- 作 者: "lei wei"
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LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3pMolecular Biotechnology (IF 2.86) Pub Date : 2023-03-21 ,DOI:10.1007/s12033-023-00706-1Jingjing Xu, Meishun Hu, Yang Gao, Yishu Wang, Xiaoning Yuan, Yan Yang, Wenjing Song, Weinan Yin, Pengju Gong, Lei Wei, Jingwei ZhangBreast cancer is one of the most common malignant tumors in women, and causes a large number of cancer-related deaths. The main cause of death of breast cancer patients is tumor recurrence and metastasis. Recent studies show that lncRNA (Long non-coding RNA) plays an important role in breast cancer. However, the overall biological activity and clinical consequences of the lncRNA MIR17HG in breast cancer ...
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Layer-dependent electronic structure and optical properties of two-dimensional PdSSePhysical Chemistry Chemical Physics (IF 3.945) Pub Date : 2023-03-20 ,DOI:10.1039/d3cp00022bFeng Xiao, Wen Lei, Wei Wang, Yiping Ma, Xujia Gong, Xing MingTwo-dimensional (2D) layered palladium dichalcogenides PdX2 (X = S and Se) have attracted emerging interests due to their tunable electronic structure and abundant physicochemical properties. Recently, as the sister material of PdX2, PdSSe have received increasing attention and shows great promise for technological applications and fundamental researches. In the present study, we focus on the layer-dependent ...
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Hybridization Engineering of Oxyfluoride Aluminosilicate Glass for Construction of Dual-Phase Optical Ceramics (Adv. Mater. 11/2023)Advanced Materials (IF 32.086) Pub Date : 2023-03-16 ,DOI:10.1002/adma.202370080Guanxin Du, Shaofei Wen, Junjie Zhao, Peng Ran, Dazhao Wang, Lei Wei, Xvsheng Qiao, Yang Yang, Jianrong Qiu, Shifeng ZhouOptical Ceramics ...
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Study on the Magnetization Force Distribution on the CFETR Blanket System Considering the Diagnostic Shielding ModulesJournal of Fusion Energy (IF 1.793) Pub Date : 2023-03-14 ,DOI:10.1007/s10894-023-00347-xZhao Liu, Ming Wang, Mingzhun Lei, Wei Dai, Yi GuAs a typical electromagnetic (EM) load during the operation of the China Fusion Engineering Test Reactor (CFETR) device, the magnetization force distribution on the blanket system is affected by the ferromagnetic material filling ratios (FMFRs) in the blankets and their locations. In phase II of the CFETR, the preliminary design of the diagnostic system was completed. The introduction of the diagnostic ...
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Laser-Cutted Epidermal Microfluidic Patch with Capillary Bursting Valves for Chronological Capture, Storage, and Colorimetric Sensing of SweatBiosensors (IF 3.24) Pub Date : 2023-03-12 ,DOI:10.3390/bios13030372Yuxin He, Lei Wei, Wenjie Xu, Huaping Wu, Aiping Liu
Flexible wearable microfluidic devices show great feasibility and potential development in the collection and analysis of sweat due to their convenience and non-invasive characteristics in health-level feedback and disease prediction. However, the traditional production process of microfluidic patches relies on resource-intensive laboratory and high-cost facilities. In this paper, a low-cost laser-cutting
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A Digital Twin system of reconfigurable tooling for monitoring and evaluating in aerospace assemblyJournal of Manufacturing Systems (IF 9.498) Pub Date : 2023-03-11 ,DOI:10.1016/j.jmsy.2023.03.004Jie Jin, Junshan Hu, Chengyu Li, Zhanghu Shi, Pei Lei, Wei TianAssembly tooling is essential equipment in aircraft production. Reconfigurable tooling can adapt to multiple aircraft products by reorganizing modular components. Its service state directly determines the final quality, production cycle, and economic cost of the aircraft assembly. This research developed a reusable Digital Twin (DT) system for reconfigurable tooling to monitor and evaluate its service ...
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Photonic Bandgap Fiber Microlaser with Dual-Band Emission for Integrated Optical Tagging and SensingLaser & Photonics Reviews (IF 10.947) Pub Date : 2023-03-10 ,DOI:10.1002/lpor.202200834Yanqiong Wang, Chaoyang Gong, Xi Yang, Tao Zhu, Ke Zhang, Yun-Jiang Rao, Lei Wei, Yuan GongLasers are emerging as novel photonic tags for single-cell labeling, anticounterfeiting, and encryption technology due to their narrow linewidth, high spectral multiplexing capacity, and superior stimuli-responsiveness. These laser-encoded photonic tags mostly distinguish the heterogeneity but do not yet provide both tagging and sensing of biosamples, which is highly desirable for disease screening ...
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General toxicity and genotoxicity studies of a new scale inhibitor for seawater desalinationEnvironmental Sciences Europe (IF 5.481) Pub Date : 2023-03-09 ,DOI:10.1186/s12302-023-00722-7Lian Duan, Yimin Li, Wen Gu, Chao Wang, Ying Shi, Hongbin Yang, Mengmeng Wang, Yuehan Long, Song Tang, Jian Kong, Shaoping Zhang, Lixia Zhang, Lei Wei, Chong Wang, Kai LuMaleic acid polymer scale inhibitor is a new domestic seawater desalination scale inhibitor. This study tested the acute oral toxicity, sub-chronic toxicity and genotoxicity of this new inhibitor. The LD50 obtained from the acute oral toxicity test was 6810 and 9260 mg/kg·BW for male and female rats, as well as 1/5, 1/10 and 1/20 LD50 were as the dose for sub-chronic toxicity test. It showed the weight ...
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Waste-biomass-derived activated carbon supported Co-Cu-P nanocatalysts for hydrolytic dehydrogenation of ammonia borane.RSC Advances (IF 4.036) Pub Date : 2023-03-08 ,DOI:10.1039/d3ra00247kLei Wei,Yanhong Lu,Ruixuan Lu,Yuxin Cui
Hydrolytic dehydrogenation of ammonia borane is a significant and promising approach for on-site hydrogen production at ambient conditions, and developing highly efficient and low-cost catalysts has attracted considerable attention. Herein, waste-biomass-derived activated carbon (AC) was prepared by hydrothermal carbonization and alkali-assisted activation, and non-precious bimetal phosphides (Co-Cu-P)
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Multifunctional Electronic Textiles by Direct 3D Printing of Stretchable Conductive FibersAdvanced Electronic Materials (IF 7.633) Pub Date : 2023-03-08 ,DOI:10.1002/aelm.202201194Yuntian Wang, Zhixun Wang, Zhe Wang, Ting Xiong, Perry Ping Shum, Lei Wei
The integration of functional fibers into wearable devices by traditional methods is commonly completed in weaving. A new post-weaving method of integrating fiber devices into textiles is needed to address the challenge of incorporating functional fiber into ready-made garments without tearing down the clothing and re-weaving. A 3D printing method to simultaneously fabricate and integrate highly stretchable
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Background subtraction via regional multi-feature-frequency model in complex scenesSoft Computing (IF 3.732) Pub Date : 2023-03-08 ,DOI:10.1007/s00500-023-07955-xQi Qi, Xin Yu, Ping Lei, Wei He, Guoyun Zhang, Jianhui Wu, Bing Tu
Although a wide variety of background subtraction methods has been proposed in recent years, none has been able to fully address multi-scale moving objects and dynamic background in real surveillance tasks. In this paper, a novel and effective background subtraction method, named regional multi-feature-frequency (RMFF), is proposed to detect multi-scale moving objects under dynamic background. Unlike
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HotSPOT: A Computational Tool to Design Targeted Sequencing Panels to Assess Early Photocarcinogenesis.Cancers (IF 6.575) Pub Date : 2023-03-05 ,DOI:10.3390/cancers15051612Sydney R Grant,Spencer R Rosario,Andrew D Patentreger,Nico Shary,Megan E Fitzgerald,Prashant K Singh,Barbara A Foster,Wendy J Huss,Lei Wei,Gyorgy Paragh
Mutations found in skin are acquired in specific patterns, clustering around mutation-prone genomic locations. The most mutation-prone genomic areas, mutation hotspots, first induce the growth of small cell clones in healthy skin. Mutations accumulate over time, and clones with driver mutations may give rise to skin cancer. Early mutation accumulation is a crucial first step in photocarcinogenesis
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Long Term Characteristics of Clinical Distribution and Resistance Trends of Carbapenem-Resistant and Extended-Spectrum β-Lactamase Klebsiella pneumoniae Infections: 2014–2022Infection and Drug Resistance (IF 4.177) Pub Date : 2023-03-04 ,DOI:10.2147/idr.s401807Na Wang, Minghua Zhan, Teng Wang, Jinlu Liu, Caiqing Li, Baoliang Li, Xuying Han, Huiying Li, Shuting Liu, Jing Cao, Xinran Zhong, Chunmei Lei, Wei Zhang, Zhihua Zhang
Purpose: Through long-term and large sample size statistical analysis, we revealed the pattern of Klebsiella pneumoniae (KP) infection and drug resistance and provided epidemiological data for the treatment and prevention and control of multidrug-resistant bacterial infection in our hospital. Patients and Methods: Strains were identified using the BD PhoenixTM 100 system, minimal inhibitory concentration
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SPRI: Structure-Based Pathogenicity Relationship Identifier for Predicting Effects of Single Missense Variants and Discovery of Higher-Order Cancer Susceptibility Clusters of MutationsbioRxiv - Bioinformatics Pub Date : 2023-02-28 ,DOI:10.1101/2022.09.27.508720Boshen Wang, Xue Lei, Wei Tian, Alan Perez-Rathke, Yan-Yuan Tseng, Jie Liang
We report the Structure-based Pathogenicity Relationship Identifier (SPRI), a novel computational tool for accurate evaluation of pathological effects of missense single mutations and prediction of higher-order spatially organized units of mutation clusters. SPRI can effectively extract properties determining pathogenicity encoded in protein structures, and can identify deleterious missense mutations
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Decoding functional cell-cell communication events by multi-view graph learning on spatial transcriptomicsbioRxiv - Bioinformatics Pub Date : 2023-02-23 ,DOI:10.1101/2022.06.22.496105Haochen Li, Tianxing Ma, Minsheng Hao, Wenbo Guo, Jin Gu, Lei Wei, Xuegong Zhang
Cell-cell communication events (CEs) are mediated by multiple ligand-receptor pairs. Usually only a particular subset of CEs directly works for a specific downstream response in a particular microenvironment. We name them as functional communication events (FCEs) of the target responses. Decoding the FCE-target gene relations is important for understanding the machanisms of many biological processes
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Oligosaccharides isolated from Rehmannia glutinosa protect LPS-induced intestinal inflammation and barrier injury in miceFrontiers in Nutrition (IF 6.59) Pub Date : 2023-02-23 ,DOI:10.3389/fnut.2023.1139006Xiao Li, Rong Gui, Xuefang Wang, Erjuan Ning, Lixian Zhang, Yi Fan, Ling Chen, Liqin Yu, Jie Zhu, Zhining Li, Lei Wei, Wei Wang, Zihong Li, Yue Wei, Xuebing Wang
ObjectivesWe investigated the protective effect of Rehmannia glutinosa oligosaccharides (RGO) on lipopolysaccharide (LPS)-induced intestinal inflammation and barrier injury among mice.MethodsRGO is prepared from fresh rehmannia glutinosa by water extraction, active carbon decolorization, ion exchange resin impurity removal, macroporous adsorption resin purification, and decompression drying. LPS could
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Nano polystyrene microplastics could accumulate in Nile tilapia (Oreochromis niloticus): Negatively impacts on the liver and intestinal health through water exposureJournal of Environmental Sciences Pub Date : 2023-02-21 ,DOI:10.1016/j.jes.2023.02.018Di Wu, Xing Lu, Li-Xue Dong, Juan Tian, Jin Deng, Lei Wei, Hua Wen, Shan Zhong, Ming JiangMicroplastics (MPs) have become a significant concern for their potential toxicity. However, the correlation between the size of plastic particles and their toxicity remains inconclusive. Here, we investigate the toxic effects of different sizes (80 nm, 800 nm, 8 µm and 80 µm) polystyrene MPs (PS-MPs) on the model organism Nile tilapia (Oreochromis niloticus). The results of bioluminescent imaging ...
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A General Framework for Representing and Annotating Multifaceted Cell Heterogeneity in Human Cell AtlasbioRxiv - Bioinformatics Pub Date : 2023-02-20 ,DOI:10.1101/2021.09.09.459281Haoxiang Gao, Kui Hua, Lei Wei, Sijie Chen, Qijin Yin, Rui Jiang, Xuegong Zhang
To create large-scale cell atlases for future molecular and cellular studies, a universal coordinate system is required to index the vast number of cells and capture their heterogeneities. However, this is challenging due to variations in anatomical structures and cellular conformation, and the fact that cells in complex organs show multifaceted heterogeneities. A learnable universal coordinate system
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Machine Learning in Lung Cancer RadiomicsInternational Journal of Automation and Computing Pub Date : 2023-02-18 ,DOI:10.1007/s11633-022-1364-xJiaqi Li, Zhuofeng Li, Lei Wei, Xuegong ZhangLung cancer is the leading cause of cancer-related deaths worldwide. Medical imaging technologies such as computed tomography (CT) and positron emission tomography (PET) are routinely used for non-invasive lung cancer diagnosis. In clinical practice, physicians investigate the characteristics of tumors such as the size, shape and location from CT and PET images to make decisions. Recently, scientists ...
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Cortical and subcortical morphological alteration in Angelman syndromeJournal of Neurodevelopmental Disorders (IF 4.074) Pub Date : 2023-02-14 ,DOI:10.1186/s11689-022-09469-3Xiaonan Du, Lei Wei, Baofeng Yang, Shasha Long, Ji Wang, Aiqi Sun, Yonghui Jiang, Zhongwei Qiao, He Wang, Yi Wang
Angelman syndrome (AS) is a neurodevelopmental disorder with serious seizures. We aim to explore the brain morphometry of patients with AS and figure out whether the seizure is associated with brain development. Seventy-three patients and 26 healthy controls (HC) underwent high-resolution structural brain MRI. Group differences between the HC group and the AS group and also between AS patients with
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Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and functionScience Translational Medicine (IF 19.319) Pub Date : 2023-02-08 ,DOI:10.1126/scitranslmed.ade3782Ienglam Lei, Wei Huang, Pierre Emmanuel Noly, Suyash Naik, Miriyam Ghali, Liu Liu, Francis D. Pagani, Ashraf Abou El Ela, Jordan S. Pober, Bertram Pitt, Jeffrey L. Platt, Marilia Cascalho, Zhong Wang, Y. Eugene Chen, Richard M. Mortensen, Paul C. TangPreservation quality of donor hearts is a key determinant of transplant success. Preservation duration beyond 4 hours is associated with primary graft dysfunction (PGD). Given transport time constraints, geographical limitations exist for donor-recipient matching, leading to donor heart underutilization. Here, we showed that metabolic reprogramming through up-regulation of the enzyme immune response ...
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Secrecy rate maximization for 6G cognitive satellite-UAV networksChina Communications Pub Date : 2023-02-07 ,DOI:10.23919/jcc.2023.01.020Chengleyang Lei, Wei Feng, Yunfei Chen, Ning GeTo cover remote areas where terrestrial cellular networks may not be available, non-terrestrial infrastructures such as satellites and unmanned aerial vehicles (UAVs) can be utilized in the upcoming sixth-generation (6G) era. Considering the spectrum scarcity problem, satellites and UAVs need to share the spectrum to save costs, leading to a cognitive satellite-UAV network. Due to the openness of both ...
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Bioinspired Self-healing Soft ElectronicsAdvanced Functional Materials (IF 19.924) Pub Date : 2023-02-07 ,DOI:10.1002/adfm.202214479Miao Qi, Ruiqi Yang, Zhe Wang, Yanting Liu, Qichong Zhang, Bing He, Kaiwei Li, Qing Yang, Lei Wei, Caofeng Pan, Mengxiao ChenInspired by nature, various self-healing materials that can recover their physical properties after external damage have been developed. Recently, self-healing materials have been widely used in electronic devices for improving durability and protecting the devices from failure during operation. Moreover, self-healing materials can integrate many other intriguing properties of biological systems, such ...
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FFHR: Fully and Flexible Hyperbolic Representation for Knowledge Graph CompletionarXiv - CS - Machine Learning Pub Date : 2023-02-07 ,DOI:arxiv-2302.04088Wentao Shi, Junkang Wu, Xuezhi Cao, Jiawei Chen, Wenqiang Lei, Wei Wu, Xiangnan HeLearning hyperbolic embeddings for knowledge graph (KG) has gained increasing attention due to its superiority in capturing hierarchies. However, some important operations in hyperbolic space still lack good definitions, making existing methods unable to fully leverage the merits of hyperbolic space. Specifically, they suffer from two main limitations: 1) existing Graph Convolutional Network (GCN) ...
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FFHR: Fully and Flexible Hyperbolic Representation for Knowledge Graph CompletionarXiv - CS - Information Retrieval Pub Date : 2023-02-07 ,DOI:arxiv-2302.04088Wentao Shi, Junkang Wu, Xuezhi Cao, Jiawei Chen, Wenqiang Lei, Wei Wu, Xiangnan HeLearning hyperbolic embeddings for knowledge graph (KG) has gained increasing attention due to its superiority in capturing hierarchies. However, some important operations in hyperbolic space still lack good definitions, making existing methods unable to fully leverage the merits of hyperbolic space. Specifically, they suffer from two main limitations: 1) existing Graph Convolutional Network (GCN) ...
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Cardiac-Specific Expression of Cre Recombinase Leads to Age-Related Cardiac Dysfunction Associated with Tumor-like Growth of Atrial Cardiomyocyte and Ventricular Fibrosis and Ferroptosis.International Journal of Molecular Sciences (IF 6.208) Pub Date : 2023-02-04 ,DOI:10.3390/ijms24043094Zhongguang Li,Qinchun Duan,Ying Cui,Odell D Jones,Danyang Shao,Jianfei Zhang,Yuru Gao,Xixi Cao,Shulin Wang,Jiali Li,Xinjuan Lei,Wei Zhang,Liyang Wang,Xin Zhou,Mengmeng Xu,Yingli Liu,Jianjie Ma,Xuehong Xu
Transgenic expression of Cre recombinase driven by a specific promoter is normally used to conditionally knockout a gene in a tissue- or cell-type-specific manner. In αMHC-Cre transgenic mouse model, expression of Cre recombinase is controlled by the myocardial-specific α-myosin heavy chain (αMHC) promoter, which is commonly used to edit myocardial-specific genes. Toxic effects of Cre expression have
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scDecouple: Decoupling cellular response and infection bias in scCRISPR-seqbioRxiv - Bioinformatics Pub Date : 2023-02-03 ,DOI:10.1101/2023.01.31.526445Qiuchen Meng, Ming Shi, Lei Wei, Yinqing Li, Xuegong Zhang
scCRISPR-seq is an emerging high-throughput CRISPR screening technology that combines CIRPSR screening with single-cell sequencing technologies. It provides rich information on gene regulation. When performing scCRISPR-seq in a population of heterogeneous cells, the observed cellular response in perturbed cells may be caused not only by the perturbation, but also by the infection bias of guide RNAs
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Strengthening the non-pre-irradiated near-infrared mechanoluminescence of CaZnOS:Nd3+ by Mn2+ coactivation for biomechanical imagingJournal of Materials Chemistry C (IF 8.067) Pub Date : 2023-02-02 ,DOI:10.1039/d3tc00152kJianxiong Lei, Wei Li, Yiqian Tang, Yiyu Cai, Shanshan Wang, Kunpeng Dou, Jun-Cheng ZhangThe development of lanthanide-activated CaZnOS mechanoluminescent (ML) phosphors that can produce non-pre-irradiated mechanoluminescence (ML) in the near-infrared (NIR) region opens a new avenue for in vivo and in situ biomechanical imaging. However, the progress in obtaining NIR ML images with a high signal-to-background ratio (SBR) has been constrained by the difficulties in achieving intense NIR ...
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Robust salt-shelled metal halide for highly efficient photoluminescence and wearable real-time human motion perceptionNano Energy (IF 19.069) Pub Date : 2023-02-02 ,DOI:10.1016/j.nanoen.2023.108235Long Chen, Meng He, Wenbin Gong, Peiying Hu, Shuanglong Yuan, Aiping Chen, Lei Wei, Qichong Zhang, Qingwen LiAll-inorganic metal halide perovskites (MHPs) with the formula CsPbX3 (X = Cl-, Br-, I-) have excellent photophysical properties and low-cost fabrication, offering exciting opportunities for flexible electronics. However, the suboptimal quantum yield and inferior stability of solid-state MHPs impede their diverse wearable applications. Here, a straightforward water evaporation crystallization strategy ...
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Phosphorus Overload Promotes Hepatic Lipolysis by Suppressing GSK3β-Dependent Phosphorylation of PPARα at Ser84 and Thr265 in a Freshwater TeleostEnvironmental Science & Technology (IF 11.357) Pub Date : 2023-02-02 ,DOI:10.1021/acs.est.2c06330Yi-Chuang Xu, Kostas Pantopoulos, Hua Zheng, Ester Zito, Tao Zhao, Xiao-Ying Tan, Xiao-Lei Wei, Yu-Feng Song, Zhi LuoExcessive phosphorus (Pi) contributes to eutrophication in an aquatic environment, which threatens human and fish health. However, the mechanisms by which Pi overload influences aquatic animals remain largely unexplored. In the present study, Pi supplementation increased the Pi content, inhibited lipid accumulation and lipogenesis, and stimulated lipolysis in the liver. Pi supplementation increased ...
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