- 作 者: ( "mingzhou chen" OR "ming-zhou chen" )
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Early prediction of sepsis using double fusion of deep features and handcrafted featuresApplied Intelligence (IF 5.019) Pub Date : 2023-01-17 ,DOI:10.1007/s10489-022-04425-zYongrui Duan, Jiazhen Huo, Mingzhou Chen, Fenggang Hou, Guoliang Yan, Shufang Li, Haihui Wang
Sepsis is a life-threatening medical condition that is characterized by the dysregulated immune system response to infections, having both high morbidity and mortality rates. Early prediction of sepsis is critical to the decrease of mortality. This paper presents a novel early warning model called Double Fusion Sepsis Predictor (DFSP) for sepsis onset. DFSP is a double fusion framework that combines
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In situ construction of green multiscale nanosilicon-based sponges for stable oil-water separationEnvironmental Technology (IF 3.475) Pub Date : 2022-12-22 ,DOI:10.1080/09593330.2022.2161948Yi Li, Ming Zhou, Chen Li, Hongchang Han, T.U. HongjunAbstract: Oil and industrial wastewater spills have caused serious ecological impacts, thus superhydrophobic materials are paid much attention for their unique oil/water selective adsorption properties. Herein, we propose a green and efficient method for preparing superhydrophobic adsorbents for oil/water separation. Superhydrophobic melamine sponges (SMS) were prepared by in situ growth of nanosilica ...
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Lighting up early metastases by phosphorescence imagingChemRxiv Pub Date : 2022-09-29 ,DOI:10.26434/chemrxiv-2022-z59dszhen, li, Kai, Chang, Leyi, Xiao, Yuanyuan, Fan, Juqing, Gu, Yunsheng, Wang, Jie, Yang, Mingzhou, Chen, Yufeng, Zhang, Qianqian, Li
Tumour metastasis is a main barrier in fully recovery of cancer, in most cases, metastasis has already occurred before the detection of cancer. Until now, the detection limit of tumour sizes is still ~1 mm in mouse models, thus, it is difficult to track tumour metastasis in the early stage by current imaging techniques and related others. Herein, we demonstrated a novel way to detect early tumour metastasis
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Vimentin inhibits α-tubulin acetylation via enhancing α-TAT1 degradation to suppress the replication of human parainfluenza virus type 3.PLoS Pathogens (IF 7.464) Pub Date : 2022-09-15 ,DOI:10.1371/journal.ppat.1010856Pengfei Liu,Shengwei Zhang,Jingyi Ma,Dongning Jin,Yali Qin,Mingzhou Chen
We previously found that, among human parainfluenza virus type 3 (HPIV3) proteins, the interaction of nucleoprotein (N) and phosphoprotein (P) provides the minimal requirement for the formation of cytoplasmic inclusion bodies (IBs), which are sites of RNA synthesis, and that acetylated α-tubulin enhances IB fusion and viral replication. In this study, using immunoprecipitation and mass spectrometry
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The nonstructural protein 2C of Coxsackie B virus has RNA helicase and chaperoning activitiesVirologica Sinica (IF 6.947) Pub Date : 2022-05-16 ,DOI:10.1016/j.virs.2022.05.004Ziyu Chen, Xiaobei Xiong, Yiyang Li, Muhan Huang, Yujie Ren, Di Wu, Yang Qiu, Mingzhou Chen, Ting Shu, Xi Zhou
RNA-remodeling proteins, including RNA helicases and chaperones, play vital roles in the remodeling of structured RNAs. During viral replication, viruses require RNA-remodeling proteins to facilitate proper folding and/or re-folding the viral RNA elements. Coxsackieviruses B3 (CVB3) and Coxsackieviruses B5 (CVB5), belonging to the genus Enterovirus in the family Picornaviridae, have been reported to
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SLC35B2 Acts in a Dual Role in the Host Sulfation Required for EV71 InfectionJournal of Virology (IF 6.549) Pub Date : 2022-04-14 ,DOI:10.1128/jvi.02042-21Dong Guo, Xinghai Yu, Dan Wang, Zhifei Li, Yu Zhou, Guodong Xu, Bing Yuan, Yali Qin, Mingzhou Chen aState Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan Universitygrid.49470.3e, Wuhan, China bWuhan Canvest Biotechnology Co., Ltd., Wuhan, Hubei, China, Bryan R. G. WilliamsJournal of Virology, Ahead of Print. ...
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18F-SynVesT-1 PET in Focal Cortical Dysplasia Type II With Thickening Cortex.Clinical Nuclear Medicine (IF 10.782) Pub Date : 2022-04-05 ,DOI:10.1097/rlu.0000000000004214Yongxiang Tang, Jie Yu, Ming Zhou, Chen Chen, Shuo HuA case of 2-year-old girl with intractable seizures underwent 18F-FDG PET and MRI for seizure focus localization. MRI demonstrated cortical thickening and blurring of the gray-white matter interface in the right postcentral gyrus with focal hypometabolism in 18F-FDG PET. The patient subsequently was enrolled in clinical trial of 18F-SynVesT-1 PET study in epilepsy; a more restricted area of reduced ...
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Probing Vibrational Strong Coupling of Molecules with Wavelength-Modulated Raman SpectroscopyAdvanced Optical Materials (IF 10.05) Pub Date : 2021-11-27 ,DOI:10.1002/adom.202102065Kishan S. Menghrajani, Mingzhou Chen, Kishan Dholakia, William L. Barnes
Raman spectroscopy is a powerful technique that enables fingerprinting of materials, molecules, and chemical environments by probing vibrational resonances. In many applications, the desired Raman signals are masked by fluorescence, either from the molecular system being studied, or from adjacent metallic nanostructures. Here, it is shown that wavelength-modulated Raman spectroscopy provides a powerful
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A hybrid adaptive large neighborhood search algorithm for the large-scale heterogeneous container loading problemExpert Systems with Applications (IF 8.665) Pub Date : 2021-10-18 ,DOI:10.1016/j.eswa.2021.115909Ying Li, Mingzhou Chen, Jiazhen HuoThis paper aims to solve the large-scale heterogeneous container loading problem (HCLP), which is an extensive form of the multiple container loading problem, in a limited time. The target is to choose a set of containers of different sizes to accommodate all products and minimize the wasted space rate. Although the heterogeneous container selection problem is a general problem in the logistics industry ...
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Enterovirus 71 2A Protease Inhibits P-Body Formation To Promote Viral RNA SynthesisJournal of Virology (IF 6.549) Pub Date : 2021-09-09 ,DOI:10.1128/jvi.00922-21Shanshan Fan, Zihang Xu, Pengfei Liu, Yali Qin, Mingzhou ChenProcessing bodies (P-bodies) are constitutively present in eukaryotic cells and play an important role in the mRNA cycle, including regulation of gene expression and mRNA degradation. The P-body is the structure that viruses manipulate to facilitate their ... ...
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P300-mediated NEDD4 acetylation drives ebolavirus VP40 egress by enhancing NEDD4 ligase activity.PLoS Pathogens (IF 7.464) Pub Date : 2021-06-10 ,DOI:10.1371/journal.ppat.1009616Linliang Zhang,Shixiong Zhou,Majuan Chen,Jie Yan,Yi Yang,Linjuan Wu,Dongning Jin,Lei Yin,Mingzhou Chen,Yali Qin
The final stage of Ebola virus (EBOV) replication is budding from host cells, where the matrix protein VP40 is essential for driving this process. Many post-translational modifications such as ubiquitination are involved in VP40 egress, but acetylation has not been studied yet. Here, we characterize NEDD4 is acetylated at a conserved Lys667 mediated by the acetyltransferase P300 which drives VP40 egress
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Collaborative task scheduling with new task arrival in cloud manufacturing using improved multi-population biogeography-based optimizationJournal of Intelligent & Fuzzy Systems (IF 1.737) Pub Date : 2021-04-13 ,DOI:10.3233/jifs-201066Ziwei Dai, Zhiyong Zhang, Mingzhou ChenTask scheduling is important in cloud manufacturing because of customers’ increasingly individualized demands. However, when various changes occur, a previous optimal schedule may become non-optimal or even infeasible owing to the uncertainty of the real manufacturing environment where dynamic taskarrival over time is a vital source. In this paper, we propose a novel collaborative task scheduling (CTS) ...
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Rationally designed hierarchical C/TiO2/Ti multilayer core–sheath wires for high-performance energy storage devicesNanoscale (IF 8.307) Pub Date : 2021-4-6 ,DOI:10.1039/d1nr00814eWei Cao, Yun Gong, Wenhao Wang, Mingzhou Chen, Junhe Yang, Yuhua XueFiber-shaped supercapacitors (FSCs) are promising power sources for wearable electronic devices due to their small size, excellent flexibility and deformability. The performance of FSCs has been severely affected by the framework of the fibrous electrodes and the interface between the electrode materials and current collector. Herein, we propose an ingenious strategy that combines anodizing etching ...
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The SARS-CoV-2 subgenome landscape and its novel regulatory featuresMolecular Cell (IF 19.328) Pub Date : 2021-03-03 ,DOI:10.1016/j.molcel.2021.02.036Jiangpeng Feng, Guangnan Li, Dong Guo, Muhammad Sajid, Kai Wu, Qiuhan Zhang, Yann Ponty, Sebastian Will, Feiyan Liu, Xinghai Yu, Shaopeng Li, Qianyun Liu, Xing-Lou Yang, Ming Guo, Xingqiao Li, Mingzhou Chen, Yu Zhou
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently a global pandemic. CoVs are known to generate negative subgenomes (subgenomic RNAs [sgRNAs]) through transcription-regulating sequence (TRS)-dependent template switching, but the global dynamic landscapes of coronaviral subgenomes and regulatory rules remain unclear. Here, using
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A study about silane modification and interfacial ultraviolet aging of hemp fiber reinforced polypropylene compositesPolymer Composites (IF 3.531) Pub Date : 2021-03-01 ,DOI:10.1002/pc.26000Hong Chang Han, Xiao Lu Gong, Ming Zhou, Chen Li, Heng Bin YangInterfacial adhesion and the potential degradation are critical to service life and performances of plant fiber polymer composites. In this paper, the interfacial ultraviolet (UV) aging was studied by silane modification of hemp fiber on UV aging of the reinforced polypropylene (PP) composites. Three silane agents of 3‐(Trimethoxysilyl)propyl methacrylate (MPS), N‐[3‐(Trimethoxysilyl)propyl]aniline ...
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Xiaoyaosan Alleviates Hippocampal Glutamate-Induced Toxicity in the CUMS Rats via NR2B and PI3K/Akt Signaling PathwayFrontiers in Pharmacology (IF 5.988) Pub Date : 2021-02-04 ,DOI:10.3389/fphar.2021.586788Xue-Ming Zhou, Chen-Yue Liu, Yue-Yun Liu, Qing-Yu Ma, Xin Zhao, You-Ming Jiang, Xiao-Juan Li, Jia-Xu Chen
Purpose: It is revealed that Xiaoyaosan could reduce glutamate level in the hippocampus of depressed rats, whose metabolism leads to the pathophysiology of depression. However, the underlying mechanism remains unclear. This study aims to explore the effect of Xiaoyaosan on glutamate metabolism, and how to regulate the excitatory injury caused by glutamate. Methods: Rats were induced by chronic unpredictable
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Sumoylation of Human Parainfluenza Virus Type 3 Phosphoprotein Correlates with A Reduction in Viral ReplicationVirologica Sinica (IF 6.947) Pub Date : 2020-11-16 ,DOI:10.1007/s12250-020-00314-2Qi Cheng, Wenjing Huai, Xiaoyan Wu, Mingzhou ChenHuman parainfluenza virus type 3 (HPIV3), a member of the Paramyxoviridae family, can cause lower respiratory disease in infants and young children. The phosphoprotein (P) of HPIV3 is an essential cofactor of the viral RNA-dependent RNA polymerase large protein (L). P connects nucleocapsid protein (N) with L to initiate genome transcription and replication. Sumoylation influences many important pathways ...
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Microscale diamond protection for a ZnO coated fiber optic sensorScientific Reports (IF 4.996) Pub Date : 2020-11-05 ,DOI:10.1038/s41598-020-76253-5Monika Kosowska, Paulina Listewnik, Daria Majchrowicz, Michał Rycewicz, Mikhael Bechelany, Yafit Fleger, Mingzhou Chen, Dror Fixler, Kishan Dholakia, Małgorzata Szczerska
Fiber optic sensors are widely used in environmental, biological and chemical sensing. Due to the demanding environmental conditions in which they can be used, there is a risk of damaging the sensor measurement head placed in the measuring field. Sensors using nanolayers deposited upon the fiber structure are particularly vulnerable to damage. A thin film placed on the surface of the fiber end-face
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The two-stage interaction of Ebola virus VP40 with nucleoprotein results in a switch from viral RNA synthesis to virion assembly/buddingProtein & Cell (IF 15.328) Pub Date : 2020-11-03 ,DOI:10.1007/s13238-020-00764-0Linjuan Wu, Dongning Jin, Dan Wang, Xuping Jing, Peng Gong, Yali Qin, Mingzhou Chen
Ebola virus (EBOV) is an enveloped negative-sense RNA virus and a member of the filovirus family. Nucleoprotein (NP) expression alone leads to the formation of inclusion bodies (IBs), which are critical for viral RNA synthesis. The matrix protein, VP40, not only plays a critical role in virus assembly/budding, but also can regulate transcription and replication of the viral genome. However, the molecular
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Through-bottle whisky sensing and classification using Raman spectroscopy in an axicon-based backscattering configurationAnalytical Methods (IF 3.532) Pub Date : 2020-08-19 ,DOI:10.1039/d0ay01101kHolly Fleming, Mingzhou Chen, Graham D. Bruce, Kishan Dholakia
Non-intrusive detection systems have the potential to characterise materials through various transparent glass and plastic containers. Food and drink adulteration is increasingly problematic, representing a serious health risk as well as an economic issue. This is of particular concern for alcoholic spirits such as Scotch whisky which are often targeted for fraudulent activity. We have developed a
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Optical analysis of homocysteine metabolites using vibrational spectroscopyOSA Continuum Pub Date : 2020-07-10 ,DOI:10.1364/osac.397780Mingzhou Chen, Lisa Strother, Gayle H. Doherty, Kishan Dholakia
Homocysteine (HCy) is a sulphur-containing amino acid that correlates with several maladaptive health conditions, including an enhanced risk of cardiovascular and neurodegenerative diseases. Detection of HCy and its potentially pathogenic metabolites are studied here for the first time, to the first of our knowledge, using Raman spectroscopy. This study shows that different HCy metabolites have distinct
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Real-time monitoring of live mycobacteria with a microfluidic acoustic-Raman platform.Communications Biology (IF 6.548) Pub Date : 2020-05-14 ,DOI:10.1038/s42003-020-0915-3Vincent O Baron,Mingzhou Chen,Björn Hammarstrom,Robert J H Hammond,Peter Glynne-Jones,Stephen H Gillespie,Kishan Dholakia
Tuberculosis (TB) remains a leading cause of death worldwide. Lipid rich, phenotypically antibiotic tolerant, bacteria are more resistant to antibiotics and may be responsible for relapse and the need for long-term TB treatment. We present a microfluidic system that acoustically traps live mycobacteria, M. smegmatis, a model organism for M. tuberculosis. We then perform optical analysis in the form
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Femtometer-resolved simultaneous measurement of multiple laser wavelengths in a speckle wavemeterOptics Letters (IF 3.56) Pub Date : 2020-03-23 ,DOI:10.1364/ol.388960Graham D. Bruce, Laura O’Donnell, Mingzhou Chen, Morgan Facchin, and Kishan Dholakia
Many areas of optical science require an accurate measurement of optical spectra. Devices based on laser speckle promise compact wavelength measurement, with attometer-level sensitivity demonstrated for single wavelength laser fields. The measurement of multimode spectra using this approach would be attractive, yet this is currently limited to picometer resolution. Here, we present a method to improve
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Fuzzy optimization model for electric vehicle routing problem with time windows and recharging stationsExpert Systems with Applications (IF 8.665) Pub Date : 2019-12-09 ,DOI:10.1016/j.eswa.2019.113123Shuai Zhang, Mingzhou Chen, Wenyu Zhang, Xiaoyu ZhuangAs fuel prices increase and emission regulations become increasingly strict, electric vehicles have been used in various logistics distribution activities. Most studies have focused on the electric vehicle routing problem under a deterministic environment, neglecting the effects of uncertain factors in practical logistics distribution. Thus, a novel fuzzy electric vehicle routing problem with time ...
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PI4KB on Inclusion Bodies Formed by ER Membrane Remodeling Facilitates Replication of Human Parainfluenza Virus Type 3.Cell Reports (IF 9.995) Pub Date : 2019-11-19 ,DOI:10.1016/j.celrep.2019.10.052Zhifei Li,Dong Guo,Yali Qin,Mingzhou Chen
Many positive-strand RNA viruses remodel the endomembrane to form specialized replication organelles. However, knowledge regarding whether negative-strand RNA viruses take advantage of intracellular membranes for replication is limited. Here we show that a negative-strand RNA virus, human parainfluenza virus type 3 (HPIV3), remodels the endoplasmic reticulum (ER) membrane to form inclusion bodies (IBs)
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Optimal compressive multiphoton imaging at depth using single-pixel detectionOptics Letters (IF 3.56) Pub Date : 2019-10-10 ,DOI:10.1364/ol.44.004981Philip Wijesinghe,Adrià Escobet-Montalbán,Mingzhou Chen,Peter R. T. Munro,Kishan Dholakia
Compressive sensing can overcome the Nyquist criterion and record images with a fraction of the usual number of measurements required. However, conventional measurement bases are susceptible to diffraction and scattering, prevalent in high-resolution microscopy. In this Letter, we explore the random Morlet basis as an optimal set for compressive multiphoton imaging, based on its ability to minimize
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Antiangiogenesis effect of timosaponin AIII on HUVECs in vitro and zebrafish embryos in vivo.Acta Pharmacologica Sinica (IF 7.169) Pub Date : 2019-09-12 ,DOI:10.1038/s41401-019-0291-zZhong-Yan Zhou,Wai-Rong Zhao,Ying Xiao,Xiang-Ming Zhou,Chen Huang,Wen-Ting Shi,Jing Zhang,Qing Ye,Xin-Lin Chen,Jing-Yi Tang
Timosaponin AIII (Timo AIII) is a natural steroidal saponin isolated from the traditional Chinese herb Anemarrhena asphodeloides Bge with proved effectiveness in the treatment of numerous cancers. However, whether Timo AIII suppresses tumor angiogenesis remains unclear. In the present study, we investigated the antiangiogenesis effects of Timo AIII and the underlying mechanisms in human umbilical vein
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Low‐temperature sintering and electrical properties of BBSZ glass‐doped ZnO‐based multilayer varistorsInternational Journal of Applied Ceramic Technology (IF 2.328) Pub Date : 2019-08-30 ,DOI:10.1111/ijac.13367Yongcheng Lu, Yuanxun Li, Rui Peng, Hua Su, Zhihua Tao, Mingzhou Chen, Daming ChenThe effect of Bi2O3‐B2O3‐SiO2‐ZnO glass (denoted as BBSZ) content on the densification, microstructure, and electrical properties of ZnO‐based multilayer varistors (MLVs) has been investigated. In ZnO‐based (MLVs), BBSZ acted as a promoter in ZnO grain growth, which increased the grain size of ZnO, resulting in a decrease in breakdown voltage. Results showed that the adding of BBSZ glass had an improvement ...
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