- 作 者: ( "xiongjie shi" OR "xiong-jie shi" )
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GRAMD1/ASTER-mediated cholesterol transport promotes Smoothened cholesterylation at the endoplasmic reticulumThe EMBO Journal (IF 14.012) Pub Date : 2022-12-16 ,DOI:10.15252/embj.2022111513Zhi-Ping Qiu, Zi-Cun Lin, Ao Hu, Yuan-Bin Liu, Wan-Er Zeng, Xiaolu Zhao, Xiong-Jie Shi, Jie Luo, Bao-Liang SongHedgehog (Hh) signaling pathway plays a pivotal role in embryonic development. Hh binding to Patched1 (PTCH1) derepresses Smoothened (SMO), thereby activating the downstream signal transduction. Covalent SMO modification by cholesterol in its cysteine-rich domain (CRD) is essential for SMO function. SMO cholesterylation is a calcium-accelerated autoprocessing reaction, and STIM1-ORAI1-mediated store-operated ...
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Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretionNature (IF 69.504) Pub Date : 2022-08-03 ,DOI:10.1038/s41586-022-05006-3Ju-Qiong Wang, Liang-Liang Li, Ao Hu, Gang Deng, Jian Wei, Yun-Feng Li, Yuan-Bin Liu, Xiao-Yi Lu, Zhi-Ping Qiu, Xiong-Jie Shi, Xiaolu Zhao, Jie Luo, Bao-Liang SongHigh cholesterol is a major risk factor for cardiovascular disease1. Currently, no drug lowers cholesterol through directly promoting cholesterol excretion. Human genetic studies have identified that the loss-of-function Asialoglycoprotein receptor 1 (ASGR1) variants associate with low cholesterol and a reduced risk of cardiovascular disease2. ASGR1 is exclusively expressed in liver and mediates internalization ...
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Niclosamide Exposure at Environmentally Relevant Concentrations Efficaciously Inhibited the Growth and Disturbed the Liver-Gut Axis of Adult Male ZebrafishEnvironmental Science & Technology (IF 11.357) Pub Date : 2022-07-28 ,DOI:10.1021/acs.est.2c02712Biran Zhu, Lei Lei, Yumiao Sun, Xiongjie Shi, Kaiyu Fu, Jianghuan Hua, Christopher J. Martyniuk, Jian Han, Lihua Yang, Bingsheng ZhouIn the current study, adult male zebrafish fed a normal diet (ND) or high-fat diet (HFD) were exposed to niclosamide (NIC) at environmentally relevant concentrations to reveal the accumulation and distribution in different tissues and evaluate the effects on liver-gut axis. Chemical analysis indicated that the liver bore a greater burden of NIC compared with the brain and gonads in adult zebrafish ...
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Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against AtherosclerosisCirculation (IF 39.918) Pub Date : 2022-02-22 ,DOI:10.1161/circulationaha.121.056491Jin-Kai Wang, Yang Li, Xiao-Lu Zhao, Yuan-Bin Liu, Jing Tan, Yu-Ying Xing, Dilare Adi, Yong-Tao Wang, Zhen-Yan Fu, Yi-Tong Ma, Song-Mei Liu, Yong Liu, Yan Wang, Xiong-Jie Shi, Xiao-Yi Lu, Bao-Liang Song, Jie LuoBackground:High blood cholesterol accelerates the progression of atherosclerosis, which is an asymptomatic process lasting for decades. Rupture of atherosclerotic plaques induces thrombosis, which results in myocardial infarction or stroke. Lowering cholesterol levels is beneficial for preventing atherosclerotic cardiovascular disease.Methods:Low-density lipoprotein (LDL) receptor (LDLR) was used as ...
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Bis(2-ethylhexyl)-tetrabromophthalate induces zebrafish obesity by altering the brain-gut axis and intestinal microbial compositionEnvironmental Pollution (IF 9.988) Pub Date : 2021-09-06 ,DOI:10.1016/j.envpol.2021.118127Yuxi Zhou, Wei Guo, Lei Lei, Yumiao Sun, Ruiwen Li, Yongyong Guo, Lihua Yang, Xiongjie Shi, Jian Han, Bingsheng ZhouMultiple environmental stressors, including chemicals termed obesogens, contribute to the susceptibility of organisms to obesity. Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH), a novel brominated flame retardant, is an environmental contaminant that may disrupt lipid metabolism. However, the risk of TBPH leading to obesity remains unknown. Herein, adult female zebrafish fed a normal-fat diet ...
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Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame RetardantEnvironmental Science & Technology (IF 11.357) Pub Date : 2021-05-02 ,DOI:10.1021/acs.est.1c01476Wei Guo, Lei Lei, Xiongjie Shi, Ruiwen Li, Qiangwei Wang, Jian Han, Lihua Yang, Lianguo Chen, Bingsheng ZhouBis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH), a novel brominated flame retardant, can potentially cause lipid metabolism disorder; however, its biological effects on lipid homeostasis remain unknown. We investigated its ability to cause nonalcoholic fatty liver disease (NAFLD) in zebrafish. Female zebrafish were fed a high-fat diet (HFD, 24% crude fat) or normal diet (ND, 6% crude fat), and ...
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Inhibition of the sodium–glucose co‐transporter SGLT2 by canagliflozin ameliorates diet‐induced obesity by increasing intra‐adipose sympathetic innervationBritish Journal of Pharmacology (IF 9.473) Pub Date : 2021-01-22 ,DOI:10.1111/bph.15381Xuping Yang, Qinhui Liu, Yanping Li, Yi Ding, Yan Zhao, Qin Tang, Tong Wu, Lei Chen, Shiyun Pu, Shihai Cheng, Jinhang Zhang, Zijing Zhang, Ya Huang, Rui Li, Yingnan Zhao, Min Zou, Xiongjie Shi, Wei Jiang, Rui Wang, Jinhan HeInhibition of the sodium–glucose cotransporter 2 (SGLT2) induces hypoglycaemia by increasing urinary glucose excretion and increasing the use of fat. However, the underlying mechanism is poorly understood. This study was aimed to determine the effects of canagliflozin, a selective SGLT2 inhibitor, on diet‐induced obesity and the underlying mechanism(s). ...
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Feeding induces cholesterol biosynthesis via the mTORC1–USP20–HMGCR axisNature (IF 69.504) Pub Date : 2020-11-11 ,DOI:10.1038/s41586-020-2928-yXiao-Yi Lu, Xiong-Jie Shi, Ao Hu, Ju-Qiong Wang, Yi Ding, Wei Jiang, Ming Sun, Xiaolu Zhao, Jie Luo, Wei Qi, Bao-Liang SongCholesterol is an essential lipid and its synthesis is nutritionally and energetically costly 1 , 2 . In mammals, cholesterol biosynthesis increases after feeding and is inhibited under fasting conditions 3 . However, the regulatory mechanisms of cholesterol biosynthesis at the fasting–feeding transition remain poorly understood. Here we show that the deubiquitylase ubiquitin-specific peptidase 20 ...
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The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1α signalling pathway.Adipocyte (IF 3.553) Pub Date : 2020-08-23 ,DOI:10.1080/21623945.2020.1807850Xuping Yang,Qinhui Liu,Yanping Li,Qin Tang,Tong Wu,Lei Chen,Shiyun Pu,Yingnan Zhao,Guorong Zhang,Cuiyuan Huang,Jinhang Zhang,Zijing Zhang,Ya Huang,Min Zou,Xiongjie Shi,Wei Jiang,Rui Wang,Jinhan He
ABSTRACT The diabetes medication canagliflozin (Cana) is a sodium glucose cotransporter 2 (SGLT2) inhibitor acting by increasing urinary glucose excretion and thus reducing hyperglycaemia. Cana treatment also reduces body weight. However, it remains unclear whether Cana could directly work on adipose tissue. In the present study, the pharmacological effects of Cana and the associated mechanism were
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POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturationProtein & Cell (IF 15.328) Pub Date : 2020-07-14 ,DOI:10.1007/s13238-020-00753-3Jian Xiao, Yanni Xiong, Liu-Ting Yang, Ju-Qiong Wang, Zi-Mu Zhou, Le-Wei Dong, Xiong-Jie Shi, Xiaolu Zhao, Jie Luo, Bao-Liang Song
Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially cleaved by site-1 protease (S1P) and site-2 protease and releases a nuclear form to modulate gene expression. To search for new genes regulating cholesterol
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POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturationProtein & Cell (IF 15.328) Pub Date : 2020-07-14 ,DOI:10.1007/s13238-020-00753-3Jian Xiao, Yanni Xiong, Liu-Ting Yang, Ju-Qiong Wang, Zi-Mu Zhou, Le-Wei Dong, Xiong-Jie Shi, Xiaolu Zhao, Jie Luo, Bao-Liang Song
Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially cleaved by site-1 protease (S1P) and site-2 protease and releases a nuclear form to modulate gene expression. To search for new genes regulating cholesterol
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Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2.Nature Communications (IF 17.694) Pub Date : 2020-01-17 ,DOI:10.1038/s41467-019-14231-wZhang-Sen Zhou,Mei-Xin Li,Jie Liu,Hengwu Jiao,Jing-Ming Xia,Xiong-Jie Shi,Huabin Zhao,Liping Chu,Jingrong Liu,Wei Qi,Jie Luo,Bao-Liang Song
Insig-2 is an ER membrane protein negatively controlling lipid biosynthesis. Here, we find that Insig-2 is increased in the tissues, including liver, but unaltered in the muscle of gp78-deficient mice. In hepatocytes and undifferentiated C2C12 myoblasts, Insig-2 is ubiquitylated on Cys215 by gp78 and degraded. However, the C215 residue is oxidized by elevated reactive oxygen species (ROS) during C2C12
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Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate Affects Lipid Metabolism in Zebrafish Larvae via DNA Methylation Modification.Environmental Science & Technology (IF 11.357) Pub Date : 2019-12-19 ,DOI:10.1021/acs.est.9b05796Wei Guo,Jian Han,Shengmin Wu,Xiongjie Shi,Qiangwei Wang,Bingsheng ZhouBis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH) is a ubiquitous environmental contaminant, but its toxicity is not fully understood. Accordingly, we investigated the effects of TBPH and its metabolite, mono-(2-ethyhexyl)tetrabromophthalate (TBMEHP), on lipid metabolism using a zebrafish model. The molecular docking study revealed that TBPH and TBMEHP bind to zebrafish peroxisome proliferator-activated ...
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Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing.Journal of Lipid Research (IF 6.676) Pub Date : 2019-08-27 ,DOI:10.1194/jlr.ra119000201Liang Chen,Mei-Yan Ma,Ming Sun,Lu-Yi Jiang,Xue-Tong Zhao,Xian-Xiu Fang,Sin Man Lam,Guang-Hou Shui,Jie Luo,Xiong-Jie Shi,Bao-Liang Song
Sterol-regulated HMG-CoA reductase (HMGCR) degradation and SREBP-2 cleavage are two major feedback regulatory mechanisms governing cholesterol biosynthesis. Reportedly, lanosterol selectively stimulates HMGCR degradation, and cholesterol is a specific regulator of SREBP-2 cleavage. However, it is unclear whether other endogenously generated sterols regulate these events. Here, we investigated the sterol
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Developmental exposure to BDE-99 hinders cerebrovascular growth and disturbs vascular barrier formation in zebrafish larvaeAquatic Toxicology (IF 5.202) Pub Date : 2019-06-12 ,DOI:10.1016/j.aquatox.2019.105224Xiali Zhong,Jianmeng Kang,Jiahuang Qiu,Wenhan Yang,Jingwei Wu,Di Ji,Yuejin Yu,Weijian Ke,Xiongjie Shi,Yanhong WeiPolybrominated diphenyl ethers (PBDEs) are distributed throughout the environment. Despite a moratorium on their use, concentrations of PBDEs in the atmosphere and in residential environments remain high due to their persistence. The environmental health risks remain concerning and one of the major adverse effects is neurodevelopmental toxicity. However, the early response and effects of PBDEs exposure ...
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Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagminsScience China Life Sciences Pub Date : 2019-05-22 ,DOI:10.1007/s11427-019-9569-9Jian Xiao, Jie Luo, Ao Hu, Ting Xiao, Meixin Li, Zekai Kong, Luyi Jiang, Zimu Zhou, Yacheng Liao, Chang Xie, Beibei Chu, Honghua Miao, Boliang Li, Xiongjie Shi, Bao-Liang SongMost mammalian cells take up cholesterol from low-density lipoproteins (LDLs) via receptor-mediated endocytosis. After reaching lysosomes, LDL-derived cholesterol continues to transport to downstream organelles including the ER for specific structural and functional needs. Peroxisomes are recently found to receive cholesterol from lysosomes through lysosome-peroxisome membrane contacts. However, whether ...
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Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins.Science China Life Sciences Pub Date : 2019-05-22 ,DOI:10.1007/s11427-019-9569-9Jian Xiao,Jie Luo,Ao Hu,Ting Xiao,Meixin Li,Zekai Kong,Luyi Jiang,Zimu Zhou,Yacheng Liao,Chang Xie,Beibei Chu,Honghua Miao,Boliang Li,Xiongjie Shi,Bao-Liang SongMost mammalian cells take up cholesterol from low-density lipoproteins (LDLs) via receptor-mediated endocytosis. After reaching lysosomes, LDL-derived cholesterol continues to transport to downstream organelles including the ER for specific structural and functional needs. Peroxisomes are recently found to receive cholesterol from lysosomes through lysosome-peroxisome membrane contacts. However, whether ...
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Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance.Nature Metabolism (IF 19.865) Pub Date : 2019-05-06 ,DOI:10.1038/s42255-019-0065-4Xue-Min Gong,Yun-Feng Li,Jie Luo,Ji-Qiu Wang,Jian Wei,Ju-Qiong Wang,Ting Xiao,Chang Xie,Jie Hong,Guang Ning,Xiong-Jie Shi,Bo-Liang Li,Wei Qi,Bao-Liang SongMetabolism in mammals is regulated by complex interplay among different organs. Fatty acid synthesis is increased in white adipose tissue (WAT) when it is inhibited in the liver. Here we identify glycoprotein non-metastatic melanoma protein B (Gpnmb) as one liver–WAT cross-talk factor involved in lipogenesis. Inhibition of the hepatic sterol regulatory element-binding protein pathway leads to increased ...
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Exposure to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) induces vascular toxicity through Nrf2-VEGF pathway in zebrafish and human umbilical vein endothelial cellsEnvironmental Pollution (IF 9.988) Pub Date : 2019-01-03 ,DOI:10.1016/j.envpol.2018.12.066Xiali Zhong,Jiahuang Qiu,Jianmeng Kang,Xiumei Xing,Xiongjie Shi,Yanhong WeiThe growing production and extensive use of organophosphate flame retardants (OPFRs) have led to an increase in their environmental distribution and human exposure. Developmental toxicity is a major concern of OPFRs' adverse health effects. However, the impact of OPFRs exposure on vascular development and the toxicity pathway for developmental defects are poorly understood. In this study, we investigated ...
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Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol.Nature Communications (IF 17.694) Pub Date : 2018-12-03 ,DOI:10.1038/s41467-018-07590-3Shi-You Jiang,Hui Li,Jing-Jie Tang,Jie Wang,Jie Luo,Bing Liu,Jin-Kai Wang,Xiong-Jie Shi,Hai-Wei Cui,Jie Tang,Fan Yang,Wei Qi,Wen-Wei Qiu,Bao-Liang Song
Statins are inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis, and have been clinically used to treat cardiovascular disease. However, a paradoxical increase of reductase protein following statin treatment may attenuate the effect and increase the side effects. Here we present a previously unexplored strategy to alleviate statin-induced reductase accumulation by
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The non-canonical NF-κB pathway promotes NPC2 expression and regulates intracellular cholesterol trafficking.Science China Life Sciences Pub Date : 2018-08-10 ,DOI:10.1007/s11427-018-9339-0Yacheng Liao,Jian Wei,Juqiong Wang,Xiongjie Shi,Jie Luo,Bao-Liang SongNiemann-Pick type C2 (NPC2) is a lysosome luminal protein that functions in concert with NPC1 to mediate egress of low-density lipoprotein-derived cholesterol from lysosome. The nuclear factor kappa B subunit 2 (NF-κB2) protein is a component of NF-κB transcription factor complex critically implicated in immune and inflammatory responses. Here, we report that NF-κB2 regulates intracellular cholesterol ...
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The non-canonical NF-κB pathway promotes NPC2 expression and regulates intracellular cholesterol traffickingScience China Life Sciences Pub Date : 2018-08-07 ,DOI:10.1007/s11427-018-9339-0Yacheng Liao, Jian Wei, Juqiong Wang, Xiongjie Shi, Jie Luo, Bao-Liang SongNiemann-Pick type C2 (NPC2) is a lysosome luminal protein that functions in concert with NPC1 to mediate egress of low-density lipoprotein-derived cholesterol from lysosome. The nuclear factor kappa B subunit 2 (NF-κB2) protein is a component of NF-κB transcription factor complex critically implicated in immune and inflammatory responses. Here, we report that NF-κB2 regulates intracellular cholesterol ...
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Waterborne exposure to low concentrations of BDE-47 impedes early vascular development in zebrafish embryos/larvaeAquatic Toxicology (IF 5.202) Pub Date : 2018-07-17 ,DOI:10.1016/j.aquatox.2018.07.012Xiumei Xing,Jianmeng Kang,Jiahuang Qiu,Xiali Zhong,Xiongjie Shi,Bingsheng Zhou,Yanhong WeiPolybrominated diphenyl ethers (PBDEs) are persistent flame retardants ubiquitously existing in various environment matrices. In spite of a recent reduction in use according to the phase-out policy, high levels of PBDEs are still found in both environmental and biological samples due to their persistent property and large-scale production over a long history. Developmental toxicity is a major health ...
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Regulation of Cholesterol Sulfotransferase SULT2B1b by Hepatocyte Nuclear Factor 4α Constitutes a Negative Feedback Control of Hepatic Gluconeogenesis.Molecular and Cellular Biology (IF 5.069) Pub Date : 2018-03-15 ,DOI:10.1128/mcb.00654-17Yuhan Bi,Xiongjie Shi,Junjie Zhu,Xiudong Guan,Wojciech G Garbacz,Yixian Huang,Li Gao,Jiong Yan,Meishu Xu,Songrong Ren,Shunlin Ren,Yulan Liu,Xiaochao Ma,Song Li,Wen Xie
The cholesterol sulfotransferase SULT2B1b converts cholesterol to cholesterol sulfate (CS). We previously reported that SULT2B1b inhibits hepatic gluconeogenesis by antagonizing the gluconeogenic activity of hepatocyte nuclear factor 4α (HNF4α). In this study, we showed that the SULT2B1b gene is a transcriptional target of HNF4α, which led to our hypothesis that the induction of SULT2B1b by HNF4α represents
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Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.Journal of Biological Chemistry (IF 5.486) Pub Date : 2018-01-28 ,DOI:10.1074/jbc.ra117.001260Lu-Yi Jiang,Wei Jiang,Na Tian,Yan-Ni Xiong,Jie Liu,Jian Wei,Kai-Yue Wu,Jie Luo,Xiong-Jie Shi,Bao-Liang Song
Cholesterol biosynthesis is tightly regulated in the cell. For example, high sterol concentrations can stimulate degradation of the rate-limiting cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase, HMGCR). HMGCR is broken down by the endoplasmic reticulum membrane-associated protein complexes consisting of insulin-induced genes (Insigs) and the E3 ubiquitin
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PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P2 homeostasis.Journal of Lipid Research (IF 6.676) Pub Date : 2018-01-22 ,DOI:10.1194/jlr.m082149Ao Hu,Xue-Tong Zhao,Heng Tu,Ting Xiao,Ting Fu,Yan Wang,Yong Liu,Xiong-Jie Shi,Jie Luo,Bao-Liang Song
The transport of LDL-derived cholesterol from lysosomes to peroxisomes is facilitated by membrane contacts formed between the lysosomal protein synaptotagmin VII and the peroxisomal lipid phosphatidylinositol 4, 5-bisphosphate [PI(4,5)P2]. Here, we used RNA interference to search for regulators of PI(4,5)P2 and to study the effects of altered PI(4,5)P2 homeostasis on cholesterol transport. We found
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The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes.Cell Reports (IF 9.995) Pub Date : 2017-06-27 ,DOI:10.1016/j.celrep.2017.06.012Jian Wei,Ying-Yu Zhang,Jie Luo,Ju-Qiong Wang,Yu-Xia Zhou,Hong-Hua Miao,Xiong-Jie Shi,Yu-Xiu Qu,Jie Xu,Bo-Liang Li,Bao-Liang Song
Proper intracellular cholesterol trafficking is critical for cellular function. Two lysosome-resident proteins, NPC1 and NPC2, mediate the egress of low-density lipoprotein-derived cholesterol from lysosomes. However, other proteins involved in this process remain largely unknown. Through amphotericin B-based selection, we isolated two cholesterol transport-defective cell lines. Subsequent whole-t
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Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae.Chemosphere (IF 8.943) Pub Date : 2015-11-01 ,DOI:10.1016/j.chemosphere.2015.10.056Biran Zhu,Qiangwei Wang,Xiongjie Shi,Yongyong Guo,Tao Xu,Bingsheng ZhouThe effect of combined exposure to decabromodiphenyl ether (BDE-209) and lead (Pb) on neurodevelopment of zebrafish (Danio rerio) larvae was investigated. Zebrafish embryos were exposed to Pb (0, 5, 10, 20 µg/L) and BDE-209 (0, 50, 100, 200 µg/L), either alone or in combination (Mix1: 5 + 50 µg/L, Mix2: 10 + 100 µg/L, Mix3: 20 + 200 µg/L) for up to 144 h post-fertilization. Growth of secondary motoneuron ...
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The developmental neurotoxicity of polybrominated diphenyl ethers: Effect of DE-71 on dopamine in zebrafish larvae.Environmental Toxicology and Chemistry (IF 4.218) Pub Date : 2015 May ,DOI:10.1002/etc.2906Xianfeng Wang,Lihua Yang,Yuanyuan Wu,Changjiang Huang,Qiangwei Wang,Jian Han,Yongyong Guo,Xiongjie Shi,Bingsheng ZhouThe potential neurotoxicity of polybrominated diphenyl ethers (PBDEs) is still a great concern. In the present study, the authors investigated whether exposure to PBDEs could affect the neurotransmitter system and cause developmental neurotoxicity in zebrafish. Zebrafish embryos (2 h postfertilization) were exposed to different concentrations of the PBDE mixture DE-71 (0-100 mug/L). The larvae were ...
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The developmental neurotoxicity of polybrominated diphenyl ethers: Effect of DE‐71 on dopamine in zebrafish larvaeEnvironmental Toxicology and Chemistry (IF 4.218) Pub Date : 2015-04-07 ,DOI:10.1002/etc.2906Xianfeng Wang, Lihua Yang, Yuanyuan Wu, Changjiang Huang, Qiangwei Wang, Jian Han, Yongyong Guo, Xiongjie Shi, Bingsheng ZhouThe potential neurotoxicity of polybrominated diphenyl ethers (PBDEs) is still a great concern. In the present study, the authors investigated whether exposure to PBDEs could affect the neurotransmitter system and cause developmental neurotoxicity in zebrafish. Zebrafish embryos (2 h postfertilization) were exposed to different concentrations of the PBDE mixture DE‐71 (0–100 μg/L). The larvae were ...
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