- 作 者: ( "liyu huang" OR "li-yu huang" )
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Overexpression of PdeGATA3 results in a dwarf phenotype.Tree Physiology (IF 4.561) Pub Date : 2022-08-06 ,DOI:10.1093/treephys/tpac086Meifeng Liu,Liyu Huang,Yan Zhang,Zhaogui Yan,Nian Wang
In previous studies, GA20 oxidase (GA20ox) has been identified to be an important enzyme in the biosynthesis of GA, and SHOOTMERISTEMLESS (STM) can repress the expression of GA20ox. In this study, the GATA transcription factor (TF) PdeGATA3 was identified in the poplar line NL895, and its overexpression (OE) transgenic lines showed a dwarf phenotype. RNA sequencing (RNA-Seq) analysis suggested that
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The chromosome-scale genome sequence of Triadica sebifera provides insight into fatty acids and anthocyanin biosynthesisCommunications Biology (IF 6.548) Pub Date : 2022-08-04 ,DOI:10.1038/s42003-022-03751-9Jie Luo, Wenyu Ren, Guanghua Cai, Liyu Huang, Xin Shen, Na Li, Chaoren Nie, Yingang Li, Nian Wang
The Chinese tallow tree (Triadica sebifera) can produce oil with high content of unsaturated fatty acids in seeds and shows attractive leaf color in autumn and winter. Here, the 739 Mb chromosome-scale genome sequence of the Chinese tallow tree was assembled and it reveals the Chinese tallow tree is a tetraploid. Numerous genes related to nutrition assimilation, energy utilization, biosynthesis of
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Evolution mechanism of Ca-containing inclusions in 20Mn23AlV high-manganese non-magnetic steel during the refining processIronmaking & Steelmaking (IF 1.703) Pub Date : 2022-07-31 ,DOI:10.1080/03019233.2022.2103782Tao Zhang, Guoguang Cheng, Xinlong Yang, Xingrun Chen, Jixiang Pan, Jingyu Li, Yu Huang, Shijian LiABSTRACT Industrial experiments and thermodynamic calculations were carried out to investigate the evolution mechanism of Ca-containing inclusions in 20Mn23AlV steel with the Al content up to 2 wt-%. After Al deoxidation in AOD, the main inclusions were spherical shape Ca–Al–Si–Mn–O inclusions. Spherical Ca–Alrich–Si–Mn–O and spherical Ca–Al–Mn–O became the main inclusions after the first Al alloying ...
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Phosphate (Pi) stress-responsive transcription factors PdeWRKY6 and PdeWRKY65 regulate the expression of PdePHT1;9 to modulate tissue Pi concentration in poplarThe Plant Journal (IF 7.091) Pub Date : 2022-07-26 ,DOI:10.1111/tpj.15922Xiaoqing Yang, Keai Zhang, Tashbek Nvsvrot, Yan Zhang, Guanghua Cai, Liyu Huang, Wenyu Ren, Yiwei Ding, John P. Hammond, Lei Shi, Nian WangPhosphorus (P) is an important nutrient for plants. Here, we identify a WRKY transcription factor (TF) in poplar (Populus deltoides × Populus euramericana) (PdeWRKY65) that modulates tissue phosphate (Pi) concentrations in poplar. PdeWRKY65 overexpression (OE) transgenic lines showed reduced shoot Pi concentrations under both low and normal Pi availabilities, while PdeWRKY65 reduced expression (RE) ...
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Gradient-Based Pulsed Excitation and Relaxation Encoding in Magnetic Particle Imaging.IEEE Transactions on Medical Imaging (IF 11.037) Pub Date : 2022-07-21 ,DOI:10.1109/tmi.2022.3193219Guang Jia,Liyu Huang,Ze Wang,Xiaofeng Liang,Yu Zhang,Yifei Zhang,Qiguang Miao,Kai Hu,Tanping Li,Ying Wang,Li Xi,Xin Feng,Hui Hui,Jie TianMagnetic particle imaging (MPI) is a radiation-free vessel- and target-imaging modality that can sensitively detect nanoparticles. A static magnetic gradient field, referred to as a selection field, is required in MPI to provide a field-free region (FFR) for spatial encoding. The image resolution of MPI is closely related to the size of the FFR, which is determined by the selection field gradient amplitude ...
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Anlotinib combined with TQB2450 in patients with platinum-resistant or -refractory ovarian cancer: A multi-center, single-arm, phase 1b trialCell Reports Medicine (IF 16.988) Pub Date : 2022-07-19 ,DOI:10.1016/j.xcrm.2022.100689Chun-Yan Lan, Jing Zhao, Fan Yang, Ying Xiong, Rong Li, Yu Huang, Jing Wang, Chang Liu, Xue-Han Bi, Hai-Hong Jin, Jin Meng, Wei-Hong Zhao, Li Zhang, Ya-Fei Wang, Min Zheng, Xin Huang
This is a phase Ib study of anlotinib plus a programmed death-ligand 1 (PD-L1) inhibitor TQB2450 for platinum-resistant or -refractory ovarian cancer. Thirty-four patients are enrolled and receive treatment. The objective response rate (ORR) is 47.1%, and the disease control rate is 97.1%. The median duration of response (DOR) has not been reached, and 61.3% of patients have a DOR of at least 8 months
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Primary Antibiotic Resistance of Helicobacter pylori in Different Regions of China: A Systematic Review and Meta-AnalysisPathogens (IF 4.531) Pub Date : 2022-07-12 ,DOI:10.3390/pathogens11070786Jinnan Chen, Puheng Li, Yu Huang, Yixian Guo, Zhaohui Ding, Hong Lu
Aim: Understanding the prevalence of antibiotic resistance can provide reliable information for selecting treatment options. The goal of this meta-analysis was to observe the primary antibiotic resistance of Helicobacter pylori (H. pylori) in different regions and time periods of China. Method: We searched PubMed, EMBASE, Chinese Biomedical databases and the China National Knowledge Infrastructure
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EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal.Molecular Cancer Research (IF 6.333) Pub Date : 2022-07-06 ,DOI:10.1158/1541-7786.mcr-21-0441Haojie Li,Xuhong Fu,Junjie Zhao,Chen Li,Lingmeng Li,Peiyan Xia,Jianping Guo,Wenyi Wei,Rong Zeng,Jiarui Wu,Yihong Sun,Liyu Huang,Xuefei Wang
In comparison with intestinal-type gastric cancer, diffuse-type gastric cancer (DGC) is more likely to recur, metastasize, and exhibit worse clinical outcomes; however, the underlying mechanism of DGC recurrence remains elusive. By employing an LC/MS-MS proteomic approach, we identified that exocyst complex component 4 (EXOC4) was significantly upregulated in DGC with recurrence, compared to those
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Circular RNA VPS18 Promotes Glioblastoma Progression by Regulating miR-1229-3p/BCAT1 AxisNeurotoxicity Research (IF 3.978) Pub Date : 2022-07-01 ,DOI:10.1007/s12640-022-00530-6Qianliang Huang, Wei Li, Yu Huang, Qiang Chen, Wenjin WeiDepartment of Neurosurgery, Ganzhou People's Hospital of Jiangxi Province, No. 16 Meiguan Avenue, Zhanggong District, Ganzhou, 341000 Jiangxi Province, China.Circular RNAs (circRNAs) have been verified to play important roles in malignant tumors, including glioblastoma. The aim of this study is to explore the biological roles and underlying mechanisms of circRNA vacuolar protein sorting 18 homolog (circVPS18) in glioblastoma. A quantitative real-time polymerase chain reaction (qRT-PCR) was performed to measure the expression of circVPS18, microRNA (miR)-1299-3p ...
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Establishment of an astrocyte-like cell line from the brain of tilapia (Oreochromis niloticus) for virus pathogenesis and a vitro model of the blood–brain barrierJournal of Fish Diseases (IF 2.58) Pub Date : 2022-06-27 ,DOI:10.1111/jfd.13674Yuan Li, Yu Huang, Jia Cai, Dongneng Jiang, Ji-chang Jian, Yi-shan Lu, Bei WangA new cell line was established from the brain of a cultured fish, tilapia (Oreochromis niloticus), designated as TA-02 (Tilapia Astrocyte clone 02 cell line). The TA-02 cells are grown for 300 days in an L-15 medium supplemented with 10% fetal bovine serum (FBS). This cell line showed excellent proliferative capacity and expressed various neuroglial cell markers, including SOX2, SOX10, Hes1, Notch1 ...
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Interfacial dependent reactive oxygen species generation over Pt-ZrO2 nanoparticles for catalytic oxidation of formaldehyde at room temperatureApplied Surface Science (IF 7.392) Pub Date : 2022-06-26 ,DOI:10.1016/j.apsusc.2022.154056Shiqi Peng, Rong Li, Yu Huang, Yufei Zhang, Jun-ji Cao, Shuncheng LeeProducing the strong metal-support interaction (SMSI) interface and highly reactive oxygen species is a great challenge for catalytic oxidation of formaldehyde (HCHO) at room temperature over supported metal catalysts. Herein, we report a conceptual oxygen vacancy (VO) associated SMSI interface of Pt-ZrO2 nanoparticles for HCHO catalysis at room temperature, exhibiting interfacial dependent reactive ...
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The Integrative Studies on the Functional A-to-I RNA Editing Events in Human CancersbioRxiv - Bioinformatics Pub Date : 2022-06-06 ,DOI:10.1101/2022.06.05.493160Sijia Wu, Zhiwei Fan, Pora Kim, Liyu Huang, Xiaobo Zhou
A-to-I RNA editing, constituting nearly 90% of all RNA editing events in human, has been reported to contribute to the tumorigenesis in diverse cancers. However, there was not enough attention to the functional A-to-I RNA editing events in human cancers. To fill this gap, we systematically and intensively analyzed multiple tumorigenic mechanisms of A-to-I RNA editing events in samples across 33 cancer
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Homologous Recombination Pathway Alternation Predicts Prognosis of Colorectal Cancer With ChemotherapyFrontiers in Pharmacology (IF 5.988) Pub Date : 2022-06-06 ,DOI:10.3389/fphar.2022.920939Yan Lin, Xiaoli Liao, Yumei Zhang, Guobin Wu, Jiazhou Ye, Shanshan Luo, Xinxin He, Min Luo, Mingzhi Xie, Jinyan Zhang, Qian Li, Yu Huang, Sina Liao, Yongqiang Li, Rong Liang
Background: Chemotherapy is the basic treatment for colorectal cancer (CRC). However, colorectal cancer cells often develop resistance to chemotherapy drugs, leading to recurrence and poor prognosis. More and more studies have shown that the Homologous recombination (HR) pathway plays an important role in chemotherapy treatment for tumors. However, the relationship between HR pathway, chemotherapy
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MiR-223-3p alleviates trigeminal neuropathic pain in the male mouse by targeting MKNK2 and MAPK/ERK signalingBrain and Behavior (IF 3.405) Pub Date : 2022-05-24 ,DOI:10.1002/brb3.2634Bixia Huang, Shaoyong Guo, Yipan Zhang, Pengxing Lin, Changgui Lin, Meixia Chen, Shengyin Zhu, Liyu Huang, Junwei He, Lingfeng Zhang, Yanping Zheng, Zhipeng WenTrigeminal neuralgia (TN) is a neuropathic pain that occurs in branches of the trigeminal nerve. MicroRNAs (miRNAs) have been considered key mediators of neuropathic pain. This study was aimed to elucidate the pathophysiological function and mechanisms of miR-223-3p in mouse models of TN. ...
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Rosmarinic acid interferes with influenza virus A entry and replication by decreasing GSK3β and phosphorylated AKT expression levelsJournal of Microbiology, Immunology and Infection (IF 10.273) Pub Date : 2022-05-18 ,DOI:10.1016/j.jmii.2022.04.012Jia-Rong Jheng, Chung-Fan Hsieh, Yu-Hsiu Chang, Jin-Yuan Ho, Wen-Fang Tang, Zi-Yi Chen, Chien-Jou Liu, Ta-Jen Lin, Li-Yu Huang, Jyh-Haur Chern, Jim-Tong Horng
Background The purpose of this study was to examine the in vivo activity of rosmarinic acid (RA) – a phytochemical with antioxidant, anti-inflammatory, and antiviral properties – against influenza virus (IAV). An antibody-based kinase array and different in vitro functional assays were also applied to identify the mechanistic underpinnings by which RA may exert its anti-IAV activity. Methods We initially
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Extracellular vesicle-derived miR-144 as a novel mechanism for chronic intermittent hypoxia-induced endothelial dysfunctionTheranostics (IF 11.6) Pub Date : 2022-5-16 ,DOI:10.7150/thno.69035Huina Zhang, Lu Peng, Yifan Wang, Wen Zhao, Wayne Bond Lau, Yajing Wang, Yu Li, Yunhui Du, Linyi Li, Yu Huang, Shaoping Nie, Yanwen Qin, Xinliang Ma, Yongxiang Wei
Rationale: Extracellular vesicles (EVs) play a significant role in cell-cell communication. However, whether and how extracellular vesicles are involved in chronic intermittent hypoxia-induced endothelial dysfunction is unknown./nMethods: Comparative transcriptomics analysis and miRNA screening were used to identify the possible pathways or target molecules mediating chronic intermittent hypoxia-induced
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Deep Learning for Subgrid-Scale Turbulence Modeling in Large-Eddy Simulations of the Convective Atmospheric Boundary LayerJournal of Advances in Modeling Earth Systems (IF 8.469) Pub Date : 2022-05-10 ,DOI:10.1029/2021ms002847Yu Cheng, Marco G. Giometto, Pit Kauffmann, Ling Lin, Chen Cao, Cody Zupnick, Harold Li, Qi Li, Yu Huang, Ryan Abernathey, Pierre Gentine
In large-eddy simulations, subgrid-scale (SGS) processes are parameterized as a function of filtered grid-scale variables. First-order, algebraic SGS models are based on the eddy-viscosity assumption, which does not always hold for turbulence. Here we apply supervised deep neural networks (DNNs) to learn SGS stresses from a set of neighboring coarse-grained velocity from direct numerical simulations
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The excellent photocatalytic NO removal performance relates to the synergistic effect between the prepositive NaOH solution and the g-C3N4 photocatalysisEnvironmental Research (IF 8.431) Pub Date : 2022-05-05 ,DOI:10.1016/j.envres.2022.113405Kai Qi, Jun Jing, Guohui Dong, Pengna Li, Yu HuangPhotocatalysis technology is used to remove the low concentration NO in recent years. However, the effect of this process is not very satisfactory. In this study, it was found that the prepositive NaOH solution could significantly improve the photocatalytic NO removal activity of g-C3N4. The apparent quantum yield of g-C3N4 in the NO removal process was increased 3.5 times by the prepositive NaOH solution ...
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Wideband, high spectral resolution UV convex grating imaging spectrometer based on an Offner structure.Applied Optics Pub Date : 2022-04-20 ,DOI:10.1364/ao.454620Qingsheng Xue,Jingyao Yang,Liyu Huang,Haoxuan Bai,Jitao LuUltraviolet is an effective electromagnetic spectrum in material detection, which has wide application prospects in aerospace and environmental monitoring. A conventional imaging spectrometer has a narrow UV band and low spectral resolution. To solve this problem, a convex grating imaging spectrometer based on an Offner structure with F#2.5 and a 13 mm long slit was designed and developed. The working ...
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Robust Optimization of High-Speed Railway Train Plan Based on Multiple Demand ScenariosMathematics (IF 2.592) Pub Date : 2022-04-12 ,DOI:10.3390/math10081278Wenliang Zhou, Jing Kang, Jin Qin, Sha Li, Yu Huang
The optimization of train plans is highly dependent on the space–time distribution of passenger demand in high-speed railway systems. A train plan usually needs to be implemented on multiple operation days, and obviously the amount and space–time distribution of demand over these days has noteworthy differences. To ensure the same train plan is able to be implemented on multiple operation days while
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Structural brain characteristics and gene co-expression analysis: A study with outcome label from normal cognition to mild cognitive impairmentNeurobiology of Learning and Memory (IF 3.109) Pub Date : 2022-04-08 ,DOI:10.1016/j.nlm.2022.107620Suping Cai, Fan Yang, Xuwen Wang, Sijia Wu, Liyu HuangSchool of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, PR China.Background Longitudinal studies reported that some elderly people with normal cognition (NC) converted to mild cognitive impairment (MCI), and some remained normal state (NC_S). The underlying factor for this difference conversion of NC is worthy of exploration Methods Eighty-three NC participants were tracked for eight years. Thirty participants transitioned from NC to MCI (NC_MCI). The remaining ...
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A Genetic Network Underlying Rhizome Development in Oryza longistaminata.Frontiers in Plant Science (IF 6.627) Pub Date : 2022-04-05 ,DOI:10.3389/fpls.2022.866165Wenfei Li,Shilai Zhang,Guangfu Huang,Liyu Huang,Jing Zhang,Zheng Li,Fengyi HuState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Research Center for Perennial Rice Engineering and Technology of Yunnan, School of Ecology and Environmental Science, School of Agriculture, Yunnan University, Kunming, China.
The rhizome is an important organ through which many perennial plants are able to propagate vegetatively. Its ecological role has been thoroughly studied on many grass species while the underlying genetic basis is mainly investigated using a rhizomatous wild rice species-Oryza longistaminata. Previous studies have revealed that the rhizome trait in O. longistaminata is jointly controlled by multiple
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An all-sky luminance and radiance distribution model for built environment studiesRenewable Energy (IF 8.634) Pub Date : 2022-03-22 ,DOI:10.1016/j.renene.2022.03.105Siwei Lou, Danny H.W. Li, Khalid A. Alshaibani, Haowei Xing, Zhengrong Li, Yu Huang, Dawei XiaThe diffuse radiance and luminance can be anisotropic over the skydome, which is important to the daylight and thermal environments of buildings and the urban areas. This paper proposes a model that can estimate the luminance and radiance distributions over the skydome by the basic global and diffuse irradiance, and the solar altitude measurements/data that are readily accessible for many places over ...
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Identification of non-small-cell lung cancer subtypes by unsupervised clustering of CT image features with distinct prognoses and gene pathway activitiesBiomedical Signal Processing and Control (IF 5.076) Pub Date : 2022-03-18 ,DOI:10.1016/j.bspc.2022.103643Kexin Huang, Lifeng Yang, Yubo Wang, Liyu Huang, Xiaobo Zhou, Wei ZhangObjective Intra-tumour heterogeneity exists in non-small-cell lung cancer (NSCLC). Medical imaging can provide a comprehensive and detailed description of the tumour. Moreover, quantitative features can reflect the potentially valuable information of tumours that is neglected by visual diagnosis. To this end, we identified imaging subtypes of NSCLC by computed tomography (CT) images. Methods We analysed ...
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The Impacts of Online Skeuomorphic Physics Inquiry–Based Learning With and Without Simulation on 8th Graders’ Scientific Inquiry PerformanceJournal of Science Education and Technology (IF 3.419) Pub Date : 2022-03-12 ,DOI:10.1007/s10956-022-09960-5Ren-Jye Chou, Chih-Ping Liang, Li-yu Huang, Hsiao-Ching SheThis study compared the effectiveness of online skeuomorphic physics inquiry–based learning with and without simulation on 8th-grade students’ performance of scientific inquiry involving the spring unit. Two classes (58 students) were assigned to the online skeuomorphic physics inquiry–based learning with simulation, and two classes (59 students) were assigned to the online skeuomorphic physics inquiry–based ...
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CL-20/TNT decomposition under shock: cocrystalline versus amorphousRSC Advances (IF 4.036) Pub Date : 2022-03-02 ,DOI:10.1039/d1ra09120dYan Li, Wen-Li Yu, Huang Huang
The cocrystallization strategy is considered to be an effective means to adjust the properties of explosives. Nevertheless, the underlying mechanism of the effect of the special cocrystal structure on the decomposition process is not clear enough. The present work compares the response processes of a CL-20/TNT cocrystal structure and an amorphous structure under shock waves with different velocities
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OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and ARCommunications Biology (IF 6.548) Pub Date : 2022-03-01 ,DOI:10.1038/s42003-022-03133-1Xuhong Fu, Junjie Zhao, Guopeng Yu, Xiaomin Zhang, Jie Sun, Lingmeng Li, Jingyi Yin, Yinan Niu, Shancheng Ren, Yasheng Zhu, Bin Xu, Liyu Huang
Ovarian tumor (OTU) subfamily deubiquitinases are involved in various cellular processes, such as inflammation, ferroptosis and tumorigenesis; however, their pathological roles in prostate cancer (PCa) remain largely unexplored. In this study, we observed that several OTU members displayed genomic amplification in PCa, among which ovarian tumor deubiquitinase 6A (OTUD6A) amplified in the top around
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Cortical thickness differences are associated with cellular component morphogenesis of astrocytes and excitatory neurons in nonsuicidal self-injuring youthCerebral Cortex (IF 4.861) Pub Date : 2022-02-21 ,DOI:10.1093/cercor/bhac103Suping Cai, Zitong Guo, Xuwen Wang, Kexin Huang, Kai Yuan, Liyu HuangNonsuicidal self-injury (NSSI) generally occurs in youth and probably progresses to suicide. An examination of cortical thickness differences (ΔCT) between NSSI individuals and controls is crucial to investigate potential neurobiological correlates. Notably, ΔCT are influenced by specific genetic factors, and a large proportion of cortical thinning is associated with the expression of genes that overlap ...
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Control method of stepping motor for spaceborne solar irradiance spectrometerScientific Reports (IF 4.996) Pub Date : 2022-02-21 ,DOI:10.1038/s41598-022-06979-xYan Wang, Jianing Wang, Zhanfeng Li, Yu Huang
The encoder is not included in the hardware design of the Spaceborne Solar Irradiance Spectrometer, so in this paper, a high precision control method of stepping motor is proposed, which can position accurately without encoder. When the wavelength scanning mechanism is controlled, the validity of the hall signal is judged by controlling the forward and reverse rotation of the motor and the fixed steps
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Three-Variable Reduction of the Spin-Flip Model for Spin-VCSELsIEEE Journal of Quantum Electronics (IF 2.52) Pub Date : 2022-02-18 ,DOI:10.1109/jqe.2022.3152772Mike Adams, Nianqiang Li, Yu Huang, Pei Zhou, Ian Henning
Recent increased interest in spin-polarised vertical-cavity surface-emitting lasers (spin-VCSELs) as potential high-speed sources has spurred research into the analysis of their dynamics. This has often been explored by combining the spin-flip model (SFM) with numerical methods. However, numerical simulation does not readily expose key dependencies and to date there is a lack of accessible closed-form
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