- 作 者: ( "zhiquan tian" OR "zhi-quan tian" )
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Smartphone-Based Quantitative Detection of Ochratoxin A in Wheat via a Lateral Flow Assay.Foods (IF 5.561) Pub Date : 2023-01-17 ,DOI:10.3390/foods12030431Yunxin Tian,Xiaofeng Hu,Jun Jiang,Xiaoqian Tang,Zhiquan Tian,Zhaowei Zhang,Peiwu Li
Ochratoxin A (OTA) poses a severe health risk to livestock along the food chain. Moreover, according to the International Agency for Research on Cancer, it is also categorized as being possibly carcinogenic to humans. The lack of intelligent point-of-care test (POCT) methods restricts its early detection and prevention. This work establishes a smartphone-enabled point-of-care test for OTA detection
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The second near-infrared window quantum dot-based fluorescence anisotropy probes for separation-free, sensitive and rapid detection of small extracellular vesicle PD-L1 in plasma samplesSensors and Actuators B: Chemical (IF 9.221) Pub Date : 2022-11-05 ,DOI:10.1016/j.snb.2022.132962Jing Liu, Zi-Li Yu, Rui Xu, Zhi-Ling Zhang, Xuechuan Hong, Shifeng Wang, Gang Chen, Zhi-Quan TianStudies revealed that the levels of small extracellular vesicle (sEV) programmed cell death-ligand 1 (PD-L1) may serve as a predictive biomarker for the clinical responses to immunotherapy. While, the currently available enzyme-linked immunosorbent assay (ELISA)-based quantitative analysis of sEV PD-L1 is tedious and time-consuming and have low sensitivity. Additionally, to avoid the interference signal ...
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Novel diketopyrrolopyrrole NIR-II fluorophores and DDR inhibitors for in vivo chemo-photodynamic therapy of osteosarcomaChemical Engineering Journal (IF 16.744) Pub Date : 2022-05-11 ,DOI:10.1016/j.cej.2022.136929Xiaoding Cheng, Chong Zhang, Kun Shen, Huifan Liu, Caihong Bai, Qihang Ding, Mengting Guan, Junzhu Wu, Zhiquan Tian, Deliang Chen, Lin Cai, Xuechuan Hong, Yuling XiaoDNA damage response (DDR) inhibitors potentiate the therapeutic efficacy in osteosarcoma (OS) treatment. However, drug resistance, severe collateral toxicity, and poor bioavailability of DDR inhibitors in vivo are the main challenges. The NIR-II fluorescence image-guided photodynamic therapy exhibits advantageous properties and shows great potential in oncology, representing an emerging class of non-invasive ...
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Photoluminescence Enhancement of NIR-II Emissive Ag2S Quantum Dots via Chloride-Mediated Growth and PassivationAdvanced Optical Materials (IF 10.05) Pub Date : 2022-03-18 ,DOI:10.1002/adom.202102806Liang-Jun Pan, Jia-Wei Tu, Ling-Ling Yang, Zhi-Quan Tian, Zhi-Ling ZhangAg2S quantum dots (QDs) with high photoluminescence quantum yield (PLQY) in the second near-infrared (NIR-II, 1000–1700 nm) window are urgently pursued. Halide atoms (especially chloride) have been studied as inorganic capping ligands on improving the PLQY of Cd-, Pb-based chalcogenide QDs; however, it remains a challenge to well replace the organic ligand with chloride ligand from silver chalcogenide ...
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A Second Near-Infrared Ru(II) Polypyridyl Complex for Synergistic Chemo-Photothermal TherapyJournal of Medicinal Chemistry (IF 8.039) Pub Date : 2022-01-07 ,DOI:10.1021/acs.jmedchem.1c01736Yishen Liu, Qianqian Li, Meijia Gu, Disheng Lu, Xiaoxing Xiong, Zhiyun Zhang, Yanna Pan, Yuqin Liao, Qihang Ding, Wanxia Gong, Dean Shuailin Chen, Mengting Guan, Junzhu Wu, Zhiquan Tian, Hai Deng, Lijuan Gu, Xuechuan Hong, Yuling XiaoThe clinical success of cisplatin ushered in a new era of the application of metallodrugs. When it comes to practice, however, drug resistance, tumor recurrence, and drug systemic toxicity make it implausible to completely heal the patients. Herein, we successfully transform an electron acceptor [1, 2, 5]thiadiazolo[3,4-g]quinoxaline into a novel second near-infrared (NIR-II) fluorophore H7. After ...
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Organic NIR-II dyes with ultralong circulation persistence for image-guided delivery and therapyJournal of Controlled Release (IF 11.467) Pub Date : 2022-01-05 ,DOI:10.1016/j.jconrel.2022.01.005Yang Li, Jianfeng Gao, Shuping Wang, Shijun Li, Xiaowen Hou, Yanna Pan, Jialu Gao, Xue Qiao, Zhiquan Tian, Deliang Chen, Hai Deng, Zixin Deng, Xuechuan Hong, Yuling XiaoNanocarriers hold great promise for the controlled release of therapeutic payloads to target organs/tissues and extended duration of anticancer agents in the bloodstream. However, limited data on their in vivo pharmacokinetics and delivery process hamper clinical applications. Here we report a series of micellar nanocarriers self-assembled from new-generation thiophenthiadiazole (TTD)-based NIR-II ...
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Self-assembled NIR-II Fluorophores with Ultralong Blood Circulation for Cancer Imaging and Image-guided SurgeryJournal of Medicinal Chemistry (IF 8.039) Pub Date : 2021-12-24 ,DOI:10.1021/acs.jmedchem.1c01615Yang Li, Jianfeng Gao, Shuping Wang, Mingxia Du, Xiaowen Hou, Tian Tian, Xue Qiao, Zhiquan Tian, Peter J. Stang, Shijun Li, Xuechuan Hong, Yuling XiaoComplete excision of the last remaining 1–2% of tumor tissue without collateral damage remains particularly challenging. Herein, we report thiophenthiadiazole (TTD)-derived fluorophores L6-PEGnk (n = 1, 2, 5) as new-generation NIR-II (1000–1700 nm) probes with exceptional nonfouling performance and significantly high fluorescence quantum yields in water. L6-PEG2k can self-assemble into vesicular micelles ...
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Recapitulating Developmental Condensation and Constructing Self-organised Cartilaginous Tissue for Cartilage Regeneration.The Chinese Journal of Dental Research Pub Date : 2021-04-23 ,DOI:10.3290/j.cjdr.b1105873Li Li Bao,Si Ying Liu,Xin Yu Qiu,Zhi Quan Tian,Yong Jie Zhang,Shi Yu LiuOBJECTIVE To develop a novel chondrocyte condensation culture strategy recapitulating developmental condensation and construct self-organised cartilaginous tissue for cartilage regeneration. METHODS Cell-condensation aggregate (CCA) was generated using the condensation culture method by sequential cell seeding. The chondrification capacities and biocompatibilities of CCA were assessed by comparison ...
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Recapitulating Developmental Condensation and Constructing Self-organised Cartilaginous Tissue for Cartilage Regeneration.The Chinese Journal of Dental Research Pub Date : 2021-04-23 ,DOI:10.3290/j.cjdr.b1105873Li Li Bao,Si Ying Liu,Xin Yu Qiu,Zhi Quan Tian,Yong Jie Zhang,Shi Yu LiuOBJECTIVE To develop a novel chondrocyte condensation culture strategy recapitulating developmental condensation and construct self-organised cartilaginous tissue for cartilage regeneration. METHODS Cell-condensation aggregate (CCA) was generated using the condensation culture method by sequential cell seeding. The chondrification capacities and biocompatibilities of CCA were assessed by comparison ...
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A near-infrared-II fluorescence anisotropy strategy for separation-free detection of adenosine triphosphate in complex mediaTalanta (IF 6.556) Pub Date : 2020-10-04 ,DOI:10.1016/j.talanta.2020.121721Ya-Ling Fan, Zhen-Ya Liu, Yu-Mei Zeng, Lu-Yao Huang, Zheng Li, Zhi-Ling Zhang, Dai-Wen Pang, Zhi-Quan TianFluorescence anisotropy (FA) has been widely applied for detecting and monitoring special targets in life sciences. However, matrix autofluorescence restricted its further application in complex biological samples. Herein, we report a near-infrared-II (NIR-II) FA strategy for detecting adenosine triphosphate (ATP) in human serum samples and breast cancer cell lysate, which employed NIR-II fluorescent ...
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Ag2Te Quantum Dots as Contrast Agents for Near-Infrared Fluorescence and Computed Tomography ImagingACS Applied Energy Materials (IF 6.959) Pub Date : 2020-05-29 ,DOI:10.1021/acsanm.0c01274Ming-Xia Yu, Jiao-Jiao Ma, Jia-Mei Wang, Wei-Guo Cai, Zheng Zhang, Ben Huang, Meng-Ying Sun, Qing-Yuan Cheng, Zhi-Ling Zhang, Dai-Wen Pang, Zhi-Quan TianMultifunctional nanoparticles hold great potential for clinical and medical research. Herein, Ag2Te QDs were applied as multifunctional contrast agents for the second near-infrared region (NIR-II) fluorescence and X-ray computed tomography (CT) imaging. In vitro and in vivo experiments demonstrated that Ag2Te QDs exhibited low toxicity and remarkable fluorescence and CT imaging contrast properties ...
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Ag2Te Quantum Dots as Contrast Agents for Near-Infrared Fluorescence and Computed Tomography ImagingACS Applied Nano Materials (IF 6.14) Pub Date : 2020-05-29 ,DOI:10.1021/acsanm.0c01274Ming-Xia Yu, Jiao-Jiao Ma, Jia-Mei Wang, Wei-Guo Cai, Zheng Zhang, Ben Huang, Meng-Ying Sun, Qing-Yuan Cheng, Zhi-Ling Zhang, Dai-Wen Pang, Zhi-Quan TianMultifunctional nanoparticles hold great potential for clinical and medical research. Herein, Ag2Te QDs were applied as multifunctional contrast agents for the second near-infrared region (NIR-II) fluorescence and X-ray computed tomography (CT) imaging. In vitro and in vivo experiments demonstrated that Ag2Te QDs exhibited low toxicity and remarkable fluorescence and CT imaging contrast properties ...
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Target-modulated sensitization of upconversion luminescence by NIR-emissive quantum dots: a new strategy to construct upconversion biosensors.Chemical Communications (IF 6.065) Pub Date : 2020-01-21 ,DOI:10.1039/c9cc09220jTianyu Yu,Dong-Mei Wei,Zhen Li,Liang-Jun Pan,Zhi-Ling Zhang,Zhi-Quan Tian,Zhihong LiuWe herein used Ag2Se quantum dots (QDs) as a target-modulated sensitizer for upconversion nanoparticles (UCNPs) and the target thrombin as the sensitizing switch to construct a biosensor, circumventing the limited luminescence resonance energy transfer (LRET) efficiency of UCNPs, with enhanced signal-to-background ratio (SBR) and assay sensitivity. ...
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Economical synthesis of ultra-small Bi2S3 nanoparticles for high-sensitive CT imagingMaterials Research Express (IF 2.025) Pub Date : 2019-07-01 ,DOI:10.1088/2053-1591/ab2b6bHui-Li Zhu,Qing-Yuan Cheng,Mei-Yan Liao,Zhi-Ling Zhang,Wei-Guo Cai,Jiao-Jiao Ma,Meng-Ying Sun,Ming-Xia Yu,Zhi-Quan Tian,Dai-Wen PangUltra-small Bi2S3 nanoparticles are potential contrast agents for high-sensitive CT imaging. However, the expensive and harmful synthesis process limited their further application. Herein, an economical and low-toxic process was developed by employing S powders as sulfur precursors for large-scale preparation of ultra-small Bi2S3 nanoparticles. The as-prepared ultra-small Bi2S3 nanoparticles were modified ...
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Bacteria photosensitized by intracellular gold nanoclusters for solar fuel productionNature Nanotechnology (IF 40.523) Pub Date : 2018-10-01 ,DOI:10.1038/s41565-018-0267-zHao Zhang,Hao Liu,Zhiquan Tian,Dylan Lu,Yi Yu,Stefano Cestellos-Blanco,Kelsey K. Sakimoto,Peidong YangThe demand for renewable and sustainable fuel has prompted the rapid development of advanced nanotechnologies to effectively harness solar power. The construction of photosynthetic biohybrid systems (PBSs) aims to link preassembled biosynthetic pathways with inorganic light absorbers. This strategy inherits both the high light-harvesting efficiency of solid-state semiconductors and the superior catalytic ...
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Gd-DTPA-coupled Ag2Se quantum dots for dual-modality magnetic resonance imaging and fluorescence imaging in the second near-infrared window†Nanoscale (IF 8.307) Pub Date : 2018-05-15 ,DOI:10.1039/c8nr02017eJiao-Jiao Ma,Ming-Xia Yu,Zheng Zhang,Wei-Guo Cai,Zhi-Ling Zhang,Hui-Li Zhu,Qing-Yuan Cheng,Zhi-Quan Tian,Dai-Wen PangNear-infrared (NIR) fluorescent quantum dots (QDs) are ideal platforms to fabricate multifunctional contrast agents for multimodal imaging. Herein, second near-infrared window fluorescent (NIR-II) Ag2Se QDs were coupled with gadopentetate dimeglumine injection (Gd-DTPA) for dual-modality T1-weighted magnetic resonance (MR) imaging and fluorescence imaging. In vitro experiments suggested that the prepared ...
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Stable CsPbBr3 perovskite quantum dots with high fluorescence quantum yields†New Journal of Chemistry (IF 3.925) Pub Date : 2018-05-10 ,DOI:10.1039/c8nj01191eMin Zhang,Zhi-Quan Tian,Dong-Liang Zhu,He He,San-Wei Guo,Zhi-Liang Chen,Dai-Wen PangAll-inorganic CsPbX3 (X = I, Br, Cl) perovskite nanocrystals have emerged as a new class of optoelectronic material with tunable emission wavelengths, narrow full-width at half-maximum (FWHM) and high photoluminescence quantum yields (PLQYs) (≥50% in general). However, the instability caused by high delocalization of surface ions is still the major issue that obstructs their application. The type of ...
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Ultrasmall Pb:Ag2S Quantum Dots with Uniform Particle Size and Bright Tunable Fluorescence in the NIR‐II WindowSmall (IF 15.153) Pub Date : 2018-01-29 ,DOI:10.1002/smll.201703296He He,Yi Lin,Zhi-Quan Tian,Dong-Liang Zhu,Zhi-Ling Zhang,Dai-Wen PangAg2S quantum dots (QDs) are well‐known near‐infrared fluorophores and have attracted great interest in biomedical labeling and imaging in the past years. However, their photoluminescence efficiency is hard to compete with Cd‐, Pb‐based QDs. The high Ag+ mobility in Ag2S crystal, which causes plenty of cation deficiency and crystal defects, may be responsible mainly for the low photoluminescence quantum ...
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Controllable synthesis of nanocrystals in droplet reactorsLab on a Chip (IF 7.517) Pub Date : 2017-11-03 ,DOI:10.1039/c7lc00800gLiang-Jun Pan,Jia-Wei Tu,Hao-Tian Ma,Yu-Jun Yang,Zhi-Quan Tian,Dai-Wen Pang,Zhi-Ling ZhangIn recent years, a broad range of nanocrystals have been synthesized in droplet-based microfluidic reactors which provide obvious advantages, such as accurate manipulation, better reproducibility and reliable automation. In this review, we initially introduce general concepts of droplet reactors followed by discussions of their main functional regions including droplet generation, mixing of reactants ...
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Real-Time Dissection of Distinct Dynamin-Dependent Endocytic Routes of Influenza A Virus by Quantum Dot-Based Single-Virus TrackingACS Nano (IF 18.027) Pub Date : 2017-04-03 ,DOI:10.1021/acsnano.6b07853En-Ze Sun,An-An Liu,Zhi-Ling Zhang,Shu-Lin Liu,Zhi-Quan Tian,Dai-Wen PangEntry is the first critical step for the infection of influenza A virus and of great significance for the research and development of antiflu drugs. Influenza A virus depends on exploitation of cellular endocytosis to enter its host cells, and its entry behaviors in distinct routes still need further investigation. With the aid of a single-virus tracking technique and quantum dots, we have realized ...
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Near‐Infrared Fluorescent Ag2Se–Cetuximab Nanoprobes for Targeted Imaging and Therapy of CancerSmall (IF 15.153) Pub Date : 2016-11-07 ,DOI:10.1002/smll.201602309Chun-Nan Zhu,Gang Chen,Zhi-Quan Tian,Wei Wang,Wen-Qun Zhong,Zheng Li,Zhi-Ling Zhang,Dai-Wen PangTheranostic nanoprobes integrated with diagnostic imaging and therapy capabilities have shown great potential for highly effective tumor therapy by realizing imaging‐guided drug delivery and tumor treatment. Developing novel high‐performance nanoprobes is an important basis for tumor theranostic application. Here, near‐infrared (NIR) fluorescent and low‐biotoxicity Ag2Se quantum dots (QDs) have been ...
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Purification of quantum dot-based bioprobes via high-performance size exclusion chromatography.Talanta (IF 6.556) Pub Date : 2016-07-31 ,DOI:10.1016/j.talanta.2016.05.078Jia-Kai Wu,Zhi-Quan Tian,Zhi-Ling Zhang,An-An Liu,Bo Tang,Li-Juan Zhang,Zhi-Liang Chen,Dai-Wen PangDue to excellent optical properties, quantum dots (QDs) have been widely applied to sensing, labeling, and imaging. For the fabrication of QD-based bioprobes, purification is usually the crucial step. Hydrophilic octylamine grafted polyacrylic acid modified QDs (OPA-QDs) were prepared, and purified by high-performance size exclusion chromatography (HPSEC) to remove excess OPA and aggregated QDs. The ...
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Near-infrared Ag2Se quantum dots with distinct absorption features and high fluorescence quantum yields†RSC Advances (IF 4.036) Pub Date : 2016-04-07 ,DOI:10.1039/c6ra04987gLi-Juan Shi,Chun-Nan Zhu,He He,Dong-Liang Zhu,Zhi-Ling Zhang,Dai-Wen Pang,Zhi-Quan TianNear-infrared Ag2Se quantum dots (QDs) with distinct absorption features ranging between 830–954 nm and fluorescence quantum yields up to 23.4% were controllably synthesized using a phosphine-free approach. Based on the distinct absorption features, the molar extinction coefficients of the Ag2Se QDs have been determined. ...
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Dissecting the Factors Affecting the Fluorescence Stability of Quantum Dots in Live Cells.ACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2016 Apr 6 ,DOI:10.1021/acsami.6b01742Zhi-Gang Wang,Shu-Lin Liu,Yuan-Jun Hu,Zhi-Quan Tian,Bin Hu,Zhi-Ling Zhang,Dai-Wen PangLabeling and imaging of live cells with quantum dots (QDs) has attracted great attention in the biomedical field over the past two decades. Maintenance of the fluorescence of QDs in a biological environment is crucial for performing long-term cell tracking to investigate the proliferation and functional evolution of cells. The cell-penetrating peptide transactivator of transcription (TAT) is a well-studied ...
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Dissecting the Factors Affecting the Fluorescence Stability of Quantum Dots in Live CellsACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2016-03-28 ,DOI:10.1021/acsami.6b01742Zhi-Gang Wang,Shu-Lin Liu,Yuan-Jun Hu,Zhi-Quan Tian,Bin Hu,Zhi-Ling Zhang,Dai-Wen PangLabeling and imaging of live cells with quantum dots (QDs) has attracted great attention in the biomedical field over the past two decades. Maintenance of the fluorescence of QDs in a biological environment is crucial for performing long-term cell tracking to investigate the proliferation and functional evolution of cells. The cell-penetrating peptide transactivator of transcription (TAT) is a well-studied ...
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Exploring Sialic Acid Receptors‐Related Infection Behavior of Avian Influenza Virus in Human Bronchial Epithelial Cells by Single‐Particle TrackingSmall (IF 15.153) Pub Date : 2014-03-20 ,DOI:10.1002/smll.201303532Zhi-Gang Wang,Shu-Lin Liu,Zhi-Ling Zhang,Zhi-Quan Tian,Hong-Wu Tang,Dai-Wen PangHuman respiratory tract epithelial cells are the portals of human infection with influenza viruses. However, the infection pathway of individual avian influenza viruses in human respiratory cells remains poorly reported so far. The single‐particle tracking technique (SPT) is a powerful tool for studying the transport mechanism of biomolecules in live cells. In this work, we use quantum dots to label ...
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Evaluation of nonspecific interactions between quantum dots and proteins†Physical Chemistry Chemical Physics (IF 3.945) Pub Date : 2014-03-05 ,DOI:10.1039/c4cp00572dQing-Ying Luo,Yi Lin,Jun Peng,Shu-Lin Liu,Zhi-Ling Zhang,Zhi-Quan Tian,Dai-Wen PangA method based on the AFM and colloidal probe techniques was proposed to directly measure nonspecific interactions between QDs and different proteins with respective sizes and isoelectric points. Results indicated that van der Waals forces were the leading force, while electrostatic interactions also played an important role in nonspecific interactions. ...
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Mechanism-Oriented Controllability of Intracellular Quantum Dots Formation: The Role of Glutathione Metabolic PathwayACS Nano (IF 18.027) Pub Date : 2013-02-15 ,DOI:10.1021/nn305346aYong Li,Ran Cui,Peng Zhang,Bei-Bei Chen,Zhi-Quan Tian,Li Li,Bin Hu,Dai-Wen Pang,Zhi-Xiong XieMicrobial cells have shown a great potential to biosynthesize inorganic nanoparticles within their orderly regulated intracellular environment. However, very little is known about the mechanism of nanoparticle biosynthesis. Therefore, it is difficult to control intracellular synthesis through the manipulation of biological processes. Here, we present a mechanism-oriented strategy for controlling the ...
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Ag2Se Quantum Dots with Tunable Emission in the Second Near-Infrared WindowACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2013-02-11 ,DOI:10.1021/am303110xChun-Nan Zhu,Peng Jiang,Zhi-Ling Zhang,Dong-Liang Zhu,Zhi-Quan Tian,Dai-Wen PangQuantum dots (QDs) with fluorescence in the second near-infrared window (NIR-II, 1000–1400 nm) are ideal fluorophores for in vivo imaging of deep tissue with high signal-to-noise ratios. Ag2Se (bulk band gap 0.15 eV) is a promising candidate for preparing NIR-II QDs. By using 1-octanethiol as ligand to effectively balance the nucleation and growth, tuning the fluorescence of Ag2Se QDs was successfully ...
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One-Step Sensitive Detection of Salmonella typhimurium by Coupling Magnetic Capture and Fluorescence Identification with Functional NanospheresAnalytical Chemistry (IF 8.008) Pub Date : 2013-01-04 ,DOI:10.1021/ac303204qCong-Ying Wen,Jun Hu,Zhi-Ling Zhang,Zhi-Quan Tian,Guo-Ping Ou,Ya-Long Liao,Yong Li,Min Xie,Zi-Yong Sun,Dai-Wen PangSensitive, rapid, and reliable detection of bacteria has always been pursued due to the great threat of the bacteria to human health. In this study, a convenient one-step strategy for detecting Salmonella typhimurium was developed. Immunomagnetic nanospheres (IMNS) and immunofluorescent nanospheres (IFNS) were used to specifically capture and recognize S. typhimurium simultaneously. After magnetic ...
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