- 作 者: ( "jiaru li" OR "jia-ru li" )
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Hydrodynamical Simulations of Black Hole Binary Formation in AGN DisksThe Astrophysical Journal Letters (IF 8.811) Pub Date : 2023-02-21 ,DOI:10.3847/2041-8213/acb934Jiaru Li, Adam M. Dempsey, Hui Li, Dong Lai, Shengtai Li
We study close encounters between two single black holes (BHs) embedded in an AGN disk using a series of global 2D hydrodynamics simulations. We find that when the disk density is sufficiently high, bound BH binaries can be formed by the collision of their circum-single disks. Our analysis demonstrates that, after a BH pair passes the pericenter of their relative trajectory, post-collision gas drag
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Preoperative 18F-FDG PET/CT radiomics analysis for predicting HER2 expression and prognosis in gastric cancer.Quantitative Imaging in Medicine and Surgery Pub Date : 2023-02-13 ,DOI:10.21037/qims-22-148Qiufang Liu,Jiaru Li,Bowen Xin,Yuyun Sun,Xiuying Wang,Shaoli Song
Background We aimed to establish and validate 2 machine learning models using 18F-flurodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) radiomic features to predict human epidermal growth factor receptor 2 (HER2) expression and prognosis in gastric cancer (GC) patients. Methods We retrospectively enrolled 90 patients diagnosed with GC, including their clinical information
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Advances in the Biosynthesis and Molecular Evolution of Steroidal Saponins in Plants.International Journal of Molecular Sciences (IF 6.208) Pub Date : 2023-01-30 ,DOI:10.3390/ijms24032620Yi Li,Huan Yang,Zihao Li,Song Li,Jiaru Li
Steroidal saponins are an important type of plant-specific metabolite that are essential for plants' responses to biotic and abiotic stresses. Because of their extensive pharmacological activities, steroidal saponins are also important industrial raw materials for the production of steroidal drugs. In recent years, more and more studies have explored the biosynthesis of steroidal saponins in plants
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The combination of red and blue light increases the biomass and steroidal saponin contents of Paris polyphylla var. yunnanensisIndustrial Crops and Products (IF 6.449) Pub Date : 2023-01-24 ,DOI:10.1016/j.indcrop.2023.116311Yi Li, Jiali Xu, Furui Zhang, Yongbin Gu, Weijun Tian, Weirong Tian, Yuxin Tong, Jiaru LiRed and blue light regulate plant development and metabolism. Paris polyphylla var. yunnanensis, for which there is great demand, is a medicinal plant mainly distributed in China and other parts of Asia. However, the effects of red and blue light on the growth and metabolites of P. polyphylla var. yunnanensis remain unknown. This study evaluated the effects of red (R), blue (B), and red-blue composite ...
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Hydrodynamical Simulations of Black-Hole Binary Formation in AGN DisksarXiv - PHYS - High Energy Astrophysical Phenomena Pub Date : 2022-11-18 ,DOI:arxiv-2211.10357Jiaru Li, Adam M. Dempsey, Hui Li, Dong Lai, Shengtai LiWe study the close encounters between two single black holes (BHs) embedded in an AGN disk using a series of global 2D hydrodynamics simulations. We find that when the disk density is sufficiently high, bound BH binaries can be formed by the collision of their circum-single disks. Our analysis demonstrates that, after a BH pair passes the pericenter of their relative trajectory, a gas post-collision ...
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Hydrodynamical Simulations of Black-Hole Binary Formation in AGN DisksarXiv - PHYS - Astrophysics of Galaxies Pub Date : 2022-11-18 ,DOI:arxiv-2211.10357Jiaru Li, Adam M. Dempsey, Hui Li, Dong Lai, Shengtai LiWe study the close encounters between two single black holes (BHs) embedded in an AGN disk using a series of global 2D hydrodynamics simulations. We find that when the disk density is sufficiently high, bound BH binaries can be formed by the collision of their circum-single disks. Our analysis demonstrates that, after a BH pair passes the pericenter of their relative trajectory, a gas post-collision ...
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Towards understanding and mitigating unintended biases in language model-driven conversational recommendationInformation Processing & Management (IF 7.466) Pub Date : 2022-11-16 ,DOI:10.1016/j.ipm.2022.103139Tianshu Shen, Jiaru Li, Mohamed Reda Bouadjenek, Zheda Mai, Scott Sanner
Conversational Recommendation Systems (CRSs) have recently started to leverage pretrained language models (LM) such as BERT for their ability to semantically interpret a wide range of preference statement variations. However, pretrained LMs are prone to intrinsic biases in their training data, which may be exacerbated by biases embedded in domain-specific language data (e.g., user reviews) used to
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Resonant Excitation of Planetary Eccentricity due to a Dispersing Eccentric Protoplanetary Disk: A New Mechanism of Generating Large Planetary EccentricitiesarXiv - PHYS - Earth and Planetary Astrophysics Pub Date : 2022-11-14 ,DOI:arxiv-2211.07305Jiaru Li, Dong LaiWe present a new mechanism of generating large planetary eccentricities. This mechanism applies to planets within the inner cavities of their companion protoplanetary disks. A massive disk with an inner truncation may become eccentric due to non-adiabatic effects associated with gas cooling, and can retain its eccentricity in long-lived coherently-precessing eccentric modes; as the disk disperses, ...
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Fermented Astragalus and its metabolites regulate inflammatory status and gut microbiota to repair intestinal barrier damage in dextran sulfate sodium-induced ulcerative colitisFrontiers in Nutrition (IF 6.59) Pub Date : 2022-11-14 ,DOI:10.3389/fnut.2022.1035912Junxiang Li, Yingchun Ma, Xiaofeng Li, Yafei Wang, Zeqi Huo, Yang Lin, Jiaru Li, Hui Yang, Zhiming Zhang, Pingrong Yang, Chunjiang Zhang
Fermentation represents an efficient biotechnological approach to increase the nutritional and functional potential of traditional Chinese medicine. In this study, Lactobacillus plantarum was used to ferment traditional Chinese medicine Astragalus, the differential metabolites in the fermented Astragalus (FA) were identified by ultra-performance liquid chromatography-Q Exactive hybrid quadrupole-Orbitrap
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Comparative transcriptome analysis reveals key genes for polyphyllin difference in five Paris speciesPhysiologia Plantarum (IF 5.081) Pub Date : 2022-11-03 ,DOI:10.1111/ppl.13810Lixiu Hou, Furui Zhang, Xincheng Yuan, Song Li, Weijun Tian, Weirong Tian, Jiaru LiParis species accumulate a large amount of steroidal saponins, which have numerous pharmacological activities and have become an essential component in many patented drugs. However, only two among all Paris species. Paris are identified as official sources due to high level of bioactive compounds. To clarify the composition of steroidal saponins and the molecular basis behind the differences between ...
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Supply of basic necessities to vulnerable populations during the COVID-19 pandemic: Empirical evidence from Shanghai, China.Frontiers in Public Health (IF 6.461) Pub Date : 2022-10-26 ,DOI:10.3389/fpubh.2022.1008180Qian Wang,Ruiming Dai,Tiantian Zhang,Jiaru Li,Tao Sheng,Bin Wu
Background In spite of initial widespread skepticism, city lockdown has been proved to be an effective short-term tool in containing and delaying the spread of a viral epidemic. The measures to ensure the supply of the basic necessities adequately and equitably, especially for those vulnerable ones has become a major challenge faced by all countries taking a city lockdown measure during the epidemic
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Potential Factors Contributing to Ozone Production in AQUAS–Kyoto Campaign in Summer 2020: Natural Source-Related Missing OH Reactivity and Heterogeneous HO2/RO2 LossEnvironmental Science & Technology (IF 11.357) Pub Date : 2022-09-07 ,DOI:10.1021/acs.est.2c03628Jiaru Li, Nanase Kohno, Yosuke Sakamoto, Huy Gia Pham, Kentaro Murano, Kei Sato, Tomoki Nakayama, Yoshizumi KajiiThis study presents total OH reactivity, ancillary trace species, HO2 reactivity, and complex isoprene-derived RO2 reactivity due to ambient aerosols measured during the air quality study (AQUAS)–Kyoto campaign in September, 2020. Observations were conducted during the coronavirus disease (COVID-19) pandemic (associated with reduced anthropogenic emissions). The spatial distribution of missing OH reactivity ...
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Long-term Evolution of Tightly Packed Stellar Black Holes in AGN Disks: Formation of Merging Black Hole Binaries via Close EncountersThe Astrophysical Journal (IF 5.521) Pub Date : 2022-08-03 ,DOI:10.3847/1538-4357/ac7c0dJiaru Li, Dong Lai, Laetitia Rodet
We study the long-term evolution of two or more stellar black holes (BHs) on initially separated but unstable circular orbits around a supermassive BH (SMBH). Such a close-packed orbital configuration can naturally arise from BH migrations in the AGN disk. Dynamical instability of the orbits leads to recurring close encounters between two BHs, during which the BH separation r p becomes less than the
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The genome of Dioscorea zingiberensis sheds light on the biosynthesis, origin and evolution of the medicinally important diosgenin saponinsHorticulture Research (IF 7.291) Pub Date : 2022-07-25 ,DOI:10.1093/hr/uhac165Jiali Xu, Ziyu Tong, Anran Xu, Xincheng Yuan, Weipeng Wang, Qingyong Yang, Lingling Chen, Zongyi Sun, Kai Wang, Bo Pan, Jianghua Chen, Yinghua Bao, Faguang Liu, Xiaoquan Qi, David R Gang, Jun Wen, Jiaru Li
Diosgenin saponins isolated from Dioscorea species such as Dioscorea zingiberensis exhibit a broad spectrum of pharmacological activities. Diosgenin, the aglycone of diosgenin saponins, is an important starting material for production of steroidal drugs. However, how plants produce diosgenin saponins, and the origin and evolution of diosgenin saponin biosynthetic pathway remain a mystery. Here, we
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Effect of exogenous jasmonic acid on physiology and steroidal saponin accumulation in Dioscorea zingiberensisPlant Physiology and Biochemistry (IF 5.437) Pub Date : 2022-06-30 ,DOI:10.1016/j.plaphy.2022.06.025Lixiu Hou, Song Li, Furui Zhang, Yongbin Gu, Jiaru LiDioscorea zingiberensis is a valuable medicinal herb rich in steroidal saponins. To reveal the role of jasmonic acid (JA) on physiology and steroidal saponins accumulation, D. zingiberensis were treated with different concentrations of JA. The antioxidant capacity, photosynthetic parameters, fatty acids and metabolites related to steroidal saponins biosynthesis (phytosterols, diosgenin and steroidal ...
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Redox-Active Crystalline Coordination Catalyst for Hybrid Electrocatalytic Methanol Oxidation and CO2 ReductionAngewandte Chemie International Edition (IF 16.823) Pub Date : 2022-06-24 ,DOI:10.1002/anie.202207282Sheng-Nan Sun, Long-Zhang Dong, Jia-Ru Li, Jing-Wen Shi, Jiang Liu, Yi-Rong Wang, Qing Huang, Ya-Qian LanThe transfer of electrons from electron-rich metal clusters (oxidation active sites) to electron-deficient metalloporphyrins (reduction active sites) leads to stronger oxidizability of Ni8 clusters and stronger reducibility of metalloporphyrin. The enhanced oxidizability of Ni8 and reducibility of metalloporphyrin, therefore, result in improved methanol electrooxidation and CO2 electroreduction with ...
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Dynamical Instability in Multi-Orbiter Systems with Gas FrictionarXiv - PHYS - High Energy Astrophysical Phenomena Pub Date : 2022-06-03 ,DOI:arxiv-2206.01755Jiaru Li, Laetitia Rodet, Dong LaiClosely-packed multi-planet systems are known to experience dynamical instability if the spacings between the planets are too small. Such instability can be tempered by the frictional forces acting on the planets from gaseous discs. A similar situation applies to stellar-mass black holes embedded in AGN discs around supermassive black holes. In this paper, we use $N$-body integrations to evaluate how ...
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Dynamical Instability in Multi-Orbiter Systems with Gas FrictionarXiv - PHYS - Earth and Planetary Astrophysics Pub Date : 2022-06-03 ,DOI:arxiv-2206.01755Jiaru Li, Laetitia Rodet, Dong LaiClosely-packed multi-planet systems are known to experience dynamical instability if the spacings between the planets are too small. Such instability can be tempered by the frictional forces acting on the planets from gaseous discs. A similar situation applies to stellar-mass black holes embedded in AGN discs around supermassive black holes. In this paper, we use $N$-body integrations to evaluate how ...
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Community structure and function of epiphytic bacteria attached to three submerged macrophytesScience of the Total Environment (IF 10.753) Pub Date : 2022-04-27 ,DOI:10.1016/j.scitotenv.2022.155546Weicheng Yu, Jiahe Li, Xiaowen Ma, Tian Lv, Ligong Wang, Jiaru Li, Chunhua LiuIn aquatic ecosystems, large amounts of epiphytic bacteria living on the leaf surfaces of submerged macrophytes play important roles in affecting plant growth and biogeochemical cycling. The restoration of different submerged macrophytes has been considered an effective measure to improve eutrophic lakes. However, the community ecology of epiphytic bacteria is far from well understood for different ...
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Impacts of missing OH reactivity and aerosol uptake of HO2 radicals on tropospheric O3 production during the AQUAS-Kyoto summer campaign in 2018Atmospheric Environment (IF 5.755) Pub Date : 2022-04-27 ,DOI:10.1016/j.atmosenv.2022.119130Nanase Kohno, Jun Zhou, Jiaru Li, Marina Takemura, Natsuki Ono, Yasuhiro Sadanaga, Yoshihiro Nakashima, Kei Sato, Shungo Kato, Yosuke Sakamoto, Yoshizumi KajiiGaining quantitative information about the HOx cycle involved in ozone (O3) production is important for reduction of tropospheric O3. In this study, we evaluated the impacts of both the missing OH reactivity and the heterogeneous loss of HO2 due to ambient aerosol uptake on the photochemical O3 production potential and regime analysis during the Air QUAlity Study (AQUAS)-Kyoto summer campaign in 2018 ...
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Metabolic Activation and Cytotoxicity of Propafenone Mediated by CYP2D6Chemical Research in Toxicology (IF 3.973) Pub Date : 2022-04-20 ,DOI:10.1021/acs.chemrestox.2c00013Jiaru Li, Junzu Shi, Chenyang Jia, Wei Li, Ying Peng, Jiang ZhengPropafenone (PPF) is a class IC antidysrhythmic drug, which is commonly used for the treatment of atrial fibrillation and other supraventricular arrhythmias. It is also a β-adrenoceptor antagonist that can cause bradycardia and bronchospasm. Hepatotoxicity is one of the adverse reactions reported, with clinical manifestations including acute cholestasis and hepatocyte necrosis. However, the mechanism ...
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Derivation and validation of a nomogram for predicting nonventilator hospital-acquired pneumonia among older hospitalized patientsBMC Pulmonary Medicine (IF 3.32) Pub Date : 2022-04-15 ,DOI:10.1186/s12890-022-01941-zChen, Zhihui, Xu, Ziqin, Wu, Hongmei, Gao, Shengchun, Wang, Haihong, Jiang, Jiaru, Li, Xiuyang, Chen, Le
Currently, there is no effective tool for predicting the risk of nonventilator hospital-acquired pneumonia (NV-HAP) in older hospitalized patients. The current study aimed to develop and validate a simple nomogram and a dynamic web-based calculator for predicting the risk of NV-HAP among older hospitalized patients. A retrospective evaluation was conducted on 15,420 consecutive older hospitalized patients
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Hot Circumsingle Disks Drive Binary Black Hole Mergers in Active Galactic Nucleus DisksThe Astrophysical Journal Letters (IF 8.811) Pub Date : 2022-04-04 ,DOI:10.3847/2041-8213/ac60fdYa-Ping Li, Adam M. Dempsey, Hui Li, Shengtai Li, Jiaru Li
Binary black hole (BBH) mergers, particularly those with component masses in the pair-instability gap, may be produced by hierarchical mergers in the disks surrounding Active Galactic Nuclei (AGNs). While the interaction of an embedded BBH with an AGN disk is typically assumed to facilitate a merger, recent high-resolution hydrodynamical simulations challenge this assumption. However, these simulations
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Unintended Bias in Language Model-drivenConversational RecommendationarXiv - CS - Information Retrieval Pub Date : 2022-01-17 ,DOI:arxiv-2201.06224Tianshu Shen, Jiaru Li, Mohamed Reda Bouadjenek, Zheda Mai, Scott SannerConversational Recommendation Systems (CRSs) have recently started to leverage pretrained language models (LM) such as BERTfor their ability to semantically interpret a wide range of preference statement variations. However, pretrained LMs are well-known to be prone to intrinsic biases in their training data, which may be exacerbated by biases embedded in domain-specific language data(e.g., user reviews) ...
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Unintended Bias in Language Model-drivenConversational RecommendationarXiv - CS - Human-Computer Interaction Pub Date : 2022-01-17 ,DOI:arxiv-2201.06224Tianshu Shen, Jiaru Li, Mohamed Reda Bouadjenek, Zheda Mai, Scott SannerConversational Recommendation Systems (CRSs) have recently started to leverage pretrained language models (LM) such as BERTfor their ability to semantically interpret a wide range of preference statement variations. However, pretrained LMs are well-known to be prone to intrinsic biases in their training data, which may be exacerbated by biases embedded in domain-specific language data(e.g., user reviews) ...
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Unintended Bias in Language Model-drivenConversational RecommendationarXiv - CS - Computation and Language Pub Date : 2022-01-17 ,DOI:arxiv-2201.06224Tianshu Shen, Jiaru Li, Mohamed Reda Bouadjenek, Zheda Mai, Scott SannerConversational Recommendation Systems (CRSs) have recently started to leverage pretrained language models (LM) such as BERTfor their ability to semantically interpret a wide range of preference statement variations. However, pretrained LMs are well-known to be prone to intrinsic biases in their training data, which may be exacerbated by biases embedded in domain-specific language data(e.g., user reviews) ...
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Unintended Bias in Language Model-drivenConversational RecommendationarXiv - CS - Artificial Intelligence Pub Date : 2022-01-17 ,DOI:arxiv-2201.06224Tianshu Shen, Jiaru Li, Mohamed Reda Bouadjenek, Zheda Mai, Scott SannerConversational Recommendation Systems (CRSs) have recently started to leverage pretrained language models (LM) such as BERTfor their ability to semantically interpret a wide range of preference statement variations. However, pretrained LMs are well-known to be prone to intrinsic biases in their training data, which may be exacerbated by biases embedded in domain-specific language data(e.g., user reviews) ...
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Metabolic activation of aegeline mediated by CYP2C19Xenobiotica (IF 1.997) Pub Date : 2021-11-07 ,DOI:10.1080/00498254.2021.1913666Min Tian, Shenzhi Zhou, Wei Li, Jiaru Li, Lan Yang, Ying Peng, Jiang ZhengAbstract Aegeline (AGL) is a natural alkaloidal amide mainly isolated from the leaves and fruits of tropical plant Aegle marmelos, with multiple pharmacological activities. As one component of several dietary supplements, AGL caused a series of acute and chronic liver injuries. Nevertheless, the mechanisms of AGL-induced hepatotoxicity remain unclear. This study was conducted to identify reactive metabolite(s) ...
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Genome-Wide Identification of CYP72A Gene Family and Expression Patterns Related to Jasmonic Acid Treatment and Steroidal Saponin Accumulation in Dioscorea zingiberensisInternational Journal of Molecular Sciences (IF 4.556) Pub Date : 2021-10-11 ,DOI:10.3390/ijms222010953Lixiu Hou, Xincheng Yuan, Song Li, Yi Li, Zihao Li, Jiaru Li
Dioscorea zingiberensis is a medicinal herb containing a large amount of steroidal saponins, which are the major bioactive compounds and the primary storage form of diosgenin. The CYP72A gene family, belonging to cytochromes P450, exerts indispensable effects on the biosynthesis of numerous bioactive compounds. In this work, a total of 25 CYP72A genes were identified in D. zingiberensis and categorized
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A quantitative understanding of total OH reactivity and ozone production in a coastal industrial area during the Yokohama air quality study (AQUAS) campaign of summer 2019Atmospheric Environment (IF 5.755) Pub Date : 2021-09-30 ,DOI:10.1016/j.atmosenv.2021.118754Jiaru Li, Nanase Kohno, Yosuke Sakamoto, Yukiko Fukusaki, Yuka Kousa, Yasuhiro Sadanaga, Yoshihiro Nakashima, Kei Sato, Sathiyamurthi Ramasamy, Akinori Takami, Ayako Yoshino, Tomoki Nakayama, Shungo Kato, Natsuki Ono, Jun Zhou, Yu Bai, Yoshizumi KajiiField measurements performed in the Keihin coastal industrial area during summer 2019 were used to characterize the air quality and ozone production potential. The total hydroxyl radical (OH) reactivity was found to be moderate, peaking with a 2-h average of 29.0 s−1, corresponding to an OH lifetime of ∼34 ms. The average hourly total OH reactivity was 11.4 ± 5.2 s−1 (average ± standard deviation) ...
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