenza vaccine has been proven to be the most effective way to prevent the flu and severe complications, particularly in children, the elderly, pregnant women, and long-term healthcare workers (1-3). The uptake rate of the influenza vaccine was 51.30% in New York schoolchildren, 71% in healthcare personnel, and 50.50% in pregnant women in 2012-2013 flu season (4-6). Influenza vaccines may also
...
-
Overexpression of monocarboxylate transporter 4 promotes the migration and invasion of non-carcinogenic L929 fibroblast cells.Oncology Letters (IF 2.9) Pub Date : 2020-11-17 , DOI:10.3892/ol.2020.12305Xiangru Li, Xiaoju Zhou, Ying Liu, Jingjing Fan, Hongjing Huo, Jingjing Yao, Lin Wang, Ningning Ma
Metastasis is a primary contributor to the low survival rates of patients with cancer. Enhanced migration and invasion are two key features of the metastatic transformation of cancer cells. Furthermore, despite the fact that overexpression of the monocarboxylate transporter (MCT)1 and 4 proteins has been found to promote the migration or invasion of cancer cells, previous findings have not been conclusive
...
-
Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing.ACS Nano (IF 17.1) Pub Date : 2020-09-15 , DOI:10.1021/acsnano.0c03064Xiaoju Zhou,Brooke A Brown,Amanda P Siegel,Mohamed El Masry,Xuyao Zeng,Woran Song,Amitava Das,Puneet Khandelwal,Andrew Clark,Kanhaiya Singh,Poornachander R Guda,Mahadeo Gorain,Lava Timsina,Yi Xuan,Stephen C Jacobson,Milos V Novotny,Sashwati Roy,Mangilal Agarwal,Robert J Lee,Chandan K Sen,David E Clemmer,Subhadip GhatakBidirectional cell–cell communication involving exosome-borne cargo such as miRNA has emerged as a critical mechanism for wound healing. Unlike other shedding vesicles, exosomes selectively package miRNA by SUMOylation of heterogeneous nuclear ribonucleoproteinA2B1 (hnRNPA2B1). In this work, we elucidate the significance of exosome in keratinocyte–macrophage crosstalk following injury. Keratinocyte-derived ...
-
Mechanical enhancement of graphene oxide-filled chitosan-based composite hydrogels by multiple mechanismsJournal of Materials Science (IF 4.5) Pub Date : 2020-07-13 , DOI:10.1007/s10853-020-05063-xYiwan Huang, Longya Xiao, Ju Zhou, Xuefeng Li, Jianxin Liu, Ming ZengAbstract Chitosan (CS) has become a favorable choice for synthesizing hydrogels due to its hydrophilic and biocompatible nature. However, achieving robust CS-based hydrogels remains challenging. Herein, we propose a multiple mechanisms-based network design for mechanical enhancement in CS-based double-network (DN) composite hydrogels. In the DN composite gels, graphene oxide-filled CS-based network ...
-
Shuttle/sink model composed of β-cyclodextrin and simvastatin-loaded discoidal reconstituted high-density lipoprotein for enhanced cholesterol efflux and drug uptake in macrophage/foam cells.Journal of Materials Chemistry B (IF 7.0) Pub Date : 2020-01-30 , DOI:10.1039/c9tb02101aJianhua He,Yun Yang,Xiaoju Zhou,Wenli Zhang,Jianping LiuTargeting drug delivery to macrophage/foam cells is challenged owing to the poor cell permeability and fluidity resulting from the massive accumulation of intracellular cholesterol in atherosclerosis (AS). Discoidal reconstituted high-density lipoprotein (d-rHDL) has been well regarded as a potential drug delivery system for AS by virtue of its plaque-targeting and cholesterol removal abilities, while ...
-
T7 Peptide-Conjugated Lipid Nanoparticles for Dual Modulation of Bcl-2 and Akt-1 in Lung and Cervical CarcinomasMolecular Pharmaceutics (IF 4.9) Pub Date : 2018-08-23 , DOI:10.1021/acs.molpharmaceut.8b00696Xinwei Cheng,Daorui Yu,Guang Cheng,Bryant C. Yung,Yang Liu,Hewen Li,Chen Kang,Xingyue Fang,Shuhong Tian,Xiaoju Zhou,Qibing Liu,Robert J. LeeExpression of Bcl-2 and Akt-1 has been associated with human cancer. G3139 and RX-0201, targeting Bcl-2 and Akt-1, respectively, are antisense oligonucleotides (ASOs) that have shown limited efficacy in clinical trials. Herein, we report a combination of newly designed ASOs based on these agents and was delivered by tumor cell-targeting lipid nanoparticles (LNPs). A “Gapmer” design strategy was applied ...
-
Biofunctional Polymer–Lipid Hybrid High-Density Lipoprotein-Mimicking Nanoparticles Loading Anti-miR155 for Combined Antiatherogenic Effects on MacrophagesBiomacromolecules (IF 6.2) Pub Date : 2017-08-03 , DOI:10.1021/acs.biomac.7b00436Jing Lu,Yi Zhao,Xiaoju Zhou,Jian Hua He,Yun Yang,Cuiping Jiang,Zitong Qi,Wenli Zhang,Jianping LiuA biofunctional polymer–lipid hybrid high-density lipoprotein-mimicking nanoparticle (HNP) loading anti-miR155 was constructed for combined antiatherogenic effects on macrophages. The HNP consisted of an anti-miR155 core condensed by acid-labile polyethylenimine (acid-labile PEI) polymers and a lipid bilayer coat that was decorated with apolipoprotein A-1, termed acid-labile PEI/HNP. The acid-labile ...
-
Biofunctional Polymer–Lipid Hybrid High-Density Lipoprotein-Mimicking Nanoparticles Loading Anti-miR155 for Combined Antiatherogenic Effects on MacrophagesBiomacromolecules (IF 6.2) Pub Date : 2017-08-03 , DOI:10.1021/acs.biomac.7b00436Jing Lu,Yi Zhao,Xiaoju Zhou,Jian Hua He,Yun Yang,Cuiping Jiang,Zitong Qi,Wenli Zhang,Jianping LiuA biofunctional polymer–lipid hybrid high-density lipoprotein-mimicking nanoparticle (HNP) loading anti-miR155 was constructed for combined antiatherogenic effects on macrophages. The HNP consisted of an anti-miR155 core condensed by acid-labile polyethylenimine (acid-labile PEI) polymers and a lipid bilayer coat that was decorated with apolipoprotein A-1, termed acid-labile PEI/HNP. The acid-labile ...
-
Hydroxyethyl Pachyman as a novel excipient for sustained-release matrix tablets.Carbohydrate Polymers (IF 11.2) Pub Date : 2016-09-01 , DOI:10.1016/j.carbpol.2016.08.029Xiaoju Zhou,Pengyu Wang,Jiong Wang,Zhi Liu,Xuechuan Hong,Yuling Xiao,Peng Liu,Xianming HuThis paper addressed the application of hydroxyethyl pachyman (HEP) as a novel matrix for sustained - release tablets, using diclofenac sodium (DS) as a model drug. The studies showed the HEP tablets prepared by wet granulation had much slower drug release as compared to those prepared by direct compression. Meanwhile, increasing the percentage of HEP in the formulations caused a decrease in drug release ...
-
Steroidal Ammonium Compounds as New Neuromuscular Blocking AgentsChemical Biology & Drug Design (IF 3.0) Pub Date : 2016-01-26 , DOI:10.1111/cbdd.12711Zhigang Rao,Hao Hu,Jiazhi Tang,Zhiying Liu,Yue Yang,Guofu Qiu,Yuling Xiao,Peng Liu,Xianming Hu,Xiaoju Zhou,Xuechuan HongNeuromuscular blocking agents are widely used as an anesthesia auxiliary in surgery, which induce relaxation of skeletal muscles by blocking signal transmission at the neuromuscular junction. Many neuromuscular blocking agents s were developed over the past decades, but none of them fully meets the needs of the clinic by various reasons. In this study, a series of quaternary ammonium steroidal neuromuscular ...
-
Extracts of Tsai Tai (Brassica chinensis): enhanced antioxidant activity and anti-aging effects both in vitro and in Caenorhabditis elegansFood & Function (IF 6.1) Pub Date : 2015-12-15 , DOI:10.1039/c5fo01241dJing Chen,Ju Zhang,Yanxia Xiang,Limin Xiang,Yongmei Liu,Xiangjiu He,Xiaoju Zhou,Xin Liu,Zebo HuangTsai Tai is one of the most widely consumed Brassica vegetables in Asian countries because of its good taste and its nutritional benefits. This study evaluated the antioxidant capacity and possible associated health benefits of 3 Tsai Tai (Brassica chinensis) varieties, namely, Hon Tsai Tai, Pak Choi and Choi Sum. The DPPH radical scavenging ability and reducing power assays were performed to evaluate ...
-
Synthesis and Pharmacological Evaluation of Novel Benzenesulfonamide Derivatives as Potential Anticonvulsant Agents.Molecules (IF 4.6) Pub Date : 2015-09-26 , DOI:10.3390/molecules200917585Zhiming Wang,Jinping Li,Xiao-Dong Zeng,Xian-Ming Hu,Xiaoju Zhou,Xuechuan Hong
A novel series of benzenesulfonamide derivatives containing 4-aminobenzenesul-fonamide and α-amides branched valproic acid or 2,2-dimethylcyclopropanecarboxylic acid moieties were synthesized and screened for their anticonvulsant activities in mice maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) test. The activity experimental study showed that 2,2-dipropyl-N¹-(4-sul
...
-
Synthesis and Pharmacological Evaluation of Novel Benzenesulfonamide Derivatives as Potential Anticonvulsant AgentsMolecules (IF 4.6) Pub Date : 2015-09-23 , DOI:10.3390/molecules200917585Zhiming Wang, Jinping Li, Xiao-Dong Zeng, Xian-Ming Hu, Xiaoju Zhou, Xuechuan Hong
A novel series of benzenesulfonamide derivatives containing 4-aminobenzenesul-fonamide and α-amides branched valproic acid or 2,2-dimethylcyclopropanecarboxylic acid moieties were synthesized and screened for their anticonvulsant activities in mice maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) test. The activity experimental study showed that 2,2-dipropyl-N1-(4-sul
...
-
Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.PLOS ONE (IF 3.7) Pub Date : 2015-09-01 , DOI:10.1371/journal.pone.0136255Li-Ping Yang,Fang-Jie Jiang,Gui-Sheng Wu,Ke Deng,Meng Wen,Xiaoju Zhou,Xuechuan Hong,Michael X Zhu,Huai-Rong Luo
Transient receptor potential canonical (TRPC) channels are widely expressed in brain and involved in various aspects of brain function. Both TRPC4 and TRPC5 have been implicated in innate fear function, which represents a key response to environmental stress. However, to what extent the TRPC4/C5 channels are involved in psychiatric disorders remains unexplored. Here, we tested the antidepressant and
...
-
Preparation and evaluation of a novel liposomal formulation of cisplatinEuropean Journal of Pharmaceutical Sciences (IF 4.6) Pub Date : 2014-10-16 , DOI:10.1016/j.ejps.2014.10.004Xiaoju Zhou, Jiong Wang, Jianhong Wu, Xiaojuan Yang, Bryant C. Yung, L. James Lee, Robert J. LeeA novel liposomal formulation of cisplatin (L-CDDP) was synthesized and characterized. The L-CDDP was formed by conjugating CDDP to the carboxyl of oleic acid incorporated into empty liposomes. Particle size (155.4 ± 16.1 nm) and zeta potential (−50.92 ± 1.19 mV) of the L-CDDP were determined. In addition, pharmacokinetic properties and antitumor activity in vitro and in vivo were evaluated. Pharmacokinetic ...
-
Preparation and evaluation of a novel liposomal formulation of cisplatin.European Journal of Pharmaceutical Sciences (IF 4.6) Pub Date : 2014 Oct 1 , DOI:10.1016/j.ejps.2014.10.004Xiaoju Zhou,Jiong Wang,Jianhong Wu,Xiaojuan Yang,Bryant C. Yung,L. James Lee,Robert J. LeeA novel liposomal formulation of cisplatin (L-CDDP) was synthesized and characterized. The L-CDDP was formed by conjugating CDDP to the carboxyl of oleic acid incorporated into empty liposomes. Particle size (155.4+/-16.1nm) and zeta potential (-50.92+/-1.19mV) of the L-CDDP were determined. In addition, pharmacokinetic properties and antitumor activity in vitro and in vivo were evaluated. Pharmacokinetic ...
-
Lactosylated gramicidin-based lipid nanoparticles (Lac-GLN) for targeted delivery of anti-miR-155 to hepatocellular carcinomaJournal of Controlled Release (IF 10.8) Pub Date : 2013-04-06 , DOI:10.1016/j.jconrel.2013.03.020Mengzi Zhang,Xiaoju Zhou,Bo Wang,Bryant C. Yung,Ly J. Lee,Kalpana Ghoshal,Robert J. Lee
Lactosylated gramicidin-containing lipid nanoparticles (Lac-GLN) were developed for delivery of anti-microRNA-155 (anti-miR-155) to hepatocellular carcinoma (HCC) cells. MiR-155 is an oncomiR frequently elevated in HCC. The Lac-GLN formulation contained N-lactobionyl-dioleoyl phosphatidylethanolamine (Lac-DOPE), a ligand for the asialoglycoprotein receptor (ASGR), and an antibiotic peptide gramicidin
...
-
Lactosylated liposomes for targeted delivery of doxorubicin to hepatocellular carcinoma.International Journal of Nanomedicine (IF 8.0) Pub Date : 2012-10-16 , DOI:10.2147/ijn.s33965Xiaoju Zhou,Mengzi Zhang,Bryant Yung,Hong Li,Chenguang Zhou,L James Lee,Robert J Lee
BACKGROUND N-lactosyl-dioleoylphosphatidylethanolamine (Lac-DOPE) was synthesized and evaluated as a liver-specific targeting ligand via asialoglycoprotein receptors for liposomal delivery of doxorubicin. METHODS Lactosylated liposomes encapsulating calcein (Lac-L-calcein) or doxorubicin (Lac-L-DOX) composed of egg phosphatidylcholine, cholesterol, monomethoxy polyethylene glycol 2000-distearoyl p
...
-
Novel liposomal gefitinib (L-GEF) formulations.Anticancer research Pub Date : 2012-07-04 , DOI:Xiaoju Zhou,Bryant Yung,Yifei Huang,Hong Li,Xianming Hu,Guangya Xiang,Robert J LeeBACKGROUND Gefitinib is a promising agent for the treatment of non-small cell lung cancer. The purpose of this study was to develop a novel liposomal formulation for gefitinib (L-GEF) to improve its therapeutic index. MATERIALS AND METHODS Several L-GEF formulations were prepared and characterized for their physical chemical properties and cytotoxicity. The pharmacokinetic parameters of the liposomes ...
-
Novel biodegradable hydrogels based on pachyman and its derivatives for drug delivery.International Journal of Pharmaceutics (IF 5.8) Pub Date : 2009 Apr 1 , DOI:10.1016/j.ijpharm.2008.12.023Yan Hu,Xiaoju Zhou,Yong Lu,Chengyang Hu,Xianming HuTwo kinds of hydrogels were synthesized based on pachyman and its hydroxyethyl derivatives (hydroxyethyl pachyman, HEP) by the crosslinking reactions with confunctional crosslinker agent epichlorohydrin (ECH). Hydrogels with different crosslinking ratio were obtained by varying the content of the crosslinker and the polymer. The structure and morphology of hydrogels were characterized and the pH-dependent ...
-
Novel biodegradable hydrogels based on pachyman and its derivatives for drug deliveryInternational Journal of Pharmaceutics (IF 5.8) Pub Date : 2009-04-01 , DOI:10.1016/j.ijpharm.2008.12.023Yan Hu, Xiaoju Zhou, Yong Lu, Chengyang Hu, Xianming HuTwo kinds of hydrogels were synthesized based on pachyman and its hydroxyethyl derivatives (hydroxyethyl pachyman, HEP) by the crosslinking reactions with confunctional crosslinker agent epichlorohydrin (ECH). Hydrogels with different crosslinking ratio were obtained by varying the content of the crosslinker and the polymer. The structure and morphology of hydrogels were characterized and the pH-dependent ...
-
Effect of N-trimethyl chitosan enhancing the dissolution properties of the lipophilic drug cyclosporin ACarbohydrate Polymers (IF 11.2) Pub Date : 2009-03-01 , DOI:10.1016/j.carbpol.2008.10.018Xiaoju Zhou,Yan Hu,Yanping Tian,Xianming HuAbstract The aim was to evaluate the influence of N-trimethyl chitosan chloride (TMC) as a carrier for solid dispersion on the dissolution of poorly water-soluble drugs. In this study, we used cyclosporin A(CyA) as a model drug and TMC as a carrier. The effect of various formulation and process variables including TMC-to-CyA mixing weight ratio, weigh molecular(Mw) of TMC and methods used to disperse ...
-
Preparation and Body Distribution of Freeze-Dried Powder of Ursolic Acid Phospholipid NanoparticlesDrug Development and Industrial Pharmacy (IF 3.4) Pub Date : 2009-03-01 , DOI:10.1080/03639040802302165Xiao Ju Zhou, Xian Ming Hu, Yi Mu Yi, Jing WanUrsolic acid (UA) is a poor soluble natural triterpenoid. It has a wide variety of antitumor activities. We extracted it from Crataegus pinnatifida for the first time. To achieve a high bioavailability, targeting effect, stability, and an intravenous (i.v.) administration, the UA phospholipid nanopowders (UA-PL-NP) were prepared, characterized, and evaluated. With soybean phospholipid as the carrier ...
广告：喜“文”乐“荐”|邀请好友使用Taylor & Francis Editing Services编辑润色服务，共享专属优惠！推荐人数无限制！
高级搜索
我的搜索条件
京公网安备 11010802027423号