- 作 者: ( "zhanqiu yang" OR "zhan-qiu yang" )
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Effect of low-dose aspirin on mortality and viral duration of the hospitalized adults with COVID-19.Medicine (IF 1.817) Pub Date : 2021-2-14 ,DOI:10.1097/md.0000000000024544Qiang Liu, Na Huang, Anni Li, Yuanhong Zhou, Liang Liang, Xinyu Song, Zhanqiu Yang, Xiaolin Zhou
To clarify the effect of aspirin on mortality and viral duration in adults infected with respiratory syndrome coronavirus 2 (SARS-Cov-2).After propensity score-matched (PSM) case-control analyses 24 pairs of patients were enrolled and followed up for 2 months. Both 30-day and 60-day mortality in the aspirin group were significantly lower than that in the non-aspirin group (P = .021 and P = .030, respectively)
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Antiviral Properties of R. tanguticum Nanoparticles on Herpes Simplex Virus Type I In Vitro and In Vivo.Frontiers in Pharmacology (IF 5.988) Pub Date : 2019-09-27 ,DOI:10.3389/fphar.2019.00959Meng-Xin Shen,Nian Ma,Min-Ke Li,Yuan-Yuan Liu,Tian Chen,Fei Wei,Dong-Ying Liu,Wei Hou,Hai-Rong Xiong,Zhan-Qiu Yang
Herpes simplex virus type 1 (HSV-1), an enveloped DNA virus, plays a key role in varieties of diseases including recurrent cold sores, keratoconjunctivitis, genital herpes and encephalitis in humans. Great efforts have been made in developing more effective and less side-effects anti-herpes simplex virus agents, including traditional Chinese herbal medicines. In the present study, we evaluated the
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Assessment of a new arbidol derivative against herpes simplex virus II in human cervical epithelial cells and in BALB/c mice.Biomedicine & Pharmacotherapy (IF 7.419) Pub Date : 2019-08-28 ,DOI:10.1016/j.biopha.2019.109359Nian Ma,Mengxin Shen,Tian Chen,Yuanyuan Liu,Yidong Mao,Liangjun Chen,Hairong Xiong,Wei Hou,Dongying Liu,Zhanqiu Yang
As one of the highly contagious forms, herpes simplex virus type 2 (HSV-2) commonly caused severe genital diseases and closely referred to the HIV infection. The lack of effective vaccines and drug-resistance proclaimed the preoccupation for alternative antiviral agents against HSV-2. Molecules bearing indole nucleus presented diverse biological properties involving antiviral and anti-inflammatory
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The antiviral activity of arbidol hydrochloride against herpes simplex virus type i in vitro and in vivoInternational Journal of Antimicrobial Agents Pub Date : 2018-01-01 ,DOI:10.1016/j.ijantimicag.2017.09.001Min-ke Li, Yuan-yuan Liu, Fei Wei, Meng-xin Shen, Yan Zhong, Shan Li, Liang-jun Chen, Nian Ma, Bing-yu Liu, Yi-dong Mao, Ning Li, Wei Hou, Hai-rong Xiong, Zhan-qiu YangHerpes simplex virus type 1 (HSV-1) causes significant human diseases ranging from skin lesions to encephalitis, especially in neonates and immunocompromised hosts. The discovery of novel anti-HSV-1 drugs with low toxicity is required for public health. Arbidol hydrochloride (ARB) is an indole derivative molecule with broad-spectrum antiviral activity. In this study, the antiviral effects of ARB against ...
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Antiviral activity of arbidol hydrochloride against herpes simplex virus I in vitro and in vivo.International Journal of Antimicrobial Agents Pub Date : 2017-09-12 ,DOI:10.1016/j.ijantimicag.2017.09.001Min-Ke Li,Yuan-Yuan Liu,Fei Wei,Meng-Xin Shen,Yan Zhong,Shan Li,Liang-Jun Chen,Nian Ma,Bing-Yu Liu,Yi-Dong Mao,Ning Li,Wei Hou,Hai-Rong Xiong,Zhan-Qiu YangHerpes simplex virus type 1 (HSV-1) causes significant human diseases ranging from skin lesions to encephalitis, especially in neonates and immunocompromised hosts. The discovery of novel anti-HSV-1 drugs with low toxicity is required for public health. Arbidol hydrochloride (ARB) is an indole derivative molecule with broad-spectrum antiviral activity. In this study, the antiviral effects of ARB against ...
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Specific Expression of Interferon-γ Induced by Synergistic Activation Mediator-Derived Systems Activates Innate Immunity and Inhibits Tumorigenesis.Journal of Microbiology and Biotechnology (IF 3.277) Pub Date : 2017-08-26 ,DOI:10.4014/jmb.1705.05081Shuai Liu,Xiao Yu,Qiankun Wang,Zhepeng Liu,Qiaoqiao Xiao,Panpan Hou,Ying Hu,Wei Hou,Zhanqiu Yang,Deyin Guo,Shuliang Chen
The synergistic activation mediator (SAM) system can robustly activate endogenous gene expression by a single-guide RNA. This transcriptional modulation has been shown to enhance gene promoter activity and leads to epigenetic changes. Human interferon-γ is a common natural glycoprotein involved in antiviral effects and inhibition of cancer cell growth. Large quantities of high-purity interferon-γ are
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Human bocavirus induces apoptosis and autophagy in human bronchial epithelial cells.Experimental and Therapeutic Medicine (IF 2.751) Pub Date : 2017-07-05 ,DOI:10.3892/etm.2017.4533You-Ping Deng,Ying-Juan Liu,Zhan-Qiu Yang,Yan-Jun Wang,Bing-Yan He,Pin Liu
Human bocavirus (HBoV) is classified in the Bocavirus genus within the Parvoviridae family, first identified from children with respiratory diseases. Previous studies have investigated the stimulating effect of HBoV on cell apoptosis and autophagy. In the present study, human bronchial epithelial cells (HBECs) were utilized to examine the mechanism of HBoV recombination expressing vector (pWHL-1) on
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Phylogenetic analysis based on mitochondrial DNA sequences of wild rats, and the relationship with Seoul virus infection in Hubei, China.Virologica Sinica (IF 6.947) Pub Date : 2017-06-26 ,DOI:10.1007/s12250-016-3940-0Dong-Ying Liu,Jing Liu,Bing-Yu Liu,Yuan-Yuan Liu,Hai-Rong Xiong,Wei Hou,Zhan-Qiu Yang
Seoul virus (SEOV), which is predominantly carried by Rattus norvegicus, is one of the major causes of hemorrhagic fever with renal syndrome (HFRS) in China. Hubei province, located in the central south of China, has experienced some of the most severe epidemics of HFRS. To investigate the mitochondrial DNA (mtDNA)-based phylogenetics of wild rats in Hubei, and the relationship with SEOV infection
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Human cytomegalovirus glycoprotein polymorphisms and increasing viral load in AIDS patients.PLOS ONE (IF 3.752) Pub Date : 2017-05-04 ,DOI:10.1371/journal.pone.0176160Xiao-Jing Jiang,Jun Zhang,Yong Xiong,Gerhard Jahn,Hai-Rong Xiong,Zhan-Qiu Yang,Yuan-Yuan Liu
BACKGROUND Multiple strains infection of human cytomegalovirus (HCMV) was found to be correlated with increased viral load in immunodeficient patients. However, the pathogenic mechanism underlying this correlation remains unclear. To evaluate genetic polymorphisms of HCMV glycoprotein and their potential role in its viral load, HCMV glycoprotein B, N, and O (gB, gN and gO) genotypes was studied in
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Diversity, evolution and population dynamics of avian influenza viruses circulating in the live poultry markets in China.Virology (IF 3.513) Pub Date : 2017-02-22 ,DOI:10.1016/j.virol.2017.02.009Liang-Jun Chen,Xian-Dan Lin,Jun-Hua Tian,Yong Liao,Xu-Hua Ying,Jian-Wei Shao,Bin Yu,Jing-Jing Guo,Miao-Ruo Wang,Ying Peng,Mang Shi,Edward C Holmes,Zhan-Qiu Yang,Yong-Zhen Zhang
Live poultry markets (LPMs) are an important source of novel avian influenza viruses (AIV). During 2015-2016 we surveyed AIV diversity in ten LPMs in Hubei, Zhejiang and Jiangxi provinces, China. A high diversity and prevalence of AIVs (totaling 12 subtypes) was observed in LPMs in these provinces. Strikingly, however, the subtypes discovered during 2015-2016 were markedly different to those reported
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Construction of a Seasonal Difference-Geographically and Temporally Weighted Regression (SD-GTWR) Model and Comparative Analysis with GWR-Based Models for Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China).International Journal of Environmental Research and Public Health (IF 4.614) Pub Date : 2016-11-02 ,DOI:10.3390/ijerph13111062Liang Ge,Youlin Zhao,Zhongjie Sheng,Ning Wang,Kui Zhou,Xiangming Mu,Liqiang Guo,Teng Wang,Zhanqiu Yang,Xixiang Huo
Hemorrhagic fever with renal syndrome (HFRS) is considered a globally distributed infectious disease which results in many deaths annually in Hubei Province, China. In order to conduct a better analysis and accurately predict HFRS incidence in Hubei Province, a new model named Seasonal Difference-Geographically and Temporally Weighted Regression (SD-GTWR) was constructed. The SD-GTWR model, which integrates
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Antiviral activity and mechanism of action of arbidol against Hantaan virus infectionTropical Journal of Pharmaceutical Research Pub Date : 2016-08-11 ,DOI:10.4314/tjpr.v15i7.12Hai-Rong Xiong, Yi-Hui Zhang, Kan Deng, Qiang Liu, Yuan-Yuan Liu, Fan Luo, Wei Hou, Zhan-Qiu Yang
Purpose : To investigate the activity and mechanism of action of arbidol against Hantaan virus (HTNV) activity by modulating inflammation via TLR-4 pathway. Methods : HUVEC cells infected with HTNV 76-118 were treated with serially diluted arbidol solutions at -2h (2 h before viral infection, pre-treatment mode), 0 h (at the same time as viral infection, simultaneous treatment mode) or 2 h (2 h after
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Antivirals for Respiratory Viral Infections: Problems and Prospects.Seminars in Respiratory and Critical Care Medicine (IF 3.921) Pub Date : 2016-08-03 ,DOI:10.1055/s-0036-1584803Qiang Liu,Yuan-Hong Zhou,Feng Ye,Zhan-Qiu Yang
In the past two decades, several newly emerging and reemerging viral respiratory pathogens including several influenza viruses (avian influenza and pandemic influenza), severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome coronavirus (MERS-CoV), have continued to challenge medical and public health systems. Thereafter, the development of cost-effective, broad-spectrum
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pH-dependent conformational changes of a Thogoto virus matrix protein reveal mechanisms of viral assembly and uncoating.Journal of General Virology (IF 5.141) Pub Date : 2016-07-15 ,DOI:10.1099/jgv.0.000551Mingrui Yang,Feng Feng,Yingfang Liu,Hui Wang,Zhanqiu Yang,Wei Hou,Huanhuan Liang
Orthomyxoviruses are a family of ssRNA virus, including influenza virus, infectious salmon anaemia virus and Thogoto virus. The matrix proteins of orthomyxoviruses play crucial roles in some essential processes of the viral life cycle. However, the mechanisms of the matrix proteins involved in these processes remain incompletely understood. Currently, only the structure and function of the matrix protein
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Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo.Acta Pharmacologica Sinica (IF 7.169) Pub Date : 2016-Apr-0 ,DOI:10.1038/aps.2015.165Yuan-yuan Liu,Liang-jun Chen,Yan Zhong,Meng-xin Shen,Nian Ma,Bing-yu Liu,Fan Luo,Wei Hou,Zhan-qiu Yang,Hai-rong Xiong
To investigate the antiviral effects of vectors expressing specific short hairpin RNAs (shRNAs) against Hantaan virus (HTNV) infection in vitro and in vivo.
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Diversity and evolution of avian influenza viruses in live poultry markets, free-range poultry and wild wetland birds in China.Journal of General Virology (IF 5.141) Pub Date : 2016-01-14 ,DOI:10.1099/jgv.0.000399Liang-Jun Chen,Xian-Dan Lin,Wen-Ping Guo,Jun-Hua Tian,Wen Wang,Xu-Hua Ying,Miao-Ruo Wang,Bin Yu,Zhan-Qiu Yang,Mang Shi,Edward C Holmes,Yong-Zhen Zhang
The wide circulation of novel avian influenza viruses (AIVs) highlights the risk of pandemic influenza emergence in China. To investigate the prevalence and genetic diversity of AIVs in different ecological contexts, we surveyed AIVs in live poultry markets (LPMs), free-range poultry and the wetland habitats of wild birds in Zhejiang and Hubei provinces. Notably, LPMs contained the highest frequency
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High Human Cytomegalovirus IgG Level is Associated with Increased Incidence of Diabetic Atherosclerosis in Type 2 Diabetes Mellitus Patients.Medical Science Monitor Pub Date : 2015-12-31 ,DOI:10.12659/msm.896071Jun Zhang,Yuan-yuan Liu,Hui-ling Sun,Shan Li,Hai-rong Xiong,Zhan-qiu Yang,Guang-da Xiang,Xiao-jing Jiang
BACKGROUND At present, whether human cytomegalovirus (HCMV) infection is associated with type 2 diabetes mellitus (T2DM) is debatable. The effect of active HCMV infection on glucose regulation has been poorly studied. Although HCMV infection is correlated with atherosclerosis in cardiovascular disease, the role of HCMV infection in the development of diabetic atherosclerosis in T2DM is unclear and
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High Human Cytomegalovirus IgG Level is Associated with Increased Incidence of Diabetic Atherosclerosis in Type 2 Diabetes Mellitus PatientsMedical Science Monitor Pub Date : 2015-12-30 ,DOI:10.12659/msm.896071Jun Zhang, Yuan-yuan Liu, Hui-ling Sun, Shan Li, Hai-rong Xiong, Zhan-qiu Yang, Guang-da Xiang, Xiao-jing Jiang
Background At present, whether human cytomegalovirus (HCMV) infection is associated with type 2 diabetes mellitus (T2DM) is debatable. The effect of active HCMV infection on glucose regulation has been poorly studied. Although HCMV infection is correlated with atherosclerosis in cardiovascular disease, the role of HCMV infection in the development of diabetic atherosclerosis in T2DM is unclear and
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Antiviral effect of emodin from Rheum palmatum against coxsakievirus B5 and human respiratory syncytial virus in vitro.Journal of Huazhong University of Science and Technology [Medical Sciences] Pub Date : 2015-12-17 ,DOI:10.1007/s11596-015-1528-9Zhao Liu,Nian Ma,Yan Zhong,Zhan-Qiu Yang
Viral infections are the major causes of morbidity and mortality in elderly people and young children throughout the world. The most common pathogens include coxsackie virus (CV) and respiratory syncytial virus (RSV). However, no antiviral agents with low toxicity and drug resistance are currently available in clinic therapy. The present study aimed to examine the antiviral activities of emodin (an
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Hepatitis B virus infection and genotype in asymptomatic people from 10 ethnic groups in Yunnan, China.World Journal of Gastroenterology (IF 5.374) Pub Date : 2015-12-08 ,DOI:10.3748/wjg.v21.i44.12586Yuan-Ying Shen,Wei Hou,Zhan-Qiu Yang,Wen Xiao
AIM To evaluate the infection and genotype distribution of hepatitis B virus (HBV) in ethnic groups in Yunnan, China. METHODS Two thousand five hundred and eighty-four asymptomatic local people from 10 ethnic groups were investigated in Yunnan, China. Infection and genotype distribution were evaluated by serological and genetic methods. Genotyping was verified by sequencing. Ethnic genotype distribution
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Antiviral Activity of Total Flavonoid Extracts from Selaginella moellendorffii Hieron against Coxsackie Virus B3 In Vitro and In Vivo.Evidence-based Complementary and Alternative Medicine (IF 2.65) Pub Date : 2014-05-19 ,DOI:10.1155/2014/950817Dan Yin,Juan Li,Xiang Lei,Yimei Liu,Zhanqiu Yang,Keli Chen
The antiviral activity of total flavonoid extracts from Selaginella moellendorffii Hieron and its main constituents amentoflavone were investigated against coxsackie virus B3 (CVB3). When added during or after viral infection, the extracts and amentoflavone prevented the cytopathic effect (CPE) of CVB3, as demonstrated in a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) colorimetric
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The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China.PLOS ONE (IF 3.752) Pub Date : 2014-03-21 ,DOI:10.1371/journal.pone.0092700Yi-Hui Zhang,Liang Ge,Li Liu,Xi-Xiang Huo,Hai-Rong Xiong,Yuan-Yuan Liu,Dong-Ying Liu,Fan Luo,Jin-Lin Li,Jia-Xin Ling,Wen Chen,Jing Liu,Wei Hou,Yun Zhang,Hong Fan,Zhan-Qiu Yang
BACKGROUND Hemorrhagic fever with renal syndrome (HFRS) is caused by different hantaviruses within the Bunyaviridae family. HFRS is a fulminant, infectious disease that occurs worldwide and is endemic in all 31 provinces of China. Since the first HFRS case in Hubei Province was reported in 1957, the disease has spread across the province and Hubei has become one of the seriously affected areas in China
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Characteristics of human infection with avian influenza viruses and development of new antiviral agents.Acta Pharmacologica Sinica (IF 7.169) Pub Date : 2013-Oct-0 ,DOI:10.1038/aps.2013.121Qiang Liu,Dong-ying Liu,Zhan-qiu Yang
Since 1997, several epizootic avian influenza viruses (AIVs) have been transmitted to humans, causing diseases and even deaths. The recent emergence of severe human infections with AIV (H7N9) in China has raised concerns about efficient interpersonal viral transmission, polygenic traits in viral pathogenicity and the management of newly emerging strains. The symptoms associated with viral infection
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In Vitro and in Vivo Studies of the Inhibitory Effects of Emodin Isolated from Polygonum cuspidatum on Coxsakievirus B4Molecules (IF 4.927) Pub Date : 2013-09-25 ,DOI:10.3390/molecules181011842Zhao Liu, Fei Wei, Liang-Jun Chen, Hai-Rong Xiong, Yuan-Yuan Liu, Fan Luo, Wei Hou, Hong Xiao, Zhan-Qiu Yang
The lack of effective therapeutics for Coxsackievirus B4 (CVB4) infection underscores the importance of finding novel antiviral compounds. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is one of the natural anthraquinone derivatives obtained from the root and rhizome of Polygonum cuspidatum. In the present study, the possibility of using emodin as a potential antiviral to treat CVB4 infection was
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In vitro and in vivo studies of the inhibitory effects of emodin isolated from Polygonum cuspidatum on Coxsakievirus B₄.Molecules (IF 4.927) Pub Date : 2013-09-25 ,DOI:10.3390/molecules181011842Zhao Liu,Fei Wei,Liang-Jun Chen,Hai-Rong Xiong,Yuan-Yuan Liu,Fan Luo,Wei Hou,Hong Xiao,Zhan-Qiu Yang
The lack of effective therapeutics for Coxsackievirus B₄ (CVB₄) infection underscores the importance of finding novel antiviral compounds. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is one of the natural anthraquinone derivatives obtained from the root and rhizome of Polygonum cuspidatum. In the present study, the possibility of using emodin as a potential antiviral to treat CVB₄ infection was
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Jiawei-Yupingfeng-Tang, a Chinese herbal formula, inhibits respiratory viral infections in vitro and in vivo.Journal of Ethnopharmacology (IF 5.195) Pub Date : 2013-09-21 ,DOI:10.1016/j.jep.2013.08.056Qiang Liu,Li Lu,Moli Hua,Yu Xu,Hairong Xiong,Wei Hou,Zhanqiu YangETHNOPHARMACOLOGICAL RELEVANCE Jiawei-Yupingfeng-Tang (JYT) is a Chinese herbal formula that is widely used to treat respiratory tract illness. However, the effect of JYT on respiratory viruses remains unknown. The influenza virus (IFV) and the human respiratory syncytial virus (HRSV) cause millions of cases of severe illness per year, and many of these illnesses develop into lethal pneumonia. The ...
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Jiawei-Yupingfeng-Tang, a Chinese herbal formula, inhibits respiratory viral infections in vitro and in vivoJournal of Ethnopharmacology (IF 5.195) Pub Date : 2013-09-16 ,DOI:10.1016/j.jep.2013.08.056Qiang Liu, Li Lu, Moli Hua, Yu Xu, Hairong Xiong, Wei Hou, Zhanqiu YangEthnopharmacological relevance Jiawei-Yupingfeng-Tang (JYT) is a Chinese herbal formula that is widely used to treat respiratory tract illness. However, the effect of JYT on respiratory viruses remains unknown. The influenza virus (IFV) and the human respiratory syncytial virus (HRSV) cause millions of cases of severe illness per year, and many of these illnesses develop into lethal pneumonia. The ...
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Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection.Acta Pharmacologica Sinica (IF 7.169) Pub Date : 2013-Aug-0 ,DOI:10.1038/aps.2013.54Qiang Liu,Hai-rong Xiong,Li Lu,Yuan-yuan Liu,Fan Luo,Wei Hou,Zhan-qiu Yang
To investigate the effects of arbidol hydrochloride (ARB), a widely used antiviral agent, on the inflammation induced by influenza virus.
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Antiviral Activity ofFolium IsatidisDerived ExtractsIn VitroandIn VivoThe American Journal of Chinese Medicine (IF 6.005) Pub Date : 2013-07-30 ,DOI:10.1142/s0192415x1350064xYou-Ping Deng, Yuan-Yuan Liu, Zhao Liu, Jin Li, Ling-Min Zhao, Hong Xiao, Xiao-Hua Ding, Zhan-Qiu YangFolium isatidis is a native Chinese herbaceous plant widely used for medicinal purposes for thousands of years. However, few studies have focused on the leaves of Isatis indigotica. In this report, we isolated a series of four fractions (I–IV) from Folium isatidis and explored the antiviral activity of each tested extract. The extracts were active against a panel of RNA and DNA viruses in vitro, namely ...
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