- 作 者: ( "aiguo shen" OR "ai-guo shen" )
-
Engineering a SERS Sensing Nanoplatform with Self-Sterilization for Undifferentiated and Rapid Detection of Bacteria.Biosensors Pub Date : 2023-01-01 ,DOI:10.3390/bios13010075Jun Cao,Wei Zhu,Ji Zhou,Bai-Chuan Zhao,Yao-Yu Pan,Yong Ye,Ai-Guo Shen
The development of a convenient, sensitive, rapid and self-sterilizing biosensor for microbial detection is important for the prevention and control of foodborne diseases. Herein, we designed a surface-enhanced Raman scattering (SERS) sensing nanoplatform based on a capture-enrichment-enhancement strategy to detect bacteria. The gold-Azo@silver-cetyltrimethylammonium bromide (Au-Azo@Ag-CTAB) SERS nanotags
...
-
Silent Raman imaging of highly effective anti-bacterial activity synchronous with biofilm breakage using poly(4-cyanostyrene)@silver@polylysine nanocompositesAnalyst (IF 5.227) Pub Date : 2022-12-22 ,DOI:10.1039/d2an01831dWei Zhu, Jing-Yi Tang, Dong Yu, Ai-Guo ShenBiofilms are known to be a great challenge for their anti-bacterial activity as they obstruct drug action for deeper and more thorough bacteria-killing effects. Therefore, developing highly effective antibacterial agents to destroy biofilms and eradicate bacteria is of great significance. Herein, a new type of nanocomposites (denoted as poly(4-cyanostyrene)@silver@polylysine) is proposed, in which ...
-
Role of cuproptosis-related gene in lung adenocarcinomaFrontiers in Oncology (IF 5.738) Pub Date : 2022-12-21 ,DOI:10.3389/fonc.2022.1080985Yuan Liu, Wei Lin, Ying Yang, JingJing Shao, Hongyu Zhao, Gaoren Wang, Aiguo Shen
BackgroundsLung adenocarcinoma (LUAD) is the most common subtype of lung cancer, which is the leading cause of cancer death. Dysregulation of cell proliferation and death plays a crucial role in the development of LUAD. As of recently, the role of a new form of cell death, cuproptosis, and it has attracted more and more attention. As of yet, it is not clear whether cuproptosis is involved in the progression
...
-
Design of branch line directional coupler for 5G millimeter wave communicationJournal of Physics: Conference Series Pub Date : 2022-12-01 ,DOI:10.1088/1742-6596/2384/1/012019Aiguo Shen, Yukai Lin, Chendong Yang, Guangsong Yang, Gaiyan Hong, Dezhi Wei
A directional coupler based on a microstrip branch line for 5G millimeter wave communication is designed. The branch line structure is simple and easy to implement. The comprehensive decomposition design method of the microwave system is proposed to improve the design efficiency. Based on the theoretical analysis of microwaves, the design method of combining automatic tuning and manual tuning optimization
...
-
Significance of Spliceosome-Related Genes in the Prediction of Prognosis and Treatment Strategies for Lung AdenocarcinomaBioMed Research International (IF 3.246) Pub Date : 2022-11-4 ,DOI:10.1155/2022/1753563Ying Yang, Tianyi Huang, Yihui Fan, Haimin Lu, Jingjing Shao, Yilang Wang, Aiguo Shen
Background. The leading cause of cancer-related fatalities globally is lung cancer; lung adenocarcinoma (LUAD) is the most common histological type in it. The spliceosome plays an important role in a majority of malignancies. However, it is yet unclear how spliceosome-related genes affect patients with LUAD in terms of treatment course and prognosis. Methods. Spliceosome-related genes were assessed
...
-
Serum alanine aminotransferase to hemoglobin ratio and radiological features predict the prognosis of postoperative adjuvant TACE in patients with hepatocellular carcinoma.Frontiers in Oncology (IF 5.738) Pub Date : 2022-09-16 ,DOI:10.3389/fonc.2022.989316Zicong Xia,Yulou Zhao,Hui Zhao,Jing Zhang,Cheng Liu,Wenwu Lu,Lele Wang,Kang Chen,Junkai Yang,Jiahong Zhu,Wenjing Zhao,Aiguo Shen
Objective To explore the prognostic value of radiological features and serum indicators in patients treated with postoperative adjuvant transarterial chemoembolization (PA-TACE) and develop a prognostic model to predict the overall survival (OS) of patients with hepatocellular carcinoma (HCC) treated with PA-TACE. Method We enrolled 112 patients (75 in the training cohort and 37 in the validation cohort)
...
-
Development and Validation of a Novel Circadian Rhythm-Related Signature to Predict the Prognosis of the Patients with Hepatocellular CarcinomaBioMed Research International (IF 3.246) Pub Date : 2022-08-12 ,DOI:10.1155/2022/4263261Yumeng Wu, Cheng Shen, Xinghui Wang, Wenjing Zhao, Yuanyuan Li, Xiao He, Yuanbin Chen, Jibin Liu, Xuming Wu, Aiguo Shen
Hepatocellular carcinoma (HCC) is one of the most important causes of cancer-related deaths and remains a major public health challenge worldwide. Considering the extensive heterogeneity of HCC, more accurate prognostic models are imperative. The circadian genes regulate the daily oscillations of key biological processes, such as nutrient metabolism in the liver. Circadian rhythm disruption has recently
...
-
Based on the Development and Verification of a Risk Stratification Nomogram: Predicting the Risk of Lung Cancer-Specific Mortality in Stage IIIA-N2 Unresectable Large Cell Lung Neuroendocrine Cancer Compared With Lung Squamous Cell Cancer and Lung Adenocarcinoma.Frontiers in Oncology (IF 5.738) Pub Date : 2022-06-30 ,DOI:10.3389/fonc.2022.825598Ying Yang,Cheng Shen,Jingjing Shao,Yilang Wang,Gaoren Wang,Aiguo Shen
Background The purpose of this study is to predict overall survival (OS) and lung cancer-specific survival (LCSS) in patients with stage IIIA-N2 unresectable lung squamous cell cancer (LUSC), lung adenocarcinoma (LUAD), and large cell neuroendocrine cancer (LCNEC) by constructing nomograms and to compare risk and prognostic factors affecting survival outcomes in different histological subtypes. Methods
...
-
Pan-Cancer Analysis Predicts the Immunological and Prognostic Role of ZC3H12C in KIRCBioMed Research International (IF 3.246) Pub Date : 2022-06-26 ,DOI:10.1155/2022/4541571Yanping Yue, Yumeng Wu, Dakun Zhao, Biao Wu, Xuming Wu, Jibin Liu, Lei Yang, Aiguo Shen
ZC3H12C is an important member of the CCCH-zinc finger protein family and is mainly involved in host immune and inflammatory diseases. However, its abnormal expression and prognostic value in cancer have not yet been established. Through comparative analysis of the Cancer Genome Atlas (TCGA) database, we found that ZC3H12C is the most relevant to the prognosis, grade, and stage of renal clear cell
...
-
Laser tweezers Raman spectroscopy combined with machine learning for diagnosis of Alzheimer’s diseaseSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (IF 4.831) Pub Date : 2022-06-22 ,DOI:10.1016/j.saa.2022.121542Manman Lin, Haisheng Ou, Peng Zhang, Yanhong Meng, Shenghao Wang, Jing Chang, Aiguo Shen, Jiming HuAlzheimer’s disease (AD) is a common nervous system disease to affect mostly elderly people over the age of 65 years. However, the diagnosis of AD is mainly depend on the imaging examination, clinical assessments and neuropsychological tests, which may get error diagnosis results and are not able to detect early AD. Here, a rapid, non-invasive, and high accuracy diagnostic method for AD especially ...
-
Prognostic Significance of Preoperative Integrated Liver Inflammatory Score in Patients with Hepatocellular Carcinoma.Medical Science Monitor Pub Date : 2022-06-21 ,DOI:10.12659/msm.937005Biao Wu,Yumeng Wu,Xianlin Guo,Yifei Liu,Yanping Yue,Wenjing Zhao,Jibin Liu,Xuming Wu,Aiguo Shen,Suqing ZhangBACKGROUND The Integrated Liver Inflammatory Score (ILIS), which includes 5 serum indicators (albumin, bilirubin, neutrophil count, alpha-fetoprotein [AFP], and alkaline phosphatase [ALP]), is a novel inflammation-based predictive model associated with poor survival in hepatocellular carcinoma (HCC) patients. Our study aimed to assess the prognostic value of ILIS in HCC patients undergoing radical ...
-
Identification and Validation of Necroptosis-Related LncRNA Signature in Hepatocellular Carcinoma for Prognosis Estimation and Microenvironment Status.Frontiers in Genetics (IF 4.772) Pub Date : 2022-06-08 ,DOI:10.3389/fgene.2022.898507Cong Chen,Yumeng Wu,Kang Chen,Zicong Xia,Xiaokan Liu,Chaojie Zhang,Hui Zhao,Aiguo Shen
Background: Hepatocellular carcinoma (HCC) is among malignancies with the highest fatality toll globally and minimal therapeutic options. Necroptosis is a programmed form of necrosis or inflammatory cell death, which can affect prognosis and microenvironmental status of HCC. Therefore, we aimed to explore the prognostic value of necroptosis-related lncRNAs (NRLs) in HCC and the role of the tumor microenvironment
...
-
Raman inks based on triple-bond-containing polymeric nanoparticles for securityNanoscale (IF 8.307) Pub Date : 2022-05-06 ,DOI:10.1039/d2nr00788fDong Yu, Yao Shen, Wei Zhu, Ji-Ming Hu, Ai-Guo ShenDeveloping security inks with spectral outputs/multiple colors, which have unique identification characteristics, is of great importance in enhancing the anti-counterfeiting strength of ink anti-counterfeiting technology. Herein, a print-driven triple-bond coding mode is proposed for the first time. Two kinds of triple-bond-containing polymeric nanoparticles (NPs) with Raman shifts at 2227 and 2241 ...
-
Predictive value of indicator of CA125 combined with D-dimer (ICD) for lymph node metastasis in patients with ovarian cancer: A two center cohort studyJournal of Cancer (IF 4.478) Pub Date : 2022-5-1 ,DOI:10.7150/jca.70737Li Zhang, Zongyu Guan, Yi Yin, Chaoyang Ou, Hongyan Qian, Min Tang, Aiguo Shen
Background: The clinical serum markers CA125 and D-dimer have been reported to predict lymph node metastasis(LNM) in several malignant tumors, but the reports in ovarian cancer(OC) are still absent. The purpose of this study was to explore the value of indicator CA125 combined with D-dimer (ICD) in predicting LNM in patients with OC./nMethods: A total of 447 patients diagnosed with OC from January
...
-
Photoreduced Ag+ surrounding single poly(4-cyanostyrene) nanoparticles for undifferentiated SERS sensing and killing of bacteriaTalanta (IF 6.556) Pub Date : 2022-04-06 ,DOI:10.1016/j.talanta.2022.123450Ya-Qin Liu, Wei Zhu, Quan Yuan, Ji-Ming Hu, Xin Zhang, Ai-Guo ShenDeveloping a rapid, low cost and sensitive sensing strategy for undifferentiated detection and fast killing of bacterial pathogens are critical to alleviating bacteria infections. Here, we propose a direct photoreduction method to synthesize the SERS tag by integrating poly(4-cyanostyrene) nanoparticles (NPs) and silver ions, which are applied as bio-sensing system for bacteria sensing and fast killing ...
-
Clinical Significance of Nutrition and Inflammation in Esophageal Cancer Patients with Surgery: A Meta-AnalysisNutrition and Cancer (IF 2.816) Pub Date : 2022-03-26 ,DOI:10.1080/01635581.2022.2056620Qiuxing Yang, Aiguo Shen, Xudong Chen, Liyuan Guo, Hui Peng, Mingde GaoAbstract Many studies have reported that the geriatric nutritional risk index (GNRI) and C-reactive protein to albumin ratio (CAR) may be associated with prognosis of esophageal cancer (EC); however, the results are inconsistent. Therefore, we performed a meta-analysis to evaluate the effect of preoperative GNRI and CAR on the prognosis of EC. PubMed, Embase, Cochrane Library, and Web of Science databases ...
-
Rational Synthesis of Three-Layered Plasmonic Nanocomposites of Copper Sulfide/Gold/Zinc-Doped Prussian Blue Analogues for Improved Photothermal Disinfection and Wound HealingJournal of Colloid and Interface Science (IF 9.965) Pub Date : 2021-11-22 ,DOI:10.1016/j.jcis.2021.11.108Jun Cao, Wei Zhu, Ai-Guo Shen, Ji-Ming HuBacteria-infected wounds have imposed serious challenges in human health whereas the abuse of antibiotics makes bacteria drug-resistant and becoming more and more difficult to deal with. Herein, we developed a drug-free three-layered photothermal bactericide from inside to outside consisting of copper sulfide (CuS), gold (Au) and zinc-doped Prussian blue analogues (ZnPBA) (named as CuS@Au@ZnPBA). The ...
-
Performance of multi-antenna wireless systems based on time reversalJournal of Physics: Conference Series Pub Date : 2021-11-01 ,DOI:10.1088/1742-6596/2079/1/012025Aiguo Shen,Guangsong Yang,Dezhi Wei
Abstract 5G wireless mobile communication system is faced with massive equipment access, information security and effective transmission is worth paying attention to. Wireless physical layer security mainly uses encryption principle to enhance the security of information transmission, while time reversal technology combines its electromagnetic characteristics and physical channel characteristics to
...
-
Recent advances in plasmonic Prussian blue-based SERS nanotags for biological applicationNanoscale Advances (IF 5.598) Pub Date : 2021-10-21 ,DOI:10.1039/d1na00464fYa-Qin Liu, Wei Zhu, Ji-Ming Hu, Ai-Guo ShenThe reliability and reproducibility of surface-enhanced Raman scattering (SERS) technology is still a great challenge in bio-related analysis. Prussian blue (PB)-based SERS tags have attracted increasing interest for improving these deficiencies due to its unique Raman band (near 2156 cm−1) in the Raman-silent region, providing zero-background bio-Raman labels without interference from endogenous biomolecules ...
-
An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human TumorsBioMed Research International (IF 3.246) Pub Date : 2021-10-12 ,DOI:10.1155/2021/7405322Biao Wu, Yumeng Wu, Xianlin Guo, Yanping Yue, Yuanyuan Li, Xiao He, Yuanbin Chen, Wenjing Zhao, Jibin Liu, Xuming Wu, Aiguo Shen, Suqing Zhang
Several studies have suggested that coatomer protein complex subunit beta 2 (COPB2) may act as an oncogene in various cancer types. However, no systematic pan-cancer analysis has been performed to date. Therefore, the present study analyzed the potential oncogenic role of COPB2 using TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) datasets. The majority of the cancer types overexpressed
...
-
Carbon quantum dot fluorescent probes for food safety detection: Progress, opportunities and challengesFood Control (IF 6.652) Pub Date : 2021-10-04 ,DOI:10.1016/j.foodcont.2021.108591Wenshuo Zhang, Hongda Zhong, Pingping Zhao, Aiguo Shen, Houbin Li, Xinghai LiuAs a new photoluminescent nanomaterial, carbon quantum dots (CDs) have great potential in the detection of food ingredients and contaminants, owing to its merits of ease in preparation, good biocompatibility, adjustable modification, and various fluorescence response methods. However, since the rules of CDs in detecting different substances are rarely summarized by existing reports, the design of probes ...
-
Predictive value of and relationship between the gamma-glutamyl transpeptidase to lymphocyte ratio and CT features in hepatocellular carcinoma patients with postoperative adjuvant TACE.Journal of B.U.ON. : official journal of the Balkan Union of Oncology Pub Date : 2021-09-27 ,DOI:Hui Zhao,Xiaokan Liu,Ruonan Xu,Xiaoli Guo,Aiguo ShenPURPOSE To explore the predictive value of and the relationship between the gamma-glutamyl transpeptidase (GGT) to lymphocyte ratio (GLR) and computed tomography (CT) features in hepatocellular carcinoma (HCC) patients with postoperative adjuvant transarterial chemoembolization (PA-TACE). METHODS Between January 2012 and June 2015, 150 HCC patients who underwent adjuvant TACE after hepatectomy in the ...
-
Comprehensive Analysis of Glutamate-Rich WD Repeat-Containing Protein 1 and Its Potential Clinical Significance for PancancerBioMed Research International (IF 3.246) Pub Date : 2021-09-27 ,DOI:10.1155/2021/8201377Yumeng Wu, Xuming Wu, Yuanyuan Li, Wenjing Zhao, Yanping Yue, Biao Wu, Jibin Liu, Xudong Chen, Aiguo Shen
Background and Objective. Glutamate-rich WD repeat-containing protein 1 (GRWD1), as a novel CDT1-binding protein, plays a critical role in the initial stage of DNA replication. To date, few studies have shown that GRWD1 is a driving factor for lung cancer, bladder cancer, and colorectal cancer. However, no systematic pancancer analysis has been carried out. This study was aimed at exploring its expression
...
-
Liver Cancer Survival: A Real World Observation of 45 Years with 32,556 CasesJournal of Hepatocellular Carcinoma (IF 4.962) Pub Date : 2021-08-31 ,DOI:10.2147/jhc.s321346Jian-Guo Chen, Jian Zhu, Yong-Hui Zhang, Yong-Sheng Chen, Lu-Lu Ding, Hai-Zhen Chen, Ai-Guo Shen, Gao-Ren Wang
Background and Aims: To explore the long-term trend of liver cancer survival, based on the real-world data (RWD) in the past 45 years from a population-based cancer registry, in Qidong, China. Methods: A number of 32,556 patients with liver cancer were registered during the period of 1972 to 2016. Mixed methods by active and passive follow-up were performed. Life table method was employed for survival
...
-
Precise Encoding of Triple-Bond Raman Scattering of Single Polymer Nanoparticles for Multiplexed Imaging ApplicationAngewandte Chemie International Edition (IF 16.823) Pub Date : 2021-07-06 ,DOI:10.1002/anie.202106136Wei Zhu, Er-Li Cai, Hao-Zheng Li, Ping Wang, Ai-Guo Shen, Jürgen Popp, Ji-Ming HuStimulated Raman scattering (SRS) microscopy in combination with innovative tagging strategies offers great potential as a universal high-throughput biomedical imaging tool. Here, we report rationally tailored small molecular monomers containing triple-bond units with large Raman scattering cross-sections, which can be polymerized at the nanoscale for enhancement of SRS contrast with smaller but brighter ...
-
Predictive value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and lymphocyte-to-monocyte ratio (LMR) in patients with non-small cell lung cancer after radical lung cancer surgery.Annals of Translational Medicine Pub Date : 2021-06-01 ,DOI:10.21037/atm-21-2120Baoqian Zhai,Jia Chen,Jiacheng Wu,Lei Yang,Xiaoli Guo,Jingjing Shao,Hong Xu,Aiguo ShenBACKGROUND Examining the analytical worth of the preoperative hemoglobin, albumin, lymphocyte, platelet (HALP) score and lymphocyte-to-monocyte ratio (LMR) within diseased persons having non-small cell lung cancer (NSCLC) after radical lung cancer surgery. METHODS Clinical data concerning 238 diseased persons with NSCLC who underwent radical lung cancer resection within Nantong Cancer Hospital between ...
-
Nano Au@Cu2-xS with near-infrared photothermal and peroxidase catalytic activities redefines efficient antibiofilm-oriented root canal therapyChemical Engineering Journal (IF 16.744) Pub Date : 2021-04-30 ,DOI:10.1016/j.cej.2021.130090Jun Cao, Qing Sun, Ai-Guo Shen, Bing Fan, Ji-Ming HuKilling harmful bacteria in biofilms is a major challenge for current root canal therapy. Although traditional chemical disinfectants have a good bactericidal effect on plankton, they have little efficiency for the removal and sterilization of bacterial biofilms, and even lead to the emergence of bacterial resistance and high toxic side effects. Herein, we propose for the first time biosafe nanocomposites ...
-
Promoted “Click” SERS Detection for Precise Intracellular Imaging of Caspase-3Analytical Chemistry (IF 8.008) Pub Date : 2021-03-04 ,DOI:10.1021/acs.analchem.0c04997Wei Zhu, Chun-Yang Wang, Ji-Ming Hu, Ai-Guo ShenAlthough homogeneous detection of some biomolecules has been of great significance in clinical assay, it faces great challenges in achieving precise in situ imaging of biomolecules. In addition, nonspecific adsorption between probes and biomolecules and low sensitivity are still unfathomed problems. Herein, we developed a promoted “Click” surface enhanced Raman scattering (SERS) strategy for realizing ...
-
Enhanced expression of FGF19 predicts poor prognosis in patients with non-small cell lung cancer.Journal of Thoracic Disease Pub Date : 2021-03-01 ,DOI:10.21037/jtd-21-126Jia Chen,Jingjing Shao,Aiguo Shen,Xinghua Zhu,Xunlei Zhang,Hui Sun,Sheng Wei,Yang Ling
BACKGROUND Lung cancer is one of the most common cancers and a leading cause of cancer-related death worldwide. Although many treatment options exist for lung cancer, some patients still suffer postoperative recurrence, and a consequent reduction of overall survival (OS). Our study aimed to investigate the correlation of FGF19 expression with the clinicopathological features and survival outcomes of
...
-
Fine Synthesis of Prussian-Blue Analogue Coated Gold Nanoparticles (Au@PBA NPs) for Sorting Specific Cancer Cell SubtypesSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (IF 4.831) Pub Date : 2021-02-07 ,DOI:10.1016/j.saa.2021.119566Ya-Min Shen, Meng-Yue Gao, Xu Chen, Ai-Guo Shen, Ji-Ming HuMultiplex surface-enhanced Raman scattering (SERS) detection of markers without background in tumor biosystems has its superiority over other optical methods. Herein, we reported a strategy of quantitative discrimination of two breast cancer cell subtypes. Based on our previous studies, two kinds of Prussian blue analogue coated gold nanoparticles (Au@PBA NPs) were designed and synthesized by the replacement ...
广告：喜“文”乐“荐”|邀请好友使用Taylor & Francis Editing Services编辑润色服务，共享专属优惠！推荐人数无限制！
共有319个结果符合您的查询条件，只显示了前300个，请优化您的查询条件，以获取更精确的结果。
高级搜索
我的搜索条件
京公网安备 11010802027423号