- 作 者: "wei jia"
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Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer's disease: a meta-analysis and systematic review.Neural Regeneration Research (IF 6.058) Pub Date : 2022-11-01 ,DOI:10.4103/1673-5374.335832Wei-Lin Liu,Hua-Wei Lin,Miao-Ran Lin,Yan Yu,Huan-Huan Liu,Ya-Ling Dai,Le-Wen Chen,Wei-Wei Jia,Xiao-Jun He,Xiao-Ling Li,Jing-Fang Zhu,Xie-Hua Xue,Jing Tao,Li-Dian Chen
Blood exosomes, which are extracellular vesicles secreted by living cells into the circulating blood, are regarded as a relatively noninvasive novel tool for monitoring brain physiology and disease states. An increasing number of blood cargo-loaded exosomes are emerging as potential biomarkers for preclinical and clinical Alzheimer's disease. Therefore, we conducted a meta-analysis and systematic review
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Novel compound heterozygous mutations in the desert hedgehog (DHH) gene in cases of siblings with 46,XY disorders of sexual developmentBMC Medical Genomics (IF 3.622) Pub Date : 2022-08-15 ,DOI:10.1186/s12920-022-01334-5Wei, Jia, Wu, Jiaqi, Ru, Wei, Chen, Guangjie, Gao, Lei, Tang, Daxing
Disorders of sex development (DSD) are congenital disorders in which the development of the chromosomal, gonadal, or anatomical sex is atypical. Mutations in various genes can impede gonadal development, hormone synthesis, or hormone function and cause DSD. Exome sequencing was performed for two siblings with 46,XY DSD. All mutations identified by exome sequencing were confirmed by Sanger sequencing
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Monitoring rock desert formation caused by two different origins (ice-snow melting and drying) in the Qinghai-Tibet Plateau of China by considering topographic and meteorological elementsJournal of Arid Land (IF 2.483) Pub Date : 2022-08-13 ,DOI:10.1007/s40333-022-0100-2Wei Jia, Peijun Shi, Jing’ai Wang, Weidong Ma, Xingsheng Xia, Yuantao ZhouMonitoring rock desert formation caused by two different origins (ice-snow melting and drying) through remote sensing is crucial to our understanding of the interaction between the underlying surface of different rock desert and land-atmosphere types, as well as the relationship between bare land and soil erosion. A number of achievements have been made in remote sensing monitoring of desert areas ...
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Increased NOX1 and DUOX2 expression in the colonic mucosa of patients with chronic functional constipation.Medicine (IF 1.817) Pub Date : 2022-8-13 ,DOI:10.1097/md.0000000000030028Xiuqin Wei, Mei Xue, Chunbo Kang, Lei Gao, Mengqiao Zhang, Chao Ma, Wei Jia, Yufeng Zheng, Lei Cao, Pan Chen, Shujing Jiang, Fong-Fong Chu, Qiang Gao
To determine whether oxidative stress and inflammation are associated with constipation by examining the expression of the main producers of reactive oxygen species, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, and pro-inflammatory cytokines in the colon of patients with chronic functional constipation. The colonic biopsies were collected from 32 patients with chronic functional constipation
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Emodin Suppresses Proliferation, Migration and Invasion in Ovarian Cancer Cells by down Regulating ILK in vitro and in vivo [Retraction]OncoTargets and Therapy (IF 4.345) Pub Date : 2022-08-10 ,DOI:10.2147/ott.s385443Jingjing Lu, Ying Xu, Zhe Zhao, Xiaoning Ke, Xuan Wei, Jia Kang, Xuan Zong, Hongluan Mao, Peishu Liu
Retraction for the article Emodin suppresses proliferation, migration and invasion in ovarian cancer cells by down regulating ILK in vitro and in vivo
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The Smallest 4f-Metalla-Aromatic Molecule of Cyclo-PrB2– with Pr–B Multiple BondsChemical Science (IF 9.969) Pub Date : 2022-08-08 ,DOI:10.1039/d2sc02852bZhen-Ling Wang, Tengteng Chen, Wei-Jia Chen, Wan-Lu Li, Jing Zhao, Xue-Lian Jiang, Jun Li, Lai-Sheng Wang, Han-Shi Hu
The concept of metalla-aromaticity proposed by Thorn-Hoffmann (Nouv. J. Chim. 1979, 3, 39) has been expanded to organometallic molecules of transition metals that have more than one independent electron-delocalized systems. Lanthanides, with highly contracted 4f atomic orbitals, are rarely found in multiply aromatic systems. Here we report the discovery of a doubly aromatic triatomic lanthanide-boron
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The role of matrix stiffness in cancer stromal cell fate and targeting therapeutic strategiesActa Biomaterialia (IF 10.633) Pub Date : 2022-08-07 ,DOI:10.1016/j.actbio.2022.08.005Jiayun Wei, Jia Yao, Mengchao Yan, Ye Xie, Pinyan Liu, Yongcui Mao, Xun LiThe tumor microenvironment (TME) is a complex macromolecular network filled with a series of stromal cells. It plays an important role in tumorigenesis, development, immune escape, drug resistance, and other processes and has received increasing attention in recent years. Currently, tumor cell-centered treatments are insufficient to eradicate malignancies, and researchers are constantly searching for ...
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Dry matter production and panicle characteristics of high yield and good taste indica hybrid rice varietiesJournal of Integrative Agriculture (IF 4.384) Pub Date : 2022-08-06 ,DOI:10.1016/j.jia.2022.08.033Min LI, Da-wei ZHU, Ming-jin JIANG, De-qiang LUO, Xue-hai JIANG, Guang-mei JI, Li-jiang LI, Wei-jia ZHOU
Both high yield and good taste are crucial targets of indica hybrid rice (Oryza sativa) production. Three types of indica hybrid rice were selected according to grain yield and taste value, including high yield and good taste (HYGT), low yield and good taste (LYGT) and high yield and poor taste (HYPT), respectively. Yield components, corresponding growth characteristics and rice taste quality were
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Decreased panicle N application alleviates negative effects of shading on rice grain yield and grain qualityJournal of Integrative Agriculture (IF 4.384) Pub Date : 2022-08-06 ,DOI:10.1016/j.jia.2022.08.045Huan-he WEI, Jia-lin GE, Xu-bin ZHANG, Wang ZHU, Fei DENG, Wan-jun REN, Ying-long CHEN, Tian-yao MENG, Qi-gen DAI
Light deficiency is a growing abiotic stress in rice production, however, few studies focus on shading effects on grain yield and quality of rice in east China. It is also interesting to investigate proper nitrogen (N) application strategy for alleviating grain yield and quality loss of rice exposed to light deficiency stress. A two-year field experiment was conducted to explore the effects of shading
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Genome- and transcriptome-wide identification and analysis of B3 superfamily members and their association with salt stress response in the common bean (Phaseolus vulgaris L)Scientia Horticulturae (IF 4.342) Pub Date : 2022-08-06 ,DOI:10.1016/j.scienta.2022.111408Yan-Li Du, Qi Zhang, Wei-Jia Li, Si-Qi Li, Wen-Jing Zhang, Qi Wang, Zhen-Gong Yin, Wen-Hui Zhang, Ji-Dao Du, Qiang ZhaoThe plant-specific transcription factor B3 superfamily members mediate plant growth, development, and stress response. Although the B3 gene has been studied in various plants, its role in the common bean (Phaseolus vulgaris L) is unknown. In this study, 110 PvB3 genes were identified from the common bean genome and analyzed based on the phylogeny, gene structure, motifs, cis-regulatory elements, collinearity ...
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In vitro magnetosome remineralization for silver-magnetite hybrid magnetosome biosynthesis and used for healing of the infected woundJournal of Nanobiotechnology (IF 9.429) Pub Date : 2022-08-06 ,DOI:10.1186/s12951-022-01532-4Xu, Junjie, Ma, Shijiao, Zhang, Wei, Jia, Lina, Zheng, Haolan, Bo, Pang, Bai, Xue, Sun, Hongyan, Qi, Lei, Zhang, Tongwei, Chen, Chuanfang, Li, Feng, Arai, Fumihito, Tian, Jiesheng, Feng, Lin
Magnetosomes (BMPs) are organelles of magnetotactic bacteria (MTB) that are responsible for mineralizing iron to form magnetite. In addition, BMP is an ideal biomaterial that is widely used in bio- and nano-technological applications, such as drug delivery, tumor detection and therapy, and immunodetection. The use of BMPs to create multifunctional nanocomposites would further expand the range of their
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Deep Learning Promotes the Screening of Natural Products with Potential Microtubule Inhibition ActivityACS Omega (IF 4.132) Pub Date : 2022-08-05 ,DOI:10.1021/acsomega.2c02854Xiao-Nan Jia, Wei-Jia Wang, Bo Yin, Lin-Jing Zhou, Yong-Qi Zhen, Lan Zhang, Xian-Li Zhou, Hai-Ning Song, Yong Tang, Feng Gao
Natural microtubule inhibitors, such as paclitaxel and ixabepilone, are key sources of novel medications, which have a considerable influence on anti-tumor chemotherapy. Natural product chemists have been encouraged to create novel methodologies for screening the new generation of microtubule inhibitors from the enormous natural product library. There have been major advancements in the use of artificial
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A randomized, open-label, multicenter, phase 3 study of high-dose vitamin C plus FOLFOX +/- bevacizumab versus FOLFOX +/- bevacizumab in unresectable untreated metastatic colorectal cancer.Clinical Cancer Research (IF 13.801) Pub Date : 2022-08-05 ,DOI:10.1158/1078-0432.ccr-22-0655Feng Wang,Ming-Ming He,Jian Xiao,Yan-Qiao Zhang,Xiang-Lin Yuan,Wei-Jia Fang,Yan Zhang,Wei Wang,Xiao-Hua Hu,Zhi-Gang Ma,Yi-Chen Yao,Zhi-Xiang Zhuang,Fu-Xiang Zhou,Jie-Er Ying,Ying Yuan,Qing-Feng Zou,Zeng-Qing Guo,Xiang-Yuan Wu,Ying Jin,Zong-Jiong Mai,Zhi-Qiang Wang,Hong Qiu,Ying Guo,Si-Mei Shi,Shuang-Zhen Chen,Hui-Yan Luo,Dong-Sheng Zhang,Feng-Hua Wang,Yu-Hong Li,Rui-Hua Xu
PURPOSE To compare the efficacy and safety of high-dose vitamin C plus FOLFOX +/- bevacizumab versus FOLFOX +/- bevacizumab as first-line treatment in patients with metastatic colorectal cancer (mCRC). PATIENTS AND METHODS Between 2017 and 2019, histologically confirmed mCRC patients (n = 442) with normal glucose-6-phosphate dehydrogenase status and no prior treatment for metastatic disease were randomized
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Clinical application of parathyroid autotransplantation in endoscopic radical resection of thyroid carcinomaFrontiers in Oncology (IF 5.738) Pub Date : 2022-08-04 ,DOI:10.3389/fonc.2022.942488Qi Zhang, Kun-Peng Qu, Ze-Sheng Wang, Jing-Wei Gao, Yu-Peng Zhang, Wei-Jia Cao
Purpose This study aimed to examine the effect of selective inferior parathyroid gland autotransplantation on central lymph node dissection(CLND) and incidence of postoperative hypoparathyroidism in patients undergoing endoscopic radical resection of thyroid carcinoma. Methods The data of 310 patients undergoing endoscopic radical resection of thyroid carcinoma will be retrospectively analyzed. The
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M cells of mouse and human Peyer's patches mediate the lymphatic absorption of an Astragalus hyperbranched heteroglycanCarbohydrate Polymers (IF 10.723) Pub Date : 2022-08-04 ,DOI:10.1016/j.carbpol.2022.119952Quanwei Zhang, Shuang Hao, Lifeng Li, Man Liu, Chuying Huo, Wanrong Bao, Huiyuan Cheng, Hauyee Fung, Tinlong Wong, Wenjie Wu, Pingchung Leung, Shunchun Wang, Ting Li, Ge Zhang, Min Li, Zhongzhen Zhao, Wei Jia, Zhaoxiang Bian, Quanbin HanThe gut cell wall is considered an impenetrable barrier to orally administrated polysaccharides. We recently reported a selective lymphatic route for Radix Astragali polysaccharide RAP to enter Peyer's patches (PPs) to trigger immune responses. However, how RAP enters PPs is unclear. Herein, we screened the intestinal epithelial cells of mice and found that the follicle-associated epithelium cells ...
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Persymmetric subspace GLRT-based detector for range-spread targetsDigital Signal Processing (IF 2.92) Pub Date : 2022-08-03 ,DOI:10.1016/j.dsp.2022.103658Tao Jian, Zikeng Xie, Haipeng Wang, Guangfen Wei, Jia HeIn this paper, adaptive signal detection is addressed for range-spread targets in unknown zero-mean Gaussian clutter with persymmetric covariance matrix. The range-spread target can be expressed as the product of a known subspace and its unknown arbitrary coordinates. Under the above assumptions, a persymmetric subspace detector is devised by utilizing the generalized likelihood ratio test (GLRT). ...
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Microstructure, guiding performance and micro-spectroscopy characterization of Ce:LuAG crystal induced by direct femtosecond laser writingJournal of Luminescence (IF 4.171) Pub Date : 2022-08-03 ,DOI:10.1016/j.jlumin.2022.119162Wei-Jia Tang, Yang Liao, Ke Liu, Liang Qiu, Chuan-Lei JiaDual-line waveguides in Ce:LuAG crystal are fabricated by femtosecond laser using 1030 nm, 450 fs pulses at a 100 kHz repetition rate. The microstructure and composition of femtosecond-laser induced waveguides are studied in detail using SEM, TEM and EDX elemental composition analyses. Efficient single-mode guidance is obtained in the type II waveguide structures with relatively low propagation loss ...
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Effects of Geometry of Plenum Chamber on Losses in the Bleed System of an Axial CompressorInternational Journal of Aerospace Engineering (IF 1.198) Pub Date : 2022-08-02 ,DOI:10.1155/2022/6819836Yuancheng Shi, Qingguo Kong, Wei Jia
To study how the geometry of the plenum chamber in the bleed system of an axial compressor influences the losses therein and to establish a theoretical loss model for this system, a 1.5-stage axial compressor with a bleed system is studied numerically by means of computational fluid dynamics (CFD). The results show that losses in the bleed system occur mainly in the axisymmetric bleed slot and plenum
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Highly sensitive fluorescent detection of EDIL3 overexpressed exosomes for the diagnosis of triple-negative breast cancer.Nanotechnology (IF 3.953) Pub Date : 2022-07-29 ,DOI:10.1088/1361-6528/ac805fYing-Xiang Wei,Jia-Hao Han,Hui-Ming Shen,Ying-Yan Wang,Min Qi,Ling Wang,Jia LiDepartment of Ultrasound, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, People's Republic of China.EDIL3 is a strong and highly accurate diagnostic marker for breast cancer, meanwhile, EDIL3 overexpressed exosomes are novel biomarkers for the early diagnosis of triple-negative breast cancer (TNBC). Here, we proposed a fluorescent detection method for EDIL3 overexpressed exosomes, which is simple and sensitive. Basically, we utilized a magnetic nanospheres (MNS) based liquid sandwich immunoassay ...
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Design and synthesis of biodegradable nonconjugated SSPAMAM dendrimers with unexpected Deep-red/NIR emission and cell membrane targeting ability for biological imagingMaterials & Design (IF 9.417) Pub Date : 2022-07-25 ,DOI:10.1016/j.matdes.2022.110982Xiao-lin Guan, Xue-qin Yang, Shou-jun Lai, Yuan-yuan Ding, Jing-yu Wei, Jia-ming Zhang, Li-yuan Zhang, Cheng-hao Li, Jin-hui Tong, Zi-qiang Lei
Fluorescent non-conjugated polymers without any π-aromatic building blocks are of great significance in biological applications due to low cytotoxicity and good biocompatibility. However, it is still a great challenge to achieve bright and deep-red/near-infrared (NIR) emissions. Herein, we have designed and synthesized a series of deep-red/NIR non-conjugated polymers with aggregation-induced emission
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Effects of Short-Chain Peptides on the Flavor Profile of Baijiu by the Density Functional Theory: Peptidomics, Sensomics, Flavor Reconstitution, and Sensory EvaluationJournal of Agricultural and Food Chemistry (IF 5.895) Pub Date : 2022-07-22 ,DOI:10.1021/acs.jafc.2c02549Wei Jia, An Du, Zibian Fan, Yongbo Wang, Lin ShiThe effect of peptides on the flavor profile of Baijiu is unclear as a result of their trace concentrations in the complex matrix, and therefore, the study involving the interaction mechanism between peptides and flavor compounds is limited. In this study, short-chain peptides (amino acid number between 2 and 4, SCPs) associated with the Feng-flavor Baijiu (FFB) were comprehensively analyzed by a dedicated ...
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Preparation and characterization of porous polyimide fibers with electromagnetic wave absorption propertiesPolymer Engineering and Science (IF 2.573) Pub Date : 2022-07-22 ,DOI:10.1002/pen.26089Ming Jiang, Daolei Lin, Wei Jia, Jiang Du, Hongqing Niu, Xiaodong Wang, Dezhen WuThe porous polyimide (PI) composite fibers, which exhibit high-efficiency electromagnetic wave adsorption (EMWA) performance, were successfully fabricated by controlling temperature of the coagulation bath during the wet spinning process. The mechanical properties of composite fiber decreased and average radius of micropores increased gradually with the rise of coagulation bath temperature. In addition ...
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Multi-wavelength injection locked semiconductor comb laserPhotonics Research (IF 7.254) Pub Date : 2022-07-22 ,DOI:10.1364/prj.455165Jia-Jian Chen, Wen-Qi Wei, Jia-Le Qin, Bo Yang, Jing-Zhi Huang, Zi-Hao Wang, Ting Wang, Chang-Yuan Yu, and Jian-Jun ZhangQuantum dot lasers on silicon have gained significant interest over the past decade due to their great potential as an on-chip silicon photonic light source. Here, we demonstrate multi-wavelength injection locking of InAs/GaAs quantum dot Fabry–Perot (FP) lasers both on GaAs and silicon substrates by optical self-injection via an external cavity. The number of locked laser modes can be adjusted from ...
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Gut Microbiome-Linked Metabolites in the Pathobiology of Major Depression With or Without Anxiety—A Role for Bile AcidsFrontiers in Neuroscience (IF 5.152) Pub Date : 2022-07-20 ,DOI:10.3389/fnins.2022.937906Siamak MahmoudianDehkordi, Sudeepa Bhattacharyya, Christopher R. Brydges, Wei Jia, Oliver Fiehn, A. John Rush, Boadie W. Dunlop, Rima Kaddurah-Daouk
Background The gut microbiome may play a role in the pathogenesis of neuropsychiatric diseases including major depressive disorder (MDD). Bile acids (BAs) are steroid acids that are synthesized in the liver from cholesterol and further processed by gut-bacterial enzymes, thus requiring both human and gut microbiome enzymatic processes in their metabolism. BAs participate in a range of important host
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Preparation and Cr (VI) adsorption of functionalized polyimide fibersJournal of Applied Polymer Science (IF 3.057) Pub Date : 2022-07-19 ,DOI:10.1002/app.52799Wei Jia, Jiang Du, Ming Jiang, Mengying Zhang, Enlin Han, Hongqing Niu, Dezhen WuIn order to overcome the shortcomings of nanofiber membranes such as low mechanical properties and poor acid resistance, amino-rich functionalized polyimide (PI)-polyethyleneimine (PEI) fibers were successfully prepared in the study. The structure and morphology in each functionalization step were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), static contact angle ...
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Sustainable removal of soil arsenic by naturally-formed iron oxides on plastic tubesJournal of Hazardous Materials (IF 14.224) Pub Date : 2022-07-16 ,DOI:10.1016/j.jhazmat.2022.129626Zhao-Feng Yuan, Tong-Yao Pu, Chen-Yu Jin, Wei-Jia Feng, Jia-Yue Wang, Williamson Gustave, Jonathan Bridge, Yi-Li Cheng, Xian-Jin Tang, Yong-Guan Zhu, Zheng Chen
Arsenic (As) pollution in paddy fields is a major threat to rice safety. Existing As remediation techniques are costly, require external chemical addition and degrade soil properties. Here, we report the use of plastic tubes as a recyclable tool to precisely extract As from contaminated soils. Following insertion into flooded paddy soils, polyethylene tube walls were covered by thin but massive Fe
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Hydrogen bonds and hydrophobicity with mucin and α-amylase induced honey aroma in Feng-flavor Baijiu during 16 years agingFood Chemistry (IF 9.231) Pub Date : 2022-07-15 ,DOI:10.1016/j.foodchem.2022.133679Wei Jia, Chenna Di, Rong Zhang, Lin ShiHoney aroma is one of the most significant factors of Feng-flavor Baijiu, which is also an essential element to attract consumers. However, the evaluation and chemical basis of honey aroma is unclear. Palmitoleic acid, lagochilin, phomotenone and ethyl behenate were confirmed to be the strongest contributors to honey aroma by time-intensity analysis and UHPLC-Q-Orbitrap-MS. Predictive modeling was ...
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The role of leptin in indirectly mediating “somatic anxiety” symptoms in major depressive disorderFrontiers in Psychiatry (IF 5.435) Pub Date : 2022-07-15 ,DOI:10.3389/fpsyt.2022.757958Yue Zhu, Yange Wei, Jia Duan, Jianing Li, Ran Zhang, Jiaze Sun, Pengshuo Wang, Zhuang Liu, Jing Lv, Shengnan Wei, Xiaowei Jiang, Fei Wang, Yanqing Tang
Background Leptin is a multifunctional hormone secreted from adipose tissue, which plays a core role in regulating energy intake and expenditure. Evidence has demonstrated that leptin receptors are located in brain areas involved in emotional processing, and major depressive disorder (MDD) is characterized by dysfunction of emotional processing. Taken together, these features suggest that leptin may
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MiR-197-3p affects angiogenesis and inflammation of endothelial cells by targeting CXCR2/COX2 axis.American journal of translational research Pub Date : 2022-07-15 ,DOI:Xuan Tian,Jianlong Liu,Wei Jia,Peng Jiang,Zhiyuan Cheng,Yunxin Zhang,Jinyong Li,Xiao Liu,Chenyang TianDepartment of Vascular Surgery, Beijing Jishuitan Hospital Beijing 100035, China.BACKGROUND Decreased circulating miR-197-3p was found in patients with recurrent deep vein thrombosis (DVT), but the specific role of miR-197-3p needs further exploration. MATERIALS AND METHODS Venous blood samples were collected from DVT patients and healthy controls, and peripheral blood mononuclear cells (PBMCs) were isolated to examine the expression patterns of miR-197-3p, CXCR2 and COX2 by qRT-PCR ...
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Pseudo-targeted metabolomics analysis of the therapeutic effect of phenolics-rich extract from Se-enriched green tea (Camellia sinensis) on LPS-stimulated murine macrophage (RAW264.7)Food Research International (IF 7.425) Pub Date : 2022-07-11 ,DOI:10.1016/j.foodres.2022.111666Zibian Fan, Wei Jia, An Du, Lin ShiSelenium (Se)-enriched green tea (Se-Te) has been recognized as a possible source of Se supplements, while the effect of Se enrichment on function of polyphenols in green tea is still unclear. In this study, a pseudo-targeted metabolomics strategy was carried out to reveal the regulatory mechanism of polyphenols extracted from Se-Te and regular green tea (Re-Te) on inflammatory response at cellular ...
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